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An approach to synthesis of(Z)-2-chloro-1,3-diarylpropen-1-ones by Vilsmeier reagent(bis-(trichloromethyl)carbonate/DMF)

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Chinese Chemical Letters 2011年第12期22卷 1395-1398页

作者： yi yi Weng jian Jun li Wei Ke Su Key Laboratory of Pharmaceutical Engineering of Ministry of Education College of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou 310014 China

A series of（Z）-2-chloro-1,3-diarylpropen-1-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2,3-epoxy-1,3-diarylpropan-1-ones with Vilsmeier reagent,which was derived from bis（trichloromethyl） carbonate（BTC, triphosgene） and DMF.A possible mechanism was also proposed,where sequential ring-opening,halogenation and elimination reactions were involved.

关键词： Ring-opening Halogenation Vilsmeier reagent Bis-(trichloromethyl)carbonate (Z)-2-Chloro-1 3-diaryl-2-enones

STYRENE POLYMERIZATION MEDIATED BY CYCliC TRITHIOCARBONATE AS RAFT AGENT

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Chinese Journal of Polymer Science 2006年第6期24卷 593-597页

作者： Qi Wang yi-xian li jian Hong Zhi-qiang Fan Department of Polymer Science ＆ Engineering Zhejiang University Hangzhou 310027 China

The novel cyclic trithiocarbonate was synthesized by dialkylation of trithiocarbonate anion with 2,2＇- bis（bromomethyl）biphenyl in a two-phase system using an onium salt as a phase-transfer agent. Styrene polymerization was carried out in the presence of cyclic trithiocarbonate （CTTC）. CTTC undergoes ring opening-polymerization and the incorporated trithiocarbonate moiety derived from CTTC performs as the reversible addition-fragmentation chain transfer （RAFT） agent. Through this mechanism, multiblock polys-tyrenes containing various narrow polydispersity blocks can be prepared.

关键词： Cyclic trithiocarbonate Multiblock polymer RAFT polymerization Styrene.

GdCl₃ abates hepatic ischemia-reperfusion injury by inhibiting apoptosis in rats

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Hepatobiliary & Pancreatic Diseases International 2009年第5期8卷 518-523页

作者： jian-yi li Xi Gu Wen-Hai Zhang Department of General Surgery Shengjing Hospital China Medical University

BACKGROUND:Gadolinium chloride(GdCl3)is a specific inhibitor of Kupffer cells(KCs),which are important promoters of various liver *** is therefore of interest to explore the role of KCs in liver ischemia-reperfusion injury and their relations with apoptosis caused by ischemia-reperfusion injury. METHODS:One hundred male Wistar rats(190-210 g, 6-7 weeks old)were divided into two groups at random, GdCl3 group and control *** were collected at 0.5,1,6,12,and 24 hours from each group after *** alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were measured by an automatic biochemical ***-αin serum was measured by enzyme-linked immunosorbent assay(EliSA). Malondialdehyde(MDA)in the liver mitochondria was measured by a colorimetric *** changes in the liver and immunohistochemical staining for caspase-3 were observed under an optical *** ratio of apoptotic cells was measured by TdT-mediated dUTP nick-end labeling(TUNEL),and ultrastructural features of apoptosis were observed with a transmission electron microscope(TEM). RESULTS:The levels of ALT in the GdCl3 group were lower than those in the control group after reperfusion for 0.5, 1,6 and 12 hours(P<0.05);and the levels of AST in the GdCl3 group were lower than those in the control group after reperfusion for 6 and 12 hours(P<0.05).The levels of TNF-αin the GdCl 3 group were lower than those in the control group after reperfusion for each time(P<0.05). The concentrations of MDA after reperfusion in the GdCl3 group were lower than those in the control group after reperfusion for 6,12 and 24 hours(P<0.05).After reperfusion for 0.5,1,6 and 12 hours,the integral optical density(IOD)of caspase-3-positive cells was lower in theGdCl3 group than in the control group(P<0.05).After reperfusion for 1,6,and 12 hours,the IOD of cells stained by TUNEL in the GdCl3 group was lower than that in the control group(P<0.05). CONCLUSIONS:GdCl3

关键词： gadolinium chloride Kupffer cell ischemia-reperfusion injury caspase-3 apoptosis

Glucocorticoid receptor expression in neonatal rat cortex following recurrent seizures The role in developing brain injury

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Neural Regeneration Research 2010年第2期5卷 146-149页

作者： Tao Bo Lu yi Tuanmei Wang jian li Xingfang li Dingan Mao Department of Pediatrics Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

BACKGROUND： Studies have explored changes in neonatal rat glucocorticoid receptor （GR） expression changes following mature brain injury. OBJECTIVE： To investigate the temporal and special changes of GR during brain development in rats with recurrent seizures. DESIGN, TIME AND SE＇n＇ING： A randomized, controlled animal experiment was performed at the Department of Pediatrics, Second Xiangya Hospital of Central South University, from February 2008 to March 2009. MATERIALS： Rabbit anti-rat GR monoclonal antibody was purchased from Santa Cruz Biotechnology, USA; goat anti-rabbit IgG was purchased from Zhongshan Goldenbridge Biotechnology, China. METHODS： A total of 48 Sprague-Dawley rats, 7 days old, were randomly assigned to control and seizure groups, with 24 animals in each group. Seizures were induced by inhalant flurothyl. MAIN OUTCOME MEASURES： Changes in GR protein expression in the rat cerebral cortex were detected by Western blotting analysis and immunohistochemistry. RESULTS： GR expression in the cerebral cortex of control rats significantly increased with aging （P 〈 0.05）, and varied in the frontal lobe, temporal lobe, and parietal lobe. GR was predominantly expressed in the cytoplasm early and rapidly increased in the nuclei. GR protein expression in the cerebral cortex after seizure was lower in the cytoplasm at 15 days and in nuclear protein at 19 days. CONCLUSION： GR expression displayed temporal and spatial changes in brain development. Recurrent seizures in neonatal rats cause abnormal GR expression and might play an important role in developing brain injury.

关键词： seizure neonatal glucocorticoid receptor brain development rats

Exploring changes of precipitation extremes under climate change through global variable-resolution modeling

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Science Bulletin 2024年第2期69卷 237-247页

作者： Wei Sun jian li Rucong Yu Nina li yi Zhang State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Institute of Tibetan Plateau Meteorology China Meteorological AdministrationChengdu 610072China Department of Atmospheric Science Yunnan UniversityKunming 650091China National Meteorological Center China Meteorological AdministrationBeijing 100081China 2035 Future Laboratory PIESAT Information Technology Co.Ltd.Beijing 100105China

Understanding the responses of precipitation extremes to global climate change remains limited owing to their poor representations in models and complicated interactions with multi-scale *** we take the record-breaking precipitation over China in 2021 as an example,and study its changes under three different climate scenarios through a developed pseudo-global-warming(PGW)experimental framework with 60-3 km variable-resolution global ensemble *** to the present climate,the precipitation extreme under a warmer(cooler)climate increased(decreased)in intensity,coverage,and total amount at a range of 24.3%-37.8%(18.7%-56.1%).With the help of the proposed PGW experimental framework,we further reveal the impacts of the multi-scale system interactions in climate change on the precipitation *** the warmer climate,large-scale water vapor transport converged from double typhoons and the subtropical high marched into central China,enhancing the convective energy and instability on the leading edge of the transport *** a result,the mesoscale convective system(Mcs)that directly contributed to the precipitation extreme became stronger than that in the present *** the contrary,the cooler climate displayed opposite changing characteristics relative to the warmer climate,ranging from the large-scale systems to local environments and to the *** summary,our study provides a promising approach to scientifically assess the response of precipitation extremes to climate change,making it feasible to perform ensemble simulations while investigating the multi-scale system interactions over the globe.

关键词： Precipitation extreme Climate change Pseudo-global-warming experiment Variable-resolution modeling Multi-scale system interaction

Synthesis and Crystal Structure of [Cd(NBA)(μ_3-OH)(4,4′-bipy)_(1/2)]_n

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Chinese Journal of Structural Chemistry 2007年第8期26卷 917-919页

作者： SHEN yi-Cheng ZHANG jian li Zhao-Ji ZHANG Lei yiN Pei-Xiu YAO Yuan-Gen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

A new cadmium polymer [Cd（NBA）（μ3-OH）（4,4＇-bipy）1/2]n 1 （NBA=m-nitrobenzoic acid and 4,4＇-bipy=4,4-bipyridine） has been synthesized by hydrothermal reaction. Its structure was determined by single-crystal X-ray diffraction method, and characterized by elemental analysis and IR spectrum. The crystal is of monoclinic, space group C2/c, with a=15.6912（9）, b=25.9394（15）, c=6.7332（4）A, β=114.7700（10）°, V=2488.4（3）A^3, C12H9CdN2O5, Mr=373.61, Z=8, Dc=1.995 g/cm^3,μ=1.776 mm^-1, F（000）=1464, R=0.0411 and wR=0.1128 for 2130 observed reflections （I 〉 2σ（I））.X-ray diffraction studies reveal that the compound features a layered structure, in which 4,4＇-bipy ligands bridge Z type of double chains [Cd（μ3-OH）]n and NBA ligands locate at the two sides of the layer. The π-π interactions between the benzene rings of NBA ligands of two adjacent layers lead to the 3D framework.

关键词： cadmium polymer 4 4'-bipyridine m-nitrobenzoic acid crystal structure

The role of radical prostatectomy and definitive external beam radiotherapy in combined treatment for high-risk prostate cancer:a systematic review and meta-analysis

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Asian Journal of Andrology 2020年第4期22卷 383-389页

作者： Xu Cheng Zhi-Hui Wang Mou Peng Zhi-Chao Huang Lu yi yi-jian li Lei yi Wen-Zhi Luo Jia-Wen Chen yin-Huai Wang Department of Urology The Second Xiangya Hospital of Central South UniversityChangsha 410011China T.H.Chan School of Public Health Harvard UniversityBostonMA 02115USA

The first-line treatment options for high-risk prostate cancer(PCa)are definitive external beam radiotherapy(EBRT)with or without androgen deprivation therapy(ADT)and radical prostatectomy(RP)with or without adjuvant ***,few randomized trials have compared the survival outcomes of these two *** systematically evaluate the survival outcomes of high-risk PCa patients treated with EBRT-or RP-based therapy,a comprehensive and up-to-date meta-analysis was performed.A systematic online search was conducted for randomized or observational studies that investigated biochemical relapse-free survival(bRFS),cancer-specific survival(CSS),and/or overall survival(OS),in relation to the use of RP or EBRT in patients with high-risk *** summary hazard ratios(HRs)were estimated under the random effects *** identified heterogeneity between studies using Q tests and measured it using I2 *** evaluated publication bias using funnel plots and Egger's regression asymmetry *** studies(including one randomized controlled trial[RCT])of low risk of bias were selected and up to 9504 patients were *** comparing EBRT-based treatment with RP-based treatment,the pooled HRs for bRFS,CSS,and OS were 0.40(95%confidence interval[CI]:0.24–0.67),1.36(95%CI:0.94–1.97),and 1.39(95%CI:1.18–1.62),*** OS for RP-based treatment and better bRFS for EBRT-based treatment have been identified,and there was no significant difference in CSS between the two ***-based treatment is recommended for high-risk PCa patients who value long-term survival,and EBRT-based treatment might be a promising alternative for elderly patients.

关键词： high risk prostatectomy prostatic neoplasms radiotherapy survival

A direct electrochemical biosensor for rapid glucose detection based on nitrogen-doped carbon nanocages

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Rare Metals 2024年第5期43卷 2184-2192页

作者： Lan-Lan li Yu Zhao li-Jia Pan jian-Bin Xu yi Shi College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China School of Electronic Science and Engineering Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China Department of Electronic Engineering The Chinese University of HongKongHongkong 999077China

Given the increasing number of diabetic patients,rapid and accurate detection of glucose in body fluids is *** study developed a direct electrochemical biosensor for glucose based on nitrogen-doped carbon nanocages(NCNCs).NCNCs possess a large specific surface area of 1395 m^(2)·g^(-1),a high N atomic content of 9.37%and good biocompatibility,which is favorable for enzyme loading and electron *** surface average concentration of electroactive glucose oxidase on NCNCs was 2.82×10^(-10)mol·cm^(-2).The NCNC-based direct electrochemical biosensor exhibited a high sensitivity of 13.7μA·(mmol·L^(-1))^(-1)·cm^(-2),rapid response time of 5 s and an impressive electron-transferrate constant(ks)of 1.87 s^(-1).Furthermore,we investigated an NCNC-based direct electron transfer(DET)biosensor for sweat glucose detection,which demonstrated tremendous promise for non-invasive wearable diabetes diagnosis.

关键词： Direct electron transfer(DET) Nitrogen-doped carbon nanocages(NCNCs) Glucose oxidase Biosensor

Comparative analysis of different feeder layers with 3T3 fibroblasts for culturing rabbits limbal stem cells

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1021-1027页

作者： Hui-Xian Wang Xiao-Wei Gao Bing Ren Yan Cai Wen-Jing li Yu-li Yang yi-jian li Medical College of Shihezi University Ophthalmic Center No.474 Hospital of Chinese PLA Southwest Hospital Third Military Medical University

AIM： To explore the possibility of human umbilical cord mesenchymal stem cells（h UCMSCs）, human umbilical vein endothelial cells（h UVECs）, human dental pulp stem cells（h DPSCs） and human periodontal ligament stem cells（h PDLSCs） serving as feeder cells in co-culture systems for the cultivation of limbal stem ***： Different feeder layers were cultured in Dulbecco＇s modified Eagle＇s medium（DMEM）/F12 and were treated with mitomycin C. Rabbits limbal stem cells（LSCs） were co-cultured on h UCMSCs, h UVECs, h DPSCs, h PDLSCs and NIH-3T3, and then comparative analysis were made between each group to see their respective colony-forming efficiency（CFE） assay and immunofluorescence（IPO13,CK3/12）.RESULTS： The efficiency of the four type cells in supporting the LSCs morphology and its cellular differentiation was similar to that of NIH-3T3 fibroblasts as demonstrated by the immunostaining properties analysis, with each group exhibiting a similar strong expression pattern of IPO13, but lacking CK3 and CK12 expression in terms of immunostaining. But h UCMSCs, h DPSCs and h PDLSCs feeder layers were superior in promoting colony formation potential of cells when compared to h UVECs and feedercell-free ***： hUCMSCs, hDPSCs and hPDLSCs can be a suitable alternative to conventional mouse NIH-3T3 feeder cells, so that risk of zoonotic infection can be diminished.

关键词： limbal stem cells feeder layers umbilical cord mesenchymal stem cells umbilical vein endothelial cells dental pulp stem cells periodontal ligament stem cells