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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian Guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Strategic games on a hierarchical network model

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 271-278页

作者： yi-xiao LI Xiao-gang JIN Fan-sheng kong Hui-lan LUO Institute of Artificial Intelligence Zhejiang University Hangzhou 310027 China Ningbo Institute of Technology Zhejiang University Ningbo 315100 China

Among complex network models,the hierarchical network model is the one most close to such real networks as world trade web,metabolic network,WWW,actor network,and so *** has not only the property of power-law degree distribution,but also the scaling clustering coefficient property which Barabási-Albert(BA)model does not *** model is a model of network growth based on growth and preferential attachment,showing the scale-free degree distribution *** this paper,we study the evolution of cooperation on a hierarchical network model,adopting the prisoner's dilemma(PD)game and snowdrift game(SG)as metaphors of the interplay between connected *** model provides a unifying framework for the emergence of *** interestingly,we found that on hierarchical model,there is no sign of cooperation for PD game,while the fre-quency of cooperation decreases as the common benefit decreases for *** comparing the scaling clustering coefficient prop-erties of the hierarchical network model with that of BA model,we found that the former amplifies the effect of *** different performances of PD game and SG on complex network,we also found that common benefit leads to cooperation in the *** our study may shed light on the emergence of cooperation in both natural and social environments.

关键词： Complex network Hierarchical network model Barabási-Albert (BA) model Prisoner's dilemma (PD) game Snowdrift game (SG)

How to build a habitable planet:an interview with Charles H. Langmuir

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National Science Review 2024年第6期11卷 76-80页

作者： yi-gang Xu the Guangzhou Institute of Geochemistry Chinese Academy of Sciences

Earth is the only known habitable planet in the solar system. Understanding how Earth developed its unique habitability has been the frontier of Earth sciences and has become one of the main themes of current deep-space explorations. What are the decisive factors that led to a habitable planet? What is the role of solid Earth processes in the origin of life and in modulating the surface environment? Are Earth’s habitability studies relevant to current challenges that human beings face? These questions have attracted the interest of both scientists and the public alike.

关键词： Earth (planet)

Effect of pile-cap connection on behavior of torsionally loaded pile groups

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第3期9卷 303-312页

作者： Ling-gang kong Li-min ZHANG Key Laboratory of Soft Soils and Geoenvironmental Engineering Ministry of Education Zhejiang University Hangzhou 310027 China Department of Civil Engineering The Hong Kong University of Science and Technology Hong Kong China

To evaluate the responses of fixed and pinned pile groups under torsion, a method is presented to analyze the nonlinear behavior of free-standing pile groups with rigid pile caps. The method is capable of simulating the nonlinear soil response in the near field usingp-y and r-θ curves, the far-field interactions through Mindlin＇s and Randolph＇s elastic solutions, and the coupling effect of lateral resistance on torsional resistance of the individual piles using an empirical factor. Based on comparisons of the solutions for fixed- and pinned-head, 1×2, 2×2, and 3×3 pile groups subjected to torsion, it was found that pile-cap connection significantly influences the torsional capacity of pile groups and the assignment of applied torques in the pile groups. In this study, the applied torques for the pinned-head pile groups are only 44%-64% of those for the corresponding fixed-head pile groups at a twist angle of 2^o. Such a difference is mainly due to the change of the lateral resistances of individual piles in the groups.

关键词： Pile group Pile foundations Torsional response Pile-cap connection Nonlinear analysis

Improved performances of lithium disilicate glass-ceramics by seed induced crystallization

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Journal of Advanced Ceramics 2021年第3期10卷 614-626页

作者： Ting ZHAO Mei-Mei LIAN yi QIN Jian-Feng ZHU Xin-gang kong Jian-Feng YANG School of Materials Science and Engineering Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science and TechnologyXi’an 710021China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China

Self-reinforced lithium disilicate(Li_(2)Si_(2)O_(5),LD)glass-ceramics were hot pressing sintered by introducing 5 wt%Li_(2)Si_(2)O_(5)crystal seeds into two different glass compositions of SiO_(2)-Li_(2)O-P2O_(5)-ZrO_(2)-Al_(2)O_(3)-K_(2)O-La_(2)O_(3)(7C LD)and SiO_(2)-Li_(2)O-K_(2)O-La_(2)O_(3)(4C LD).The results show that the seeds play an important role in the crystallization inducement,and microstructural and property improvement of the glass,especially for the glass powder without the nucleating agent of P_(2)O_(5).The microstructure features a wider bimodal grain size distribution with large rod-like crystals epitaxially grown along the seeds and small crystals nucleated from the glass powder itself,contributing to the improvement of the performance especially the fracture *** specimen of 4C LD glass with the addition of 5 wt%Li_(2)Si_(2)O_(5) seeds exhibited the best comprehensive properties with a good flexural strength(396±7 MPa),improved fracture toughness(3.31±0.19 MPa·m^(1/2)),and comparable translucency as IPS *** research provides a new idea and method for the improvement of the fracture toughness of lithium disilicate glass-ceramics without affecting its aesthetic appearance,and lays the foundation for its clinical applications.

关键词： lithium disilicate(LD) seeds mechanical properties translucency

Morphology and electrical contact properties of electrical connection materials in corrosive atmosphere

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Rare Metals 2013年第2期32卷 174-178页

作者： Zhi-gang kong Liang-Jun Xu Research Laboratory of Electrical Contacts Beijing University of Posts and Telecommunications

The impact mechanism of environmental fac tors, such as corrosive atmosphere, on connector materials was investigated, and the porosity of gold plating was tested. Series of inspections and analytical research meth ods were introduced in this article. The surface morphology of specimens after corrosion was observed by stereoscopic microscope and scanning electron microscope. Chemical constitution was examined by Xray energy spectrum. The contact resistances were measured by fourpoint method. The experiment results show that after exposure to certain environment, the corrosion products, such as Cu20, Cu（NO3）2.3H20, and NiO, are observed on the surface of the specimens without gold coatings, whereas the corrosion products appear to have circleshaped spots on goldplating surface after corrosion test, which indicate that the gold plating has good corrosion protection. The porosity is increased with the increase of corrosion time for every kind of specimens gold plated, and the corrosion degree of gold plating specimens is decreased with the increase of the thickness of gold coatings. The static contact resistances of circleshaped spots appear higher contact resistance than normal value, which can reach to 2,000 mr2 nearly. It is found that the high and unstable contact resistance of the pore and products is more likely to cause contact failure.

关键词： Electrical contact Porosity Corrosion Temperature

Histological changes of gastric mucosa after Helicobacter pylori eradication:a systematic review and meta-analysis

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World Journal of Gastroenterology 2014年第19期20卷 5903-5911页

作者： Yan-Jun kong Hong-gang yi Jun-Cheng Dai Mu-Xin Wei Division of Traditional Chinese Medicine the First Affiliated Hospital of Nanjing Medical University Division of Epidemiology Nanjing Medical University School of Public Health National Institute for Physiological Sciences OkazakiAichi 444-8585Japan HiPep Laboratories Kyoto 602-8158Japan

AIM: To systematically review pathological changes of gastric mucosa in gastric atrophy (GA) and intestinal metaplasia (IM) after Helicobacter pylori (H. pylori) eradication.

关键词： Helicobacter pylori eradication Gastric atrophy Intestinal metaplasia Pathological changes Gastric mucosa Meta-analysis

Precision measurement and compensation of kinematic errors for industrial robots using artifact and machine learning

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Advances in Manufacturing 2022年第3期10卷 397-410页

作者： Ling-Bao kong yi Yu Shanghai Engineering Research Center of Ultra-precision Optical Manufacturing Department of Optical Science and EngineeringFudan UniversityShanghai 200438People's Republic of China

Industrial robots are widely used in various areas owing to their greater degrees of freedom(DOFs)and larger operation space compared with traditional frame movement systems involving sliding and rotational ***,the geometrical transfer of joint kinematic errors and the relatively weak rigidity of industrial robots compared with frame movement systems decrease their absolute kinematic accuracy,thereby limiting their further application in ultraprecision *** imposes a stringent requirement for improving the absolute kinematic accuracy of industrial robots in terms of the position and orientation of the robot arm *** measurement and compensation methods for industrial robots either require expensive measuring systems,producing positioning or orientation errors,or offer low measurement ***,a kinematic calibration method for an industrial robot using an artifact with a hybrid spherical and ellipsoid surface is proposed.A system with submicrometric precision for measuring the position and orientation of the robot arm end is developed using laser displacement ***,a novel kinematic error compensating method involving both a residual learning algorithm and a neural network is proposed to compensate for nonlinear errors.A six-layer recurrent neural network(RNN)is designed to compensate for the kinematic nonlinear errors of a six-DOF industrial *** results validate the feasibility of the proposed method for measuring the kinematic errors of industrial robots,and the compensation method based on the RNN improves the accuracy via parameter *** studies show that the measuring system and compensation method can reduce motion errors by more than 30%.The present study provides a feasible and economic approach for measuring and improving the motion accuracy of an industrial robot at the submicrometric measurement level.

关键词： Industrial robot Kinematic error Calibration Machine learning Recurrent neural network(RNN)