Nomogram based on inflammation-related markers for predicting survival of patients undergoing hepatectomy for hepatocellular carcinoma

作     者：Tian Pu Zi-Han Li Dong Jiang Jiang-Ming Chen Qi Guo Ming Cai Zi-Xiang Chen Kun Xie Yi-Jun Zhao Fu-Bao Liu 

作者机构：Department of General SurgeryThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of General SurgeryThe First Affiliated Hospital of University of Science and Technology of ChinaHefei 230022Anhui ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第36期

页      面：11193-11207页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Key Research and Development Plan of Anhui Province No.1804h08020239(Dr.Liu FB) 

主　　题：Liver malignancy Nomogram Overall survival Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio 

摘      要：BACKGROUND Previous nomograms for hepatocellular carcinoma(HCC)did not include the neutrophil-to-lymphocyte ratio(NLR)or platelet-to-lymphocyte ratio(PLR).This study aimed to establish an effective nomogram capable of estimating the association between preoperative inflammatory factors and overall survival(OS)of HCC patients after *** To analyse the factors affecting the prognosis of HCC and establish a *** A total of 626 HCC patients(410 training set patients from the First Affiliated Hospital of Anhui Medical University and 216 validation set patients from the First Affiliated Hospital of University of Science and Technology of China)underwent hepatectomy from January 2014 to December 2017 and were followed up every 3–6 *** nomogram was based on OS-related independent risk factors identified by Cox regression *** C-index,calibration curve,and area under the curve(AUC)were used to evaluate the nomogram’s *** The 1-,2-and 3-year OS rates were 79.0%,68.0%and 45.4%in the training cohort(median OS=34 mo)and 92.1%,73.9%and 51.2%in the validation cohort(median OS=38 mo).Higherα-fetoprotein[hazard ratio(HR)=1.812,95%confidence interval(CI):1.343–2.444],NLR(HR=2.480,95%CI:1.856–3.312)and PLR(HR=1.974,95%CI:1.490–2.616),tumour size≥5 cm(HR=1.323,95%CI:1.002–1.747),and poor differentiation(HR=3.207,95%CI:1.944–5.290)were significantly associated with shortened *** developed nomogram integrating these variables showed good reliability in both the training(C-index=0.71)and validation cohorts(C-index=0.75).For predicting 1-,2-and 3-year OS,the nomogram had AUCs of 0.781,0.743 and 0.706 in the training cohort and 0.789,0.815 and 0.813 in the validation *** nomogram was more accurate in predicting prognosis than the AJCC TNM staging *** The prognostic nomogram combining pathological characteristics and inflammation indicators could provide a more accurate individualized risk estimate for the OS of HCC patie