Changes in intrinsic excitability of ganglion cells in degenerated retinas of RCS rats
Changes in intrinsic excitability of ganglion cells in degenerated retinas of RCS rats作者机构：Southwest Hospital/Southwest Eye Hospital Third Military Medical University (Army Medical University) Key Lab of Visual Damage and Regeneration & Restoration of ChongqingChongqing 400038 China
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2018年第11卷第5期
页 面：756-765页
核心收录：
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
基 金：Supported by the National Basic Research Program of China(973 Program,No.2013CB967002) the Military Key Program(No.BWS13C015) the Chongqing International Cooperation Key Projects(No.CSTC2013GJHZ10004)
主 题：retinal degeneration ganglion cell intrinsicexc itability patch clamp
摘 要：AIM：To evaluate the intrinsic excitability of retinal ganglion cells（RGCs） in degenerated ***：The intrinsic excitability of various morphologically defined RGC types using a combination of patch-clamp recording and the Lucifer yellow tracer in retinal wholemount preparations harvested from Royal College of Surgeons（RCS） rats,a common retinitis pigmentosa（RP） model,in a relatively late stage of retinal degeneration（P90） were *** parameters of RGC morphologies and action potentials（APs） were measured and compared to those of non-dystrophic control rats,including dendritic stratification,dendritic field diameter,peak amplitude,half width,resting membrane potential,AP threshold,depolarization to threshold,and firing ***：Compared with non-dystrophic control RGCs,more depolarizations were required to reach the AP threshold in RCS RGCs with low spontaneous spike rates and in RCS OFF cells（especially A2o cells）,and RCS RGCs maintained their dendritic morphologies,resting membrane potentials and capabilities to generate ***：RGCs are relatively well preserved morphologically and functionally,and some cells are more susceptible to decreased excitability during retinal *** findings provide valuable considerations for optimizing RP therapeutic strategies.
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