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LM23 is a novel member of the Speedy/Ringo family at the ：rossroads of life and death of spermatogenic cell

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Asian Journal of Andrology 2011年第3期13卷 446-452,513页

作者： yi-ming cheng Mei-Ling Liu Meng-Chun Jia Graduate School of the Peking Union Medical College Beijing 100005 China Department of Reproductive Endocrinology National Research Institute for Family Planning Beijing 100081 China Air Force Institute of Aviation Medicine Beijing 100142 China

LM23 is a gene specifically expressed in the testis of Rattus norvegicus, as previously reported by our laboratory. The aim of the study is to further investigate the biological function of LM23. Several bioinformatic tools were utilized, including PROSITE and BLAST. To determine the subcellullar localization of LM23, a polyclonal antibody specific for LM23 was generated via the immunization of rabbits. The LM23gene was cloned from rat testis tissue, and LM23 protein was expressed in Escherichia co/i. The biological function of LM23 was analyzed with microarray analysis and immunohistochemistry, using a rat model of LM23 gene knockdown. The results suggested that LM23 belongs to the Speedy/Ringo family. LM23 regulated the GI/S and G2/M transitions of the cell cycle during spermatogenesis. Downregulation of the LM23gene during spermatogenesis could lead to the activation of both the Fas-FasL pathway and the mitochondrial pathway. These novel findings indicate that LM23 has a diverse array of functions that are important in both the life and death of the spermatogenic cell.

关键词： cell cycle LM23 spermatogenesis spermatogenic cell

Establishing a rabbit model of perianal fistulizing Crohn's disease

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World Journal of Gastroenterology 2022年第15期28卷 1536-1547页

作者： Shuang-Shuang Lu Wen-Jia Liu Qiu-Ya Niu Chun-Yan Huo Yu-Qing cheng En-Jing Wang Rong-Nan Li Fang-Fang Feng yi-ming cheng Rong Liu Jin Huang Gastroenterology Center The Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Medical Statistics Center Changzhou UniversityChangzhou 213000Jiangsu ProvinceChina

BACKGROUND Crohn’s disease(CD)is a chronic nonspecific intestinal inflammatory *** aetiology and pathogenesis of CD are still *** fistula is the main complication of CD and is a difficult problem to solve at *** main limitation of developing new therapies is bound up with the short of preclinical security and effectiveness ***,an ideal animal model is needed to establish persistent anal fistula and an inflamed rectal *** To improve the induction method of colitis and establish a reliable and reproducible perianal fistulizing Crohn’s disease animal model to evaluate new treatment *** Twenty male New Zealand rabbits underwent rectal enema with different doses of 2,4,6-trinitrobenzene sulfonic acid to induce *** A was treated with an improved equal interval small dose increasing *** dosage of group B was *** days later,the rabbits underwent surgical creation of a transsphincteric ***,three rabbits were randomly selected from each group every 7 d to remove the seton from the *** rabbits were examined by endoscopy every 7 days,and biopsy forceps were used to obtain tissue samples from the obvious colon lesions for histological *** disease activity index(DAI),colonoscopy and histological scores were *** endoscopic ultrasonography(EUS)was used to evaluate the healing of *** Except for the DAI score,the colonoscopy and histological scores in group A were significantly higher than those in group B(P<0.05).In the ideal model rabbit group,on the 7 th day after the removal of the seton,all animals had persistent lumens on EUS imaging,showing continuous fullthickness high *** inspection of the fistula showed acute and chronic inflammation,fibrosis,epithelialization and peripheral proctitis of the adjoining *** The improved method of CD colitis induction successfully established a rabbit perianal fistula CD pre

关键词： Crohn’s disease Perianal fistula Model Endoscopy Histology

Renoprotective Effect of the Combination of Renin-angiotensin System Inhibitor and Calcium Channel Blocker in Patients with Hypertension and Chronic Kidney Disease

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Chinese Medical Journal 2016年第5期129卷 562-569页

作者： Rong-Shuang Huang yi-ming cheng Xiao-Xi Zeng Sehee Kim Ping Fu Department of Internal Medicine Renal Division West China Hospital of Sichuan University Chengdu Sichuan 610041 China West China Biostatistics and Cost-Benefit Analysis Center West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Biostatistics University of Michigan Ann Arbor Michigan 48109 USA

Background：Renin-angiotensin system inhibitor and calcium channel blocker （CCB） are widely used in controlling blood pressure （BP） in patients with chronic kidney disease （CKD）.We carried out a meta-analysis to compare the renoprotective effect of the combination of angiotensin-converting enzyme inhibitor （ACEI） or angiotensin receptor blocker （ARB） and CCB （i.e.,ACEI/ARB ＋ CCB） with ACEI/ ARB monotherapy in patients with hypertension and ***：Publications were identified from PubMed,Embase,Medline,and Cochrane *** randomized controlled trials （RCTs） of BP lowering treatment for patients with hypertension and CKD were *** outcomes of end-stage renal disease （ESRD）,cardiovascular events,BP,urinary protein measures,estimated glomerular filtration rate （GFR）,and adverse events were ***：Based on seven RCTs with 628 patients,ACEI/ARB ＋ CCB did not show additional benefit for the incidence of ESRD （risk ratio [RR] =0.84;95% confidence interval [CI]：0.52-1.33） and cardiovascular events （RR =0.58;95% CI：0.21-1.63） significantly,compared with ACEI/ARB *** were no significant differences in change from baseline to the end points in diastolic BP （weighted mean difference [WMD] =-1.28 mmHg;95% CI：-3.18 to-0.62）,proteinuria （standard mean difference =-0.55;95% CI：-1.41 to-0.30）,GFR （WMD =-0.32 ml/min;95% CI：-1.53 to-0.89）,and occurrence of adverse events （RR =1.05;95% CI：0.72-1.53）.However,ACEI/ARB ＋ CCB showed a greater reduction in systolic BP （WMD =-4.46 mmHg;95% CI：-6.95 to-1.97）,compared with ACEI/ARB ***：ACEI/ARB ＋ CCB had no additional renoprotective benefit beyond than what could be achieved with ACEI/ARB monotherapy.

关键词： Calcium Channel Blocker Chronic Kidney Disease Hypertension Renin-angiotensin System Inhibitor Renoprotection Therapy

基于即时学习的高炉炼铁过程数据驱动自适应预测控制

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控制理论与应用 2020年第2期37卷 295-306页

作者：易诚明周平柴天佑东北大学流程工业综合自动化国家重点实验室辽宁沈阳110819

针对高炉炼铁过程,本文提出一种基于即时学习的高炉铁水质量自适应预测控制方法(JITL–APC).该方法的特点是控制器通过k向量近邻(k–VNN)方法搜索数据库中的输入输出(I/O)数据信息,对非线性系统进行局部建模,并在此基础上计算控制律.而... 详细信息

针对高炉炼铁过程,本文提出一种基于即时学习的高炉铁水质量自适应预测控制方法(JITL–APC).该方法的特点是控制器通过k向量近邻(k–VNN)方法搜索数据库中的输入输出(I/O)数据信息,对非线性系统进行局部建模,并在此基础上计算控制律.而且,该方法中引入了工业异常数据处理机制,利用JITL学习子集中的平均数据项,对异常数据项进行填补或替换,从而消除异常数据对控制系统的影响.此外,本文提出一种JITL模型保留策略(MRS),避免由于数据库中相似数据样本不足导致的局部模型严重失配,并通过实时收集I/O数据更新数据库,使控制器自适应不同的工况条件,MRS还可以有效抑制噪声干扰的影响,从而提高控制系统的稳定性.最后,基于某大型钢铁厂2#高炉的数值仿真实验,充分验证了该方法的有效性.

关键词：高炉数据驱动即时学习线性化模型预测控制工业数据异常

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng cheng Lijuan Shi Qun yi Yao Liu yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction

Lysine malonylation occurs in human sperm and is related to sperm motility

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Lysine malonylation occurs in human sperm and is related to ...

Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Zhen Peng yi-ming cheng Xiao-nian Hu Ting-ting Pan Hou-yang Chen Tao Luo Xu-hui Zeng Institute of Life Science and School of Life Science Nanchang University Reproductive Medical Center Jiangxi Provincial Maternal and Child Health Hospital Key Laboratory of Reproductive Physiology and Pathology in Jiangxi Province

Currently,post transcription modifications(PTMs)are supposed to regulate cellular functions by affecting the protein *** mature sperm are specialized cells generally considered transcriptionally and translation silently,their physiological functions are likely to be mediated by various types of *** instance,phosphorylation occurring on corresponding proteins has

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang Fei Long Liyuan Han Qifeng Han yi‑Bing cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

Spin-modulated near-infrared-Ⅰ emission in a xanthene-decorated Fe(Ⅱ) spin-crossover complex

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Science China Chemistry 2025年

作者： cheng yi Duyong Chen Shihui Zhang Rui Cai Chunying Duan yinshan Meng Tao Liu State Key Laboratory of Fine Chemicals Frontier Science Center for Smart Materials and Chemical Engineering School of Chemical Engineering Dalian University of Technology Instrumental Analysis Center Dalian University of Technology School of Chemistry Dalian University of Technology Liaoning Binhai Laboratory

Molecular materials showing synergetic coupling of near-infrared （NIR） fluorescence and spin-crossover （SCO） are promisingly applicable in in-vivo bioimaging,temperature sensing,and spintronic *** the related study faces formidable *** this work we graft the NIR fluorophore xanthene onto the dipyridyl substituted triazole ligand and construct a new Febased SCO material,{FeⅡ（ddxc-abpt）2[N（CN）2]2}(1,ddxc-abpt:（E）-4-(((3,5-di（pyridin-2-yl）-4H-1,2,4-triazol-4-yl)imino)methyl)-N,N-diethyl-2,3-dihydro-1H-xanthen-6-amine).Magnetic studies indicate that compound 1 exhibits thermally induced SCO property in both the solid and solution ***-temperature fluorescence emission spectra reveal a remarkable 7-fold increase in photoluminescence intensity upon the transition from the low-spin state at 110 K to the high-spin state at 280 K,which is the record of all reported coupled fluorescence-SCO ***-temperature ultraviolet-visible （UV-Vis）absorption spectra show a significant change in absorption intensity within the fluorescence emission window,consistent with the F?rster resonance energy transfer （FRET） ***-dependent density functional theory （TD-DFT） calculations demonstrate that the strong coupling is attributed to disrupted energy transfer between the xanthene fluorophore and high-spin *** work provides a feasible approach for expanding the synergetic SCO-fluorescence materials to the NIR-Iwavelength region,and hopefully contributes to the applications of tunable NIR-SCO molecule-based sensors and devices.

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半轴轴承游隙对整车传动效率影响的探究

机械设计 2016年第10期33卷 36-41页

作者：莫易敏柴淑枫王俊平曹甜马易成名武汉理工大学机电工程学院湖北武汉430070

针对某微型汽车油耗高、滑行距离短、稳态阻力过大的现象,在理论分析的基础上,结合对标试验,提出增大后桥半轴轴承游隙的改进意见,并利用CRUISE对其进行模拟仿真及实车试验。仿真结果与最终试验结果一致,表明:增大轴承游隙能够提升整车... 详细信息

针对某微型汽车油耗高、滑行距离短、稳态阻力过大的现象,在理论分析的基础上,结合对标试验,提出增大后桥半轴轴承游隙的改进意见,并利用CRUISE对其进行模拟仿真及实车试验。仿真结果与最终试验结果一致,表明:增大轴承游隙能够提升整车的传动效率,降低稳态阻力,减少整车油耗。该研究为整车试验提供了一种方法与思路,对以低成本降低汽车油耗研究方面有着重要的借鉴作用。

关键词：轴承游隙传动效率油耗 CRUISE仿真转鼓试验