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中国颗粒学会2006年年会暨海峡两岸颗粒技术研讨会

作者： Ming-fong Tai Jong-Kai Hsiao yi-fong chou Kuo-Chih Wang Bor-Zin La Shin-Tai Chen Department of Optoelectronic System Engineering Minghsin University of Science and Technology HsinchuChina Department of Medical Imaging Taiwan University Hospital and College of Medicine TaipeiChina Department of Electronic Engineering WeFeng Institute of Technology ChiayiChina Department of Electric Engineering WeFeng Institute of Technology ChiayiChina Musculoskeletal Disease Center J.L.Pettis VA Medical Center Loma Linda CA 92357USA Department of Biochemistry Loma Linda University Loma Linda CA 92357 USA

In this study, we compared FeNi alloy magnetic nanoparticles (MNPs) prepared by either combustion or chemical precipitation methods. We found that the FeNi MNPs generated by combustion method have a rather high saturation magnetization Ms of -180 emu/g and a coercivity field Hc of near zero. However, the alloy nanoparticles are easily aggregated and are not well dispersive such that size distribution of the nanoparticle clusters are wide and clusters are rather big (around 5000 nm). To prepare a better quality and well dispersed Fe-Ni MNPs, we also developed a thermal reflux chemical precipitation method to synthesize FeNi3 alloy MNPs. The precursor chemicals of Fe(acac)3 and Ni(acac)2 in a molecular ratio of 1:3 reacted in octyl ether solvent at the boiling point of solvent (00 ℃) by the thermal reflux process. The 1,2-hexadecandiol and tri-n-octylphosphine oxide (TOPO) were used as reducer and surfactant, respectively. The chemically precipitated FeNi3 MNPs are well dispersed and have well-controlled particle sizes around 10-20 nm with a very narrow size distribution (±1.2 nm). The highly monodispersive FeNi3 NPs present good uniformity in particle shape and crystallinity on particle surfaces. The MNPs exhibit well soft magnetism with saturation magnetization of -61 emu/g and Hc. The biomedical compatible FeNi MNPs which were coated with biocompatible polyethyleneimine (PEI) polymer were also synthesized. We demonstrated that the PEI coated FeNi MNPs can enter the mammalian cells in vitro and can be used as a magnetic resonance imagine (MRI) contrast agent. The results demonstrated that FeNi MNPs potentially could be applied in the biomedical field. The functionalized magnetic beads with biocompatible polymer coated on MNPs are also completed for biomedical applications.

关键词： magnetic nanoparticles Fe-Ni alloy chemical precipitation method biologic labeling

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Measuring the orbital periods of low mass X-ray binaries in the X-ray band

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Research in Astronomy and Astrophysics 2014年第11期14卷 1367-1382页

作者： yi chou Graduate Institute of Astronomy National Central University

A low mass X-ray binary （LMXB） contains either a neutron star or a black hole accreting materials from its low mass companion star. It is one of the primary astrophysical sources for studying stellar-mass compact objects and accreting phe- nomena. As with other binary systems, the most important parameter of an LMXB is the orbital period, which allows us to learn about the nature of the binary system and constrain the properties of the system＇s components, including the compact ob- ject. As a result, measuring the orbital periods of LMXBs is essential for investigating these systems even though fewer than half of them have known orbital periods. This article introduces the different methods for measuring the orbital periods in the X-ray band and reviews their application to various types of LMXBs, such as eclipsing and dipping sources, as well as pulsar LMXBs.

关键词： X-rays: binaries -- binaries: close -- methods: data analysis

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Modeling postpartum depression in rats： theoretic and methodological issues

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Zoological Research 2016年第4期37卷 229-236页

作者： Ming LI Shinn-yi chou Department of Psychology University of Nebraska-Lincoln Lincoln Nebraska 68588-0308 USA

The postpartum period is when a host of changes occur at molecular, cellular, physiological and behavioral levels to prepare female humans for the challenge of maternity. Alteration or prevention of these normal adaptions is thought to contribute to disruptions of emotion regulation, motivation and cognitive abilities that underlie postpartum mental disorders, such as postpartum depression. Despite the high incidence of this disorder, and the detrimental consequences for both mother and child, its etiology and related neurobiological mechanisms remain poorly understood, partially due to the lack of appropriate animal models. In recent decades, there have been a number of attempts to model postpartum depression disorder in rats. In the present review, we first describe clinical symptoms of postpartum depression and discuss known risk factors, including both genetic and environmental factors. Thereafter, we discuss various rat models that have been developed to capture various aspects of this disorder and knowledge gained from such attempts. In doing so, we focus on the theories behind each attempt and the methods used to achieve their goals. Finally, we point out several understudied areas in this field and make suggestions for future directions.

关键词： Postpartum depression Rat models HPA axis Stress Estrogen

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Study on the Carbon Nanotube Separative Structure for the Extended Gate H^+-Ion Sensitive Field Effect Transistor

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稀有金属材料与工程 2006年第A3期35卷 225-227页

作者： yi-Hung Liao Jung-Chuan chou Graduate School of Engineering Science and Technology National Yunlin University of Science and TechnologyDouliouYunlinTaiwan 640China

We use the carbon nanotube (CNT) as the material of the pH sensing layer of the separative structure for the extended gate H^+-ion sensitive field effect transistor (EGFET) *** CNT paste was prepared with CNT powder,Ag powder,silicagel,the di-n-butyl phthalate and the toluene solvents by appropriate ratio,then immobilized on the silicon substrate to form the carbon nanotube sensing *** measured theⅠ_(DS)-Ⅴ_G curves of the carbon nanotube separative structure EGFET device in the different pH buffer solutions by the Keithley 236Ⅰ-Ⅴmeasurement *** to the experimental results,we can obtain the pH sensitivities of the carbon nanotube separative structure EGFET device,which is 62.54mV/pH from pH1 to pH13.

关键词： carbon nanotube extended gate field effect transistor pH sensitivity buffer solution

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Study on Extended Gate Field Effect Transistor with Nano-TiO-2 Sensing Membrane by Sol-Gel Method

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稀有金属材料与工程 2006年第A3期35卷 252-253页

作者： yi-Hung Liao Jung-Chuan chou Graduate School of Engineering Science and Technology National Yunlin University of Science and TechnologyDouliouTaiwan 640China

The nano-titanium dioxide (nano-TiO_2) sensing membrane,fabricated by sol-gel technology,was used as the pH-sensing layer of the extended gate field effect transistor (EGFET) *** objective of this research is the preparation of titanium dioxide materials by sol-gel method using Ti(OBu)_4 as the *** this study,we fabricated a nano-titanium dioxide sensing layer on the ITO glass by dip *** order to examine the sensitivity of the nano-TiO_2 films applied to the EGFET devices,we adopted the ITO glass as substrate,and measured theⅠ_(DS)-Ⅴ_G curves of the nano-titanium dioxide separative structure EGFET device in the pH buffer solutions that have different pH values by the Keithley 236 *** the experimental results,we can obtain the pH sensitivities of the EGFET with nano-TiO_2 sensing membrane prepared by sol-gel method,which is 59.86mV/pH from pH 1 to pH 9.

关键词： extended gate field effect transistor(EGFET) sol-gel nano-TiO2 sensing membrane buffer solution

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Clinical trials for treating recurrent head and neck cancer with boron neutron capture therapy using the Tsing-Hua Open Pool Reactor

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Cancer Communications 2018年第1期38卷 393-399页

作者： Ling-Wei Wang Yen-Wan Hsueh Liu fong-In chou Shiang-Huei Jiang Department of Oncology Taipei Veterans General HospitalNo.201Section 2Shih-Pai RoadTaipei 11217TaiwanChina School of Medicine National Yang Ming UniversityTaipei 11217TaiwanChina Institute of Nuclear Engineering and Science National Tsing Hua UniversityHsin-ChuTaiwanChina Nuclear Science and Technology Development Center National Tsing Hua UniversityHsin-ChuTaiwanChina

Head and neck(HN)cancer is an endemic disease in Taiwan,*** recurrent HN cancer after full-dose irradia-tion poses a therapeutic challenge,and boron neutron capture therapy(BNCT)may be a solution that could provide durable local control with tolerable *** Tsing-Hua Open Pool Reactor(THOR)at National Tsing-Hua University in Hsin-Chu,provides a high-quality epithermal neutron source for basic and clinical BNCT *** first clinical trial,entitled“A phase I/II trial of boron neutron capture therapy for recurrent head and neck cancer at THOR”,was carried out between 2010 and 2013.A total of 17 patients with 23 recurrent HN tumors who had received high-dose photon irradiation were enrolled in the *** fructose complex of l-boronophenylalanine was used as a boron carrier,and a two-fraction BNCT treatment regimen at 28-day intervals was used for each *** was acceptable,and although the response rate was high(12/17),re-recurrence within or near the radiation site was *** obtain better local control,another clinical trial entitled“A phase I/II trial of boron neutron capture therapy combined with image-guided intensity-modulated radiotherapy(IG-IMRT)for locally recurrent HN cancer”was initiated in *** first administration of BNCT was performed according to our previous protocol,and IG-IMRT was initiated 28 days after *** of May 2017,seven patients have been treated with this *** treatment-related toxicity was similar to that previously observed with two BNCT *** patients had a complete response,but locoregional recurrence was the major cause of failure despite initially good *** clinical trials combining BNCT with other local or systemic treatments will be carried out for recurrent HN cancer patients at THOR.

关键词： Head and neck cancer Boron neutron capture therapy Tsing-Hua Open Pool Reactor Boronophenylalanine

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Primary thymic mucosa-associated lymphoid tissue lymphoma with multiple thin walled lung cysts: case report and literature review

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Chinese Journal of Cancer Research 2013年第3期25卷 354-357页

作者： Lung-Yun Kang Szu-Pei Ho yi-Pin chou Department of Emergency Medicine Kaohsiung Veterans General Hospital Department of Pathology Kaohsiung Veterans General Hospital

Mucosa-associated lymphoid tissue （MALT） lymphoma of the thymus is rare. We reported a case of a 37-year-old Chinese female with Sjtgren＇s syndrome and hyperglobulinemia. She suffered from chronic cough for 3 weeks. Chest computed tomography （CT） demonstrated a multiloculated cystic mass in mediastinum prevascular space and multiple lung cysts. Laboratory exam of autoimmune markers showed positive of antinuclear antibody （ANA）, Sjtgren＇s syndrome A （SSA）, Sjtgren＇s syndrome B （SSB）, and rheumatoid factors （RF）. Thymectomy with lymph node dissection was performed. The pathology report revealed thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Under immunohistochemical stains, CD20 and Bcl-2 were positive. No evidence of recurrence of disease was found.

关键词： Mucosa-associated lymphoid tissue (MALT) lymphoma thymus Sj6gren's syndrome hyperglobulinemia

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An Analytical Solution for Wave Transformation Over Axi-Symmetric Topography

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China Ocean Engineering 2019年第6期33卷 694-703页

作者： CUONG San Sieu CHANG Jen-yi TSAI Chia-Cheng chou Wan-Rong aInstitute of Oceanography National Taiwan UniversityTaipei 10617China Tainan University of Technology Tainan 71002China Department of Marine Environmental Engineering National Kaohsiung University of Science and TechnologyKaohsiung 81164China Department of Marine Environment and Engineering National Sun Yat-Sen UniversityKaohsiung 80424China Department of Hydraulic and Ocean Engineering National Cheng Kung UniversityTainan 701China

The present study considers wave scattering phenomena around a cylindrical island mounted on a general axisymmetric topography or a general submerged truncated axi-symmetric shoal based on the mild-slope equation. The method of separation of variables and Taylor series expansion are invoked to find the approximate solution to the variable water depth region which varies proportionally to an arbitrary power of radial distance. Validations against the solutions for the combined wave refraction and diffraction around a cylindrical island mounted on a paraboloidal shoal of Liu et al. in 2004 and the scattering and trapping of wave energy by a submerged truncated paraboloidal shoal of Lin and Liu in 2007 show excellent agreements as the power of radial distance being equal to two. For the solutions of wave refraction and diffraction around a cylindrical island mounted on a shoal with depth proportionally to an arbitrary power of radial distance, good agreements with Zhai et al.’s(2013) solutions are demonstrated. Since the robustness of the assumption of a general axi-symmetric geometry based on an arbitrary power variability of the radial distance, the present solution can be very conveniently employed to investigate the effects of bottom topography on wave scattering and trapping patterns.

关键词： general axi-symmetric topography mild-slope equation submerged truncated shoal wave refraction wave diffraction

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Glucose detection in a highly scattering medium with diffuse photon-pair density wave

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Journal of Innovative Optical Health Sciences 2017年第1期10卷 53-58页

作者： Li-Ping Yu Jheng-Syong Wu Sheng-yi Chang Chien chou Biomedical Engineering Research Center Chang Gung University Taoyuan 333Taiwan Graduate Institute of Electro-Optical Engineering Chang Gung University Taoyuan 333Taiwan Institute of Chemistry A cademic SinicaNankangTaipei 115Taiwan Ph.D Program of Biomedical Engineering Chang Gung University Taoyuan 333Taiwan Department of Mechanics Ming Chi University of Technology New Taipei 243Taiwan

We propose a novel optical method for glucose measurement based on difuse photon-pair density wave(DPPDW)in a multiple scattering medium(MSM)where the light scattering of photon-pair is induced by refractive index mismatch between scatters and phantom ***-mentally,the DPPDW propagates in MSM via a two frequency laser(TFL)beam wherein highly correlated pairs of linear polarized photons are *** reduced scattering coefficientμ2s and absorption coefficientμ2a of DPPDW are measured simultaneously in terms of the amplitude and phase measurements of the detected heterodyne signal under arrangement at different dis-tances between the source and detection fibers in *** results show that the sensitivity of glucose detection via glucose-induced change of reduced scattering coefficient(δμ′2)is 0.049%mM^(-1)in a 1%intralipid *** addition,the linear range ofδμ′2s vs glucose concentration implies that this DPPDW method can be used to monitor glucose concentration continuously and noninvasively subcutaneously.

关键词： Difuse photon-pair density wave glucose multiple scattering polarization gating spatial coherence gating.

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Eco-Environmental Impact Assessment of Pre-Leisure Beach Nourishment on the Benthic Invertebrate Community at Anping Coast

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China Ocean Engineering 2011年第2期25卷 215-236页

作者： Chun-Han SHIH yi-Yu KUO Ta-Jen CHU Wen-Chieh chou Wei-Tse CHANG ying-chou LEE Institute of Fisheries Science National Taiwan University Taipei 10617 China Department of Civil Engineering National Chiao Tung University Hsinchu 30010 China Department of Leisure and Recreation Management Chung Hua University Hsinchu 30012 China Department of Civil Engineering Chung Hua University Hsinchu 30012 China

In recent years, owing to global warming and the rising sea levels, beach nourishment and groin building have been increasingly employed to protect coastal land from shoreline erosion. These actions may degrade beach habitats and reduce biomass and invertebrate density at sites where they were employed. We conducted an eco-environmental evaluation at the Anping artificial beach-nourishment project area. At this site, sand piles within a semi-enclosed spur groin have been enforced by use of eco-engineering concepts since 2003. Four sampling sites were monitored during the study period from July 2002 to September 2008. The environmental impact assessment and biological investigations that we conducted are presented here. The results from this study indicate that both biotic （number of species, number of individual organisms, and Shannon-Wiener diversity） and abiotic parameters （suspended solids, biological oxygen demand, chemical oxygen demand, dissolved inorganic nitrogen, dissolved inorganic phosphorus, total phosphorus, total organic carbon, median diameter, and water content） showed significant differences before and after beach engineering construction. Biological conditions became worse in the beginning stages of the engineering but improved after the restoration work completion. This study reveals that the composition of benthic invertebrates changed over the study period, and two groups of organisms, Bivalvia and Gastropoda, seemed to be particularly suitable to this habitat after the semi-enclosed artificial structures completion.

关键词： beach nourishment benthic invertebrate eco-engineering ecological restoration spur groin

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