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Oxcarbazepine oral suspension in pediatric patients with partial seizures and/or generalized tonic-clonic seizures: a multi-center, single arm, observational study in China

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World Journal of Pediatrics 2017年第6期13卷 551-559页

作者： yi Wang yin-Bo Chen Yu-Qin Zhang Rong Luo Hua Wang jun-Lan Lv Dong Wang Sui-Qiang Zhu Zhong-Dong Lin Jiong Qin Department of Neurology Children's Hospital of Fudan UniversityShanghaiChina Department of Pediatric Neurology The First Bethune Hospital of Jilin UniversityChangchunChina Department of Neurology Tianjin Children's HospitalTianjinChina Department of Pediatric Neurology West China Second University Hospital of Sichuan UniversityChengduChina Department of Pediatric Neurology Shengjing Hospital of China Medical UniversityShenyangChina Department of Neurology Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Neurology Xi'an Children's HospitalXi'anChina Department of Neurology Tongji HospitalTongji Medical College of Huazhong University of Science&TechnologyWuhanChina Department of Pediatric Neurology The 2nd Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of Pediatrics Peking University People's HospitalBeijingChina

Background:To assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-16 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in ***:This 26-week,single arm,multicenter and observational study recruited patients aged 2-16 years with PS or GTCS suitable for OXC oral suspension *** patients received OXC oral suspension treatment for 26 *** endpoints included mean seizure frequency at the end of the treatment and mean seizure frequency reduction at the end of the treatment *** efficacy-related endpoints and safety parameters were also ***:Nine hundred and eighty-seven pediatric patients were enrolled and 912 (92.4%) completed the *** mean seizure frequencies at baseline and the end of week 26 were 13.40±64.92 and 1.62±19.47 times/month,*** mean seizure frequency reduction was 10.03±63.67 times/month and the mean seizure frequency reduction percentage was 90.02%±5127.0% (P<0.0001).After 26 weeks of treatment,82.36%,7.24% and 3.86% of the patients became controlled,significantly improved and improved,*** events (AEs) were reported in 74 (7.65%) *** was the most common *** efficacy of OXC was not affected by seizure types,age or ***:This study confirms the efficacy and good safety profile of OXC oral suspension in Chinese pediatric patients aged 2-16 years with PS and/or GTCS.

关键词： children efficacy generalized tonic-clonic seizures oxcarbazepine oral suspension partial seizures

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QTL Mapping of Isoflavone,Oil and Protein Contents in Soybean (Glycine max ***.)

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Agricultural Sciences in China 2010年第8期9卷 1108-1116页

作者： LIANG Hui-zhen YU Yong-liang WANG Shu-feng LIAN Yun WANG Ting-feng WEI Yan-li GONG Peng-tao LIU Xue-yi FANG Xuan-jun ZHANG Meng-chen Industrial Crops Research Institute Henan Academy of Agricultural Sciences/National Soybean Improvement Sub-Center of Zhengzhou Zhengzhou 450002 P.R.China Hainan Institute of Tropieal Agriculture Resources Sanya 572025 P.R. China Economical Crops Institute Shanxi Academy of Agricultural Sciences Fenyang 032200 P.R.China Institue of Cereal and Oil Crops Hebei Academy of Agricultural and Forestry Sciences Shijiazhuang 050031 P.R. China

Soybean （Glycine max L. Merr.） is the world＇s foremost source of edible plant oil and proteins, meantime, the biologically active secondary metabolites such as saponins and isoflavones are benefit to human health. The objective of this study was to identify quantitative trait loci （QTL） and epistatic interactions associated with isoflavone, protein, and oil contents in soybean seeds. An F13 recombinant inbred line （RIL） comprising 474 lines was derived from a cross between Jindou 23 and Huibuzhi cultivars. SSR technique was employed for mapping of the QTLs. The QTLs for isoflavone, protein, and oil contents were analyzed and 23 QTLs were detected based on the constructed linkage map. Six QTLs for isoflavone content were localized in linkage groups J, N, D2, and G, eleven QTLs for oil content were localized in the linkage groups A1, A2, B2, C2, and D2, and six QTLs for protein content were localized in linkage groups B2, C2, G, and H1. The correlative analysis demonstrated that the isoflavone content had significant correlation with protein content, while significantly negative correlations was existed between oil and protein content, and significantly positive correlations was existed between protein and oil content. All these findings have laid an important basis for the marker assisted breeding in soybean. The phenotypic correlations of quantitative traits may be resulted from the correlation of the QTL controlling those traits.

关键词： soybean SSR QTL quality isoflavone

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Percutaneous needle decompression in treatment of malignant small bowel obstruction

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World Journal of Gastroenterology 2015年第8期21卷 2467-2474页

作者： Ting-Hui Jiang Xian-jun Sun Yue Chen Hui-Qin Cheng Shi-Ming Fang Hao-Sheng Jiang Yan cao Bing-Yan Liu Shao-Qiu Wu Ai-Wu Mao Interventional Center St. Luke’s Hospital of Jiaotong University School of Medicine Department of Radiology Renji Hospital of Shanghai Jiaotong University School of Medicine Yangpu Daqiao Community Healthy Service Center

AIM:To investigate the efficacy and safety of percutaneous needle decompression in the treatment ofmalignant small bowel obstruction(MSBO).METHODS:A prospective analysis of the clinical data of 52 MSBO patients undergoing percutaneous needle decompression was ***:Percutaneous needle decompression was successful in all 52 *** significant differences were observed in symptoms such as vomiting,abdominal distension and abdominal pain before and after treatment(81.6%vs 26.5%,100%vs 8.2%,and 85.7%vs 46.9%,respectively;all P<0.05).The overall significantly improved rate was 19.2%(11/52)and the response rate was 94.2%(49/52)using decompression combined with nasal tube placement,local arterial infusion of chemotherapy and nutritional *** the one-month follow-up period,puncture-related complications were ***:Percutaneous needle intestinal decompression is a safe and effective palliative treatment for MSBO.

关键词： Arterial infusion chemotherapy Malignant small bow

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A novel flexible endoscope-based transumbilical fenestration of liver cyst

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Chinese Medical Journal 2008年第23期121卷 2461-2462页

作者： CAI Xiu-jun DAI yi WANG Jian-guo YU Hong LIANG Xiao ZHENG Xue-yong WANG yi-fan Department of General Surgery Sir Run Run Shaw Hospital Affiliated with School of Medicine Zhejiang University Hangzhou Zhejiang 310016 China

Laparoscopic procedure as a minimally invasive surgery had been introduced into many abdominal surgery. Smaller incisions of the abdominal wall reduce postoperative pain and the risk of wound complications, and provide an excellent cosmetic result compared with open surgery. Flexible endoscope-based transgastric, transcolonic, or transvaginal surgery for abdominal exploration, cholecystectomy, appendectomy, and tubal ligation may further reduce the surgical invasion.

关键词： liver cyst fenestration flexible endoscope, transumbilical

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A decrease in macular microvascular perfusion after retinal detachment repair with silicone oil

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 875-880页

作者： Wei Fang Jing Zhai Jian-Bo Mao Hai-Dong Li Zhen-Bin Qian Chao-Qiao Chen Jia-Hao Xu Li-jun Shen yi-Qi Chen The Eye Hospital of Wenzhou Medical University School of Opthalmology&OptometryWMUZhejiang Eye HospitalHangzhou 310000Zhejiang ProvinceChina

AIM:To observe whether silicone oil(SO)tamponade could decrease macular perfusion after retinal detachment ***:A prospective observational case-control *** diagnosed with primary macular off rhegmatogenous retinal detachment undergoing successful retinal repair surgery with vitrectomy were strictly *** coherence tomography angiography findings were compared between SO and air tamponade *** postoperative visiting points were set(1 and 3 mo).RESULTS:Totally 29 patients(29 eyes)were *** cases had SO tamponade while 9 cases were with air *** the first visiting point,superficial parafoveal vessel density(PFSVD)significantly decreased in the SO group(P=0.0403),especially in the superior quadrant or superior-hemi area(P=0.0089,0.0426,respectively).Parafoveal deep vessel density(PFDVD)had no difference between the two *** the second visiting point,all quadrants of PFSVD reduced significantly in the SO group(P=0.0256,0.0001,0.0031,<0.0001 in temporal,superior,nasal,and inferior area,respectively),but PFDVD remained no *** the air group,all areas of PFSVD showed significantly improving from the first visit to the second one(P=0.0324,0.0001,0.0371,0.0026,in temporal,superior,nasal,and inferior area,respectively);however,almost all quadrants of PFDVD showed no changes during this *** the SO group,both PFSVD and PFDVD showed no obvious changes between the two visiting ***,parafoveal full retinal thickness in the SO group reduced significantly at both visiting points over the air tamponade,while the foveal avascular zone area showed no difference in the two ***:After retinal detachment surgery with vitrectomy and SO tamponade,superficial macular perfusion and full retinal thickness could decrease obviously when compared to air *** reduction process could persist throughout the tamponade period.

关键词： macular perfusion vessel density silicone oil optical coherence tomography angiography retinal detachment

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Nomogram based on inflammation-related markers for predicting survival of patients undergoing hepatectomy for hepatocellular carcinoma

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World Journal of Clinical Cases 2021年第36期9卷 11193-11207页

作者： Tian Pu Zi-Han Li Dong Jiang Jiang-Ming Chen Qi Guo Ming Cai Zi-Xiang Chen Kun Xie yi-jun Zhao Fu-Bao Liu Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230022Anhui ProvinceChina

BACKGROUND Previous nomograms for hepatocellular carcinoma(HCC)did not include the neutrophil-to-lymphocyte ratio(NLR)or platelet-to-lymphocyte ratio(PLR).This study aimed to establish an effective nomogram capable of estimating the association between preoperative inflammatory factors and overall survival(OS)of HCC patients after *** To analyse the factors affecting the prognosis of HCC and establish a *** A total of 626 HCC patients(410 training set patients from the First Affiliated Hospital of Anhui Medical University and 216 validation set patients from the First Affiliated Hospital of University of Science and Technology of China)underwent hepatectomy from January 2014 to December 2017 and were followed up every 3–6 *** nomogram was based on OS-related independent risk factors identified by Cox regression *** C-index,calibration curve,and area under the curve(AUC)were used to evaluate the nomogram’s *** The 1-,2-and 3-year OS rates were 79.0%,68.0%and 45.4%in the training cohort(median OS=34 mo)and 92.1%,73.9%and 51.2%in the validation cohort(median OS=38 mo).Higherα-fetoprotein[hazard ratio(HR)=1.812,95%confidence interval(CI):1.343–2.444],NLR(HR=2.480,95%CI:1.856–3.312)and PLR(HR=1.974,95%CI:1.490–2.616),tumour size≥5 cm(HR=1.323,95%CI:1.002–1.747),and poor differentiation(HR=3.207,95%CI:1.944–5.290)were significantly associated with shortened *** developed nomogram integrating these variables showed good reliability in both the training(C-index=0.71)and validation cohorts(C-index=0.75).For predicting 1-,2-and 3-year OS,the nomogram had AUCs of 0.781,0.743 and 0.706 in the training cohort and 0.789,0.815 and 0.813 in the validation *** nomogram was more accurate in predicting prognosis than the AJCC TNM staging *** The prognostic nomogram combining pathological characteristics and inflammation indicators could provide a more accurate individualized risk estimate for the OS of HCC patie

关键词： Liver malignancy Nomogram Overall survival Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio

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小模型大数据:一种分析软件行为的代数方法

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软件学报 2017年第6期28卷 1488-1497页

作者：俞一峻刘春 School of Computing and Communications The Open University Milton Keynes 河南大学计算机与信息工程学院河南开封475001

问题框架方法分析软件需求时需要通过借助领域知识及其之间的结构关系来论述用户的需求是可以被软件系统满足的.这类定性的可满足性论述支持早期需求决策,选择合理的软件体系结构和设计方案.但是,当前的移动软件需求方是偏好各异的用户... 详细信息

问题框架方法分析软件需求时需要通过借助领域知识及其之间的结构关系来论述用户的需求是可以被软件系统满足的.这类定性的可满足性论述支持早期需求决策,选择合理的软件体系结构和设计方案.但是,当前的移动软件需求方是偏好各异的用户个体,需求差异化明显,而且根据应用场景,这些需求会动态地发生变化.在这种情况下,现有的定性分析方法不再适用.大数据分析提供一种数据驱动的深度学习机制,为很多实践者采用.但依靠数据驱动的软件分析往往就事论事,仍然不能从根本上提供一个合理的论述来说明大量软件用户的需求到底是什么,也无法对可信软件的安全性和私密性提供可靠的论证.再多的数据也只能提供统计意义的表象,而无法彻底防范借用漏洞的攻击.尝试从提炼软件抽象目标行为的角度进一步深化问题框架的研究思路,针对各类个体行为建立概率模型,提出一种基于模型代数分析的方法,以避开纯粹数据驱动思路的大数据分析盲点.通过对安全和隐私性问题的分析,对所提出的方法可用性及局限性进行探讨,对未来大数据软件需求研究给予一定的启示.

关键词：软件需求分析概率模型运营需求代数分析安全和私密性

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Mast Cells in Adjacent Normal Colon Mucosa rather than Those in Invasive Margin are Related to Progression of Colon Cancer

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Chinese Journal of Cancer Research 2011年第4期23卷 276-282页

作者： Qing Xia Ya Ding Xiao-jun Wu Rui-qing Peng Qiang Zhou Jing Zeng Jing-hui Hou Xing Zhang yi-xin Zeng Xiao-shi Zhang ying-bo Chen State Key Laboratory of Oncology in South China Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Medical Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China Biotherapy Center Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Colorectal Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Medical Oncology the First People Hospital of Yueyang Yueyang 414000 China Department of Pathology Cancer Center Sun Yat-sen University Guangzhou 510060 China Department of Gastric and Pancreatic Oncology Cancer Center Sun Yat-sen University Guangzhou 510060 China

Objective: Mast cells (MC) reside in the mucosa of the digestive tract as the first line against bacteria and toxins. Clinical evidence has implied that the infiltration of mast cells in colorectal cancers is related to malignant phenotypes and a poor prognosis. This study compared the role of mast cells in adjacent normal colon mucosa and in the invasive margin during the progression of colon cancer. Methods: Specimens were obtained from 39 patients with colon adenomas and 155 patients with colon cancers treated at the Sun Yat-sen University Cancer Center between January 1999 and July 2004. The density of mast cells was scored by an immunohistochemical assay. The pattern of mast cell distribution and its relationship with clinicopathologic parameters and 5-year survival were analyzed. Results: The majority of mast cells were located in the adjacent normal colon mucosa, followed by the invasive margin and least in the cancer stroma. Mast cell count in adjacent normal colon mucosa (MCCadjacent) was associated with pathologic classification, distant metastases and hepatic metastases, although it was not a prognostic factor. In contrast, mast cell count in the invasive margin (MCCinvasive) was associated with neither the clinicopathlogic parameters nor overall survival. Conclusion: Mast cells in the adjacent normal colon mucosa were related to the progression of colon cancer, suggesting that mast cells might modulate tumor progression via a long-distance mechanism.

关键词： Mast cell Colon cancer Mucosa Invasive margin Prognosis

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Schwinger Bose实现下自旋相干态Wigner函数的特性分析

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物理学报 2010年第10期59卷 6806-6813页

作者：宋军范洪义中国科学技术大学材料科学与工程系合肥230026 皖西学院数理系六安237012

在Schwinger Bose实现下,引入纠缠态表象及Wigner算符在该表象下的表示,得到自旋相干态的Wigner函数,数值计算画出相空间中Wigner函数的分布图,并加以分析,发现在SchwingerBose实现下自旋相干态确实体现出纠缠特性。

关键词：自旋相干态 Schwinger Bose实现 Wigner函数纠缠态表象

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Fundamentals and photocatalytic hydrogen evolution applications of quaternary chalcogenide semiconductor:Cu_(2)ZnSnS_(4)

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Rare Metals 2022年第7期41卷 2153-2168页

作者： Xin-Long Zheng ying-Jie Yang Yu-Hao Liu Pei-Lin Deng Jing Li Wei-Feng Liu Peng Rao Chun-Man Jia Wei Huang Yan-Lian Du yi-jun Shen Xin-Long Tian State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Laboratory of Fine ChemistrySchool of ScienceHainan UniversityHaikou 570228China Mechanical and Electrical Engineering College Hainan UniversityHaikou 570228China

Inexpensive,safe,and efficient conversion of solar energy to hydrogen from water splitting requires the development of effective and durable ***_(2)ZnSnS_(4)(CZTS),the emerging quaternary chalcogenide material for solar energy conversion,possesses many advantages,such as narrow direct band gap(1.5 eV),nontoxic,earth-abundance,and low melting ***,CZTS-based photocatalysts have been extensively investigated for their application as an active photocatalyst in hydrogen evolution from water splitting,while the performance is still highly needed to be improved for the practical *** this review,first,the crystal and band structure properties of CZTS are briefly introduced,and afterward,the basic principle of photocatalytic hydrogen evolution from water splitting is ***,the performance and status of bare CZTS,the combination of CZTS and co-catalysts,and CZTSbased heterojunction photocatalysts for hydrogen evolution are reviewed and discussed in ***,the issues and challenges currently encountered in the application of CZTS and their possible solutions for developing advanced CZTS photocatalysts are provided.

关键词： Cu_(2)ZnSnS_(4) Quaternary chalcogenide Photocatalyst Hydrogen evolution

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