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Tunable non-Markovian and quantum coherence in the single-qubit dephasing noise channel

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Na-Na Zhang Chao-yi Wu Xu Zhou Qi-Yuan Liu Cheng-ge Liu Yong-rui Guo Ren-Pu Li School of Optoelectronic Engineering Chongqing University of Posts and Telecommunications Department of Physics Applied Optics Beijing Area Major Laboratory Beijing Normal University

In this paper, we construct a single-qubit dephasing noise channel based on the nuclear magnetic resonance（NMR） system by employing the bath-engineering technology, and achieve the construction of the tunable non-Markovian environment in the dephasing noise channel. Our findings indicate that for the single-qubit system, the transition of system dynamics from Markovian to non-Markovian can be achieved by adjusting the base frequency of the noise power spectrum. However, the base frequency corresponding to this phase transition point is not fixed, and there is a certain relationship between it and the total evolution time of the single-qubit system. Through our research, we discovered a fundamental relationship: if the single-qubit system dynamics undergoe a transition from Markovian to non-Markovian at ω0within 0-2t ms, shortening the evolution time to 0-t ms results in an increase of the phase transition point to 2ω0. This insight offers crucial guidance for artificially crafting non-Markovian environments across arbitrary time scales in single-qubit systems, and it is not limited by the type of noise. Apart from system dynamics, quantum coherence is also a focal point of our research. We find that when the system dynamics exhibit non-Markovian behavior, the quantum coherence of the single-qubit system experiences revivals. Notably, the timing of these coherence revivals aligns with the instants of the non-Markovianity enhancement. Therefore, our research also serves as a pivotal foundation for the artificial manipulation and realization of quantum coherence revivals within diverse single-qubit systems.

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睑板腺功能障碍型和水液缺乏型干眼患者视觉质量比较

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国际眼科杂志 2022年第4期22卷 637-641页

作者：何晶叶芬余婷高颖葛轶睿黄振平中国人民解放军东部战区总医院眼科中国江苏省南京市210002

目的:分析睑板腺功能障碍型干眼(MGD)和水液缺乏型干眼(ADDE)患者的像差和散射相关参数,评估两种干眼类型患者的视觉质量。方法:将2018-01/10在我院门诊就诊的MGD患者25例(MGD组),ADDE患者25例(ADDE组),同时期就诊的健康人25例(对照组)... 详细信息

目的:分析睑板腺功能障碍型干眼(MGD)和水液缺乏型干眼(ADDE)患者的像差和散射相关参数,评估两种干眼类型患者的视觉质量。方法:将2018-01/10在我院门诊就诊的MGD患者25例(MGD组),ADDE患者25例(ADDE组),同时期就诊的健康人25例(对照组)纳入此次研究。三组受试对象填写眼表疾病指数量表(OSDI),接受泪液相关检查:泪液分泌试验(SⅠt)、泪膜破裂时间(TBUT)、角膜荧光染色(FL)。使用iTrace分析仪记录三组受试对象的高阶像差(HO)、球差(SA)、彗差(CA)和三叶草差(TA)的均方根值(RMS)。利用双通道视觉分析仪(OQASⅡ)记录三组受试对象自然状态下的散射值,包括调制传递函数截止频率(MTF cutoff)、斯特列尔比(SR)、客观散射指数(OSI),以及持续睁眼状态下OSI动态变化值(OSI均值)。结果:MGD组的OSDI评分明显高于ADDE组(38.2±5.6 vs 32.2±7.2分,P0.05;CA:t=1.80,P>0.05;TA:t=1.50,P>0.05;SA:t=1.97,P>0.05)。MGD和ADDE组之间的MTF cutoff、SR、OSI无差异(MTF cutoff:33.28±8.28 vs 37.12±9.53,SR:0.19±0.06 vs 0.22±0.08,OSI:1.30±0.32 vs 1.12±0.52,MTF cutoff:t=1.52,P>0.05;SR:t=1.50,P>0.05;OSI:t=1.47,P>0.05)。持续睁眼状态下MGD组的OSI均值明显高于ADDE组(2.386±0.118 vs 1.554±0.058,P<0.001)。结论:治疗干眼的同时需要关注改善患者的视觉质量,MGD患者的视觉质量影响比ADDE患者更加严重。泪膜动态状态下的OSI均值是评估干眼患者视觉质量的敏感指标。

关键词：干眼视敏度睑板腺泪液

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期68卷 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei yi Taikang Li Mingwei Chen Jiayun Chen ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

METTL3介导的m^(6)A甲基化修饰经Notch通路调控血管内皮细胞生物学活性

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国际眼科杂志 2023年第5期23卷 723-730页

作者：唐韵陈思叶巍王文喆高颖葛轶睿黄振平南京大学医学院附属金陵医院(东部战区总医院)眼科江苏省南京市210002

目的:探索甲基转移酶3(METTL3)介导的N6-甲基腺苷(m6A)甲基化修饰在脉络膜新生血管发病中对血管内皮细胞生物学活性的调控作用及机制。方法:将体外培养的人脐静脉内皮细胞(HUVEC)分为:对照组(正常培养)、低密度脂蛋白(LDL)组、荧光标记L... 详细信息

目的:探索甲基转移酶3(METTL3)介导的N6-甲基腺苷(m6A)甲基化修饰在脉络膜新生血管发病中对血管内皮细胞生物学活性的调控作用及机制。方法:将体外培养的人脐静脉内皮细胞(HUVEC)分为:对照组(正常培养)、低密度脂蛋白(LDL)组、荧光标记LDL(Dil-LDL)组、12.5μg/mL、25μg/mL氧化低密度脂蛋白(ox-LDL)组、12.5μg/mL、25μg/mL荧光标记ox-LDL(Dil-ox-LDL)组、DMSO组、STM2457(METTL3抑制剂)组、DAPT组;将体外培养的猴视网膜-脉络膜内皮细胞(RF/6A)分为:对照组、DMSO组、12.5μg/mL ox-LDL组、DAPT组。荧光显微镜观察细胞内吞脂蛋白水平,dot blot检测m6A甲基化水平,Western blot检测METTL3及血管形成相关蛋白的表达水平,实时荧光定量聚合酶链反应(RT-qPCR)检测METTL3及血管形成相关标志物的mRNA表达水平,免疫荧光检测METTL3表达水平及定位,transwell实验检测细胞迁移能力,体外成管实验检测细胞血管形成能力。结果:与对照组相比,Dil-LDL组、12.5μg/mL、25μg/mL Dil-ox-LDL组细胞内荧光标记的脂蛋白含量显著升高,12.5μg/mL、25μg/mL ox-LDL组m6A甲基化水平显著升高(均P0.05),血管内皮生长因子(VEGF)等血管形成相关标志物表达水平显著下降(均P<0.05),细胞迁移及血管形成能力显著下降(均P<0.01),NICD表达水平显著下降(P<0.05);与DMSO组相比,DAPT组NICD、VEGF表达水平显著下降(均P<0.05),HUVEC及RF/6A细胞迁移及血管形成能力显著下降(均P<0.01)。结论:METTL3介导的m6A甲基化修饰在脉络膜新生血管发病中可经Notch通路促进血管内皮细胞的血管形成。

关键词：脉络膜新生血管 N6-甲基腺苷(m_(6)A)甲基化修饰甲基转移酶3(METTL3)

经反向巩膜瓣IOL睫状沟缝合固定术的疗效分析

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国际眼科杂志 2019年第8期19卷 1385-1388页

作者：朱小敏王文喆陈月芹葛轶睿黄振平东部战区总医院(原南京军区南京总医院)眼科

目的:探讨经反向巩膜瓣IOL睫状沟缝合固定术的临床应用。方法:回顾性分析就诊于我院眼科需行Ⅱ期IOL植入的14例14眼无晶状体眼患者临床资料。采用经反向巩膜瓣睫状沟缝合固定术行IOL植入。术中制作以穹窿部为基底的插袋式巩膜瓣。观察... 详细信息

目的:探讨经反向巩膜瓣IOL睫状沟缝合固定术的临床应用。方法:回顾性分析就诊于我院眼科需行Ⅱ期IOL植入的14例14眼无晶状体眼患者临床资料。采用经反向巩膜瓣睫状沟缝合固定术行IOL植入。术中制作以穹窿部为基底的插袋式巩膜瓣。观察患者手术前后的视力、术后眼压、眼前节反应和IOL稳定性。结果:术后随访时间3.5~6mo。术前最佳矫正视力(LogMAR视力表)为0.50±0.54,术后1mo裸眼视力0.46±0.39,两者无差异(P>0.05)。术后1mo最佳矫正视力0.36±0.35,较术前最佳矫正视力有所提高。1例1眼患者术后IOL倾斜,经调整后IOL位正。3例3眼患者在术后早期眼压升高,给予降眼压药物对症处理后眼压正常,术后1mo随访眼压在正常范围内(16.4±2.6mmHg)。1例1眼患者术后玻璃体腔出血,1例1眼患者术后眼内炎症反应重,治疗后均恢复。术后无黄斑囊样水肿、脉络膜脱离、视网膜脱离等严重并发症。结论:经反向巩膜瓣IOL睫状沟缝合固定术是一种简便、安全、有效的术式。

关键词：反向巩膜瓣睫状沟缝合固定悬吊人工晶状体无晶状体眼

DecMamba:Mamba Utilizing Series Decomposition for Multivariate Time Series Forecasting

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Computers, Materials & Continua 2025年第1期82卷 1049-1068页

作者： Jianxin Feng Jianhao Zhang ge Cao Zhiguo Liu Yuanming Ding Communication and Network Key Laboratory Dalian UniversityDalian116622China

Multivariate time series forecasting iswidely used in traffic planning,weather forecasting,and energy *** decomposition algorithms can help models better understand the underlying patterns of the original series to improve the forecasting accuracy of multivariate time ***,the decomposition kernel of previous decomposition-based models is fixed,and these models have not considered the differences in frequency fluctuations between *** problems make it difficult to analyze the intricate temporal variations of real-world time *** this paper,we propose a series decomposition-based Mamba model,DecMamba,to obtain the intricate temporal dependencies and the dependencies among different variables of multivariate time series.A variable-level adaptive kernel combination search module is designed to interact with information on different trends and periods between *** backbone structures are proposed to emphasize the differences in frequency fluctuations of seasonal and trend *** with superior performance is used instead of a Transformer in backbone structures to capture the dependencies among different variables.A new embedding block is designed to capture the temporal features better,especially for the high-frequency seasonal component whose semantic information is difficult to acquire.A gating mechanism is introduced to the decoder in the seasonal backbone to improve the prediction accuracy.A comparison with ten state-of-the-art models on seven real-world datasets demonstrates that DecMamba can better model the temporal dependencies and the dependencies among different variables,guaranteeing better prediction performance for multivariate time series.

关键词： Data prediction time series Mamba series decomposition

m^(6)A甲基化转移酶3在糖尿病性白内障发病中的作用机制

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国际眼科杂志 2023年第8期23卷 1250-1259页

作者：陈思叶巍唐韵王文喆葛轶睿王雪莹黄振平东南大学医学院中国江苏省南京市210003 东部战区总医院眼科中国江苏省南京市210002 南京大学医学院中国江苏省南京市210008

目的:探讨N6-甲基腺嘌呤(N6-methyladenosine,m^(6)A)甲基化转移酶3(METTL3)在糖尿病性白内障发病中的作用机制。方法:用低糖和高糖培养基培养人晶状体上皮细胞系(SRA01/04)24h后,采用RT-qPCR和Western blot实验检测细胞的上皮-间质转分... 详细信息

目的:探讨N6-甲基腺嘌呤(N6-methyladenosine,m^(6)A)甲基化转移酶3(METTL3)在糖尿病性白内障发病中的作用机制。方法:用低糖和高糖培养基培养人晶状体上皮细胞系(SRA01/04)24h后,采用RT-qPCR和Western blot实验检测细胞的上皮-间质转分化(EMT)指标:E-钙黏蛋白(E-Cadherin)、N-钙黏蛋白(N-Cadherin)、紧密连接蛋白1(ZO-1)和α-平滑肌肌动蛋白(α-SMA)的变化情况;transwell和划痕实验检测细胞迁移能力。采用免疫荧光染色检测人晶状体前囊膜组织中METTL3的表达量及定位,m^(6)A dot blot实验检测在低糖和高糖培养基中培养24h细胞的m^(6)A甲基化水平,RT-qPCR和Western blot实验检测细胞中METTL3的RNA和蛋白表达量。加入METTL3抑制剂的培养基中培养24h的细胞,RT-qPCR和Western blot实验检测EMT指标的变化情况;m^(6)A dot blot实验检测细胞m^(6)A甲基化水平;Transwell和划痕实验检测细胞迁移能力。免疫荧光染色检测细胞中转化生成因子β(TGFβ1)的表达;RT-qPCR和Western blot实验检测细胞中的TGFβ1和SNAIL的表达量。结果:与低糖条件相比,高糖条件能够促进细胞EMT的发生,促进METTL3的表达和上调了细胞总RNA的m^(6)A甲基化水平(P<0.05)。高糖能够促进细胞的迁移能力。糖尿病性白内障患者晶状体前囊膜中METTL3表达较单纯年龄相关性白内障患者增高。与高糖+DMSO组相比,加入METTL3抑制剂STM2457,能够抑制细胞的EMT发生,抑制TGFβ1和SNAIL的表达,抑制细胞总RNA的m^(6)A甲基化水平(均P<0.05)。加入METTL3抑制剂STM2457后细胞迁移能力较高糖+DMSO组降低。结论:m^(6)A甲基化转移酶METTL3通过激活TGFβ1/SNAIL通路促进了在高糖条件下人晶状体上皮细胞的EMT发生从而诱导糖尿病性白内障的发生。

关键词：糖尿病性白内障甲基化转移酶3(METTL3) N6-甲基腺嘌呤(m^(6)A) 上皮-间质转分化

Synergistically S/N self-doped biochar as a green bifunctional cathode catalyst in electrochemical degradation of organic pollutant

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Green Energy & Environment 2025年第1期10卷 214-230页

作者： Xuechun Wang Huizhong Wu Jiana Jing ge Song Xuyang Zhang Minghua Zhou Raf Dewil Key Laboratory of Pollution Process and Environmental Criteria Ministry of EducationCollege of Environmental Science and EngineeringNankai UniversityTianjin300350China Tianjin Key Laboratory of Environmental Technology for Complex Trans-Media Pollution Nankai UniversityTianjin300350China Tianjin Advanced Water Treatment Technology International Joint Research Center College of Environmental Science and EngineeringNankai UniversityTianjin300350China Department of Chemical Engineering KU LeuvenJ.De Nayerlaan 5Sint-Katelijne-Waver B2860Belgium

Biomass-derived heteroatom self-doped cathode catalysts has attracted considerable interest for electrochemical advanced oxidation processes(EAOPs)due to its high performance and sustainable ***,we illustrated the morphological fates of waste leaf-derived graphitic carbon(WLGC)produced from waste ginkgo leaves via pyrolysis temperature regulation and used as bifunctional cathode catalyst for simultaneous H_(2)O_(2) electrochemical generation and organic pollutant degradation,discovering S/N-self-doping shown to facilitate a synergistic effect on reactive oxygen species(ROS)*** the optimum temperature of 800℃,the WLGC exhibited a H_(2)O_(2) selectivity of 94.2%and tetracycline removal of 99.3%within 60 *** functional theory calculations and in-situ Fourier transformed infrared spectroscopy verified that graphitic N was the critical site for H_(2)O_(2) *** pyridinic N and thiophene S were the main active sites responsible for_OH generation,N vacancies were the active sites to produce ^(1)O_(2) from *** performance of the novel cathode for tetracycline degradation remains well under a wide pH range(3–11),maintaining excellent stability in 10 *** is also industrially applicable,achieving satisfactory performance treating in real water *** system facilitates both radical and non-radical degradation,offering valuable advances in the preparation of cost-effective and sustainable electrocatalysts and hold strong potentials in metal-free EAOPs for organic pollutant degradation.

关键词： Biochar S and N self-doping H_(2)O_(2)production In-situ FTIR Metal-free electrochemical advanced oxidation processes

Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

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Science China Chemistry 2025年

作者： Yuan Tian Jiang-Bo Chen Jie ying ge Tian Yu-Xuan Xiao yi Lu Si-Ming Wu Wei geng Ling Shen Xiao-Yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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