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2,3-Butanediol from the leachates of pine needles induces the resistance of Panax notoginseng to the leaf pathogen Alternaria panax

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Plant Diversity 2023年第1期45卷 104-116页

作者： Tian-Yao Li Chen Ye yi-jie zhang Jun-Xing zhang Min Yang Xia-Hong He Xin-Yue Mei yi-Xiang Liu You-Yong Zhu Hui-Chuan Huang Shu-Sheng Zhu School of Agriculture Yunnan UniversityKunming650500China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming650201China Key Laboratory of Agro-Biodiversity and Pest Management of Education Ministry of China Yunnan Agricultural UniversityKunming650201China Southwest Forestry University Kunming650224China

Compared with the use of monocultures in the field,cultivation of medicinal herbs in forests is an effective strategy to alleviate disease.Chemical interactions between herbs and trees play an important role in disease suppression in forests.We evaluated the ability of leachates from needles of Pinus armandii to induce resistance in Panax notoginseng leaves,identified the components via gas chromatography-mass spectrometry(GC-MS),and then deciphered the mechanism of 2,3-Butanediol as the main component in the leachates responsible for resistance induction via RNA sequencing(RNA-seq).Prespraying leachates and 2,3-Butanediol onto leaves could induce the resistance of P.notoginseng to Alternaria panax.The RNA-seq results showed that prespraying 2,3-Butanediol onto leaves with or without A.panax infection upregulated the expression of large number of genes,many of which are involved in transcription factor activity and the mitogen-activated protein kinase(MAPK) signaling pathway.Specifically,2,3-Butanediol spraying resulted in jasmonic acid(JA)-mediated induced systemic resistance(ISR) by activating MYC2 and ERF1.Moreover,2,3-Butanediol induced systemic acquired resistance(SAR) by upregulating pattern-triggered immunity(PTI)-and effector-triggered immunity(ETI)-related genes and activated camalexin biosynthesis through activation of WRKY33.Overall,2,3-Butanediol from the leachates of pine needles could activate the resistance of P.notoginseng to leaf disease infection through ISR,SAR and camalexin biosynthesis.Thus,2,3-Butanediol is worth developing as a chemical inducer for agricultural production.

关键词： Pinus armandii Allelopathy Herbs Induce resistance Diversity Leaf disease

Sex-biased single-cell genetic landscape in mice with autism spectrum disorder

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Journal of Genetics and Genomics 2024年第3期51卷 338-351页

作者： Qian zhang Yongjie Wang jie Tao Ruixue Xia yijie zhang Zhirui Liu Jiwei Cheng Department of Neurology and Central Laboratory Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang 311121China Department of Respiratory and Critical Care Medicine Henan University Huaihe HospitalKaifengHenan 475099China

Autistic spectrum disorder(ASD)is a male-biased,heterogeneous neurodevelopmental disorder that affects approximately 1%e2%of the population.Prenatal exposure to valproic acid(VPA)is a recognized risk factor for ASD,but the cellular and molecular basis of VPA-induced ASD at the single-cell resolution is unclear.Here,we aim to compare the cellular and molecular differences in the hippocampus between male and female prenatal mice with ASD at the single-cell transcriptomic level.The transcriptomes of more than 45,000 cells are assigned to 12 major cell types,including neurons,glial cells,vascular cells,and immune cells.Cell type-specific genes with altered expression after prenatal VPA exposure are analyzed,and the largest number of differentially expressed genes(DEGs)are found in neurons,choroid plexus epithelial cells,and microglia.In microglia,several pathways related to inflammation are found in both males and females,including the tumor necrosis factor(TNF),nuclear factor kappa B(NF-kB),toll-like receptor(TLR),and mitogen-activated protein kinase(MAPK)signaling pathways,which are important for the induction of autistic-like behavior.Additionally,we note that several X-linked genes,including Bex1,Bex3,and Gria3,were among the male-specific DEGs of neurons.This pioneering study describes the landscape of the transcriptome in the hippocampus of autistic mice.The elucidation of sexual differences could provide innovative strategies for the prevention and treatment of ASD.

关键词： Autistic spectrum disorder(ASD) Sex Single cell Neurons Microglia

Axonal mRNA localization and local translation in neurodegenerative diseases

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Neural Regeneration Research 2021年第10期16卷 1950-1957页

作者： Jin-Xin Lu Yang Wang yi-jie zhang Mei-Fen Shen Hai-ying Li Zheng-Quan Yu Gang Chen Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurosurgery The First Affiliated Hospital of University of Science and Technology of ChinaHefeiAnhui ProvinceChina

The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function.Many human neurodegenerative diseases,such as fragile X syndrome,amyotrophic lateral sclerosis,Alzheimer’s disease,and spinal muscular atrophy,have been characterized by pathological changes in neuronal axons,including abnormal mRNA translation,the loss of protein expression,or abnormal axon transport.Moreover,the same protein and mRNA molecules have been associated with variable functions in different diseases due to differences in their interaction networks.In this review,we briefly examine fragile X syndrome,amyotrophic lateral sclerosis,Alzheimer’s disease,and spinal muscular atrophy,with a focus on disease pathogenesis with regard to local mRNA translation and axon transport,suggesting possible treatment directions.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis axonal transport fragile X syndrome local translation mRNA localization neuron spinal muscular atrophy

Microstructure and mechanical properties of in-situ TiB_2/A356 composites and a prediction model of yield strength

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China Foundry 2015年第4期12卷 251-260页

作者： yi-jie zhang Ming-liang Wang Xian-feng Li Dong Chen Nai-heng Ma Hao-wei Wang State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University

The in-situ TiB_2/A356 composites were successfully synthesized through the mixed salt reaction method.The advantage of this technique was that the particle sizes and morphology can be controlled by the melt reaction.Therefore,the technique can be designed to obtain expected properties,such as high strength at high and room temperatures,high damping capacity,high modulus and good fatigue life.Results showed that in the as-cast state of A356 alloy and TiB_2/A356 composites,the eutectic Si phase is normally in the needle shape,and TiB_2 particles are mostly in the cubic or near spherical shape,with the size ranging from 30 to 500 nm uniformly distributed in the grains.Also,TiB_2 particle clusters are observed in composites.With an increase in TiB_2particles,the average grain size of composites decreases both in as-cast and T6 state.It is found that both the yield stength and ultimate tensile strength increase with an increase in the TiB_2 volume fraction.On the contrary,the elongation reduces with the addition of TiB_2 particles.Based on the experimental results and Clyne's report,a revised model related to particle strengthening mechanism was proposed to fairly predict yield strengths of TiB_2/A356 composites.The satisfactory agreement between the calculated values and experimental data reported in the literature was obtained.

关键词： metal matrix composites AI alloy mechanical properties melt reaction phenomenological model

Discovery and analysis of pancreatic adenocarcinoma genes using cDNA microarrays

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World Journal of Gastroenterology 2005年第41期11卷 6543-6548页

作者： Gang Jin Xian-Gui Hu Kang ying Yan Tang Rui Liu yi-jie zhang Zai-Ping Jing yi Xie Yu-Min Mao Department of General Surgery Changhai Hospital Second Military Medical University Shanghai 200433 China State Key Laboratory of Genetic Engineering Institute of Genetics School of Life Science Fudan University Shanghai 200433 China

AIM: To study the pathogenetic processes and the role of gene expression by microarray analyses in expediting our understanding of the molecular pathophysiology of pancreatic adenocarcinoma, and to identify the novel cancer-associated genes.METHODS: Nine histologically defined pancreatic head adenocarcinoma specimens associated with clinical data were studied. Total RNA and mRNA were isolated and labeled by reverse transcription reaction with Cy5 and Cy3 for cDNA probe. The cDNA microarrays that represent a set of 4 096 human genes were hybridized with labeled cDNA probe and screened for molecular profiling analyses.RESULTS: Using this methodology, 184 genes were screened out for differences in gene expression level after nine couples of hybridizations. Of the 184 genes,87 were upregulated and 97 downregulated, including 11 novel human genes. In pancreatic adenocarcinoma tissue, several invasion and metastasis related genes showed their high expression levels, suggesting that poor prognosis of pancreatic adenocarcinoma might have a solid molecular biological basis.CONCLUSION: The application of cDNA microarray technique for analysis of gene expression patterns is a powerful strategy to identify novel cancer-associated genes, and to rapidly explore their role in clinical pancreatic adenocarcinoma. Microarray profiles provide us new insights into the carcinogenesis and invasive process of pancreatic adenocarcinoma. Our results suggest that a highly organized and structured process of tumor invasion exists in the pancreas.

关键词： cDNA 胰腺癌基因表达病理机制

Hyperspectral remote sensing identification of marine oil spills and emulsions using feature bands and double-branch dual-attention mechanism network

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Journal of Oceanology and Limnology 2024年第3期42卷 728-743页

作者： Ning zhang Junfang YANG Shanwei LIU yi MA jie zhang College of Oceanography and Space Informatics China University of PetroleumQingdao 266580China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China

The accurate identification of marine oil spills and their emulsions is of great significance for emergency response to oil spill pollution.The selection of characteristic bands with strong separability helps to realize the rapid calculation of data on aircraft or in orbit,which will improve the timeliness of oil spill emergency monitoring.At the same time,the combination of spectral and spatial features can improve the accuracy of oil spill monitoring.Two ground-based experiments were designed to collect measured airborne hyperspectral data of crude oil and its emulsions,for which the multiscale superpixel level group clustering framework(MSGCF)was used to select spectral feature bands with strong separability.In addition,the double-branch dual-attention(DBDA)model was applied to identify crude oil and its emulsions.Compared with the recognition results based on original hyperspectral images,using the feature bands determined by MSGCF improved the recognition accuracy,and greatly shortened the running time.Moreover,the characteristic bands for quantifying the volume concentration of water-in-oil emulsions were determined,and a quantitative inversion model was constructed and applied to the AVIRIS image of the deepwater horizon oil spill event in 2010.This study verified the effectiveness of feature bands in identifying oil spill pollution types and quantifying concentration,laying foundation for rapid identification and quantification of marine oil spills and their emulsions on aircraft or in orbit.

关键词： hyperspectral image spectral analysis dimensionality reduction multiscale superpixel level group clustering framework(MSGCF) double-branch dual-attention(DBDA)

2D multifunctional devices:from material preparation to device fabrication and neuromorphic applications

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International Journal of Extreme Manufacturing 2024年第3期6卷 91-118页

作者： Zhuohui Huang Yanran Li yi zhang jiewei Chen Jun He jie Jiang Hunan Key Laboratory of Nanophotonics and Devices School of PhysicsCentral South UniversityChangshaHunanPeople’s Republic of China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Neuromorphic computing systems,which mimic the operation of neurons and synapses in the human brain,are seen as an appealing next-generation computing method due to their strong and efficient computing abilities.Two-dimensional (2D) materials with dangling bond-free surfaces and atomic-level thicknesses have emerged as promising candidates for neuromorphic computing hardware.As a result,2D neuromorphic devices may provide an ideal platform for developing multifunctional neuromorphic applications.Here,we review the recent neuromorphic devices based on 2D material and their multifunctional applications.The synthesis and next micro–nano fabrication methods of 2D materials and their heterostructures are first introduced.The recent advances of neuromorphic 2D devices are discussed in detail using different operating principles.More importantly,we present a review of emerging multifunctional neuromorphic applications,including neuromorphic visual,auditory,tactile,and nociceptive systems based on 2D devices.In the end,we discuss the problems and methods for 2D neuromorphic device developments in the future.This paper will give insights into designing 2D neuromorphic devices and applying them to the future neuromorphic systems.

关键词： 2D material micro–nano fabrication multifunctional system neuromorphic electronics artificial intelligence

Reducing the voltage loss of Y-series acceptor based organic solar cells via ternary/quaternary strategies

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Chinese Chemical Letters 2024年第2期35卷 70-86页

作者： Pengyu zhang Zhiyang zhang Heng Sun jie Li yi Chen Jiang Wang Chuanlang Zhan Key Laboratory of Advanced Materials Chemistry and Devices (AMC&DLab) of the Department of Education of Inner Mongolia Autonomous Region Inner Mongolia Key Laboratory of Green CatalysisCollege of Chemistry and Environment ScienceInner Mongolia Normal UniversityHuhehot 010022China

In recent years, with the emergence of non-fullerene fused-ring acceptors, power conversion efficiencies (PCEs) of organic solar cells (OSCs) have exceeded 19%.However, compared to inorganic or perovskite photovoltaic cells, a higher voltage loss has become one of the key factors limiting further improvement in the PCEs of OSCs.The ternary/quaternary strategy has been identified as a feasible and effective way to obtain high-efficiency OSCs.In this review, a brief outline is given of the key roles that guest materials played in reducing voltage losses in solar cell devices and a brief look at the future material design and the design of ternary/quaternary systems.

关键词： Organic solar cell Ternary/quaternary strategy Open-circuit voltage Voltage loss Non-radiative recombination loss

Numerical study of submerged bending vegetation under unidirectional flow

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Water Science and Engineering 2024年第1期17卷 92-100页

作者： Pei-pei zhang yi-qing Gong Ken Vui Chua jie Dai Jing-qiao Mao College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China Institute of Water Science and Technology Hohai UniversityNanjing 210098China School of Engineering Cardiff UniversityCardiff CF243AAUK

Submerged vegetation commonly grows and plays a vital role in aquatic ecosystems,but it is also regarded as a barrier to the passing flow.Numerical simulations of flow through and over submerged vegetation were carried out to investigate the effect of vegetation density on flow field.Numerical simulations were computationally set up to replicate flume experiments,in which vegetation was mimicked with flexible plastic strips.The fluid-structure interaction between flow and flexible vegetation was solved by coupling the two modules of the COMSOL packages.Two cases with different vegetation densities were simulated,and the results were successfully validated against the experimental data.The contours of the simulated time-averaged streamwise velocity and Reynolds stress were extracted to highlight the differences in mean and turbulent flow statistics.The turbulence intensity was found to be more sensitive to vegetation density than the time-averaged velocity.The developing length increased with the spacing between plants.The snapshots of the bending vegetation under instantaneous velocity and vorticity revealed that flexible vegetation responded to the effects of eddies in the shear layer by swaying periodically.The first two rows of vegetation suffered stronger approaching flow and were prone to more streamlined postures.In addition,the origin of tip vortices was investigated via the distribution of vorticity.The results reveal the variation of flow properties with bending submerged vegetation and provide useful reference for optimizationofrestorationprojects.

关键词： Computational fluid dynamics Fluid-structure interaction Turbulence Flexible and submerged vegetation