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Microscopic colitis:A large retrospective analysis from a health maintenance organization experience

World Journal of Gastroenterology 2009年第25期15卷 3122-3127页

作者： Kevin T Kao Benito A Pedraza Amy C McClune David A Rios yi-qiong mao Robert H Zuch Michael H Kanter Sony Wirio Chris N Conteas Department of Gastroenterology Kaiser PermanenteLos Angeles Medical Center Los Angeles California 90027United States Department of Internal Medicine Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 United States Department of Pathology Southern California Kaiser Permanente Medical Group California 90027 United States

AIM： To examine the demographic data on a large multi-ethnic population of patients with microscopic colitis （MC） in Southern California and to determine the association of MC with inflammatory bowel disease （IBD） and colorectal cancer. METHODS： All patients diagnosed with MC by co- Ionic biopsy from 1996-2005 were identified utilizing a pathology database. All biopsies were reviewed by experienced pathologists utilizing standard histologic criteria. Patients＇ medical records were reviewed and data regarding patient age, co-morbidities, sex, ethnic- ity, and medications were analyzed. An age- and sex- matched standard control group was also generated. Chi-square test was used to evaluate the associations of co-morbidities between lymphocytic colitis （LC）, col- lagenous colitis （CC） and the control group. RESULTS： A total of 547 cases of MC were identified, 376 patients with LC and 171 patients with CC. The fe- male/male ratio was 3：1 in CC and 2.7：1 in LC patients. Celiac disease （P 〈 0.001）, irritable bowel syndrome （IBS）（P 〈 0.001）, and thyroid diseases （P 〈 0.001） were found to have a higher occurrence in MC com- pared to the control group. No statistical differences in the occurrence of colorectal cancer, diabetes and IBD were found between the MC group and the control group. CONCLUSION： This is the largest group of patients with MC known to the authors that has been studied to date. Conditions such as celiac disease, IBS, and thyroid diseases were found to be related to MC. Fur- thermore, neither an increased risk of colorectal cancer nor IBD was associated with MC in this study.

关键词： Collagenous colitis Inflammatory bowel disease Lymphocytic colitis Microscopic colitis

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Neddylation Regulation of Immune Responses

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Research 2024年第3期2023卷 545-559页

作者： Hongmei mao Xin Lin yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Institute for Immunology School of MedicineTsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Cancer Center of Zhejiang University Hangzhou 310029China Zhejiang Provincial Clinical Research Center for Cancer HangzhouZhejiang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences HangzhouZhejiang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China.

Neddylation plays a vital role in post-translational modification, intricately shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts control over both innate and adaptive immune systems via various mechanisms. Specifically, neddylation influences the function and survival of innate immune cells, activation of pattern recognition receptors and GMP-AMP synthase–stimulator of interferon genes pathways, as well as the release of various cytokines in innate immune reactions. Moreover, neddylation also governs the function and survival of antigen-presenting cells, which are crucial for initiating adaptive immune reactions. In addition, neddylation regulates T cell activation, proliferation, differentiation, survival, and their effector functions, thereby ensuring an appropriate adaptive immune response. In this review, we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders, especially inflammatory diseases. Lastly, we propose future directions and potential treatments for these diseases by targeting neddylation.

关键词： activation thereby initiating

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Current optimization-based control of dual three-phase PMSM for low-frequency temperature swing reduction

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Defence Technology（防务技术） 2024年第4期34卷 238-246页

作者： Linlin Lu Xueqing Wang Luhan Jin qiong Liu Yun Zhang Yao mao Key Laboratory of Optical Engineering Chinese Academy of SciencesChengdu 610209China Institute of Optics and Electronics Chinese Academy of SciencesChengdu 610209China University of Chinese Academy of Sciences Beijing 100049China College of Electrical Engineering Sichuan UniversityChengdu 610065China

In this paper,a control scheme based on current optimization is proposed for dual three-phase permanent-magnet synchronous motor(DTP-PMSM)drive to reduce the low-frequency temperature *** reduction of temperature swing can be equivalent to reducing maximum instantaneous phase copper loss in this ***,a two-level optimization aiming at minimizing maximum instantaneous phase copper loss at each electrical angle is ***,the optimization is transformed to a singlelevel optimization by introducing the auxiliary variable for easy *** that singleobjective optimization trades a great total copper loss for a small reduction of maximum phase copper loss,the optimization considering both instantaneous total copper loss and maximum phase copper loss is proposed,which has the same performance of temperature swing reduction but with lower total *** this way,the proposed control scheme can reduce maximum junction temperature by 11%.Both simulation and experimental results are presented to prove the effectiveness and superiority of the proposed control scheme for low-frequency temperature swing reduction.

关键词： Dual three-phase PMSM Low-frequency temperature swing Copper loss Current optimization Connected neutral points

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Shape optimisation of basin insulator for DC gas insulated switchgear/gas insulated transmission lines based on artificial bee colony algorithm

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High Voltage 2024年第2期9卷 275-286页

作者： yi Luo Shiyi mao Ju Tang Zijun Pan Cheng Pan State Key Laboratory of Power Grid Environmental Protection School of Electrical Engineering and AutomationWuhan UniversityWuhanChina

The surface charge accumulation on the basin insulator is a particular problem in high-voltage direct current(HVDC)gas insulated switchgears(GIS)and gas insulated trans-mission lines(GIL),which restricts the development and application of extra/ultra high-voltage(EHV/UHV)*** surface charge distribution and anti-flashover performance are closely related to the insulator *** obtain the optimal basin insulator,a shape optimisation model based on artificial bee colony algorithm was established,and the minimisation objective functions based on capacitive(initial)electric field distribution and resistive(steady-state)electric field distribution were respectively *** optimisation results of the two objective functions were calculated,and the electric field and charge distribution on the surface of the insulator before and after optimisation were evaluated and compared using the simulation *** results indicated that the optimisation based on the capacitive electric field can significantly inhibit the surface charge accumulation,and the optimised insulator can significantly reduce the surface normal electric field and make the distribution of the tangential electric field more uniform,and the maximum tangential electric field can be reduced by 10%;the optimisation based on resistive electric field can achieve similar results,but requires more computational *** on the results,the‘anti-charge’basin insulator structure suitable for the DC field was given.

关键词： insulator artificial charge

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Advances of machine learning in materials science: Ideas and techniques

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Frontiers of physics 2024年第1期19卷 155-194页

作者： Sue Sin Chong yi Sheng Ng Hui-qiong Wang Jin-Cheng Zheng Department of New Energy Science and Engineering Xiamen University MalaysiaSepang 43900Malaysia Engineering Research Center of Micro-nano Optoelectronic Materials and Devices Ministry of EducationFujian Key Laboratory of Semiconductor Materials and ApplicationsCI Center for OSEDand Department of PhysicsXiamen UniversityXiamen 361005China

In this big data era, the use of large dataset in conjunction with machine learning (ML) has been increasingly popular in both industry and academia. In recent times, the field of materials science is also undergoing a big data revolution, with large database and repositories appearing everywhere. Traditionally, materials science is a trial-and-error field, in both the computational and experimental departments. With the advent of machine learning-based techniques, there has been a paradigm shift: materials can now be screened quickly using ML models and even generated based on materials with similar properties;ML has also quietly infiltrated many sub-disciplinary under materials science. However, ML remains relatively new to the field and is expanding its wing quickly. There are a plethora of readily-available big data architectures and abundance of ML models and software;The call to integrate all these elements in a comprehensive research procedure is becoming an important direction of material science research. In this review, we attempt to provide an introduction and reference of ML to materials scientists, covering as much as possible the commonly used methods and applications, and discussing the future possibilities.

关键词： machine learning materials science

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Acylfluorination of enynes via phosphine and silver catalysis

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Chinese Chemical Letters 2024年第8期35卷 260-264页

作者： Yu mao yilin Liu Xiaochen Wang Shengyang Ni yi Pan yi Wang State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

This work describes intermolecular acylfluorination of gem-difluoroenynes using acyl fluorides as both acyl source and fluorine ***-substituted allenones or furans could be selectively achieved via phosphine and silve... 详细信息

关键词： Phosphine catalysis Silver catalysis Difunctionalization Allenone Furan Trifluoromethyl

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A framework of force of information influence and application for C4KISR system

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Journal of Systems Engineering and Electronics 2024年第2期35卷 430-443页

作者： mao Shaojie DIAO Lianwang SUN Yu WANG Heng yi Kan XU Xin mao Xiaobin ZHANG Kecheng SHENG Long Science and Technology on Information Systems Engineering Laboratory The 28th Research Institute of China Electronics Technology Group CorporationNanjing 210007China Unit 94860 of the PLA Nanjing 210008China

The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and effect of information flow through command, control, communications, computer, kill, intelligence,surveillance, reconnaissance (C4KISR) system. In this work, we propose a framework of force of information influence and the methods for calculating the force of information influence between C4KISR nodes of sensing, intelligence processing,decision making and fire attack. Specifically, the basic concept of force of information influence between nodes in C4KISR system is formally proposed and its mathematical definition is provided. Then, based on the information entropy theory, the model of force of information influence between C4KISR system nodes is constructed. Finally, the simulation experiments have been performed under an air defense and attack scenario. The experimental results show that, with the proposed force of information influence framework, we can effectively evaluate the contribution of information circulation through different C4KISR system nodes to the corresponding tasks. Our framework of force of information influence can also serve as an effective tool for the design and dynamic reconfiguration of C4KISR system architecture.

关键词： information warfare command control communications computer kill intelligence surveillance reconnaissance(C4KISR)system information circulation force of information influence information entropy

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Curation,nomenclature,and topological classification of receptor-like kinases from 528 plant species for novel domain discovery and functional inference

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Molecular Plant 2024年第4期17卷 658-671页

作者： Qian Liu qiong Fu Yujie Yan Qian Jiang Longfei mao Long Wang Feng Yu Heping Zheng State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University College of BiologyChangshaHunan 410082China Bioinformatics Center Hunan University College of BiologyChangshaHunan 410082China

Receptor-like kinases(RLKs)are the most numerous signal transduction components in plants and play important roles in determining how different plants adapt to their ecological *** on RLKs has focused mainly on a small number of typical RLK members in a few model *** is an urgent need to study the composition,distribution,and evolution of RLKs at the holistic level to increase our understanding of how RLKs assist in the ecological adaptations of different plant *** this study,we collected the genome assemblies of 528 plant species and constructed an RLK *** this dataset,we identified and characterized 524948 RLK family *** member underwent systematic topological classification and was assigned a gene ID based on a unified nomenclature ***,we identified two novel extracellular domains in some RLKs,designated Xiao and *** analysis of the RLK family revealed that the RLCK-XVII and RLCK-XII-2 classes were present exclusively in dicots,suggesting that diversification of RLKs between monocots and dicots may have led to differences in downstream cytoplasmic *** also used an interaction proteome to help empower data mining for inference of new RLK functions from a global perspective,with the ultimate goal of understanding how RLKs shape the adaptation of different plants to the environments/*** assembled RLK dataset,together with annotations and analytical tools,forms an integrated foundation of multiomics data that is publicly accessible via the metaRLK web portal(http://***).

关键词： RLK RLCK domain signaling pathway receptor-protein interactions

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The influences of perforating phase and bedding planes on the fracture deflection in laminated shale

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Petroleum Science 2024年第2期21卷 1221-1230页

作者： Ming-Zhe Gu mao Sheng Xiao-ying Zhuang Xin-yi Li Gen-Sheng Li National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China College of Petroleum Engineering China University of PetroleumBeijing102249China College of Civil Engineering Tongji UniversityShanghai200092China

The perforating phase leads to complex and diverse hydraulic fracture propagation behaviors in laminated shale formations. In this paper, a 2D high-speed imaging scheme which can capture the interaction between perforating phase and natural shale bedding planes was proposed. The phase field method was used to simulate the same conditions as in the experiment for verification and hydraulic fracture propagation mechanism under the competition of perforating phase and bedding planes was *** results indicate that the bedding planes appear to be no influence on fracture propagation while the perforating phase is perpendicular to the bedding planes, and the fracture propagates along the perforating phase without deflection. When the perforating phase algins with the bedding planes, the fracture initiation pressure reserves the lowest value, and no deflection occurs during fracture propagation. When the perforating phase is the angle 45°, 60°and 75°of bedding planes, the bedding planes begin to play a key role on the fracture deflection. The maximum deflection degree is reached at the perforating phase of75°. Numerical simulation provides evidence that the existence of shale bedding planes is not exactly equivalent to anisotropy for fracture propagation and the difference of mechanical properties between different shale layers is the fundamental reason for fracture deflection. The findings help to understand the intrinsic characteristics of shale and provide a theoretical basis for the optimization design of field perforation parameters.

关键词： Shale Propagation Perforating Bedding Structure

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Experimental Study on Mixed-Mode(Ⅰ–Ⅱ)Fracture Toughness of Freshwater Ice

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Acta Mechanica Solida Sinica 2024年第2期37卷 252-264页

作者： Yaozhong Xu mao Zhou Xian yi Wen Hua Jiuzhou Huang Wenyu Zhang Shiming Dong Key Laboratory of Deep Underground Science and Engineering Ministry of EducationCollege of Architecture and EnvironmentSichuan UniversityChengdu610065China Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan Province Sichuan UniversityChengdu610065China China Aerodynamics Research and Development Center/Low Speed Aerodynamics Research Institute Mianyang621000China College of Mechanical and Electrical Engineering Xichang UniversityXichang615000China

In recent years,the issue of aircraft icing has gained widespread *** breaking and detachment of dynamic ice can pose a threat to flight ***,the shedding and fracture mechanisms of dynamic ice are unclear and cannot meet the engineering needs of ice-shedding hazard ***,studying the fracture toughness of ice bodies has extremely important practical *** address this issue,this article uses a centrally cracked Brazilian disk(CCBD)specimen to measure the pure modeⅠtoughness and pure modeⅡfracture toughness of freshwater ice at different loading *** mixed-mode(Ⅰ–Ⅱ)fracture characteristics of ice are discussed,and the experimental results are compared and analyzed with the theoretical values of the generalized maximum tangential stress(GMTS)criterion considering the influence of *** results indicated that as the loading rate increases,the pure modeⅠtoughness and pure modeⅡfracture toughness of freshwater ice decrease,and the fracture toughness of freshwater ice is more sensitive to the loading rate.Ⅰn terms of fracture criteria,the theoretical value of the ratio of pure modeⅡfracture toughness to pure modeⅠfracture toughness based on the GMTS criterion is in good agreement with the experimental value,while the theoretical value based on the maximum tangential stress(MTS)criterion deviates significantly from the experimental value,indicating that the GMTS criterion considering the influence of T-stress can better predict the experimental results.

关键词： Freshwater ice Fracture criteria Centrally cracked Brazilian disk(CCBD) Mixed-mode(Ⅰ-Ⅱ) Loading rate

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