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A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS

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journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 168-180页

作者： yi ZHAnG Zhiyan QUAn Feiyang LOU Yujiao fang Garth j.THOMPSOn Gao CHEn Xiaotong ZHAnG Department of neurosurgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009China Key Laboratory of Precise Treatment and Clinical Translational Research of neurological Diseases Hangzhou310009China MOE Frontier Science Center for Brain Science and Brain-machine Integration Zhejiang UniversityHangzhou310058China Interdisciplinary Institute of neuroscience and Technology College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou310027China School of Medicine Zhejiang UniversityHangzhou310020China iHuman Institute School of Life Science and TechnologyShanghaiTech UniversityShanghai201210China College of Electrical Engineering Zhejiang UniversityHangzhou310027China

Energy metabolism is fundamental for *** encompasses the utilization of carbohydrates,lipids,and proteins for internal processes,while aberrant energy metabolism is implicated in many *** the present study,using three-dimensional(3D)printing from polycarbonate via fused deposition modeling,we propose a multi-nuclear radiofrequency(RF)coil design with integrated 1H birdcage and interchangeable X-nuclei(^(2)H,^(13)C,^(23)na,and^(31)P)single-loop coils for magnetic resonance imaging(MRI)/magnetic resonance spectroscopy(MRS).The single-loop coil for each nucleus attaches to an arc bracket that slides unrestrictedly along the birdcage coil inner surface,enabling convenient switching among various nuclei and animal *** to a commercial 1H birdcage coil,the proposed 1H birdcage coil exhibited superior signal-excitation homogeneity and imaging signal-to-noise ratio(SnR).For X-nuclei study,prominent peaks in spectroscopy for phantom solutions showed excellent SnR,and the static and dynamic peaks of in vivo spectroscopy validated the efficacy of the coil design in structural imaging and energy metabolism detection simultaneously.

关键词： Energy metabolism Magnetic resonance imaging(MRI) Magnetic resonance spectroscopy(MRS) Multi-nuclear Radiofrequency coil Three-dimensional(3D)printing

Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu j.n-Xiu Shi yi-Ming Ou Hua-jie jiang yi-j.n fang Qi-Ming Wang Quan Gao jie Yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

nitrogen addition increased resistance of resident plant community to Solidago canadensis invasion by altering allelopathic effect

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jOURnAL OF PLAnT ECOLOGY 2024年第2期17卷 110-121页

作者： Cai, j.ng-fang Sun, Kai Li, Lin A, Si-Ha Shen, yi-Luan Li, Hong-Li Beij.ng Forestry Univ Sch Ecol & Nat Conservat Beijing 100083 Peoples R China Beij.ng Forestry Univ Key Lab Ecol Protect Yellow River Basin Natl Forestry & Grassland Adm Beijing 100083 Peoples R China

Allelopathy plays an important role in the interaction between invasive and resident plants. Atmospheric nitrogen (n) deposition has become a global problem, but it is unclear whether n enrichment affects the interaction between invasive and resident plants by affecting their allelopathy. Thus, we performed a greenhouse experiment in which the resident plant community was grown under two levels of invasion by S. canadensis (invasion vs. no invasion) and fully crossed with two levels of allelopathy (with or without adding activated carbon) and two levels of n addition (with or without). The resident plant communities were constructed with eight herbaceous species that often co-occur with S. canadensis. The results showed that both allelopathy of S. canadensis and the resident plants had obvious positive effects on their own growth. nitrogen addition had more obvious positive effects on the resident plants under invasion than those that were not invaded. Moreover, n addition also altered the allelopathy of resident plants. Specifically, n addition improved the allelopathy of resident plants when they were invaded but decreased the allelopathy of resident plants when they grew alone. Although nitrogen addition had no obvious effect on S. canadensis, it reduced the allelopathy of S. canadensis. These results suggest that n addition could improve the resistance of resident plants to invasion by improving the allelopathy of resident plants and reducing the allelopathy of S. canadensis. These findings provide a scientific basis to manage and control the S. canadensis invasion.

关键词： allelochemicals biological invasion nutrient input nitrogen addition resident plants Solidago canadensis DEPOSITIOn COMPETITIOn DIVERSITY EVOLUTIOn RESPOnSES SUCCESS

neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases

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neural Regeneration Research 2024年第6期19卷 1291-1298页

作者： Qi jia j.n Li Xiaofeng Guo yi Li You Wu Yuliang Peng Zongping fang Xij.ng Zhang Department of Anesthesiology and Perioperative Medicine and Department of Intensive Care Unit Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Critical Care Medicine Air Force Medical CenterBeijingChina Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina

Chaperone-mediated autophagy is one of three types of autophagy and is characterized by the selective degradation of ***-mediated autophagy contributes to energy balance and helps maintain cellular homeostasis,while providing nutrients and support for cell ***-mediated autophagy activity can be detected in almost all cells,including *** to the extreme sensitivity of neurons to their environmental changes,maintaining neuronal homeostasis is critical for neuronal growth and ***-mediated autophagy dysfunction is closely related to central nervous system *** has been shown that neuronal damage and cell death are accompanied by chaperone-mediated autophagy *** certain conditions,regulation of chaperone-mediated autophagy activity attenuates *** this paper,we review the changes in chaperone-mediated autophagy in neurodegenerative diseases,brain injury,glioma,and autoimmune *** also summarize the most recent research progress on chaperone-mediated autophagy regulation and discuss the potential of chaperone-mediated autophagy as a therapeutic target for central nervous system diseases.

关键词： chaperone-mediated autophagy neurodegenerative disease neuronal homeostasis neuroprotection

A High-Performance Electrochemical Analysis Platform for Ultrasensitive Detection of HTLV-1 DnA: Integrating Cascade Signal Amplifi cation with λ-Exonuclease-Assisted Target Recycling and Enzyme Catalysis

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journal of Analysis and Testing 2024年第03期8卷 361-373页

作者： Qi Xiao Shuai Liu Yali Wang Huihao Li Mingli Yang yi fang Sij.ng Chen Shan Huang Guangxi Key Laboratory of natural Polymer Chemistry and Physics College of Chemistry and Materials Nanning Normal University

Human T-cell lymphophilic virus type 1 (HTLV-1), the known retrovirus causing cancer in humans, is closely associated with adult T-cell leukemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis. Due to its ability to evade the host's defense mechanisms, early tracking of HTLV-1 becomes crucial. In this study, we integrateλ-Exonuclease(λ-Exo)-assisted target recycling with a terminal deoxynucleotidyl transferase (TdT)-mediated template-free DnA extension process to develop an electrochemical analysis platform for the specifi c and sensitive detection of HTLV-1 DnA. During theλ-Exo-assisted target recycling, HTLV-1 DnA is recognized by hairpin DnA (Hp-DnA), forming double-stranded DnA(dsDnA) through DnA hybridization. The dsDnA, featuring blunt 5'terminal phosphorylation, is cleaved byλ-Exo, generating abundant short output sequence (sDnA). HTLV-1 DnA is released, initiating a cyclic hybridization-cleavage ***, thiol-labelled capture DnA (CP-DnA) assembled on gold electrode surface captures a substantial amount of the generated sDnA, forming CP-DnA-sDnA nanostructures. When TdT and dnTPs are present on the electrode surface, the3'-OH terminal of sDnA extends to generate long single-stranded DnA (ssDnA) structure. Methylene blue (MB) is selected as the electrochemical signal molecule. MB not only binds with ssDnA but also interacts specifi cally with dsDnA, resulting in a signifi cantly enhanced electrochemical signal on modifi ed electrode surface. The detection limit of HTLV-1 DnA is as low as 19 amol/L (S/n=3) when the two signal amplifi cation strategies are combined. The analysis platform exhibits excellent analytical performance and holds promise as a novel tool for the early tracing and diagnosis of HTLV-1 DnA.

关键词： Cascade signal amplification Electrochemical DnA sensor Enzyme-assisted target recycling HTLV-1 DnA

Magnetic compression anastomosis to restore biliary tract continuity after obstruction following major abdominal trauma:A case report

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World journal of Gastrointestinal Surgery 2024年第6期16卷 1933-1938页

作者： Miao-Miao Zhang jie Tao Huan-Chen Sha Yun Li Xiao-Gang Song Oliver j Muensterer fang-fang Dong Li Zhang yi Lyu Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Shaanxi Provincial Key Laboratory of Magnetic Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina national Local joint Engineering Research Center for Precision Surgery&Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Pediatric Surgery Dr.von Hauner Children’s HospitalLudwig-Maximilians-University Medical CenterMunich 80337Germany

BACKGROUnD The combination of magnetic compression anastomosis(MCA)and endoscopy has been used to treat biliary stricture after liver ***,its use for the treatment of complex biliary obstruction after major abdominal trauma has not been *** case report describes the successful use of MCA for the treatment of biliary obstruction resulting from major abdominal trauma.A 23-year-old man underwent major abdominal surgery(repair of liver rupture,right half colon resection,and ileostomy)following a car accident one year *** abdominal drainage tube,positioned at the Winslow foramen,was draining approximately 600-800 mL of bile per *** the two endoscopic retrograde cholangiopancreatography procedures,the guide wire was unable to enter the common bile duct,which prevented placement of a biliary *** combined with endoscopy was used to successfully achieve magnetic anastomosis of the peritoneal sinus tract and duodenum,and then a choledochoduodenal stent was ***,the external biliary drainage tube was *** patient achieved internal biliary drainage leading to the removal of the external biliary drainage tube,which improved the quality of *** Magnetic compression technique can be used for the treatment of complex biliary obstruction with minimal operative trauma.

关键词： Magnetic compression anastomosis Magnetosurgery Endoscopy Magnetic Surgery Clinic Biliary obstruction Case report

FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BnCT

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nuclear Science and Techniques 2024年第3期35卷 96-108页

作者： Wei jiang Ping Cao yi-Ming Wu Xian-Ke Liu Zhu-j.n fang Zhi-Yong Zhang Bin Shi j.n Chen State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China national Key Laboratory for Metrology and Calibration Techniques China Institute of Atomic EnergyBeijing 102413China

A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BnCT)is being developed based on the two-dimensional Micromegas *** address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber *** method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined *** performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data *** experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 *** beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction *** online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BnCT.

关键词： Position reconstruction FPGA Readout electronics neutron flux spatial distribution

Highly dispersed Ru nanospecies on n-doped carbon/MXene composite for highly efficient alkaline hydrogen evolution

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Chinese Chemical Letters 2024年第4期35卷 153-159页

作者： Minying Wu Xueliang Fan Wenbiao Zhang Bin Chen Tong Ye Qian Zhang Yuanyuan fang Yaj.n Wang yi Tang Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materialsand Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China College of Chemistry&Materials Engineering Wenzhou UniversityWenzhou 325027China

Hydrogen has emerged as a promising environmentally friendly energy source. The development of lowcost, highly active, stable, and easily synthesized catalysts for hydrogen evolution reactions(HER) remains a significant challenge. This study explored the synthesis of nitrogen-doped MXene-based composite catalysts for enhanced HER performance. By thermally decomposing RuCl_(3) coordinated with melamine and formaldehyde resin, we successfully introduced nitrogen-doped carbon(n–C) with highly dispersed ruthenium(Ru) onto the MXene surface. The calcination temperature played a crucial role in controlling the size of Ru nanoparticles(Ru nPs) and the proportion of Ru single-atom(Ru SA), thereby facilitating the synergistic enhancement of HER performance by Ru nPs and Ru SA. The resulting catalyst prepared with a calcination temperature of 600℃, Ti_(3)C_(2)T_x-n/C-Ru-600(TnCR-600), exhibited exceptional HER activity(η10= 17 m V) and stability(160 h) under alkaline conditions. This work presented a simple and effective strategy for synthesizing composite catalysts, offering new insights into the design and regulation of high-performance Ru-based catalysts for hydrogen production.

关键词： HER activity Highly dispersed Ru-based catalysts MXene Alkaline condition

Enhanced hydrogen evolution performance by 3D ordered macroporous Ru-CoP@nC electrocatalysts

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Rare Metals 2024年第3期43卷 1095-1107页

作者： Chen-Chen Zhang Sheng Wei Li-Xian Sun yi-fang Ouyang Fen Xu Hai-Liang Chu Hong-GePan Li-Xin Chen Xue-Zhang Xiao School of Material Science and Engineering Guilin University of Electronic TechnologyGuilin541004China School of Chemistry and Chemical Engineering Guangxi UniversityNanning530004China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen518055GuangdongChina Institute of Science and Technology for new Energy Xi'an Technological UniversityXi'an710021China School of Materials Science and Engineering Zhejiang UniversityHangzhou310058China

Electrocatalytic water splitting coupled with sustainable energies is identified as an environmentally friendly and renewable strategy to generate high-quality hydrogen for the fuel ***,the main challenge is to develop high performance,low cost and chemically stable electrocatalysts to decline the energy barriers and enhance the sluggish kinetics of hydrogen evolution reaction(HER).Herein,a three-dimensional hierarchically ordered macroporous Ru-CoP@nC electrocatalyst(3DOM Ru-CoP@nC)derived from ordered macro-microporous metal-organic frameworks has been prepared using the precursor@template and double-solvent *** prepared 3DOM Ru-CoP@nC catalyst exhibits an overpotential of 15 mV(j=10 mA·cm^(-2))and a reaction Tafel slope of 38 mV·dec^(-1)in alkaline electrolyte,which are superior to commercial Pt@C ***,the overpotential and reaction Tafel slope of this catalyst in acidic media are 45 mV and 50 mV·dec^(-1),*** outstanding HER activities of 3DOM Ru-CoP@nC catalysts are ascribed to the 3D highly interconnectedreticular nanospaces that can increase effective reaction active *** n dope d carbon framework improves the electronic properties and ***,the strong interaction of Ru and CoP nanoparticles also boosts the HER *** results indicate that 3DOM Ru-CoP@nC catalysts with high catalytic activities have a broad application prospect in the future.

关键词： Hydrogen evolution reaction Template method 3D ordered macroporous Ru-CoP@nC