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Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells

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Cellular & Molecular Immunology 2013年第5期10卷 393-402页

作者： Cong Wu yi Zhang yingnling Jiang Quanxing Wang Yao Long Chunmei Wang Xuetao cao Guoyou Chen Institute of Immunology Zhejiang University School of Medicine Hangzhou China National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University Shanghai China National Key Laboratory of Medical Molecular Biology & Department of Immunology Chinese Academy of Medical Sciences Beijing China The first two authors contributed to this work equally.

cell transfer has been found to be able to facilitate engraftment of allograft. However, the underlying mechanisms remain to be fully understood. Here we demonstrate that intravenous administration of donor apoptotic splenocytes can promote pancreatic islet engraftment by inducing generation of tolerogenic dendritic cells （ToI-DCs） and expansion of CD4＋Foxp3＋ regulatory T cells （Tregs）. In vivo clearance of either dendritic cells （DCs） or Tregs prevented the induction of immune tolerance by apoptotic cell administration. Transient elimination of Tregs using anti-CD25, monoclonal antibody （mAb） abrogated the generation of ToI-DCs after administration of apoptotic splenocytes. Reciprocally, depletion of DCs within CD1 lc-DTR mice using diphtheria toxin （DT） prevented the generation of Tregs in the recipients with administration of apoptotic splenocytes. Induction of Tregs by ToI-DCs required direct cell contact between the two cell types, and programmed death 1 ligand （PD-L1） played important role in the Tregs expansion. Apoptotic cell administration failed to induce ToI-DCs in IL-lO-deficient and Smad3-deficient mice, suggesting that IL-10 and transforming growth factor-β （TGF-β） are needed to maintain DCs in the tolerogenic state. Therefore, we demonstrate that ToI-DCs promote the expansion of Tregs via PD-L1 on their surface and reciprocally Tregs facilitate ToI-DCs to maintain transplantation tolerance induced by apoptotic cells via secreting IL-IO and TGF-β.

关键词： apoptotic cell dendritic cell regulatory T cell PD-L1 transplantation tolerance

3/6-SPS型Stewart并联机构奇异轨迹的性质识别

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中国机械工程 2006年第4期17卷 391-396页

作者：曹毅黄真李艳文江南大学无锡214122 燕山大学秦皇岛066004

基于并联机构奇异位形产生的运动学原理,推导出3/6-SPS型Stewart机构奇异轨迹的解析表达式,并基于此原理提出了分析并联机构奇异位形的等效机构法,利用此方法推导出了3/6-SPS型Stewart机构处于一般姿态时在θ-平面上的奇异轨迹方程,并... 详细信息

基于并联机构奇异位形产生的运动学原理,推导出3/6-SPS型Stewart机构奇异轨迹的解析表达式,并基于此原理提出了分析并联机构奇异位形的等效机构法,利用此方法推导出了3/6-SPS型Stewart机构处于一般姿态时在θ-平面上的奇异轨迹方程,并对其轨迹的性质进行了识别。研究结果表明,3/6-SPS型Stewart机构在相互平行的θ-平面上的奇异轨迹总是一二次多项式,包括四对相交直线、一条抛物线及双曲线束。在分析的基础上,对该并联机构处于各种姿态时的奇异轨迹的性质进行了总结。

关键词： Stewart机构等效机构法奇异轨迹性质识别

Liquid−liquid structure transition in metallic melt and its impact on solidification:A review

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Transactions of Nonferrous Metals Society of China 2020年第9期30卷 2293-2310页

作者： yi-xuan HE Jin-shan LI jun WANG Eric BEAUGNON State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China UniversitéGrenoble Alpes INSA ToulouseUniversitéToulouse Paul SabatierEMFLCNRSLNCMI38000 GrenobleFrance

Understanding the nature of liquid structures and properties has always been a hot field in condensed matter physics and metallic materials *** liquid is not homogeneous and the local structures inside change discontinuously with temperature,pressure,*** liquid will experience liquid−liquid structure transition under a certain ***−liquid structure transition widely exists in many metals and alloys and plays an important role in the final microstructure and the properties of the solid *** work provides a comprehensive review on this unique structure transition in the metallic liquid together with the recent progress of its impact on the following microstructure and properties after *** effects are discussed by integrating them into different experimental results and theoretical *** application of liquid−liquid structure transition as a strategy to tailor the properties of metals and alloys is proven to be practical and efficient.

关键词： liquid−liquid structure transition metals and alloys thermal history solidification

Fabrication of High-Quality Niobium Superconducting Tunnel junctions

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Chinese Physics Letters 2011年第8期28卷 289-292页

作者： XU Qin-yin cao Chun-Hai LI Meng-Yue JIANG yi ZHA Shi-Tong KANG Lin XU Wei-Wei CHEN Jian WU Pei-Heng Research Institute of Superconductor Electronics(RISE) Nanjing UniversityNanjing 210093

For high-quality superconducting tunnel junctions(STJs),it is necessary to reduce leakage current as much as *** describe the fabrication of niobium STJs using the selective niobium(Nb)etching process and various ways to minimize the leakage *** experiment shows that the leakage current mainly comes from shorts in the tunnel barrier layer rather than those around the junction *** systematic analysis of the thin film stress,surface morphology and modified junction structures,we fabricate high-quality Nb STJs with a gap voltage of 2.8 mV and a leakage current at 1 mV as low as 8.1%and 0.023%at 4.2 K and 0.3 K,respectively.

关键词： leakage tunnel film

Solvation Effects on Claisen Rearrangement Investigated by QM/MM MD

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Solvation Effects on Claisen Rearrangement Investigated by Q...

Clinical features of AMPAR2 antibody-positive autoimmune encephalitis with gastrointestinal hemorrhage: a case report

中国化学会第十二届全国量子化学会议

作者： jun Zhang yi Qin Gao College of Chemistry and Molecular Engineering Peking University

QM/MM hybrid molecular simulations of aliphatic Claisen rearrangement in several solvents have been *** adopting a highly efficient sampling method,SITS,an unreported but not unexpected result was observed that the reactant underwent a conformational pre-adjustment before it arrived at the transition *** to this outcome in addition to the echo from the structure of natural enzyme,a two-step process of Claisen rearrangement has been proposed,which consists of the necessary trapping into a favorable compact conformation and the subsequent reorganization of chemical bonds and *** to the post-simulation analysis,solvents with high CED were able to accommodate compact conformers *** were found to be partially polarized during the conformational transitions in solvents like water and ionic *** different substituents would shift the conformational ***,by virtue of the enhanced sampling of reactive trajectories（ESo RT）,the rate constant of electron rearrangement of parent AVE in water has been statistically calculated,which was about hundreds of times faster than that in benzene or di-（n）butyl *** result was in line with the experimental measurement and provided more insight to the well-known but mysterious"in/on water"facilitation effect.

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Journal of Translational Neuroscience 2023年第3期8卷 28-32页

作者： yi Bao Zhixuan Chen Yong Liu jun Chen Department of Neurology Taihe Hospital of ShiyanAffiliated Hospital of Hubei University of MedicineShiyan 442000China

Objective:To describe the clinical features of autoimmune encephalitis complicated with gastrointestinal ***:The clinical data of one patient whose initial symptom was mental abnormality were collected and the related examinations,such as cerebrospinal fluid and magnetic resonance imaging (MRI),were ***: Cerebrospinal fluid examination found that anti-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor(AMPAR)2 antibody was strongly positive,although the patient had repeated gastrointestinal hemorrhage but,after hormone combined with immunoglobulin treatment,the symptoms gradual-ly ***:Mental disorders are not all psychosis,and autoimmune encephalitis should not be *** is very important to perform anti-AMPAR encephalitis antibody test;accurate diagnosis and timely treatment can improve the prognosis.

关键词： gastrointestinal hemorrhage autoim-mune encephalitis α-Amino-3-hydroxy-5-methylisox-azole-4-propionic acid subtype glutamate receptor(AM-PAR) cerebrospinal fluid

Four New Limonoids from the Barks of Toona ciliata

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Natural Products and Bioprospecting 2021年第1期11卷 81-86页

作者： Pan-Pan Zhang Yun-Ge Bu Shang Xue Zhi-Rong Cui Peng-Fei Tang jun Luo Ling-yi Kong State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009People’s Republic of China

Four new limonoids,toonayunnanaes F−I(1−4),and six known compounds(5−10)were isolated from the barks of Toona *** structures were elucidated by thoroughly analyzing of NMR and HRMS data,and single-crystal X-ray diffraction of *** oxetane ring moiety in 1 was rare in limonoids and other natural *** 1 showed nitric oxide(NO)inhibitory effect with an IC5038.45±0.41μM in lipopolysaccharide(LPS)-activated RAW 264.7 macrophages.

关键词： Meliaceae Toona ciliate Limonoids NO inhibitory effects

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基于凸集模型的多学科耦合系统不确定性分析

西安电子科技大学学报 2005年第3期32卷 335-338,382页

作者：曹鸿钧段宝岩西安电子科技大学机电工程学院陕西西安710071

研究了用凸集模型描述不确定参数时,多学科系统的不确定性分析方法.为了减少计算量,采用一阶泰勒近似并结合全局敏度方程推导了系统状态变量变差范围的近似计算公式,可用于超椭球凸集与区间变量并存的情形.该方法只需借助各学科分析的... 详细信息

研究了用凸集模型描述不确定参数时,多学科系统的不确定性分析方法.为了减少计算量,采用一阶泰勒近似并结合全局敏度方程推导了系统状态变量变差范围的近似计算公式,可用于超椭球凸集与区间变量并存的情形.该方法只需借助各学科分析的敏度信息,易于与各种基于敏度的寻优算法融合,进行不确定环境下的多学科优化设计.实例计算表明,在不确定程度较小时,该方法可以给出状态变量变差范围,而计算量远远小于MonteCarlo仿真算法.

关键词：超椭球凸集非概率的不确定性分析多学科系统

High-rate removal of As(Ⅲ) from aqueous system with sulfhydryl magnetic biological bamboo charcoal nanocomposites prepared by chemical co-precipitation method

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Transactions of Nonferrous Metals Society of China 2022年第8期32卷 2757-2769页

作者： yi-wei LUO Si WAN Jiang-jun XIAO Dai-she WU College of Resources Environment and Chemical Engineering Nanchang UniversityNanchang 330031China College of Environmental Science and Engineering Central South University of Forestry and TechnologyChangsha 410004China Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China Hunan Research Institute for Nonferrous Metals Co. Ltd.Changsha 410007China Hunan Research Academy of Environmental Sciences Changsha 410014China

Sulfhydryl magnetic biological bamboo charcoal nanocomposite(BBC@nFe-SH)was prepared by chemical co-precipitation method for the robust capture of As(Ⅲ)from aqueous *** novel BBC@nFe-SH shows favorable magnetic field strength(83376 A/m),which enables BBC@nFe-SH to be quickly recovered from aqueous *** maximum As(Ⅲ)adsorption capacity is as high as 98.63 mg/g at pH 5.0 and 40°C,reaching reaction equilibrium within 120 *** characterizations(e.g.,SEM,FTIR,VSM and XPS)suggest that As(Ⅲ)prefers to coordinate with surface oxygen groups bonded to the ***@nFe-SH displayed high stability and recyclability throughout the removal process,which could be easily activated by 1 mol/L NaOH after ***,the novel BBC@nFe-SH has promising applications for As(Ⅲ)treatment.

关键词： arsenic-containing wastewater bamboo biochar chemical co-precipitation adsorption recyclability wastewater treatment