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杂交鲟稚鱼对几种药物敏感性的试验

水产学杂志 2003年第1期16卷 35-39页

作者：吴文化刘晓勇中国水产科学研究院黑龙江水产研究所黑龙江哈尔滨150070 中国水产科学研究院鲟鱼繁育技术工程中心北京100039

对杂交鲟 (Husohuso♀×Acipenserruthenus♂ )进行几种药物 (高锰酸钾、硫酸酮、甲醛 )的敏感性试验 ,结果表明 :杂交鲟对三种药物的敏感性由强到弱依次为 :硫酸酮、高锰酸钾、甲醛 ;安全浓度分别为 :硫酸酮 0 0 1 2.7ppm ,高锰酸钾 0... 详细信息

对杂交鲟 (Husohuso♀×Acipenserruthenus♂ )进行几种药物 (高锰酸钾、硫酸酮、甲醛 )的敏感性试验 ,结果表明 :杂交鲟对三种药物的敏感性由强到弱依次为 :硫酸酮、高锰酸钾、甲醛 ;安全浓度分别为 :硫酸酮 0 0 1 2.7ppm ,高锰酸钾 0 0 71 0ppm ,甲醛1 1 9750ppm。

关键词：杂交鲟鱼稚鱼药物敏感性试验安全浓度水质

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中成药临床合理用药处方点评北京共识

中国中药杂志 2018年第5期43卷 1049-1053页

作者：金锐赵奎君郭桂明张冰王宇光薛春苗杨毅恒王丽霞李国辉唐进法聂黎行张相林赵婷婷张毅严灿袁锁中孙路路冯兴中鄢丹无首都医科大学附属北京世纪坛医院临床合理用药评价北京市重点实验室北京100038 首都医科大学附属北京友谊医院北京100050 首都医科大学附属北京中医医院北京100010 北京中医药大学北京100029 北京中医药大学第三附属医院北京100029 北京中医药大学东直门医院北京100700 北京大学第三医院北京100191 中国中医科学院广安门医院北京100053 中国医学科学院肿瘤医院北京100021 河南中医药大学第一附属医院河南郑州450008 中国食品药品检定研究院北京100050 中日友好医院北京100029 国家食品药品监督管理总局药品审评中心北京100045 重庆市食品药品检验检测研究院重庆401121 广州中医药大学广东广州510405 北京中医药学会中药药理与中成药专业委员会北京中医药学会临床合理用药评价专业委员会

随着中成药品规数和临床使用的增长，中成药临床合理使用问题日趋严峻。由于中成药本身的复杂性和临床应用的不确定性影响，中成药处方点评长期缺乏行业技术规范，导致其临床合理使用缺乏科学的风险管控措施。遵循中医药基本理论及独特... 详细信息

随着中成药品规数和临床使用的增长，中成药临床合理使用问题日趋严峻。由于中成药本身的复杂性和临床应用的不确定性影响，中成药处方点评长期缺乏行业技术规范，导致其临床合理使用缺乏科学的风险管控措施。遵循中医药基本理论及独特的临床治疗学特点，结合中成药临床实践经验和专家意见，形成北京市中成药临床合理用药处方点评专家共识，包括中成药处方点评基本方法、技术以及主要点评要点，以期为规范中成药临床合理用药处方点评行为，提升中成药临床合理用药水平提供技术参考。

关键词：临床合理用药处方点评中成药专家共识

基于“气血水”理论对于糖尿病视网膜病变的初探

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中国中医眼科杂志 2024年第6期34卷 553-557页

作者：于方海梁凤鸣天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津300381

糖尿病视网膜病变(DR)是糖尿病的常见并发症,常致患者视瞻昏渺,严重影响患者生活质量。“气血水”理论与DR的联系是在气血与津液的生理病理联系上提出的。DR在肝、脾、肾三脏失调亏虚的病机基础上,气化不利,致血与津液失司,瘀血与病水互... 详细信息

糖尿病视网膜病变(DR)是糖尿病的常见并发症,常致患者视瞻昏渺,严重影响患者生活质量。“气血水”理论与DR的联系是在气血与津液的生理病理联系上提出的。DR在肝、脾、肾三脏失调亏虚的病机基础上,气化不利,致血与津液失司,瘀血与病水互结,进一步阻碍气机,气、血、水搏结于目络,终成糖尿病性黄斑水肿。治疗上,气、血、水三者同调是治疗的关键,同时注重疏肝理脾,补肾填精等,调气重于黄芪、党参,注重添加风药,如防风、葛根等,血、水同治重用丹参、茯苓、泽兰之品,糖尿病病情日久应考虑精气不足,可予褚实子、茺蔚子等起填精明目之功。“气血水”理论可进一步完善中药在DR的应用。

关键词：糖尿病视网膜病变 “气血水”理论消渴目病糖尿病性黄斑水肿

Chemical and Biochemical Basis of the Anti-tumor Properties of Ganoderma lucidum

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Chemical and Biochemical Basis of the Anti-tumor Properties ...

Antiproliferative piperidine alkaloids from giant taro(Alocasia macrorrhiza)

2.02.际灵芝专题研讨会

作者： Hin Wing Yeung Qing-yi Lu Qi-Feng Zhang Vay liang W. Go UCLA {2. for Human Nutrition , Los Angeles , California , USA

The fruiting bodies of Ganoderma lucidum are edible, medicinal mushrooms known as Ling Zhi in China. Ling Zhi has been used in traditional chinese medicine (TCM) for over 2.00 years with a reputation rivaling that of ginseng. In addition to the fruiting bodies, the spores and cultivated mycelia have recently been used as health foods and herbal medicines. As a superior herbal medicine, it has been used in TCM for promotion of vitality and longevity. In modern chinese medicine, Ganoderma lucidum is used in the treatment of debility and weakness, hepatitis, diabetes, altitude sickness, cardiovascular diseases, AIDS and cancer. Scientific studies on extracts and substances from Ganoderma lucidum have demonstrated their anti-aging, cardiovascular, hepato-protective, hypoglycemic, immuno-modulatory, anti-viral and anti-tumor effects. This evidence provides a pharmacological basis for their ancient and contemporary medical *** investigations on the fruiting bodies, spores and mycelia of Ganoderma lucidum have shown that these mushrooms contain various hioactive substances. Active constituents of Ganoderma lucidum include polysaccharides, proteins, nucleosides, fatty acids, terpenoids and sterols. Water or alcohol extracts have been used for investigation of its biological activities. Water extract contains biological compounds that are responsible for its immunological and anti-inflammatory properties. In contrast, alcohol extract contains biological compounds that lower blood cholesterol levels, blood glucose levels, and platelet aggregation. While the anti-tumor effects can be attributed both to the water soluble polysaccharide and alcohol soluble triterpenes. Recent clinical and pharmacological research substantiating the benefits and effects of Ganoderma lucidum has focused on tumor activities. This presentation attempts to review and analyze our current knowledge on the anti-tumor properties and mechanism of Ganoderma lucidum *** teipenoid

关键词： Ganoderma lucidum ,anti-tumor, polysaccharides, triterpenoids

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chinese Journal of Natural medicines 2022年第7期20卷 541-550页

作者： GAO Wei WANG yi WANG Ru WANG yi-Hai XU Jing-Wen HE Xiang-Jiu School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Engineering research center for Lead Compounds&Drug Discovery Guangzhou 510006China

The rhizome of giant taro(Alocasia macrorrhiza(L.)Schott),which is a highly adaptable wild plant,is a traditional chinese herbal *** the current study,the antiproliferative constituents of giant taro were investigated and six new(1−6)and four known piperidine alkaloids(7−10)were isolated from its *** chemical structures and absolute configurations were elucidated using various spectroscopic methods and the Mosher ester *** isolated alkaloids were screened for the antiproliferative activity through MTT *** results indicated that piperidine alkaloids exerted potential antiproliferative activity against HepG2.AGS and MCF-7 tumor *** researches showed that compounds 3−5 dose-dependently decreased the colony formation rate and induced the apoptosis of AGS cells,while compound 4 induced AGS cell death via the proapoptotic *** study demonstrates that the piperidine alkaloids isolated from giant taro exhibit significant antitumor activity,which provides phytochemical evidence for further development and utilization.

关键词： Giant taro Alocasia macrorrhiza Piperidine alkaloids Antiproliferative Apoptosis

中国穴位埋线疗法系列讲座(84) 针灸推拿配合揿针治疗颈源性头痛的临床观察

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中国中医药现代远程教育 2018年第19期16卷 118-120页

作者：朱晓玲罗会用李信明冯庆奎任正强安嘉懿杨才德遂宁市中心医院康复中心四川遂宁629000 兰州大学第一医院东岗院区中西医结合科甘肃兰州730020

目的观察针灸推拿配合揿针治疗颈源性头痛的临床疗效。方法选择颈源性头痛患者60例,随机分为治疗组和对照组各30例,治疗组患者予以针灸推拿配合揿针治疗,对照组患者予以洛索洛芬钠片联合替扎尼定治疗。观察2.患者治疗前及治疗7天、14天... 详细信息

目的观察针灸推拿配合揿针治疗颈源性头痛的临床疗效。方法选择颈源性头痛患者60例,随机分为治疗组和对照组各30例,治疗组患者予以针灸推拿配合揿针治疗,对照组患者予以洛索洛芬钠片联合替扎尼定治疗。观察2.患者治疗前及治疗7天、14天、3个月后VAS评分并评价临床疗效。结果 2.患者治疗前VAS评分比较,差异无统计学意义(P>0.05),治疗7天、14天、3个月后,治疗组VAS评分显著低于对照组,差异均有统计学意义(P2./30),高于对照组的90.00%(2./30),差异有统计学意义(P<0.05)。结论针灸推拿配合揿针治疗颈源性头痛可有效改善患者头痛症状,值得临床推广应用。

关键词：颈源性头痛针灸推拿揿针

Insight into early-phase trials for lung cancer in the United States

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chinese Journal of Cancer 2015年第7期34卷 288-294页

作者： Jin-Ji Yang yi-Long Wu Guangdong Lung Cancer Institute(GLCI) Guangdong General Hospital (GGH)Guangdong Academy of Medical Sciences(GAMS)

Introduction:Few data have been published comparing early-phase trials for lung cancer between China and the United States(US).This study was to investigate the differences of phase 1 trials for lung cancer between these two ***:In 2.14,a cross-sectional survey was conducted to compare phase 1 trials for lung cancer between the Guangdong Lung Cancer Institute(GLCI),the University of Wisconsin Carbone Cancer center(UWCCC),and the University of Texas MD Anderson Cancer center(MDACC).Results:We found that the GLCI had a lower percentage of phase 1 lung cancer trials than the MDACC in December2.14(2..8%[5/2.]vs.59.8%[2./47],P = 0.006) and the UWCCC in September 2.14(16.7%[3/18]vs.34.8%[8/2.],P = 0.345).Descriptive analyses were performed for early-phase trials conducted by the CancerTherapy Evaluation Program at the National Cancer Institute(CTEP/NCI),the MDACC,and the {2. Thoracic Oncology Group(CTONG).There were 149 ongoing early-phase trials in the Department of Investigational Cancer Therapeutics(Phase 1 program) at the MDACC in October *** contrast,no phase 1 trials had been initiated by the CTONG since its establishment in ***:These data suggest that a significantly higher percentage of phase 1 trials for lung cancer were conducted in the US than in ***-phase oncology trials with robust preclinical data had a higher chance of being approved by the Investigational Drug Branch at the CTEP/*** the importance of early-phase oncology trials in developing innovative cancer medicines,such studies should be highly encouraged and strategically funded in China.

关键词：阶段试验早期肺癌美国 phase Program 临床试验 was

Genome mining of fungal globin-like enzymes for catalyzing the synthesis of linear terpenes

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chinese Journal of Natural medicines 2022年第10期20卷 795-800页

作者： LIU Li CHEN Xiwei ZOU yi Lab Teaching&Management center Biochemistry and Molecular Biology LaboratoryChongqing Medical UniversityChongqing 401331China College of Pharmaceutical Sciences Southwest UniversityChongqing 400715China

Genome mining for the search and discovery of two new globin-like enzymes,TriB from Fusarium poae and TutaA from Schizophyllum commne,are involved in the synthesis of two linear terpenes tricinonoic acid(1)and 2.butenedioic acid(3).Both in vivo heterologous biosynthesis and in vitro biochemical assays showed that these two enzymes catalyzed the C-C double bond cleavage of a cyclic sesquiterpene precursor(-)-germacrene D(7)and a linear diterpene backbone schizostain(2.,*** work presents an unusual formation mechanism of linear terpenes from fungi and expands the functional skills of globin-like enzymes in the synthesis of terpene compounds.

关键词： Genome mining Globin-like enzyme Linear terpene C-C double bond cleavage Fungi

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基于拉曼光谱的中药辛味辨识方法研究

世界中医药 2024年第13期19卷 1939-1945页

作者：李文妍梁浩程虹赵紫薇王慧王耘北京中医药大学中药学院中药信息工程研究中心北京102488 北京中医药大学生命科学学院北京102488

目的:基于中药拉曼光谱的检测分析,测得拉曼光谱数据进行特征选择并建立辛味辨识模型。方法:132.辛味中药及156种非辛味中药经样品前处理后,利用SEED 3000拉曼光谱仪分析,得到每味中药的拉曼谱图,并以1 cm^(-1)为单位量化;对量化后的... 详细信息

目的:基于中药拉曼光谱的检测分析,测得拉曼光谱数据进行特征选择并建立辛味辨识模型。方法:132.辛味中药及156种非辛味中药经样品前处理后,利用SEED 3000拉曼光谱仪分析,得到每味中药的拉曼谱图,并以1 cm^(-1)为单位量化;对量化后的拉曼数据进行基于随机森林(RF)和极端梯度提升(XGBoost)算法的特征选择,筛选出与辛味密切相关的特征拉曼位移及其峰强,然后基于RF、K近邻(KNN)、梯度提升算法(GBM)、朴素贝叶斯(GNB)、自适应提升算法(AdaBoost)5种分类算法建立辨识模型并对模型进行评价。结果:相较于非辛味中药,辛味中药在2.500~3 000 cm^(-1)范围内呈现出高强度的拉曼散射;基于RF算法和XGBoost算法筛选重要性排序在前100的拉曼位移数据为特征,在所有模型中GBM算法所建立的分类模型表现出最佳效能,曲线下面积(AUC)为0.978,准确率为0.943,精确度为0.970。结论:中药拉曼谱图与辛味药性具有显著的相关性,可作为辛味药性整体量化表征,结合GBM算法可以进行高效、准确地对药性进行辨识分析。

关键词：中药药性拉曼光谱辛味特征筛选随机森林辨识模型