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Ten-year observation of corneal densitometry and associated factors following small incision lenticule extraction

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 485-490页

作者： Xiao-Song Han Fei Xia Zhuo-yi Chen Pei-Jun Yao Dong-Mei Yang jing Zhao Xing-tao Zhou Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200031China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200031China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000) Shanghai 200031China

●AIM:To investigate the long-term changes of corneal densitometry(CD)and its contributing elements after small incision lenticule extraction(SMILE).●METHODS:Totally 31 eyes of 31 patients with mean spherical equivalent of-6.46±1.50 D and mean age 28.23±7.38y were enrolled.Full-scale examinations were conducted on all patients preoperatively and during followup.Visual acuity,manifest refraction,axial length,corneal thickness,corneal higher-order aberrations,and CD were evaluated.●RESULTS:All surgeries were completed successfully without complications or adverse events.Ten-year safety index was 1.17±0.20 and efficacy 1.04±0.28.CD value of 0–6 mm zones in central layer was statistically significantly lower 10y postoperatively,compared with preoperative values(0–2 mmΔ=-1.62,2–6 mmΔ=-1.24,P<0.01).There were no correlations between CD values and factors evaluated.●CONCLUSION:SMILE is a safe and efficient procedure for myopia on a long-term basis.CD values get lower 10y postoperatively,whose mechanism is to be further discussed.

关键词： myopia small incision lenticule extraction corneal densitometry

Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases

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World Journal of Gastroenterology 2024年第11期30卷 1524-1532页

作者： yi-Fan Chang Jia-jing Li tao Liu Chong-Qing Wei Li-Wei Ma Vladimir N Nikolenko Wei-Long Chang Department of Gastrointestinal Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Clinical Laboratory The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Human Anatomy and Histology I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia

Autophagy is a cellular catabolic process characterized by the formation of double-membrane autophagosomes.Transmission electron microscopy is the most rigorous method to clearly visualize autophagic engulfment and degradation.A large number of studies have shown that autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal(GI)cells.However,the role of autophagy in GI diseases remains controversial.This article focuses on the morphological and biochemical characteristics of autophagy in GI diseases,in order to provide new ideas for their diagnosis and treatment.

关键词： Autophagy Morphological study Biochemical characteristics Subcellular structure Transmission electron microscopy Gastrointestinal diseases

High-precision nondestructive evaluation of a thermal barrier coating based on perovskite quantum dot anion exchange

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Nano Research 2024年第5期17卷 4582-4592页

作者： tao Han Shufang Ding Zifan Wang Sirong Jiang Pengjiang jing Tianshang yi Yaqi Chen Chunzhi Jiang Xiaofeng Zhang Microelectronics and Optoelectronics Technology Key Laboratory of Hunan Higher Education School of Physics and Electronic Electrical EngineeringXiangnan UniversityChenzhou 423000China National Engineering Laboratory for Modern Materials Surface Engineering Technology&The Key Lab of Guangdong for Modern Surface Engineering Technology Guangdong Institute of New MaterialsGuangdong Academy of SciencesGuangzhou 510650China

Thermal barrier coatings(TBCs)in gas turbine engines are used in expressly harsh environments;thus,assessing TBC integrity status is critical for safety and reliability.However,traditional periodic maintenance involves visual inspections of the TBCs,requiring the gas turbine to be decommissioned and partially dismantled.Most importantly,tiny defects or internal damages that easily cause coating failure cannot be identified.In this work,a new nondestructive evaluation(NDE)technique of TBCs based on quantum dot(QD)anion exchange is first explored internationally.By exchanging anions between the Cl ions and the CsPbBr_(3) QDs,the degrees of salt corrosion of the TBCs are evaluated.The resultant NDE technique shows that the colour of the TBCs obviously changes from green to blue,accompanied by a large blueshift(~100 nm)of the photoluminescence(PL)peak position.In addition,the relationship between the PL peak position and coating thermophysical properties indicates that the precision of this NDE technique may easily identify theμm-level of the thermal growth oxide(TGO)changes inside the TBCs.

关键词： thermal barrier coatings nondestructive evaluation CsPbBr_(3)quantum dot anion exchange thermal growth oxide

The Ananthakrishna Model Under Non-synchronous Perturbation

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Acta Mathematicae Applicatae Sinica 2024年

作者： yi-wen tao Sue Ann CAMPBELL jing-li REN School of Mathematics and Statistics Zhengzhou University Department of Applied Mathematics University of Waterloo

The Ananthakrishna model, seeking to explain the Portevin-Le Chatelier effect, is studied with or without non-synchronous perturbations. For the unperturbed model, Bogdanov-Takens bifurcation and zeroHopf bifurcation are detected. For the perturbed model, rich dynamical behaviors are given by researching the Poincaré map, including solutions of different periods, quasi-periodic solutions, chaotic solutions, and bistability.Moreover, an augmented temperature-dependent perturbation amplitude induces a transition from non-serrated to serrated flow on the stress-time curve. Notably, on the stress-strain curve, the phenomenon of repeated yielding diminishes with an increase in the value of a temperature-dependent parameter, while it persists with an increase in the value of a temperature-independent parameter. Sensitivity analysis sheds light on the factors exerting the most significant influence on dislocation density.

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NFHP-RN:AMethod of Few-Shot Network Attack Detection Based on the Network Flow Holographic Picture-ResNet

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 929-955页

作者： tao yi Xingshu Chen Mingdong Yang Qindong Li yi Zhu School of Cyber Science and Engineering Sichuan UniversityChengdu610065China CyberScience Research Institute Sichuan UniversityChengdu610065China Chengdu Fengwei Technology Co. Ltd.Chengdu610041China

Due to the rapid evolution of Advanced Persistent Threats(APTs)attacks,the emergence of new and rare attack samples,and even those never seen before,make it challenging for traditional rule-based detection methods to extract universal rules for effective detection.With the progress in techniques such as transfer learning and meta-learning,few-shot network attack detection has progressed.However,challenges in few-shot network attack detection arise from the inability of time sequence flow features to adapt to the fixed length input requirement of deep learning,difficulties in capturing rich information from original flow in the case of insufficient samples,and the challenge of high-level abstract representation.To address these challenges,a few-shot network attack detection based on NFHP(Network Flow Holographic Picture)-RN(ResNet)is proposed.Specifically,leveraging inherent properties of images such as translation invariance,rotation invariance,scale invariance,and illumination invariance,network attack traffic features and contextual relationships are intuitively represented in NFHP.In addition,an improved RN network model is employed for high-level abstract feature extraction,ensuring that the extracted high-level abstract features maintain the detailed characteristics of the original traffic behavior,regardless of changes in background traffic.Finally,a meta-learning model based on the self-attention mechanism is constructed,achieving the detection of novel APT few-shot network attacks through the empirical generalization of high-level abstract feature representations of known-class network attack behaviors.Experimental results demonstrate that the proposed method can learn high-level abstract features of network attacks across different traffic detail granularities.Comparedwith state-of-the-artmethods,it achieves favorable accuracy,precision,recall,and F1 scores for the identification of unknown-class network attacks through cross-validation onmultiple datasets.

关键词： APT attacks spatial pyramid pooling NFHP(network flow holo-graphic picture) ResNet self-attention mechanism meta-learning

Electrochemical Analysis of Single Glucose Oxidase with a Nanopipette

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Chemical Research in Chinese Universities 2024年第2期40卷 272-278页

作者： WANG Yongyong MA Hui LONG yi-tao yiNG yi-Lun School of Chemistry and Chemical Engineering Molecular Sensing and Imaging Center(MSIC)Nanjing UniversityNanjing210023P.R.China

Nanopore-based electrochemical technique is a promising tool for detecting single proteins.However,detecting single proteins using a nanopipette in their native state without labeling is challenging due to the rapid translocation,which results in an inefficient signal identification.In our study,we finely tuned the driving force equilibrium between electrophoretic force(EPF)and electroosmotic flow(EOF)inside the nanopipette for efficient sensing of single glucose oxidase(GOD)molecules.The duration time of GOD within the nanopipette is extended to about 4 ms.This strategy provided clear ionic current signals with a signal-to-noise ratio of 3.3.As EPF increased in the direction opposite to the motion of GOD,we observed a nonlinear growth in GOD’s duration time.This extended the duration to about 4.4 times longer at−1000 mV compared to at−800 mV.Hence,nanopore-based electrochemical sensing could be used for single GOD molecule analysis as an ultrasensitive method.

关键词： Nanopore Single-molecule analysis Glucose oxidase Electrophoretic force Electroosmotic flow

Enhanced organic degradation and microbial community cooperation by inoculating Bacillus licheniformis in low temperature composting

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Journal of Environmental Sciences 2024年第9期143卷 189-200页

作者： jing Su Kaiyun Zhou Wenjie Chen Shaoqi Xu Ziwei Feng Yuan Chang Xiaoyan Ding yi Zheng Xingling tao Ake Zhang Yue Wang Ji Li Guochun Ding Yuquan Wei Nanjing Institute of Environmental Sciences Ministry of Ecology and EnvironmentNanjing 210042China College of Resources and Environmental Science Beijing Key Laboratory of Biodiversity and Organic FarmingChina Agricultural UniversityBeijing 100193China Organic Recycling Institute(Suzhou)of China Agricultural University Wuzhong DistrictSuzhou 215128China Fuyang Academy of Agricultural Sciences Fuyang 236065China

Microbial activity and interaction are the important driving factors in the start-up phase of food waste composting at low temperature.The aim of this study was to explore the effect of inoculating Bacillus licheniformis on the degradation of organic components and the potential microbe-driven mechanism from the aspects of organic matter degradation,enzyme activity,microbial community interaction,and microbial metabolic function.The results showed that after inoculating B.licheniformis,temperature increased to 47.8℃ on day2,and the degradation of readily degraded carbohydrates(RDC)increased by 31.2%,and the bioheat production increased by 16.5%.There was an obvious enhancement of extracellular enzymes activities after inoculation,especially amylase activity,which increased by 7.68 times on day 4.The inoculated B.licheniformis colonized in composting as key genus in the start-up phase.Modular network analysis and Mantel test indicated that inoculation drove the cooperation between microbial network modules who were responsible for various organic components(RDC,lipid,protein,and lignocellulose)degradation in the start-up phase.Metabolic function prediction suggested that carbohydrate metabolisms including starch and sucrose metabolism,glycolysis/gluconeogenesis,pyruvate metabolism,etc.,were improved by increasing the abundance of related functional genes after inoculation.In conclusion,inoculating B.licheniformis accelerated organic degradation by driving the cooperation between microbial network modules and enhancing microbial metabolism in the start-up phase of composting.

关键词： Microbial agent Organic matter degradation Microbial interaction Food waste Low temperature composting

Therapeutic Effectiveness of Leukocyte-and Platelet-rich Fibrin for Diabetic Foot Ulcers:A Retrospective Study

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Current Medical Science 2024年第3期44卷 568-577页

作者： Fen WANG Xiao-ling ZHANG jing ZHANG Song GONG jing tao Hui XIANG Xiao-qing FU Xu-na BIAN Xue-feng YU An-hui XU Cheng-la yi Shi-ying SHAO Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Branch of National Clinical Research Center for Metabolic Diseases Wuhan430030China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Trauma Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Diabetic foot ulcer(DFU)is one of the most serious complications of diabetes.Leukocyte-and platelet-rich fibrin(L-PRF)is a second-generation autologous platelet-rich plasma.This study aims to investigate the clinical effects of L-PRF in patients with diabetes in real clinical practice.Methods Patients with DFU who received L-PRF treatment and standard of care(SOC)from 2018 to 2019 in Tongji Hospital were enrolled.The clinical information including patient characteristics,wound evaluation(area,severity,infection,blood supply),SOC of DFU,and images of ulcers was retrospectively extracted and analyzed.L-PRF treatment was performed every 7±2 days until the ulcer exhibited complete epithelialization or an overall percent volume reduction(PVR)greater than 80%.Therapeutic effectiveness,including overall PVR and the overall and weekly healing rates,was evaluated.Results Totally,26 patients with DFU were enrolled,and they had an ulcer duration of 47.0(35.0,72.3)days.The severity and infection of ulcers varied,as indicated by the Site,Ischemia,Neuropathy,Bacterial Infection,and Depth(SINBAD)scores of 2–6,Wagner grades of 1–4,and the Perfusion,Extent,Depth,Infection and Sensation(PEDIS)scores of 2–4.The initial ulcer volume before L-PRF treatment was 4.94(1.50,13.83)cm3,and the final ulcer volume was 0.35(0.03,1.76)cm3.The median number of L-PRF doses was 3(2,5).A total of 11 patients achieved complete epithelialization after the fifth week of treatment,and 19 patients achieved at least an 80%volume reduction after the seventh week.The overall wound-healing rate was 1.47(0.63,3.29)cm3/week,and the healing rate was faster in the first 2 weeks than in the remaining weeks.Concurrent treatment did not change the percentage of complete epithelialization or healing rate.Conclusion Adding L-PRF to SOC significantly improved wound healing in patients with DFU independent of the ankle brachial index,SINBAD score,or Wagner grade,indicating that this method is appropriate for DFU treatment under different clinical conditions

关键词： diabetic foot ulcer autologous platelet-rich plasma leukocyte-and platelet-rich fibrin standard of care percentage volume reduction

Unraveling the role of NiSnPH@OOH/CC perovskite hydroxide for efficient electrocatalytic oxidation of methanol to formate

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Nano Research 2024年第4期17卷 2388-2399页

作者： jing Shao Yusheng Fang Xiaobing Wu Muhammad Imran Abdullah Youkun tao College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China School of Science Harbin Institute of TechnologyShenzhen 518055China

The sluggish kinetics of oxygen evolution reaction(OER)is the key tailback for hydrogen production from the water electrolysis.Masking OER with thermodynamically auspicious methanol oxidation reaction(MOR)can significantly boost the H_(2) and value-added products production.However,it is currently challenging to achieve a synergistic manipulation of product selectivity and performance for MOR electrocatalyst.Herein,we report NiSnPH@OOH/CC(CC=carbon cloth)perovskite hydroxide nanosphere as an efficient MOR electrocatalyst with high activity,stability,and selectivity towards methanol oxidation to formate.A surface amorphous layer of defect rich NiOOH was generated in operando by selective Sn leaching with stable perovskite hydroxide bulk structure,which mitigates the oxidative power and optimizes the local coordination environment of the active NiOOH sites.In situ Raman combined with electrochemical studies further confirm the key active species,NiOOH,generated in operando enhance the MOR and blocking the over oxidation of methanol to CO_(2).As a result,NiSnPH@OOH/CC effectively masks the OER and attains>99%selectivity with 100%Faradic efficiency for methanol-to-formate.The results of this study show the advances of NiSnPH@OOH/CC as an efficient electrocatalyst for MOR and also suggest its potential applications for various small organic molecules oxidation.

关键词： perovskite hydroxide small organic molecules nickel oxy(hydroxide) value-added products methanol oxidation reaction