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川芎嗪对感染性坏死性急性胰腺炎患者器官功能的保护作用研究

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中华医院感染学杂志 2017年第12期27卷 2737-2739,2743页

作者：张益维陈益君玉珏朱浩梁国晋宁波市第一医院麻醉科浙江宁波315012

目的探讨川芎嗪对感染性坏死性急性胰腺炎患者器官功能的保护作用。方法前瞻性收集医院重症监护病房2015年1月-2016年1月收治的感染性坏死性急性胰腺炎患者80例,将患者随机分为观察组和对照组,每组40例,两组患者均给予抑酸、抑酶等常规... 详细信息

目的探讨川芎嗪对感染性坏死性急性胰腺炎患者器官功能的保护作用。方法前瞻性收集医院重症监护病房2015年1月-2016年1月收治的感染性坏死性急性胰腺炎患者80例,将患者随机分为观察组和对照组,每组40例,两组患者均给予抑酸、抑酶等常规治疗,观察组在此基础上给予丹参川芎嗪注射液治疗,观察两组患者预后情况。结果与对照组相比,观察组患者单脏器功能衰竭率显著降低(P<0.05);器官功能损伤持续时间显著缩短(P<0.05);住院时间显著缩短(P<0.05);两组患者入院时白介素-6(IL-6)和肿瘤坏死因子-ɑ(TNF-ɑ)水平差异无统计学意义;与对照组比较,观察组患者7天后IL-6及TNF-ɑ水平显著降低,差异有统计学意义(P<0.05)。结论川芎嗪有助于降低感染性坏死性急性胰腺炎患者炎症因子水平,保护器官功能。

关键词：感染性坏死性急性胰腺炎器官功能川芎嗪炎症因子

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao yue Lin Gen Wei jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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星状神经节阻滞治疗紧张性头痛的效果观察

中国当代医药 2016年第16期23卷 68-70页

作者：何兵荣谢江易玉军江西省上栗县人民医院内三科江西上栗337009

目的探讨星状神经节阻滞治疗紧张性头痛的临床效果。方法选取2014年2月～2015年3月我院收治的紧张性头痛患者52例为研究对象,采用星状神经阻滞治疗4周,治疗后对患者随访3个月,比较治疗前后患者头痛发作次数、疼痛评分、持续时间及疗效... 详细信息

目的探讨星状神经节阻滞治疗紧张性头痛的临床效果。方法选取2014年2月～2015年3月我院收治的紧张性头痛患者52例为研究对象,采用星状神经阻滞治疗4周,治疗后对患者随访3个月,比较治疗前后患者头痛发作次数、疼痛评分、持续时间及疗效。结果治疗后患者疼痛发作次数、疼痛评分及持续时间均少于治疗前[（2.3±0.5）次/d vs（8.8±2.1）次/d,（2.1±0.4）分vs（5.2±2.0）分,（3.2±0.8）min vs（12.1±3.2）min,P〈0.01]。治疗后患者症状优良率高于治疗前（90.38%vs 17.31%,P〈0.01）。结论星状神经节阻滞治疗紧张性头痛可显著改善患者症状,具有显著的临床疗效。

关键词：星状神经节阻滞紧张性头痛疗效

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu yu Wang Hanlin Huang jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Raman Scattering in Ga_xIn_(1-x)P and (Al_xGa_(1-x) )_0.51 In_0.49 P Alloys

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Semiconductor Photonics and Technology 2002年第3期8卷 129-134页

作者： LU yi jun 1, GAO yu lin 1, ZHENG Jian sheng 1, LI Zhi feng 2, CAI Wei ying 2, WANG Xiao guang 2 (1.Dept. of Physics, Xiamen University, Xiamen 361005, CHN 2.Shanghai Institute of Technical Physics, Shanghai 200083, CHN) Dept. of Physics. Xiamen University Xiamen 361005 Shanghai Institute of Technical Physics 上海 200083

Raman scattering spectroscopy is applied to investigate the phonon modes in Ga x In 1- x P ( x =0.52) and (Al x Ga 1- x ) 0.51 In 0.49 P ( x =0.29) alloys. Two mode behavior in Ga x In 1- x P and three mode behavior in (Al x Ga 1- x ) 0.51 In 0.49 P are observed. In ordered Ga x In 1- x P, we clearly distinguish the TO 1(GaP like) mode and the splitting of LO 1(GaP like) and LO 2 (InP like) modes, which is believed to be the result of superlattice effect of ordering, and the LO 1+LO 2 mode, which is observed for the first time. In addition to the b/a ratio, it’s found that the relative intensity of the FLA and the LO 1+LO 2 modes also corresponds to the degree of order. The TO 1 and the splitting of LO 1 and LO 2 devote together to the reduction of the "valley depth". In (Al x Ga 1- x ) 0.51 In 0.49 P, the doubling of FLA is observed. Due to the influence of Al composition, the GaP like LO mode becomes a shoulder of the InP like LO mode. The unresolved Raman spectra indicate the existence of ordered structure in (Al x Ga 1- x ) 0.51 In 0.49 P alloys.

关键词： Semiconductors Order-disorder effects Phonons Luminescence

Low-Temperature Fabrication of Stable Black-Phase CsPbI₃ Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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NANO-MICRO LETTERS 2025年第1期17卷 1-14页

作者： Zhao, yingjie Sun, yicheng Pei, Chaoxin yin, Xing Li, Xinyi Hao, yi Zhang, Mengru yuan, Meng Zhou, Jinglin Chen, yu Song, Yanlin Zhengzhou Univ Coll Chem Zhengzhou 450001 Peoples R China Zhengzhou Univ Pingyuan Lab Zhengzhou 450001 Peoples R China Chinese Acad Sci Inst Chem Key Lab Green Printing Beijing 100190 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Key Lab Bioinspired Mat & Interfacial Sci Beijing 100190 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China

Low-temperature fabrication of black-phase CsPbI3 perovskite films is first demonstrated by using diphenylphosphinic chloride additive under 30-50 degrees C, arising from the steric effect and chloride insertion ***-area high-quality all-inorganic perovskite films with fewer defects enhanced crystallographic orientation, and excellent environmental stability is *** record performances are demonstrated for flexible wearable photodetectors with a responsivity of 42.1 A W-1, a detectivity of 1.3 x 1014 Jones, high-fidelity image, photoplethysmography sensor functions, and high mechanical stability. Flexible wearable optoelectronic devices fabricated from organic-inorganic hybrid perovskites significantly accelerate the development of portable energy, biomedicine, and sensing fields, but their poor thermal stability hinders further applications. Conversely, all-inorganic perovskites possess excellent thermal stability, but black-phase all-inorganic perovskite film usually requires high-temperature annealing steps, which increases energy consumption and is not conducive to the fabrication of flexible wearable devices. In this work, an unprecedented low-temperature fabrication of stable black-phase CsPbI3 perovskite films is demonstrated by the in situ hydrolysis reaction of diphenylphosphinic chloride additive. The released diphenyl phosphate and chloride ions during the hydrolysis reaction significantly lower the phase transition temperature and effectively passivate the defects in the perovskite films, yielding high-performance photodetectors with a responsivity of 42.1 A W-1 and a detectivity of 1.3 x 1014 Jones. Furthermore, high-fidelity image and photoplethysmography sensors are demonstrated based on the fabricated flexible wearable photodetectors. This work provides a new perspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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三基色白光LED的司辰节律因子研究

发光学报 2016年第11期37卷 1384-1389页

作者：郑莉莉郭自泉严威吴挺竹吕毅军高玉琳史园陈忠厦门大学电子科学系福建省半导体照明工程技术研究中心福建厦门361005 厦门市产品质量监督检验院国家半导体发光器件(LED)应用产品质量监督检验中心福建厦门361004

采用司辰节律因子模型,通过计算三基色白光LED光源在不同工作电流下的司辰节律因子,对可调色温的三基色白光LED光源进行非视觉效应研究。为了获取与自然光非视觉效应类似的LED白光,建立了司辰节律因子和相关色温分别相对于工作电流的关... 详细信息

采用司辰节律因子模型,通过计算三基色白光LED光源在不同工作电流下的司辰节律因子,对可调色温的三基色白光LED光源进行非视觉效应研究。为了获取与自然光非视觉效应类似的LED白光,建立了司辰节律因子和相关色温分别相对于工作电流的关系模型,从而已知自然光的司辰节律因子和相关色温,就可以确定三基色LED的工作电流。通过测试一天内不同时刻的自然光光谱,根据上述模型推算出了三基色LED的工作电流。在所推算的三基色电流下,测试了白光LED光谱参数并计算了相应的司辰节律因子。与自然光司辰节律因子的对比结果表明,理论值和实验值的误差在1.1%以内,证实该方法具有可行性。本文所呈现的方法对于利用三基色白光LED模拟自然光具有一定的指导意义。

关键词：非视觉效应三基色白光LED 司辰节律因子自然光

老年危重患者在外科手术后早期应用乌司他丁的临床研究

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上海医学 2005年第2期28卷 113-115页

作者：郑毅刘俊于亮赵勤刘育健交通大学附属第一人民医院普外科上海200080

　目的　探讨乌司他丁在外科老年危重患者手术后早期应用的临床治疗作用。方法　将 30 例术后收入外科重症监护病房(ICU)的老年患者(>60 岁)随机均分为乌司他丁组和对照组,两组均给予外科 ICU的常规治疗。乌司他丁组在入 ICU后第1天加... 详细信息

　目的　探讨乌司他丁在外科老年危重患者手术后早期应用的临床治疗作用。方法　将 30 例术后收入外科重症监护病房(ICU)的老年患者(>60 岁)随机均分为乌司他丁组和对照组,两组均给予外科 ICU的常规治疗。乌司他丁组在入 ICU后第1天加用40万U乌司他丁,第2、3、4 天分别加用 20 万 U乌司他丁。比较两组术后7 d内的临床症状、全身炎症反应综合征(SIRS)的改善情况和营养、免疫情况。结果　乌司他丁组预防应激性溃疡、改善SIRS症状以及减少蛋白分解的能力优于对照组。结论　乌司他丁对老年危重患者手术后的恢复治疗有一定积极作用。

关键词：乌司他丁老年危重患者 ICU SIRS 术后早期对照组外科恢复随机分解

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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