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Biological characteristics of dynamic expression of nerve regeneration related growth factors in dorsal root ganglia after peripheral nerve injury

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Neural Regeneration Research 2020年第8期15卷 1502-1509页

作者： yin-ying Shen Xiao-Kun Gu Rui-Rui Zhang Tian-mei Qian Shi-ying Li Sheng yi Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Hand Surgery Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

The regenerative capacity of peripheral nerves is limited after nerve injury.A number of growth factors modulate many cellular behaviors,such as proliferation and migration,and may contribute to nerve repair and *** previous study observed the dynamic changes of genes in L4–6 dorsal root ganglion after rat sciatic nerve crush using transcriptome *** current study focused on upstream growth factors and found that a total of 19 upstream growth factors were dysregulated in dorsal root ganglions at 3,9 hours,1,4,or 7 days after nerve crush,compared with the 0 hour ***-six rat models of sciatic nerve crush injury were prepared as described ***,they were divided into six groups to measure the expression changes of representative genes at 0,3,9 hours,1,4 or 7 days post *** current study measured the expression levels of representative upstream growth factors,including nerve growth factor,brain-derived neurotrophic factor,fibroblast growth factor 2 and amphiregulin genes,and explored critical signaling pathways and biological process through bioinformatic *** data revealed that many of these dysregulated upstream growth factors,including nerve growth factor,brain-derived neurotrophic factor,fibroblast growth factor 2 and amphiregulin,participated in tissue remodeling and axon growth-related biological processes Therefore,the experiment described the expression pattern of upstream growth factors in the dorsal root ganglia after peripheral nerve *** analysis revealed growth factors that may promote repair and regeneration of damaged peripheral *** animal surgery procedures were performed in accordance with Institutional Animal Care Guidelines of Nantong University and ethically approved by the Administration Committee of Experimental Animals,China(approval No.20170302-017)on March 2,2017.

关键词： axon growth bioinformatic analysis dorsal root ganglia growth factors Ingenuity Pathway Analysis nerve regeneration peripheral nerve injury rat sciatic nerve crush injury transcriptome sequencing upstream regulators

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Tor被动流量分析综述

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软件学报 2025年第1期36卷 253-288页

作者：梅汉涛程光朱怡霖周余阳东南大学网络空间安全学院江苏省泛在网络安全工程研究中心(东南大学) 网络空间国际治理研究基地(东南大学) 紫金山实验室

随着网络的蓬勃发展,用户隐私正面临着前所未有的挑战.人们开发出多种匿名通信系统来保护隐私,第2代洋葱路由Tor (the second-generation onion router)是目前最为广泛使用的匿名通信系统.然而,卓越的匿名性也使之成为不法分子犯罪的温... 详细信息

随着网络的蓬勃发展,用户隐私正面临着前所未有的挑战.人们开发出多种匿名通信系统来保护隐私,第2代洋葱路由Tor (the second-generation onion router)是目前最为广泛使用的匿名通信系统.然而,卓越的匿名性也使之成为不法分子犯罪的温床,如今Tor中充斥着非法交易、网络犯罪等. Tor被动流量分析通过被动观察网络流量对Tor进行去匿名化,已成为最热门的去匿名化技术.从Tor与流量分析基本概念出发,介绍Tor被动流量分析技术的应用场景与威胁模型.按照技术类型将现有工作分为流量分类技术与流关联技术,依据分析流程分别对比其流量采集方法、特征提取方法、使用算法.最后探讨当前研究面临的主要挑战与未来可能的研究趋势.

关键词： Tor 流量分析流量分类网站指纹流关联

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Optimization of pipe circuits in energy tunnels

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Underground Space 2023年第6期13卷 166-182页

作者： Jie He mei yin Xiangyang Wei Zhenhuang Wu College of Civil Engineering Tongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China Department of Civil and Environmental Engineering Brunel UniversityUxbridgeLondon UB83PHUK

Geothermal energy is a kind of green and renewable ***,ground source heat pumps can be used to harvest geothermal energy from the *** reduce the initial investment,a good solution is to use tunnel linings as heat exchangers to extract/dump *** special infrastructure is called an energy *** addition to the thermal performance,the impact of pipe network configuration on thermal efficiency is still challenging in the design of energy *** solve this problem,this study makes the first attempt to carry out research on the optimization of pipe circuits in energy tunnels by a series of numerical analyses.A fully coupled thermo-hydraulic 3D finite element model is established to investigate the response of tunnel-soil interaction under cyclical thermal loading(initial soil temperature varies from 8C to 18C),as well as the thermal transient interactions among air,absorber pipe,tunnel linings and ground,to quantify the amount of useful heat that can be extracted from the tunnel and the *** the other hand,the influence of 3 various heat-carrying pipes layout is also *** is found that higher heat transfer efficiency can be obtained when the entrance and exit of pipelines are located below the tunnel in the *** spatial location of pipelines will also affect the exchanged heat output.

关键词： Energy tunnel Thermal efficiency Finite element model Heat transfer

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The effect of f(T) gravity on an interplanetary clock and its time transfer link

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Research in Astronomy and Astrophysics 2013年第10期13卷 1225-1230页

作者： Xue-mei Deng yi Xie Purple Mountain Observatory Chinese Academy of Sciences Key Laboratory of Modern Astronomy and Astrophysics Nanjing University Ministry of Education School of Astronomy & Space Science Nanjing University

As an extension of the＂teleparallel＂equivalent of general relativity,f（T）gravity is proposed to explain some puzzling cosmological behaviors,such as accelerating expansion of the *** the fact that modified gravity also has impacts on the Solar System,we might test it during future interplanetary missions with ultrastable *** this work,we investigate the effects of f（T）gravity on the dynamics of the clock and its time transfer *** these influences,theΛ-term and theα-term of f（T）gravity play important ***,Λis the cosmological constant andαrepresents a model parameter in f（T）gravity that determines the divergence from teleparallel gravity at the first order *** find that the signal of f（T）gravity in the time transfer is much more difficult to detect with the current state of development for clocks than those effects on dynamics of an interplanetary spacecraft with a bounded orbit with parameters 0.5 au≤a≤5.5 au and 0≤e≤0.1.

关键词： gravitation celestial mechanics space vehicles:clock time

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Prediction of three-dimensional elastic behavior of filament-wound composites based on the bridging model

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Defence Technology（防务技术） 2021年第2期17卷 609-616页

作者： Dong-mei yin Bao-ming Li Hong-cheng Xiao National Key Laboratory of Transient Physics Nanjing University of Science&TechnologyNanjing210094China

This work provides a method to predict the three-dimensional equivalent elastic properties of the filament-wound composites based on the multi-scale homogenization *** the meso-scale,a representative volume element(RVE)is defined and the bridging model is adopted to establish a theoretical predictive model for its three-dimensional equivalent elastic *** results obtained through this method for the previous experimental model are compared with the ones gained respectively by experiments and classical laminate theory to verify the reliability of this *** addition,the effects of some winding parameters,such as winding angle,on the equivalent elastic behavior of the filament-wound composites are *** rules gained can provide a theoretical reference for the optimum design of filament-wound composites.

关键词： Lightweight design Filament-wound composites Bridging model Three-dimensional elastic properties

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Spacecraft Doppler tracking with possible violations of LLI and LPI: a theoretical modeling

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Research in Astronomy and Astrophysics 2014年第3期14卷 319-328页

作者： Xue-mei Deng yi Xie Purple Mountain Observatory Chinese Academy of Sciences Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityMinistry of Education School of Astronomy & Space Science Nanjing University

Currently two-way and three-way spacecraft Doppler tracking techniquesare widely used and play important roles in control and navigation of deep space mis-sions. Starting from a one-way Doppler model, we extend the theory to two-way andthree-way Doppler models by making them include possible violations of the localLorentz invariance （LLI） and the local position invariance （LPI） in order to test theEinstein equivalence principle, which is the cornerstone of general relativity and allother metric theories of gravity. After taking the finite speed of light into account,which is the so-called light time solution （LTS）, we make these models depend on thetime of reception of the signal only for practical convenience. We find that possibleviolations of LLI and LPI cannot affect two-way Doppler tracking under a linear ap-proximation of LTS, although this approximation is sufficiently good for most cases inthe solar system. We also show that, in three-way Doppler tracking, possible violationsof LLI and LPI are only associated with two stations, which suggests that it is betterto set the stations at places with significant differences in velocities and gravitationalpotentials to obtain a high level of sensitivity for the tests.

关键词： space vehicles techniques: radial velocities gravitation

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Analysis for the residual prestress of composite barrel for railgun with tension winding

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Defence Technology（防务技术） 2020年第4期16卷 893-899页

作者： Dong-mei yin Bao-ming Li Hong-cheng Xiao National Key Laboratory of Transient Physics Nanjing University of Science&TechnologyNanjing210094China

Based on the elastic theory of cylindrical shells and the theory of composite laminates,a prediction model for the residual prestress of the simplified round composite barrel for railgun is *** the fibre pretension is considered in this model.A three dimensional numerical simulation for the residual prestress in the railgun barrel is carried out,by combining the temperature differential method with the element birth and death *** results obtained by the two methods are *** reveals that the distribution trends of residual prestress are *** the difference for residual prestress in the filament wound composite housing of barrel is relatively *** same finite element method is used to analysis the residual prestress in the non-simplified composite barrels for railgun,which are under different control modes of winding *** results mean that the residual prestress in barrel will increase while the taper coefficient for winding is ***,the sealing performance in bore is improved,but the strength of the filament wound composite housing *** addition,the axial and circumferential residual prestress in the filament wound composite housing with constant torque winding are close to the ones in iso-stress design for barrel.

关键词： Railgun Barrel Composite materials Filament winding Winding tension Residual prestress

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Full-scale study of removal effect on Cyclops of zooplankton with chlorine dioxide

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Journal of Environmental Sciences 2004年第5期16卷 746-750页

作者： LINTao CUIFu-yi LIUDong-mei ANDong SchoolofMunicipalandEnvironmentalEngineering HarbinInstituteofTechnologyHarbin150090China

Cyclops of zooplankton propagated excessively in eutrophic water body and could not be effectively inactivated by the conventional disinfections process like chlorination due to its stronger resistance to oxidation. In this paper, a full-scale study of chlorine dioxide preoxidation cooperating with routine clarification process for Cyclops removal was conducted in a waterworks. The experimental results were compared with that of the existing prechlorination process in several aspects: including the Cyclops removal efficiencies of water samples taken from the outlets of sedimentation tank and sand filter and the security of drinking water and so on. The results showed that chlorine dioxide might be more effective to inactivate Cyclops than chlorine and Cyclops could be thoroughly removed from water by pre-dosing chlorine dioxide process. The GC-MS examination and Ames test further showed that the sort and amount of organic substance in the treated water by chlorine dioxide preoxidation were evidently less than that of prechlorination and the mutagenicity of drinking water treated by pre-dosing chlorine dioxide was substantially reduced compared with prechlorination.

关键词： Cyclops of zooplankton chlorine dioxide chlorine preoxidation water treatment

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Proanthocyanidins prevent tau protein aggregation and disintegrate tau filaments

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Chinese Journal of Chemical Engineering 2023年第5期57卷 63-71页

作者： Huan-Huan yin yin-Lei Han Xiao Yan yi-Xin Guan College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027China Max Planck Institute of Molecular Cell Biology and Genetics Dresden 01307Germany

Occurrence of neurofibrillary tangles of the tau protein is a hallmark of tau-related neurodegenerative diseases, i.e. Alzheimer's disease(AD) and frontotemporal dementia. The pathological mechanism underlying AD remains poorly understood, and effective treatments are still unavailable to mitigate the *** of tau aggregation and disrupting the existing fibrils are key targets in drug discovery towards preventing or curing AD. In this study, grape seed proanthocyanidins(GSPs) was found to effectively inhibit the repeat domain of tau(tau-RD) aggregation and disaggregate tau-RD fibrils in a concentrationdependent manner by inhibiting β-sheet formation of tau-RD. In cells, GSPs relieved cytotoxicity induced by tau-RD aggregates. Molecular dynamics simulations indicated that strong hydrogen bonding,hydrophobic interaction and π-π stacking between GSPs and tau-RD protein were major reasons why GSPs had high inhibitory activity on tau-RD fibrillogenesis. These results provide preliminary data to develop GSPs into medicines, foodstuffs or nutritional supplements for AD patients, suggesting that GSPs could be a candidate molecule in the drug design for AD therapeutics.

关键词： Protein Aggregation Disaggregation Molecular simulation Proanthocyanidins Alzheimer’s disease(AD)

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Synthesis and Resolution of 10,11-Dihydro-10-hydroxycyproheptadine

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Chinese Chemical Letters 2006年第4期17卷 444-446页

作者： Jian mei CUI Da Li yin Institute of Materia Medica Peking Union Medical College ＆ Chinese Academy of Medical Sciences Beijing 100050

10, 11-Dihydro-10-hydroxycyproheptadine was synthesized in a new and facile synthetic route and resolved by L-（-）-2-（1, 3）-dioxo-1, 3-dihydroisoindol-2-yl）-propionic acid and D-（＋）-tartaric acid, respectively.... 详细信息

关键词： H1 receptor antagonist, chiral center, racemate resolution, specific rotation.

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