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Socioeconomic and Environmental Determinants to Preterm Birth in Tibetan Women： An Analysis Based on the Hierarchically Conceptual Frame

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Chinese Medical Journal 2017年第19期130卷 2307-2315页

作者： Xiao-Jing Fan Jian-Min Gao yi-jun kang Shao-Nong Dang Wei-Hua Wang Hong Yan Duo-Lao Wang Department of Epidemiology and Health Statistics School of Public Health Xi'an Jiaotong University Health Science Center Xi'an Shaanxi 710061 China Department of Health Management and Policy School of Public Policy and Administration Xi'an Jiaotong University Xi'an Shaanxi 710049 China Shaanxi Provincial Centre for Disease Control and Prevention Xi'an Shaanxi 710054 China Department of Clinical Sciences Liverpool School of Tropical Medicine Liverpool L3 5QA UK

Background： Preterm birth is a common cause of death in newborns and may result from many determinants, but evidence for the socioeconomic and environmental determinants of preterm birth in Tibetan women of childbearing age is limited. The aim of this study was to understand the current status of preterm birth in native Tibetan women and investigate the socioeconomic and environmental determinants. Methods： Data were drawn from a cohort study which was conducted from August 2006 to August 2012 in rural Lhasa, Tibet, China. A total of 1419 Tibetan pregnant women were followed from 20 weeks＆#39; gestation until delivery; the loss to follow-up rate was 4.69%. The incidence of preterm birth was estimated to show the status of preterm births in Tibet. Logistic regression models for longitudinal data were established, and odds ratios （ORs） together with 95% confidence intervals （CIs） were used to evaluate the association between the occurrence of preterm birth and 16 selected potential determinants based on the hierarchical conceptual frame. Results： The incidence of preterm birth was 4.58% （95% CI = 3.55–5.80%）. After adjusting for health-related variables of the mothers and newborns, socioeconomic and environmental determinants associated with preterm birth included season （spring： OR = 0.28, 95%CI = 0.09–0.84; autumn： OR = 0.21, 95% CI = 0.06–0.69; and winter： OR = 0.31, 95% CI = 0.12–0.82） and calendar year of delivery （2010： OR = 5.03, 95% CI = 1.24–20.35; 2009： OR = 6.62, 95% CI = 1.75–25.10; and 2007–2008： OR = 5.93, 95% CI = 1.47–23.90）. Conclusions： The incidence of preterm birth among native Tibetan women was low and there was a decreasing trend in recent years;however, it is still essential to strengthen seasonal maternal care, extend the spacing between pregnancies, and reinforce adequate maternal nutrition.

关键词： Determinants Preterm Birth Tibet

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用于场致发射电推力器的微发射针制造技术

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上海交通大学学报 2009年第12期43卷 1968-1972,1977页

作者：段君毅康小明赵万生上海交通大学机械与动力工程学院上海200240

通过对场致发射电推力器的微针尖成形机理的分析以及多次电化学腐蚀实验,研究了溶液浓度、浸润深度、腐蚀电压等因素对发射极针尖尺寸的影响,最后得出了电化学腐蚀加工发射针的最优化加工参数.在KOH溶液浓度为5 mol/L、浸润深度为2 mm... 详细信息

通过对场致发射电推力器的微针尖成形机理的分析以及多次电化学腐蚀实验,研究了溶液浓度、浸润深度、腐蚀电压等因素对发射极针尖尺寸的影响,最后得出了电化学腐蚀加工发射针的最优化加工参数.在KOH溶液浓度为5 mol/L、浸润深度为2 mm、腐蚀电压为6 V等优化工艺参数下制作出发射针,并利用交流电粗化处理制作出了符合场致发射电推力器应用的发射极针尖.

关键词：场致发射电推力器电化学腐蚀钨微针尖

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场致发射电推力器发射尖端理论模型及机理

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推进技术 2011年第6期32卷 756-761页

作者：段君毅康小明赵万生上海交通大学机械与动力工程学院/机械系统与振动国家重点实验室上海200240

为了研究铟场致发射电推力器的发射过程及机理,对椭球顶喷流柱模型离子发射区流柱的形状及尺寸进行了数学描述并通过数值计算加以验证,结果表明,椭球顶喷流柱模型具有合理性,从Taylor理论出发,结合电磁场理论、流体力学理论以及场致发... 详细信息

为了研究铟场致发射电推力器的发射过程及机理,对椭球顶喷流柱模型离子发射区流柱的形状及尺寸进行了数学描述并通过数值计算加以验证,结果表明,椭球顶喷流柱模型具有合理性,从Taylor理论出发,结合电磁场理论、流体力学理论以及场致发射理论,讨论了离子形成的机理,发现场蒸发是离子产生的重要原因。

关键词：电推进场蒸发 FEEP LMIS 喷流柱模型

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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基于“虚气留滞”探讨化疗所致周围神经病变病机及论治

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中华中医药杂志 2022年第11期37卷 6418-6421页

作者：移康军徐晓华吴煜李刘生郝腾腾周芮北京中医药大学研究生院北京100029 中国中医科学院北京100700 中国中医科学院西苑医院北京100091

中医药治疗化疗所致周围神经病变尽管具有较好的临床疗效,但缺乏以病机为核心的理论指导。恶性肿瘤、化疗药物致使机体“气血阴阳失和”“脏腑精气亏虚”后的病理状态——“虚气”;痰、湿、瘀、毒等各种病理产物致使机体经络阻滞——“... 详细信息

中医药治疗化疗所致周围神经病变尽管具有较好的临床疗效,但缺乏以病机为核心的理论指导。恶性肿瘤、化疗药物致使机体“气血阴阳失和”“脏腑精气亏虚”后的病理状态——“虚气”;痰、湿、瘀、毒等各种病理产物致使机体经络阻滞——“留滞”,二者是中医对化疗所致周围神经病变病因病机的高度概括。文章根据“虚气”和“留滞”二者的关系对疾病的动态病机演变进行探讨,提出化疗所致周围神经病变的“虚气留滞”病机,总结其论治思路重点在于“培元补虚、开郁行滞”。以期为化疗所致周围神经病变提供新的临床治疗思路,丰富并发展中医相关理论。

关键词：虚气留滞化疗所致周围神经病变培元补虚开郁行滞十味益元颗粒

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基于“和”思想探讨恶性肿瘤的病机与治疗

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北京中医药 2021年第12期40卷 1352-1354页

作者：移康军徐晓华李刘生吴煜北京中医药大学研究生院北京100029 中国中医科学院北京100700 中国中医科学院西苑医院肿瘤科北京100091

"和"思想是中国传统文化的精髓之一,在中医学领域得到了继承和发展。吴煜教授长期从事中西医结合防治恶性肿瘤的研究,认为恶性肿瘤最基本的病机是失"和",可概括为四个方面:"正邪失和"是恶性肿瘤发病之基本病机;"情志失和""饮食失和"是... 详细信息

"和"思想是中国传统文化的精髓之一,在中医学领域得到了继承和发展。吴煜教授长期从事中西医结合防治恶性肿瘤的研究,认为恶性肿瘤最基本的病机是失"和",可概括为四个方面:"正邪失和"是恶性肿瘤发病之基本病机;"情志失和""饮食失和"是恶性肿瘤发病之诱因;"天人失和"是恶性肿瘤发病之外环境;"脏腑失和"是恶性肿瘤发病之具体体现。因此,复"和"是论治恶性肿瘤的基本大法,临床上提倡"合和法"(中西医结合、三辨相和)论治恶性肿瘤,逐步形成了基于"和"思想论治恶性肿瘤的学术思想,为恶性肿瘤的治疗提供了新的临床治疗思路。

关键词：恶性肿瘤中医学中西结合三辨相和

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-Hong Wu Dan-Dan Xu kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li kang yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Risk assessment of oil and gas investment environment in countries along the Belt and Road Initiative

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Petroleum Science 2024年第2期21卷 1429-1443页

作者： Bao-jun Tang Chang-Jing Ji Yu-Xian Zheng kang-Ning Liu yi-Fei Ma jun-Yu Chen Center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing100081China School of Management and Economics Beijing Institute of TechnologyBeijing100081China Collaborative Innovation Center of Electric Vehicles in Beijing BeijingChina Sustainable Development Research Institute for Economy and Society of Beijing BeijingChina Institute of Carbon Neutrality ShanghaiTech UniversityShanghai201210China

With the implementation of the Belt and Road Initiative, China is deepening its cooperation in oil and gas resources with countries along the Initiative. In order to better mitigate risks and enhance the safety of investments, it is of significant importance to research the oil and gas investment environment in these countries for China's overseas investment macro-layout. This paper proposes an indicator system including 27 indicators from 6 dimensions. On this basis, game theory models combined with global entropy method and analytic hierarchy process are applied to determine the combined weights, and the TOPSIS-GRA model is utilized to assess the risks of oil and gas investment in 76 countries along the Initiative from 2014 to 2021. Finally, the GM(1,1) model is employed to predict risk values for 2022-2025. In conclusion, oil and gas resources and political factors have the greatest impact on investment environment risk, and 12 countries with greater investment potential are selected through cluster analysis in conjunction with the predicted results. The research findings may provide scientific decisionmaking recommendations for the Chinese government and oil enterprises to strengthen oil and gas investment cooperation with countries along the Belt and Road Initiative.

关键词： Belt and Road Initiative Oil and Gas Investment Risk assessment

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Production of high-purity Mg metal from dolomite through novel molten salt electrolysis and vacuum distillation

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Journal of Magnesium and Alloys 2023年第4期11卷 1308-1320页

作者： Hyeong-jun Jeoung Tae-Hyuk Lee Jin-Young Lee Kyung-Woo yi jungshin kang Korea Institute of Geoscience and Mineral Resources 124 Gwahak-ro Yuseong-guDaejeon 34132Republic of Korea Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Resources Engineering University of Science and Technology217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea School of Materials Science and Engineering Pusan National University2 Busandaehak-roGeumjeong-guBusan 46241Republic of Korea

In this study,a novel Mg production process for producing high-purity Mg metal from dolomite was *** the electrolysis of calcined dolomite was conducted using Cu cathode and C anode in MgF_(2)–LiF molten salt at 1083–1173 K by applying an average current of 1.42–1.46 A for 9.50–21.0 h,the current efficiency of 66.4–88.6%was *** produced Mg alloys consisted of MgCu_(2)and Cu(Mg)or MgCu_(2)and CuMg_(2)phases,depending on the Mg concentration in the Mg *** the electrolysis of calcined dolomite was conducted in MgF_(2)–LiF–CaF_(2)molten salt at 1083 K,the current efficiency was 40.9–71.4%,owing to undesired reactions such as electroreduction of Ca^(2+)or/and CO_(3)^(2−)***,the current efficiency increased from 40.9%to 63.2%by utilizing a Pt anode,because the occurrence of CO_(3)^(2−)ions in the molten salt was *** vacuum distillation of the obtained Mg alloys at 1300 K for 10 h,Mg metal with a purity of 99.9996–99.9998%was ***,the feasibility of this novel process for the production of high-purity Mg metal from dolomite was demonstrated.

关键词： High-purity magnesium Dolomite Magnesium oxide Electrolytic process Copper metal cathode Vacuum distillation

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