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Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 1024-1033页

作者： Rong ZHU yi-ping chen Yue-yi DENG Rong ZHENG yi-fei ZHONG Lin WANG Lan-ping DU Department of Nephrology Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200032 China

Background and Objectives:Chronic kidney disease(CKD) is a growing public health problem with an urgent need for new pharmacological *** cicadae is widely used in traditional Chinese medicine(TCM) and has potential renoprotective *** current study aimed to determine any scientific evidence to support its clinical ***:We analyzed the potential of two kinds of *** extract,total extract(TE) and acetic ether extract(AE),in treating kidney disease simulated by a subtotal nephrectomy(SNx) ***-Dawley rats were divided randomly into seven groups:sham-operated group,vehicle-treated SNx,Cozaar,2 g/(kg·d) TE SNx,1 g/(kg·d) TE SNx,92 mg/(kg·d) AE SNx,and 46 mg/(kg·d) AE *** injury was monitored using urine and serum analyses,and hematoxylin and eosin(HE) and periodic acid-Schiff(PAS) stainings were used to analyze the level of *** expression of type IV collagen(Col IV),fibronectin(FN),transforming growth factor-β1(TGF-β1),and connective tissue growth factor(CTGF) was detected by ***:Renal injury,reflected in urine and serum analyses,and pathological changes induced by SNx were attenuated by TE and AE *** depositions of Col IV and FN were also decreased by the treatments and were accompanied by reduced expression of TGF-β1 and *** some respects,2 g/(kg·d) of TE produced better effects than ***:For the first time,we have shown that *** may inhibit renal fibrosis in vivo through the TGF-β1/CTGF ***,we conclude that the use of *** could provide a rational strategy for combating renal fibrosis.

关键词： Chronic kidney disease Cordyceps cicadae TGF-β Traditional Chinese medicine

Establish a special conservation zone for the captive giant panda

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Ecosystem Health and Sustainability 2018年第2期4卷 16-21页

作者： yi-ping chen Aaron M.Ellison Yong-long Lu SKLLQG Institute of Earth EnvironmentChinese Academy of SciencesXi'anChina College of Geography and Environment science Northwest Normal UniversityLanzhouChina Harvard University Harvard ForestPetershamMAUSA Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijingChina

The giant panda(Ailuropoda melanoleuca)is recognized worldwide as an icon for wildlife *** the introduction in 1992 of reliable methods for artificial insemination,the population of captive pandas has grown to approximately 350 individuals in ***,ca ptive panda populations are harmed by environmental pollution,diseases trans-mitted from domestic animals,and other anthropologenic *** the Chinese government has proposed the creation of a Giant Panda National Park,there are at least three reasons that suggest that it is premature to reintroduce captive pandas into this proposed national ***,habitat fragmentation remains the greatest threat to survival of giant pandas;second,most captive pandas are hybrids of the Sichuan and Qinling subspecies and release of hybrids may lead to further introgression between the two subspecies;and third,captive pandas may be competitively inferior to wild pandas in the region,and may not survive fights for food or *** an alternative,we suggest establishing a special con-servation zone in the Shennongjia National Nature Reserve for wild training of captive pandas prior to their reintroduction into the National Park.

关键词： Giant panda habitat protection captive breeding centers wildlife conservation panda special zone Giant Panda National Park

Synthesis and Pharmacological Evaluation of Novel Conjugates of Indomethacin with Antioxidant Activity

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Chinese Journal of Chemistry 2005年第11期23卷 1523-1529页

作者： ZHANG, yi-Chun chen, ping-Tao GUAN, Hua-Shi LI, ying-Xia Key Laboratory of Marine Drugs The Ministry of Education of China Marine Drug and Food Institute Ocean University of China Qingdao Shandong 266003 China

A series of new conjugates of indomethacin with phenolic anfioxidants were synthesized for enhanced antiinflammatory activity as well as reduced ulcerogenic potency. It was found that all conjugates were very potent antioxidants in vitro. They could inhibit lipid peroxidafion significantly, while 11b-11e and 13b-13e could also interact with DPPH. However these conjugates showed little inhibition against croton oil induced mouse ear swelling.

关键词： antioxidant indomethacin antiinflammation conjugate nonsteroidal antiinflammatory drugs (NSAID)

Absorption Characteristics of Novel Compound Calcium Carbonate Granules:Effects of Gastric Acid Deficiency and Exogenous Weak Acids

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Current Medical Science 2019年第2期39卷 337-342页

作者： Hong-dan chen yi-ping chen Rui XIE Qin-yu HU Qi chenG Ming XIANG Department of Pharmacology School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pediatric Infectious Diseases Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhou 325000China

Calcium carbonates are commonly administered as supplements for conditions of calcium *** report here pharmacokinetic characteristics of a novel formulation,calcium carbonate compound granules(CCCGs).forming complexes of calcium carbonate and calcium citrate in *** were compared to a kind of commonly?used calcium carbonate preparation(CC)in the market in 5-week-old mice that had been treated with omeprazole,to suppress gastric acid secretion,and in untreated control *** results showed that:(1)CCCGs had better water solubility than CC in vitro;(2)In control mice,calcium absorption rates after CCCGs administration were comparable to those after CC administration;(3)Inhibition of gastric acid secretion did not affect calcium absorption after CCCGs,but moderately decreased it after CC;(4)The presence of phytic acid or tannin did not affect calcium absorption rates after CCCGs but did for CC;and(5)In nonnal mice,CCCGs did not inhibit gastric emptying and intestinal propulsion,and did not alter the gastrointestinal *** results suggest that CCCGs may be therapeutically advantageous over more commonly used calcium supplement formulations,particularly for adolescents,because of their stable calcium absorption characteristics and their relatively favorable adverse effect profile.

关键词： calcium carbonate gastric acid inhibition phytic acid tannin calcium absorption

Synthesis and characterization of a new catalyst for RhB degradation constructed by[SiMo_(12)O_(40)]^(4-) anionic cluster

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Chinese Chemical Letters 2015年第2期26卷 187-192页

作者： Hao Wang yi-ping chen Zhu-Chai You Meng-Xi Zhou Ning Zhang Yan-Qiong Sun College of Chemistry Fuzhou University State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences

A Keggin-type polyoxomolybdate[H2biim]{Ni（biim）3（SiMO12O40）}[biim =1H,1＇H-[2,2＇]biimidazolyl]has been synthesized under hydrothermal condition and characterized by XRD,temperature-dependent IR,TG,temperature-induced and magnetism-induced 2D infrared correlation spectroscopy（2D-IR COS）and UV-vis DRS in order to explore the relationship between structure and *** 2D-IR COS spectroscopy indicates that the terminal Mo-Oμ/υbonds are more sensitive than the bridging Mo=Ot,bands to temperature variation,which is in agreement with the conclusion of temperature-dependent ***-dependent 2D-IR COS spectroscopy reveals the stretching vibration of the Mo=Ot,occurs prior to the stretching vibration of the Mo-Oμ/υ,which is due to the coordination environment and the valence of the Si *** stability of compound 1 is investigated via TG and temperature-dependent *** RhB degradation,compound 1 shows good photocatalytic abilities.

关键词： 2D infrared correlation spectroscopy Photocatalytic degradation of RhB Silicon molybdenum polyoxometalate

Identifying miRNA-disease association based on integrating miRNA topological similarity and functional similarity

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Quantitative Biology 2019年第3期7卷 202-209页

作者： Qingfeng chen Zhao Zhe Wei Lan Ruchang Zhang Zhiqiang Wang cheng Luo yi-ping Pheobe chen School of Computer Electronic and InformationGuangxi UniversityNanning 530004China The State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources Guangxi UniversityNanning 530004China Xingjian College of Science and Liberal Arts Guangxi UniversityNanning 530004China Department of Computer Science and Computer Engineering La Trobe UniversityMelboumeVic 3086Australia

Background:MicroRNAs(miRNAs)are a significant type of non-coding RNAs,which usually were encoded by endogenous genes with about?22 nt *** biological experiments have shown that miRNAs have close associations with various human *** traditional experimental methods achieve great successes in miRNA-disease interaction identification,these methods also have some ***,it is necessary to develop computational method to predict miRNA-disease ***:Here,we propose a computational framework(MDVSI)to predict interactions between miRNAs and diseases by integrating miRNA topological similarity and functional ***,the CosRA index is utilized to measure miRNA similarity based on network topological ***,in order to enhance the reliability of miRNA similarity,the functional similarity and CosRA similarity are integrated based on linear weight ***,the potential miRNA-disease associations are predicted by using recommendation *** addition,in order to overcome limitation of recommendation method,for new disease,a new strategy is proposed to predict potential interactions between miRNAs and new disease based on disease functional ***:To evaluate the performance of different methods,we conduct ten-fold cross validation and de novo test in experiment and compare MDVSI with two the-state-of-art *** experimental result shows that MDVSI achieves an AUC of 0.91,which is at least 0.012 higher than other compared ***:In summary,we propose a computational framework(MDSVI)for miRNA-disease interaction *** experiment results demonstrate that it outperforms other the-state-of^the-art *** study shows that it can effectively identify potential miRNA-disease interactions.

关键词： miRNA-disease association CosRA index miRNA functional similarity recommendation method

Simultaneously Improved Curing,Mechanical,Antioxidative Properties and Reduced ZnO Loading of Silica Filled NR Composites by Incorporation of Low-cost Crude Carbon Dots via Conventional Melt-milling Method

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Chinese Journal of Polymer Science 2024年第6期42卷 815-825页

作者： Chao-ying Sun Hai-Jun Ji Li-Wei Li Hui Yang Xiao-Peng An yi-ping chen Ming-Jian Han Can Jiang Li-Qun Zhang Peng Yu Run-Guo Wang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan430205China

Rubbers or elastomers play an important role in hi-tech technology and civilian daily life because of their unique and strategical ***,the rubber additives are essential components for rubbers’practical ***,developing novel multifunctional additives has attracted increasing research *** this work,low-cost crude carbon dots(CCDs)were used as multifunctional additives for natural rubber/silica system(without any additional modification)through industrial compatible melt-mixing *** results revealed that the CCDs could disperse well in the NR/silica system,and they could not only endow the rubber compound with excellent anti-aging capability due to CCDs’radical scavenging activity because of their plenty of nitrogen-containing species,but also improve the curing rate and mechanical performance of the rubber ***,the CCDs could reduce the rolling resistance of the rubber composites(tanδvalue at 7%strain of the rubber composite could be decreased by 34%),which is promising for the application of energy-saving tire ***,the addition of CCDs could effectively reduce the ZnO dosage by at least 40%in the rubber composite without deteriorating its ***,this work provides valuable guidance to develop novel cheap yet effective additives for the elastomer.

关键词： Natural rubber Crude carbon dots Antioxidant ZnO reduction Vulcanization

Hybrid Method: Review, Modularization and Application

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Systems Science and Systems Engineering 1999年第4期9卷 2-8页

作者： XU yi\|ping,\ chen Xi\|kang,\ LU Yan Institute of Systems Science, Academia Sinica, Beijing 100080,China

The objective of this approach is to introduce the idea of modular design into the construction of hybrid model, thus, each step has it own unique function, the entries of superior data decrease and the directions of data flow are more clear. Although the approach itself cannot guarantee the accuracy of the target table which depends on the accuracy of the survey data, experience of experts and assumption in deriving, it does can help constructors to arrange their thoughts, thereby subjective errors could be brought down significantly. As an example, a case analysis is employed to show the effectiveness of the method in detail.

关键词： hybrid method coefficient updating method input\|output model

Furfural residues from straw become complex fertilizer by addition method

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Journal of Environmental Sciences 2000年第2期12卷 74-77页

作者： LIU Jun\|feng,yi ping\|gui,chen An\|guo (Department of Chemical Engineering, Xiangtan Polytechnic University, Xiangtan 411201, China)

The additives such as phosphoric acid, calcium phosphate, calcium super phosphate, calcium over super phosphate, calcium carbonate, sodium hydrosulphite, etc. were used to produce furfural from the straw by hydrolysis with sulfuric acid. The effect of amount of the additives, the content of the added substance and the conditions of distillation on the acidity of the residues were studied. The experiment results showed that the all residues became neutral complex fertilizer, and the productivity of furfural increases under the following conditions: sulfuric acid concentration is 20% (by weight), the ratio of liquid to solid is 3∶1—4∶1 (by weight), the ratio of the additives to straw is suitable.

关键词： straw furfural residues complex fertilizer CLC number: X712 Document code: A