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Morphological and electrophysiological changes of retina after different light damage in three patients:Three case reports

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World Journal of Clinical Cases 2022年第30期10卷 11128-11138页

作者： Xi Zhang Tao Luo Yan-Rong Mou Wei Jiang Yan Wu Heng Liu yi-ming ren Pan Long Fei Han Department of Ophthalmology General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina

BACKGROUND Light-induced retinal damage is a serious vision-threatening disease,resulting from unsuitable laser irradiation,high-power light and sustaining light ***,effectively evaluate the morphological and functional of retinal damage is urgently ***,we mainly reported three patients suffered from typical light *** SUMMARY Patient 1 suffered from old laser pointer irradiation and followed with amblyopia *** 2 suffered from acute high-energy light *** 3suffered from sustaining optical fiber *** morphological and functional examinations of the retina revealed that the lesions of the three patients had many similar characteristics,such as macular morphological changes,patent pattern visual monitoring amplitude or peak time abnormalities,multi-fucus electroretinograms macular central amplitude density *** In conclusion,light-induced retinopathy has many common features,which can help clinical medical staff to diagnose retinal photodamage diseases.

关键词： Light-induced retinopathy Diagnosis Morphology Electrophysiology Case report

一种内容中心网络中的热区控制及内容调度缓存算法

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电子学报 2017年第5期45卷 1182-1188页

作者：方馨蔚陈庶樵江逸茗任泽荣国家数字交换系统工程技术研究中心河南郑州450002

针对内容中心网络中同质化缓存造成的节点负载不均和存储资源无法有效利用的问题,提出一种热区控制及内容调度缓存算法.在内容请求时,根据节点介数与节点访问度综合判断节点热度,筛选出负载过重节点;缓存决策时,以流行度为依据将内容调... 详细信息

针对内容中心网络中同质化缓存造成的节点负载不均和存储资源无法有效利用的问题,提出一种热区控制及内容调度缓存算法.在内容请求时,根据节点介数与节点访问度综合判断节点热度,筛选出负载过重节点;缓存决策时,以流行度为依据将内容调度至空闲邻居节点,并设置生命期控制机制,从而达到分散请求、消除热区的目的.仿真结果表明该算法减少了请求时延与路由跳数,在提高缓存命中率的同时,有效改善了负载在节点上分布的均衡性.

关键词：内容中心网络协作缓存负载均衡内容调度

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu Jiaxin ren yingying Sun Zhen-Ni Guo yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao yi Hui ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui ren yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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乳铁蛋白减轻肠道功能障碍的研究进展

食品科学 2025年第2期46卷 317-326页

作者：李懿任鑫鑫王勤贺晓云中国农业大学食品科学与营养工程学院北京100083 中国农业大学动物科学技术学院北京100083

肠道屏障保持机体内环境稳定,当肠黏膜受损、肠道细胞间紧密连接被破坏和肠道菌群失调时会引发多种疾病。天然活性蛋白在肠道屏障修复中起着关键作用,乳铁蛋白是存在于哺乳动物乳汁中的糖蛋白,具有抗氧化、抗炎和抗菌等多种生物学功能... 详细信息

肠道屏障保持机体内环境稳定,当肠黏膜受损、肠道细胞间紧密连接被破坏和肠道菌群失调时会引发多种疾病。天然活性蛋白在肠道屏障修复中起着关键作用,乳铁蛋白是存在于哺乳动物乳汁中的糖蛋白,具有抗氧化、抗炎和抗菌等多种生物学功能。大量研究表明乳铁蛋白能够增强肠道紧密连接蛋白水平,促进肠细胞生长发育,下调炎症因子表达,调节免疫反应和肠道微生物多样性,参与维持肠道屏障稳态。本文对乳铁蛋白缓解肠道屏障功能障碍研究进展展开综述,有助于了解乳铁蛋白在肠道损伤中的作用机制,为乳铁蛋白制品干预肠道疾病提供参考。

关键词：乳铁蛋白肠道屏障生理活性肠道微生物

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从玄府理论探析脑血管病

天津中医药大学学报 2016年第6期35卷 373-375页

作者：陈易王明三任健李毓秋山东中医药大学济南250014

玄府理论是指运用开通玄府法治疗玄府失司的疾病,强调的是玄府的上下开阖顺畅。短暂性脑缺血发作(TIA)、脑梗死(CIS)、脑出血(ICH)等脑血管病是因脑部微循环发生障碍,气血周流失常,玄府闭塞,神机出入不遂导致。临床从玄府理论入手,解释... 详细信息

玄府理论是指运用开通玄府法治疗玄府失司的疾病,强调的是玄府的上下开阖顺畅。短暂性脑缺血发作(TIA)、脑梗死(CIS)、脑出血(ICH)等脑血管病是因脑部微循环发生障碍,气血周流失常,玄府闭塞,神机出入不遂导致。临床从玄府理论入手,解释脑血管病发生发展过程,并且通过开通玄府法来治疗脑血管病,以期对该病的中医药临床有指导和治疗意义。

关键词：玄府理论脑血管病短暂性脑缺血发作脑梗死脑出血

Si中D3d对称性态密度分布和缺陷对电子结构

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物理学报 1987年第6期 736-744页

作者：顾一鸣任尚元中国科学技术大学物理系

本文考虑了晶体中总的电子态密度在低对称性下用点群不可约表示基函数分解的问题,并给出了Si中用D3d群不可约表示基函数分解最近邻两原子总态密度的计算结果。结合在位势近似Koster-Slater格林函数方法,文中将计算结果用于Si中双空位和... 详细信息

本文考虑了晶体中总的电子态密度在低对称性下用点群不可约表示基函数分解的问题,并给出了Si中用D3d群不可约表示基函数分解最近邻两原子总态密度的计算结果。结合在位势近似Koster-Slater格林函数方法,文中将计算结果用于Si中双空位和硫属元素杂质对（S20,Se20和Te20）缺陷态电子结构的讨论。讨论得到的结果是:与点缺陷和缺陷对的深缺陷态对称性相匹配的部分态密度的分布是相似的;在态密度对缺陷能级的驱赶作用下,S20等的As能级在As能级之上,双空位的Eg能级在Eu能级之上,这种情况与通常双原子分子成反键能级位置完全相反;所讨论的缺陷对的波函数在Bloch空间的分布情况与对应的点缺陷类似。

关键词：态密度双空位价带硫属元素能级禁带能带结构电子结构 Si

Si中S~0/Se~0,S~0/Te~0和Se~0/Te~0对的电子结构

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物理学报 1987年第5期 555-561页

作者：顾一鸣任尚元中国科学技术大学物理系

利用紧束缚近似下的格林函数方法,讨论了Si中硫属元素混对杂质（即 S0/Se0,S0/Te0和Se0/Te0）基态的电子结构。混对杂质在Si禁带中引入两个A1能级,其中成键性的A1能级位置在反键性的A1能级之上。数值计算得到的混对杂质能级与实验符合... 详细信息

利用紧束缚近似下的格林函数方法,讨论了Si中硫属元素混对杂质（即 S0/Se0,S0/Te0和Se0/Te0）基态的电子结构。混对杂质在Si禁带中引入两个A1能级,其中成键性的A1能级位置在反键性的A1能级之上。数值计算得到的混对杂质能级与实验符合得相当好。理论分析表明,在Si中测到的那些未定的比最近邻混对杂质能级更浅的能级（S0/Se0（X1）,S0/Te0（X1）,Se0/Te0（X1）…）不是由非最近邻位型的混对杂质引入的。本文还指出了一个极性分子放入Si晶体中,两个不同原子间s波函数的转移方向与通常极性分子相反,并讨论其物理原因。

关键词：硫属元素 Se~0/Te~0 S~0/Se~0,S~0/Te~0 能级点缺陷晶体缺陷电子结构原子构成波函数波动力学最近邻极性键原子势 Si