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Droplet digital polymerase chain reaction assay for methylated ring finger protein 180 in gastric cancer

World Journal of Gastrointestinal Oncology 2022年第10期14卷 2038-2047页

作者： Guang-Hong Guo yi-bin xie Tao Jiang Yang An Department of Laboratory Medicine The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Medicine Innovation Research Division of Chinese PLA General Hospital Beijing 100853China Faculty of Hepato-Pancreato-Biliary Surgery The Sixth Medical Center of Chinese PLA General HospitalBeijing 100048China

BACKGROUND Gastric cancer(GC)is one of the most prevalent malignant tumors that endangers human *** diagnosis is essential for improving the prognosis and survival rate of GC *** finger protein 180(RNF180)is involved in the regulation of cell differentiation,proliferation,apoptosis,and tumorigenesis,and aberrant hypermethylation of CpG islands in the promoter is strongly associated with the occurrence and development of ***,methylated RNF180 can be used as a potential biomarker for GC *** To use droplet digital polymerase chain reaction(ddPCR)to quantify the methylation level of the RN180 gene.A reproducible ddPCR assay to detect methylated RNF180 from trace DNA was designed and *** The primer and probe were designed and selected,the conversion time of bisulfite was optimized,the ddPCR system was adjusted by primer concentration,amplification temperature and amplification cycles,and the detection limit of ddPCR was *** The best conversion time for blood DNA was 2 h 10 min,and that for plasma DNA was 2 h 10 min and 2 h 30 *** results of ddPCR were better when the amplification temperature was 56°C and the number of amplification cycles was *** concentrations showed little effect on the assay ***,the primer concentration could be adjusted according to the reaction system and DNA *** assay required at least 0.1 ng of input *** In summary,a ddPCR assay was established to detect methylated RNF180,which is expected to be a new diagnostic biomarker for GC.

关键词： Gastric cancer Ring finger protein 180 DNA methylation Droplet digital polymerase chain reaction

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Evaluation of the diagnostic value of serum-based proteomics for colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1562-1573页

作者： Hui-Juan Wang yi-bin xie Peng-Jun Zhang Tao Jiang Department of Respiratory and Critical Care Medicine Beijing Chao-Yang HospitalBeijing Institute of Respiratory MedicineCapital Medical UniversityBeijing 100020China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Interventional Therapy DepartmentPeking University Cancer Hospital and InstituteBeijing 100142China Medical Innovation Research Division of Chinese PLA General Hospital Beijing 100853China

BACKGROUND Colorectal cancer(CRC)is a highly malignant cancer with a high incidence and mortality in *** is urgent to find a diagnostic marker with higher sensitivity and specificity than the traditional approaches for CRC *** To provide new ideas for the diagnosis of CRC based on serum *** Specimens from 83 healthy people,62 colon polyp(CRP)patients,and 101 CRC patients were analyzed by matrix-assisted laser desorption/ionization time-offlight mass *** diagnostic value of the profiles of differentially expressed proteins was then *** Compared with the healthy control group,CRC patients had elevated expression of 5 proteins and reduced expression of 14 *** area under the curve(AUC)for a differentially expressed protein with a mass-to-charge ratio of 2022.34 was the largest;the AUC was 0.843,which was higher than the AUC of 0.717 observed with carcinoembryonic antigen(CEA),and the sensitivity and specificity of this identified marker were 75.3%and 79.5%,*** cross-validation,the accuracy of diagnosis using levels of this differentially expressed protein was 82.37%.Compared with the CRP group,the expression of 3 proteins in the serum of CRC patients was elevated and 11 proteins were expressed at reduced *** possessing mass-to-charge ratio values of 2899.38 and 877.3 were selected to establish a classification tree *** results showed that the accuracy of CRC diagnosis was 89.5%,the accuracy of CRP diagnosis was 81.6%,and the overall accuracy of this approach was 86.3%.The overall sensitivity and specificity of diagnosis using the proteomics approach were 81.8%and 66.75%,*** sensitivities and specificities of diagnoses based on CEA and carbohydrate antigen 19-9 expression were 55.6%and 91.3%and 65.4%and 65.2%,*** We demonstrated that serum proteomics may be helpful for the detection of CRC,and it may assist clinical practice for CRC diagnosis

关键词： Colorectal cancer Colorectal polyps Serum Proteomics Diagnostic value

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Diagnostic value of four serum exosome microRNAs panel for the detection of colorectal cancer

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 970-979页

作者： Lei Han Wen-Jie Shi yi-bin xie Zhi-Guo Zhang Department of Oncology Beijing Daxing District People’s HospitalBeijing 102600China Department of Medicine Innovation Research Chinese PLA General HospitalBeijing 100853China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100121China

BACKGROUND Early detection,early diagnosis,and early treatment are currently accepted methods that can effectively improve the efficacy of colorectal cancer(CRC)*** were demonstrated to be potential tumor molecular *** To evaluate the diagnostic value of CRC by detecting four exosomal microRNAs(miRNAs)(miR-15b,miR-16,miR-21,and miR-31)that were demonstrated to have potential diagnostic value in *** Relative expression levels of miR-15b,miR-16,miR-21,and miR-31 in 123 CRC,117 colorectal adenoma,and 150 healthy controls were detected,and single and panel models were *** 2-ΔΔCt method was used to calculate the relative expression of miRNA compared to the internal control(U6).Eighty-one CRC patients,67 colorectal adenoma patients,and 90 healthy controls were used for *** Compared to the healthy control group,the best indicator of the four miRNAs was miR-15b,and the sensitivity and specificity were 81.33%and 91.80%,*** miR-15b,miR-21,and miR-31 individually,the sensitivity and specificity were 91.95%and 97.62%,95.06%and 94.44%,*** to the colorectal adenoma group,miR-15b,miR-16,and miR-21 in the CRC group showed significant differences(P<0.05).The best single indicator was miR-16,with a sensitivity and specificity of 79.05%and 71.55%.The sensitivity and specificity of a panel that included miR-15b,miR-16,and miR-21 were 81.21%and 81.03%,and 85.19%and 82.09%,respectively,in the *** We built and validated a diagnostic model containing miR-15b,miR-21,and miR-31 expression levels to discriminate the healthy control group and CRC group,and its sensitivity and specificity were 95.06%and 94.44%,*** miR-15b,miR-16,and miR-21 panel was used to discriminate the colorectal adenoma group and CRC group with a sensitivity and specificity of 85.19%and 82.09%,respectively.

关键词： Colorectal cancer Exosome Serum miRNAs Biomarker

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Construction and analysis of an ulcer risk prediction model after endoscopic submucosal dissection for early gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1823-1832页

作者： San-Dong Gong Huan Li yi-bin xie Xiao-Hui Wang Department of Gastroenterology Hainan Hospital of Chinese PLA General HospitalSanya 572013Hainan ProvinceChina Department of Gastroenterology Sixth Medical Center of Chinese PLA General HospitalBeijing 100048China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Endoscopic submucosal dissection(ESD) has been widely used in the treatment of early gastric cancer(EGC). A personalized and effective prediction method for ESD with EGC is urgently *** To construct a risk prediction model for ulcers after ESD for EGC based on LASSO *** A total of 196 patients with EGC who received ESD treatment were prospectively selected as the research subjects and followed up for one month. They were divided into an ulcer group and a non-ulcer group according to whether ulcers occurred. The general data, pathology, and endoscopic characteristics of the groups were compared, and the best risk predictor subsets were screened by LASSO regression and tenfold cross-validation. Multivariate logistic regression was applied to analyze the risk factors for ulcers after ESD in patients with EGC. A receiver operating characteristic(ROC) curve was used to estimate the predictive model *** One month after the operation, no patient was lost to follow-up. The incidence of ulcers was 20.41%(40/196)(ulcer group), and the incidence of no ulcers was 79.59%(156/196)(non-ulcer group). There were statistically significant differences in the course of disease, Helicobacter pylori infection history, smoking history, tumor number, clopidogrel medication history, lesion diameter, infiltration depth, convergent folds, and mucosal discoloration between the groups. Gray’s medication history, lesion diameter, convergent folds, and mucosal discoloration, which were the 4 nonzero regression coefficients, were screened by LASSO regression analysis. Further multivariate logistic analysis showed that lesion diameter [Odds ratios(OR) = 30.490, 95%CI: 8.584-108.294], convergent folds(OR = 3.860, 95%CI: 1.060-14.055), mucosal discoloration(OR = 3.191, 95%CI: 1.016-10.021), and history of clopidogrel(OR = 3.554, 95%CI: 1.009-12.515) were independent risk factors for ulcers after ESD in patients with EGC(P < 0.05). The ROC curve showed

关键词： Endoscopic submucosal dissection Early gastric cancer Endoscopic features Ulcer Model

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Blood index panel for gastric cancer detection

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 1026-1036页

作者： Guang-Hong Guo yi-bin xie Peng-Jun Zhang Tao Jiang Department of Laboratory Medicine The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Interventional Therapy DepartmentPeking University Cancer Hospital and InstituteBeijing 100142China Medicine Innovation Research Division of Chinese PLA General Hospital Beijing 100853China

BACKGROUND Gastric cancer is a common malignant *** detection and diagnosis are crucial for the prevention and treatment of gastric *** To develop a blood index panel that may improve the diagnostic value for discriminating gastric cancer and gastric *** Thirteen tumor-related detection indices,38 clinical biochemical indices and 10 cytokine indices were examined in 139 gastric cancer patients and 40 gastric polyp patients to build the *** additional 68 gastric cancer patients and 22 gastric polyp patients were enrolled for *** area under the curve evaluation and univariate and multivariate *** Five tumor-related detection indices,12 clinical biochemical indices and 1 cytokine index showed significant differences between the gastric cancer and gastric polyp *** antigen(CA)724,phosphorus(P)and ischemia-modified albumin(IMA)were included in the blood index panel,and the area under the curve(AUC)of the index panel was 0.829(0.754,0.905).After validation,the AUC was 0.811(0.700,0.923).Compared to the conventional index CA724,the blood index panel showed significantly increased diagnostic *** We developed an index model that included CA724,P and IMA to discriminate the gastric cancer and gastric polyp groups,which may be a potential diagnostic method for clinical practice.

关键词： Gastric cancer Gastric polyp Blood Index Panel

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Glycemic Variation in Tumor Patients with Total Parenteral Nutrition

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Chinese Medical Journal 2015年第15期128卷 2034-2039页

作者： Jin-Cheng Yang Yuan-Yuan Dai Li-Ming Wang yi-bin xie Hai-Yan Zhou Guo-Hui Li Department of Pharmacy Cancer Hospital/Institute Chinese Academy of Medical Sciences Beijing 100021 China Department of Abdominal Surgery Cancer Hospital/Institute Chinese Academy of Medical Sciences Beijing 100021 China

Background：Hyperglycemia is associated with poor clinical outcomes and mortality in several ***,studies evaluating hyperglycemia variation in tumor patients receiving total parenteral nutrition （TPN） are *** aim of this study was to assess the relationship between glycemia and tumor kinds with TPN by monitoring glycemic variation in tumor ***：This retrospective clinical trial selected 312 patients with various cancer types,whose unique nutrition treatment was TPN during the monitoring *** patients had blood glucose （BG） values assessed at least six times daily during the TPN *** glycemic variation before and after TPN was set as the indicator to evaluate the factors influencing ***：The clinical trial lasted 7.5 ± 3.0 days adjusted for age,gender,family cancer history and blood *** were six cancer types：Hepatic carcinoma （HC,21.8%）,rectal carcinoma （17.3%）,colon carcinoma （CC,14.7%）,gastric carcinoma （29.8%）,pancreatic carcinoma （11.5%）,and duodenal carcinoma （DC,4.8%）.The patients were divided into diabetes and nondiabetes *** statistical differences in TPN glucose content between diabetes and nondiabetes groups were found;however,the tumor types affected by BG values were *** increasing BG values,DC,HC and CC were more represented than other tumor types in this sequence in diabetic individuals,as well as in the nondiabetic *** was inclined to be more easily influenced in the nondiabetes *** factors did not impact BG values,includiug gender,body mass index,and TPN infusion duration ***：When tumor patients are treated with TPN,BG levels should be monitored according to different types of tumors,besides differentiating diabetes or nondiabetes *** BG control is needed for DC,HC and CC in both diabetic and nondiabetic *** BG overtly increases,positive measurements are needed to control BG *** *** ID is NCT02024321.

关键词： Blood Glucose Total Parenteral Nutrition Tumor Patients

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Investigation of the factors influencing surgical treatment of duodenal gastrointestinal stromal tumors

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 959-969页

作者： Yun-Zi Wu Yang Li Ming Wu Xiao-Hao Zheng Yan-Tao Tian yi-bin xie Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gastric Surgery Yun Cheng Center HospitalYucheng 043300Shanxi ProvinceChina

BACKGROUND Duodenal gastrointestinal stromal tumor(DGIST)is a rare tumor with a specific anatomic site and biological *** the incidence of lymph node metastasis is very low,the main treatment method is *** main surgical techniques(local resection and Whipple)are performed in patients with *** critical question is which surgical technique to *** To identify factors influencing the choice of surgery for *** The clinicopathological data of patients with DGISTs who underwent surgery between January 1999 and January 2021 were *** used the Student’s ttest or Mann-Whitney U-test and theχ2 test or Fisher’s exact test to determine the differences between the two groups of ***,we used logistic analysis to identify the relevant factors and independent factors related to the type of *** Kaplan-Meier method was used to analyze the patient’s survival information and Cox regression analysis was performed to determine prognostic risk *** Overall,86 patients were analyzed,including 43 men(50%)and 43 women(50%).We divided the patients into two groups based on surgical technique(local resection or Whipple surgery).There were no differences in the age,mitotic figures,and complications between the two groups;however,the tumor size,tumor location,risk grade,postoperative hospital stay,and abdominal drainage time were significantly *** on univariate logistic analysis,the Whipple procedure was chosen if the tumor size was≥5.0 cm,the tumor was located in the descending part of the duodenum,or the risk grade was medium or *** our research,the five-year overall survival rate of patients was more than 90%.We also describe two DGIST patients with liver metastases at first diagnosis and analyzed their management in order to provide advice on complicated *** The Whipple procedure was performed if the primary tumor was in the descending part of the duodenum,tumor size was≥5.0 c

关键词： Duodenal gastrointestinal stromal tumors Whipple Surgery Tumor size Tumor risk grade

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Risk factors for surgical-site infections after radical gastrectomy for gastric cancer:a study in China

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Chinese Medical Journal 2020年第13期133卷 1540-1545页

作者： Yong-Qi Qiao Li Zheng Bei Jia Wei-Hua Wang Xiao-Hao Zheng Lin-Lin Fan yi-bin xie Yan-Tao Tian Department of Pharmacy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery Beijing Dongcheng First People's HospitalBeijing 100075China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background:About 10%of patients get a surgical-site infection(SSI)after radical gastrectomy for gastric cancer,but SSI remains controversial among *** aim of this study was to explore the risk factors for SSIs after radical gastrectomy in patients with gastric cancer to guide clinical therapies and reduce the incidence of ***:The study was a retrospective cohort study in patients who underwent radical gastrectomy for gastric *** was defined in accordance with the National Nosocomial Infection Surveillance *** evaluated patient-related and peri-operative variables that could be risk factors for *** Chi-squared test and logistic regression analysis were used to assess the association between these risk factors and ***:Among the 590 patients,386 were men and 204 were *** mean age was 56.6(28-82)years and 14.2%(84/590)of these patients had an *** them,incisional SSI was observed in 23 patients(3.9%)and organ/space SSI in 61 patients(10.3%).Multivariate logistic regression analysis identified sex(odds ratios[ORs]=2.548,and 95%confidence interval[CI]:1.268-5.122,P=0.009),total gastrectomy(OR=2.327,95%CI:1.352-4.004,P=0.002),albumin level(day 3 after surgery)<30 g/L(OR=1.868,95%CI:1.066-3.274,P=0.029),and post-operative total parenteral nutrition(OR=2.318,95%CI:1.026-5.237,P=0.043)as independent risk factors for ***:SSI was common among patients after radical gastrectomy for gastric *** method supporting post-operative nutrition and the duration of prophylactic antibiotics may be important modifiable influencing factors for SSI.

关键词： Radical gastrectomy Gastric cancer Risk factor Surgical-site infection

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Neuroendocrine carcinoma of the gastric stump:A case report and literature review

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World Journal of Gastroenterology 2018年第4期24卷 543-548页

作者： Fu-Hai Ma Li-Yan Xue ying-Tai Chen yi-bin xie Yu-Xin Zhong Quan Xu Yan-Tao Tian Department of Pancreatic and Gastric Surgery National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

We herein report a case of neuroendocrine carcinoma of the gastric stump found 47 years after Billroth II gastric resection for a benign gastric ulcer. A 74-yearold man was referred to another hospital with melena. Endoscopic examination revealed a localized ulcerative lesion at the gastrojejunal anastomosis. The diagnosis by endoscopic biopsy was neuroendocrine carcinoma. A total gastrectomy of the remnant stomach with D2 lymphadenectomy was performed at our hospital. The lesion invaded the subserosa, and metastasis was found in two of nine the lymph nodes retrieved. The lesion was positive for synaptophysin and chromogranin A, and the Ki-67 labeling index was 60%. The diagnosis of neuroendocrine carcinoma of the gastric stump was confirmed using World Health Organization 2010 criteria. Subsequently, the patient underwent one course of adjuvant chemotherapy with the etoposide plus cisplatin(EP) regimen; however, treatment was discontinued due to grade 3 myelosuppression. The patient showed lymph node metastasis in the region around the gastrojejunal anastomosis in the abdominal cavity 7 mo post-surgery. He then underwent radiotherapy and platinum-based combination chemotherapy; however, the disease progressed and liver recurrence was observed on follow-up computedtomography at 16 mo post-surgery. The patient then received chemotherapy with regimens used for the treatment of small cell lung cancer in first-and secondline settings. The patient died of disease progression 31 months after surgery.

关键词： Gastric stump Gastric stump cancer Neuroendocrine carcinoma

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Role of D2 gastrectomy in gastric cancer with clinical para-aortic lymph node metastasis

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World Journal of Gastroenterology 2019年第19期25卷 2338-2353页

作者： Xiao-Hao Zheng Wen Zhang Lin Yang Chun-Xia Du Ning Li Gu-Sheng Xing Yan-Tao Tian yi-bin xie Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND Owing to the technical difficulty of pathological diagnosis, imaging is still the most commonly used method for clinical diagnosis of para-aortic lymph node metastasis(PALM) and evaluation of therapeutic effects in gastric cancer, which leads to inevitable false-positive findings in imaging. Patients with clinical PALM may have entirely different pathological stages(stage IV or not), which require completely different treatment strategies. There is no consensus on whether surgical intervention should be implemented for this group of patients. In particular, the value of D2 gastrectomy in a multidisciplinary treatment(MDT)approach for advanced gastric cancer with clinical PALM remains *** To investigate the value of D2 gastrectomy in a MDT approach for gastric cancer patients with clinical *** In this real-world study, clinico-pathological data of all gastric cancer patients treated at the Cancer Hospital, Chinese Academy of Medical Sciences between 2011 and 2016 were reviewed to identify those with clinically enlarged PALM. All the clinico-pathological data were prospectively documented in the patient medical record. For all the gastric cancer patients with advanced stage disease,especially those with suspicious distant metastasis, the treatment methods were determined by a multidisciplinary *** In total, 48 of 7077 primary gastric cancer patients were diagnosed as having clinical PALM without other distant metastases. All 48 patients received chemotherapy as the initial treatment. Complete or partial response was observed in 39.6%(19/48) of patients in overall and 52.1%(25/48) of patients in the primary tumor. Complete response of PALM was observed in 50.0%(24/48)of patients. After chemotherapy, 45.8%(22/48) of patients received D2 gastrectomy, and 12.5%(6/48) of patients received additional radiotherapy. The postoperative major complication rate and mortality were 27.3%(6/22) and 4.5%(1/22), respectively. The median overall sur

关键词： Gastric cancer Para-aortic lymph node Multidisciplinary Gastrectomy Conversion Neoadjuvant

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