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Establishing a rabbit model of perianal fistulizing Crohn's disease

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World Journal of Gastroenterology 2022年第15期28卷 1536-1547页

作者： Shuang-Shuang Lu Wen-Jia Liu Qiu-Ya Niu Chun-Yan Huo Yu-Qing cheng En-Jing Wang Rong-Nan Li Fang-Fang Feng yi-ming cheng Rong Liu Jin Huang Gastroenterology Center The Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Medical Statistics Center Changzhou UniversityChangzhou 213000Jiangsu ProvinceChina

BACKGROUND Crohn’s disease(CD)is a chronic nonspecific intestinal inflammatory *** aetiology and pathogenesis of CD are still *** fistula is the main complication of CD and is a difficult problem to solve at *** main limitation of developing new therapies is bound up with the short of preclinical security and effectiveness ***,an ideal animal model is needed to establish persistent anal fistula and an inflamed rectal *** To improve the induction method of colitis and establish a reliable and reproducible perianal fistulizing Crohn’s disease animal model to evaluate new treatment *** Twenty male New Zealand rabbits underwent rectal enema with different doses of 2,4,6-trinitrobenzene sulfonic acid to induce *** A was treated with an improved equal interval small dose increasing *** dosage of group B was *** days later,the rabbits underwent surgical creation of a transsphincteric ***,three rabbits were randomly selected from each group every 7 d to remove the seton from the *** rabbits were examined by endoscopy every 7 days,and biopsy forceps were used to obtain tissue samples from the obvious colon lesions for histological *** disease activity index(DAI),colonoscopy and histological scores were *** endoscopic ultrasonography(EUS)was used to evaluate the healing of *** Except for the DAI score,the colonoscopy and histological scores in group A were significantly higher than those in group B(P<0.05).In the ideal model rabbit group,on the 7 th day after the removal of the seton,all animals had persistent lumens on EUS imaging,showing continuous fullthickness high *** inspection of the fistula showed acute and chronic inflammation,fibrosis,epithelialization and peripheral proctitis of the adjoining *** The improved method of CD colitis induction successfully established a rabbit perianal fistula CD pre

关键词： Crohn’s disease Perianal fistula Model Endoscopy Histology

Renoprotective Effect of the Combination of Renin-angiotensin System Inhibitor and Calcium Channel Blocker in Patients with Hypertension and Chronic Kidney Disease

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Chinese Medical Journal 2016年第5期129卷 562-569页

作者： Rong-Shuang Huang yi-ming cheng Xiao-Xi Zeng Sehee Kim Ping Fu Department of Internal Medicine Renal Division West China Hospital of Sichuan University Chengdu Sichuan 610041 China West China Biostatistics and Cost-Benefit Analysis Center West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Biostatistics University of Michigan Ann Arbor Michigan 48109 USA

Background：Renin-angiotensin system inhibitor and calcium channel blocker （CCB） are widely used in controlling blood pressure （BP） in patients with chronic kidney disease （CKD）.We carried out a meta-analysis to compare the renoprotective effect of the combination of angiotensin-converting enzyme inhibitor （ACEI） or angiotensin receptor blocker （ARB） and CCB （i.e.,ACEI/ARB ＋ CCB） with ACEI/ ARB monotherapy in patients with hypertension and ***：Publications were identified from PubMed,Embase,Medline,and Cochrane *** randomized controlled trials （RCTs） of BP lowering treatment for patients with hypertension and CKD were *** outcomes of end-stage renal disease （ESRD）,cardiovascular events,BP,urinary protein measures,estimated glomerular filtration rate （GFR）,and adverse events were ***：Based on seven RCTs with 628 patients,ACEI/ARB ＋ CCB did not show additional benefit for the incidence of ESRD （risk ratio [RR] =0.84;95% confidence interval [CI]：0.52-1.33） and cardiovascular events （RR =0.58;95% CI：0.21-1.63） significantly,compared with ACEI/ARB *** were no significant differences in change from baseline to the end points in diastolic BP （weighted mean difference [WMD] =-1.28 mmHg;95% CI：-3.18 to-0.62）,proteinuria （standard mean difference =-0.55;95% CI：-1.41 to-0.30）,GFR （WMD =-0.32 ml/min;95% CI：-1.53 to-0.89）,and occurrence of adverse events （RR =1.05;95% CI：0.72-1.53）.However,ACEI/ARB ＋ CCB showed a greater reduction in systolic BP （WMD =-4.46 mmHg;95% CI：-6.95 to-1.97）,compared with ACEI/ARB ***：ACEI/ARB ＋ CCB had no additional renoprotective benefit beyond than what could be achieved with ACEI/ARB monotherapy.

关键词： Calcium Channel Blocker Chronic Kidney Disease Hypertension Renin-angiotensin System Inhibitor Renoprotection Therapy

New rabbit model for benign biliary stricture formation with repeatable administration

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World Journal of Gastrointestinal Surgery 2024年第11期16卷 3538-3545页

作者： Qiu-Yue Sun yi-ming cheng Yu-Hui Sun Jin Huang Department of Gastroenterology The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213161Jiangsu ProvinceChina Department of Gastroenterology Graduate School of Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

BACKGROUND The treatment of benign biliary strictures(BBS)is a challenging clinical *** present,there is a lack of ideal models for the study of BBS *** To develop a novel animal model of BBS to simulate studies on the processes and mechanisms in the human *** A rabbit model of benign bile duct stricture was established by surgical injury of the bile *** removal of the gallbladder,a drainage tube was placed th-rough the cystic duct at the stump,and a BBS model was induced by surgical injury at the lower end of the common bile *** Compared with the control group,the model rabbits showed gross jaundice,increased serum bilirubin,and decreased liver *** showed segmental bile duct stenosis in the model *** staining showed inflammatory cell infiltration and fibrosis in the biliary tract of rabbits in the model *** was consistent with the clinical manifestations of *** model provided serology,imaging,pathology,and other aspects of *** We have successfully established an animal model of benign stricture of the lower bile duct with repeatable administration,which is consistent with the clinical manifestations of BBS.

关键词： Benign biliary stricture Animal model Cholangiography Surgery Histopathological analysis

基于即时学习的高炉炼铁过程数据驱动自适应预测控制

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控制理论与应用 2020年第2期37卷 295-306页

作者：易诚明周平柴天佑东北大学流程工业综合自动化国家重点实验室辽宁沈阳110819

针对高炉炼铁过程,本文提出一种基于即时学习的高炉铁水质量自适应预测控制方法(JITL–APC).该方法的特点是控制器通过k向量近邻(k–VNN)方法搜索数据库中的输入输出(I/O)数据信息,对非线性系统进行局部建模,并在此基础上计算控制律.而... 详细信息

针对高炉炼铁过程,本文提出一种基于即时学习的高炉铁水质量自适应预测控制方法(JITL–APC).该方法的特点是控制器通过k向量近邻(k–VNN)方法搜索数据库中的输入输出(I/O)数据信息,对非线性系统进行局部建模,并在此基础上计算控制律.而且,该方法中引入了工业异常数据处理机制,利用JITL学习子集中的平均数据项,对异常数据项进行填补或替换,从而消除异常数据对控制系统的影响.此外,本文提出一种JITL模型保留策略(MRS),避免由于数据库中相似数据样本不足导致的局部模型严重失配,并通过实时收集I/O数据更新数据库,使控制器自适应不同的工况条件,MRS还可以有效抑制噪声干扰的影响,从而提高控制系统的稳定性.最后,基于某大型钢铁厂2#高炉的数值仿真实验,充分验证了该方法的有效性.

关键词：高炉数据驱动即时学习线性化模型预测控制工业数据异常

Lysine malonylation occurs in human sperm and is related to sperm motility

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Cooperation Enforcement Mechanism Considering Battery Cost in Ad hoc Networks

中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Zhen Peng yi-ming cheng Xiao-nian Hu Ting-ting Pan Hou-yang Chen Tao Luo Xu-hui Zeng Institute of Life Science and School of Life Science Nanchang University Reproductive Medical Center Jiangxi Provincial Maternal and Child Health Hospital Key Laboratory of Reproductive Physiology and Pathology in Jiangxi Province

Currently,post transcription modifications(PTMs)are supposed to regulate cellular functions by affecting the protein *** mature sperm are specialized cells generally considered transcriptionally and translation silently,their physiological functions are likely to be mediated by various types of *** instance,phosphorylation occurring on corresponding proteins has

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Cooperation Enforcement Mechanism Considering Battery Cost i...

IEEE 2007 International Symposium on Microwave,Antenna,Propagation and EMC Technologies for Wireless Communications(ISMAPE-2007)

作者： Wu Hao Ding yi-ming Li cheng-shu State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong University,Beijing,P.R.China 100044

Mobile ad hoc networks have been an active research area for several *** nodes' selfish behavior to save the battery for their own communication cannot be neglect. However,general cooperation enforcement mechanisms do not consider node battery,so hotspot node issue may exist;even badly lead to network *** paper proposes a kind of cooperation enforcement reputation mechanisms considering node battery in ad hoc *** analysis and numerical simulation results show that the reputation mechanism considering battery cost,comparing with the traditional reputation mechanisms,can prolong networks existence time and improve network throughput,but at the cost of a little more packets delay.

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半轴轴承游隙对整车传动效率影响的探究

机械设计 2016年第10期33卷 36-41页

作者：莫易敏柴淑枫王俊平曹甜马易成名武汉理工大学机电工程学院湖北武汉430070

针对某微型汽车油耗高、滑行距离短、稳态阻力过大的现象,在理论分析的基础上,结合对标试验,提出增大后桥半轴轴承游隙的改进意见,并利用CRUISE对其进行模拟仿真及实车试验。仿真结果与最终试验结果一致,表明:增大轴承游隙能够提升整车... 详细信息

针对某微型汽车油耗高、滑行距离短、稳态阻力过大的现象,在理论分析的基础上,结合对标试验,提出增大后桥半轴轴承游隙的改进意见,并利用CRUISE对其进行模拟仿真及实车试验。仿真结果与最终试验结果一致,表明:增大轴承游隙能够提升整车的传动效率,降低稳态阻力,减少整车油耗。该研究为整车试验提供了一种方法与思路,对以低成本降低汽车油耗研究方面有着重要的借鉴作用。

关键词：轴承游隙传动效率油耗 CRUISE仿真转鼓试验

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沌口长江公路大桥加劲梁选型与设计

世界桥梁 2017年第1期45卷 5-9页

作者：任蒙付坤陈毅明冯鹏程中交第二公路勘察设计研究院有限公司湖北武汉430056

沌口长江公路大桥主桥为(100+275+760+275+100)m双塔双索面半飘浮体系斜拉桥。针对该桥车道数较多、通行重载货车比例高的特点,提出整幅式P-K断面钢箱梁、双层钢桁梁以及分幅式钢箱梁3种加劲梁方案,采用有限元软件分析各方案静动力性能... 详细信息

沌口长江公路大桥主桥为(100+275+760+275+100)m双塔双索面半飘浮体系斜拉桥。针对该桥车道数较多、通行重载货车比例高的特点,提出整幅式P-K断面钢箱梁、双层钢桁梁以及分幅式钢箱梁3种加劲梁方案,采用有限元软件分析各方案静动力性能,综合考虑各方案静动力性能、景观效果、造价等,确定该桥选用整幅式P-K断面钢箱梁方案。该方案钢箱梁由2个流线型扁平边箱、箱间顶板及横隔板组成,宽46.0m,中心线处梁高4.0m,横隔板采用整体式(标准间距3.0m);剪力滞和横向偏载效应导致的截面应力不均匀及局部应力增大,通过分段调整钢箱梁板厚以及加强局部构造,使钢箱梁应力在容许范围内;针对大跨重载的特点,采用了疲劳细节等级较高的构造细节,加强了桥面板与加劲肋的焊缝设计,提高了钢箱梁正交异性钢桥面板的疲劳强度。

关键词：斜拉桥宽梁重载货车加劲梁方案整幅式P-K钢箱梁剪力滞横向偏载正交异性钢桥面板桥梁设计

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南朝皇室与士族在文学地位上的互动

重庆三峡学院学报 2003年第4期19卷 24-27页

作者：曾毅程明四川师范大学文学院四川成都610066

南朝皇室与士族在文学地位上有一个互动关系,即皇室文化素养不断提高,文学地位逐渐上升,士族文学地位逐渐下降。这种互动关系形成的原因便是庶族皇室对士族文化的认同和重视,从而导致了南朝社会普遍的爱文风气。

关键词：南朝皇室士族文学地位互动