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Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant

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World Journal of Pediatrics 2024年第9期20卷 966-975页

作者： Yue Tao Cheng-Juan Luo Bing-Hua Zhang Xin-Yan Shen Rui-Ke Zhao Bei-ying Ma Nan Shen Chang-ying Luo Jian-Min Wang yi-jun xia Li Xie Jing Chen Xi Mo Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang Rd.Shanghai200127China Department of Hematology and Oncology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang Rd.Shanghai200127China Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Medical Affairs BioMérieux(Shanghai)CompanyLimitedShanghaiChina Clinical Research Institute School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Diarrhea is a common complication of hematopoietic stem cell transplantation(HSCT)and is associated with substantial morbidity,but its etiology is often *** of diarrhea in this population include infectious causes,chemotherapy-or medication-induced mucosal injury and graft-versus-host disease(GVHD).Distinguishing these potential causes of diarrhea is challenging since diarrheal symptoms are often multifactorial,and the etiologies often overlap in transplant *** objectives of this study were to evaluate whether the FilmArray gastrointestinal(GI)panel would increase diagnostic yield and the degree to which pre-transplantation colonization predicts post-transplantation *** From November 2019 to February 2021,a total of 158 patients undergoing HSCT were prospectively included in the *** specimens were obtained from all HSCT recipients prior to conditioning therapy,28±7 days after transplantation and at any new episode of *** stool samples were tested by the FilmArray GI panel and other clinical microbiological *** The primary cause of post-transplantation diarrhea was infection(57/84,67.86%),followed by medication(38/84,45.24%)and GVHD(21/84,25.00%).Ninety-five of 158 patients were colonized with at least one gastrointestinal pathogen before conditioning therapy,and the incidence of infectious diarrhea was significantly higher in colonized patients(47/95,49.47%)than in non-colonized patients(10/63,15.87%)(Pyield by almost twofold in our study(55/92,59.78%vs.30/92,32.61%).Conclusions Our data show that more than half of pediatric patients who were admitted for HSCT were colonized

关键词： Children Diarrhea Hematopoietic stem cell transplantation Multiplexed polymerase chain reaction

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羟乙基纤维素接枝丙烯酰胺共聚物的合成及表征

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塑料 2010年第2期39卷 32-34页

作者：易俊霞李瑞海四川大学高分子科学与工程学院四川成都610065

以K2S2O8-NaHSO3氧化还原体系为引发剂合成羟乙基纤维素与丙烯酰胺的接枝共聚物,探讨反应时间、反应温度、引发剂用量对接枝共聚物特性黏数的影响,采用红外光谱(FI-IR)对聚合物进行结构表征,用热重分析法(TGA)分析接枝聚合物的热稳定性。

关键词：羟乙基纤维素丙烯酰胺接枝共聚特性黏数热稳定性

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广州市能源供需结构问题及趋势预测分析

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环境科学 2006年第4期27卷 620-623页

作者：钟晓青纪秀江朱海燕易霞俊任舫中山大学生命科学学院广州510275 中山大学岭南学院广州510275 中山大学园林及生态经济规划研究所广州510275

针对广州市经济高速发展对能源需求与供给的紧张局面，分析了广州市能源供需现状及存在的问题．运用部门分析法、时间序列法对广州市2005～2010年的能源需求进行预测，得出了2010年能源总需求的预测值为4534．7×100t标准煤，能源供需... 详细信息

针对广州市经济高速发展对能源需求与供给的紧张局面，分析了广州市能源供需现状及存在的问题．运用部门分析法、时间序列法对广州市2005～2010年的能源需求进行预测，得出了2010年能源总需求的预测值为4534．7×100t标准煤，能源供需差额为4500×100t标准煤．根据实证分析，结合全国和广东省能源供应和消费的大环境，认为广州市未来的能源发展战略应该包括以下要点：①立足于国家的整体能源发展规划即依靠“西电东送”、三峡的并网水电、核电和新能源；②停止建立或扩充目前污染较重、能耗物耗较高且布局在广州夏季上风方向上的黄埔火力发电厂；③不应该完全依靠广东的贫困山区的煤炭和小水电但可以充分发挥其资源潜力．

关键词：广州能源需求能源供给能源结构发展预测

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Stable copper boron–imidazolate cage as Cu-riched enzyme for highly efficient electrocatalytic CO2 reduction to ethylene

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Science China Chemistry 2025年

作者： jun-Qiang Chen Qiao-Hong Li Qin-Long Hong Ping Shao Hai-xia Zhang Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Single-atom catalyst has garnered widespread attention to mimic mature enzymes due to its well-defined atomic structure and coordination environments. However, since the carbon–carbon（C–C） coupling reactions require synergistic catalysis of multiple sites, single-atom catalysts suffer from insufficient active sites and unclear reaction mechanisms. Controlling the reaction intermediates in a precisely targeted pocket through careful metal–organic cage design is therefore crucial. Here, we prepare a tetrahedral [Cu6L4]-type boron–imidazolate cage integrating highly active Cu sites and optimized cavity, which exhibits enzyme like specific catalytic performance in electrochemical CO2reduction reaction（CO2RR） to enhance the selectivity of *** analyses and computational calculations suggest that the single Cu site together with neighboring boron–imidazolate ligands provides suitably synergistic effects that enable the energetically favorable formation of an *COCHO intermediate, a key step determining selectivity. As a result, the [Cu6L4]-type cage of BIC-145 achieves a Faradaic efficiency of 28% for C2H4maintaining an average current density of -3.54 mA cm-2over a 5-hour electrolysis period. This work represents the first example for studying single-metal site catalysts with ultra-low coordination numbers through the rational design of metal–organic cages.

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SEBS-g-MAH增韧聚苯硫醚性能研究

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塑料工业 2009年第3期37卷 71-74页

作者：高西萍张辉易俊霞李瑞海四川大学高分子科学与工程学院四川成都610065

采用熔融挤出法制备了聚苯硫醚(PPS)与马来酸酐接枝苯乙烯-乙烯-丁二烯-苯乙烯嵌段共聚弹性体(SEBS-g-MAH)的共混物,并考察了共混物的热行为、力学性能、相形态及增韧机理。结果表明,两组分的玻璃化温度有相互靠近的趋势,显示PPS和SEBS-... 详细信息

采用熔融挤出法制备了聚苯硫醚(PPS)与马来酸酐接枝苯乙烯-乙烯-丁二烯-苯乙烯嵌段共聚弹性体(SEBS-g-MAH)的共混物,并考察了共混物的热行为、力学性能、相形态及增韧机理。结果表明,两组分的玻璃化温度有相互靠近的趋势,显示PPS和SEBS-g-MAH部分相容;随着SEBS-g-MAH用量增加,共混物的韧性得到很好的提高,当SEBS-g-MAH的质量分数为30%时,其冲击强度达到7.5kJ/m2。PPS/SEBS-g-MAH/Kevlar纤维共混体系中,SEBS-g-MAH既可以作为增韧剂,又可以作为两相相容剂来提高PPS基体和Kevlar纤维的界面黏结能力,使共混物达到增强增韧的效果。

关键词：聚苯硫醚苯乙烯-乙烯-丁二烯-苯乙烯接枝马来酸酐共聚物 Kevlar纤维增韧

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Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun xia Biao Yang Ronghao Wang yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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同向啮合双螺杆挤出机螺杆组合对玻纤增强AS力学性能的影响

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塑料工业 2009年第4期37卷 49-52页

作者：陶巍杜发钊李海霞黄熠汪克风王成望易俊霞李瑞海中山赛特工程塑料有限公司广东中山528429 四川大学高分子学院四川成都610065

研究了不同螺杆组合方式对玻纤增强苯乙烯-丙烯腈共聚物(AS)材料挤出工艺和材料力学性能的影响;并设计出一种适合于玻纤增强AS材料加工的螺杆组合方式。结果表明:合理的螺杆组合可改善玻纤增强AS材料的挤出工艺,提高材料的力学性能。通... 详细信息

研究了不同螺杆组合方式对玻纤增强苯乙烯-丙烯腈共聚物(AS)材料挤出工艺和材料力学性能的影响;并设计出一种适合于玻纤增强AS材料加工的螺杆组合方式。结果表明:合理的螺杆组合可改善玻纤增强AS材料的挤出工艺,提高材料的力学性能。通过改善熔融段和剪切段的螺纹组合,使玻纤增强AS材料的拉伸强度和弯曲强度分别由原来的105 MPa和115 MPa提高到了116 MPa和125 MPa,并保证了设备产量。采用合适的螺杆组合生产的材料能够满足国内外家电企业的要求。

关键词：苯乙烯-丙烯腈共聚物玻璃纤维增强螺杆组合力学性能

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竞争环境下双目标零售平台销售模式选择

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管理工程学报 2025年第1期39卷 227-242页

作者：张冲朱祎宋君南京邮电大学管理学院

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求... 详细信息

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求自身利润最大化,另外一个零售平台追求自身利润和消费者剩余的线性组合最大化,即考虑双目标最优。本文具体考虑两个零售平台分别选择转售模式或代理模式共四种情形,进而研究双目标零售平台销售模式选择问题,及其对供应链成员最优决策和供应链整体绩效的影响。结果表明:(1)在一定条件下,双目标零售平台能获得比竞争对手更高的利润;(2)当双目标零售平台选择转售模式时,无论其竞争对手选择哪种销售模式,其双目标策略都能使供应链总体利润得到优化;(3)当双目标零售平台的竞争对手选择代理模式时,其自身根据不同情况选择转售模式或者代理模式可以使两个零售平台的销售模式选择形成均衡。

关键词：双目标企业社会责任零售平台销售模式双渠道

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蒲公英胶囊联合头孢克洛治疗扁桃体炎的临床研究

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现代药物与临床 2018年第3期33卷 609-612页

作者：杨雅添郭会义夏军监利县人民医院耳鼻喉科湖北荆州433300

目的探讨蒲公英胶囊联合头孢克洛胶囊治疗扁桃体炎的临床效果。方法选取2016年4月—2017年4月监利县人民医院耳鼻喉科收治的扁桃体炎患者161例为研究对象,将所有患者随机分为对照组(80例)和治疗组(81例)。对照组口服头孢克洛胶囊,1粒/... 详细信息

目的探讨蒲公英胶囊联合头孢克洛胶囊治疗扁桃体炎的临床效果。方法选取2016年4月—2017年4月监利县人民医院耳鼻喉科收治的扁桃体炎患者161例为研究对象,将所有患者随机分为对照组(80例)和治疗组(81例)。对照组口服头孢克洛胶囊,1粒/次,3次/d。治疗组在对照组基础上口服蒲公英胶囊,4粒/次,3次/d。两组患者均连续治疗7 d。观察两组的临床疗效,比较两组的临床症状改善、白细胞计数、C反应蛋白和视觉模拟评分法(VAS)评分。结果治疗后,对照组和治疗组的总有效率分别为87.50%、97.53%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组发热消退时间、咽部不适消失时间和扁桃体红肿消失时间均明显短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组白细胞计数、C反应蛋白和VAS评分均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论蒲公英胶囊联合头孢克洛胶囊治疗扁桃体炎具有较好的临床疗效,可改善临床症状,降低炎性反应,安全性较好,具有一定的临床推广应用价值。

关键词：蒲公英胶囊头孢克洛胶囊扁桃体炎临床症状白细胞计数 C反应蛋白 VAS评分

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