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Enantioselective reductive conjugate alkenylation of α,β-enones with keto alkenyl acetates by nickel catalysis

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Science China Chemistry 2025年第1期68卷 157-162页

作者： rong-De He Yun-Lei Luo Qiu-Quan Pan Qi-Wei Yao Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

Reactions involving alkenyl acetates offer cost-effective and environmentally friendly routes for alkene synthesis, yet their asymmetric variant remains elusive. Concurrently, asymmetric conjugate alkenylation predominantly centered on nucleophilic addition using alkenyl–M. This manuscript presents an asymmetric reductive conjugate alkenylation reaction involving alkenyl acetates. The method facilitates the enantioselective addition of keto alkenyl groups to α,β-enones, resulting in the formation of unsaturated diketones—a class of useful structural motifs that are challenging to access otherwise. The use of electron-rich Pyroxy ligand is essential for achieving both high reaction efficiency and enantioselectivity.

关键词： nickel alkenylation asymmetric cross-coupling alkenes

Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai Zhong Lirou Su Mingkun Xu Desmond Loke Bin Yu yishu Zhang rong Zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第1期68卷 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词： neurotransmitters panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

黑磷/黑砷异质结纳米器件热电性质应力调控研究

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原子与分子物理学报 2025年第1期42卷 69-74页

作者：戎杙邱乙峰张蓓新疆大学物理科学与技术学院乌鲁木齐830046

探索新型高性能低维热电纳米材料已成为国家重大发展策略.论文采用密度泛函理论结合非平衡态格林函数方法研究了由黑磷、黑砷纳米带构建异质结构在2%、4%、6%和8%四种拉伸应变作用下热电性能调控机理.研究结果表明,6%拉伸应变较其他情形... 详细信息

探索新型高性能低维热电纳米材料已成为国家重大发展策略.论文采用密度泛函理论结合非平衡态格林函数方法研究了由黑磷、黑砷纳米带构建异质结构在2%、4%、6%和8%四种拉伸应变作用下热电性能调控机理.研究结果表明,6%拉伸应变较其他情形,能够更有效抑制声子输运行为;与此同时,拉伸应变对于器件的电子输运的调控效果并不明显.在费米能附近,黑磷/黑砷异质结纳米器件在6%拉伸应变调控下热电优值达到最大值2.31.

关键词：黑磷黑砷异质结应力热电性质

Isotropic Tuning of Electrochemical Etching forthe Nanometric Finishing of Metals

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Nanomanufacturing and Metrology 2022年第3期5卷 283-296页

作者： rong yi Zejin Zhan hui Deng Department of Mechanical and Energy Engineering Southern University of Science and TechnologyNo.1088Xueyuan RoadShenzhen 518055GuangdongChina

Isotropic etching polishing(IEP)based on the merging of isotropic etch pits has been proposed as a generic metal finishing *** this work,the tuning of the etching isotropy of various metals,which is the key to realizing the finishing effect of IEP,is studied by theoretical analysis and etching *** isotropic etching of various metals can be realized through mass transfer polarization by adjusting the electrochemical *** addition of sulfuric acid in the electrolyte is the most effective for tuning the isotropy of electrochemical *** can decrease the diffusion coefficient of metal ions,thereby increasing the resistance of mass transfer and transforming the electrochemical dissolution of metal into mass transfer *** this study,the atomic and close-to-atomic scale surface finishing of various metals and alloys has been successfully achieved through isotropic *** etching at a current of 1.5 A for 3 min,the surface Sa roughness of TA2 is drastically reduced from 242 to 3.98 *** etching for 1 min at a current of 3 A,the surface Sa roughness of pure tungsten,NiTi,and CoCrNi decreases from 9.33,76.4,and 37.6 nm,respectively,to 1.16,2.01,and 2.51 nm,respectively.

关键词： ACSM Metal finishing Isotropic etching polishing Electrochemical polishing

MOFs和COFs在选择性富集及色谱分离中药活性成分中的应用进展

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分析测试学报 2025年第1期44卷 82-90页

作者：司甜甜赵薇孙启慧容蓉孙敏山东中医药大学药学院山东济南250355 济南大学化学与化工学院山东济南250022

金属有机框架材料(MOFs)和共价有机框架材料(COFs)具有超大比表面积和可调节的孔径等结构特点,可以实现目标化合物的选择性富集和分离,在中药活性成分领域表现出广泛的应用前景。该文综述了MOFs、COFs的常用制备方法,阐述了MOFs、COFs... 详细信息

金属有机框架材料(MOFs)和共价有机框架材料(COFs)具有超大比表面积和可调节的孔径等结构特点,可以实现目标化合物的选择性富集和分离,在中药活性成分领域表现出广泛的应用前景。该文综述了MOFs、COFs的常用制备方法,阐述了MOFs、COFs及其复合材料在选择性富集、色谱分离不同中药基质活性成分方面的应用,并结合网络药理学探讨了其在靶向中药活性成分方面的发展前景,为新型有机框架材料在中药有效成分领域的研究提供了思路。

关键词：金属有机框架共价有机框架中药活性成分选择性富集色谱分离

Federated local causal structure learning

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Science China(Information Sciences) 2025年

作者： Kui YU Chen rong Hao WANG Fuyuan CAO Jiye LIANG School of Computer and Information Hefei University of Technology School of Computer and Information Technology Shanxi University

Local causal structure learning (LCS) efficiently identifies a set of direct neighbors of a specified variable from observational data. Additionally, it distinguishes direct causes and direct effects of this variable without learning the entire causal structure. While many LCS algorithms have been proposed, they do not consider the data privacy-preserving problem,which has attracted extensive attention from academia and industry. To address this issue, we propose a federated local causal structure learning (FedLCS) algorithm to learn local causal structures in privacy-preserving data in a federated ***, FedLCS introduces a layer-wise federated local skeleton learning algorithm to construct the local skeleton. Based on this skeleton, it introduces a federated local skeleton orientation algorithm and an extension-and-backtracking orientation algorithm to orient the edges. Finally, FedLCS uses a federated local extension-and-backtracking orientation algorithm to orient the remaining edges. Extensive experiments on benchmark, synthetic, and real datasets demonstrate that FedLCS can learn the local causal structure of a given variable in a federated setting.

关键词：

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Pressure-induced bimetallic carbon nanotubes from metalorganic frameworks as optimized bifunctional electrocatalysts for water splitting

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Rare Metals 2023年第1期42卷 155-164页

作者： Hong-Xu Chen hui Xu Zhi-rong Song yi Liu hui Cui Jun-Kuo Gao Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province Institute of Optoelectronic Materials and DevicesCollage of Optical and Electronic TechnologyChina Jiliang UniversityHangzhou310018China Institute of Functional Porous Materials School of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou310018China Institute for Composites Science Innovation School of Materials Science and EngineeringZhejiang UniversityHangzhou310027China Argonne National Laboratory Physics DivisionLemontIL60439USA Department of Chemistry and International Institute for Nanotechnology(IIN) Northwestern UniversityEvanstonIL60208USA

Carbon nanotubes(CNTs)have attracted great interest in numerous applications due to their excellent electronic and structural ***,harsh synthesis conditions and high energy consumption limit the further application of ***,we developed a facile and innovative strategy to generate CNTs by physically pressurizing metal-organic frameworks(MOFs)and then *** synthesized bimetallic nitrogen/sulfur double-doped carbon nanotubes are denoted as Fe_(x)Co_(1-x)P(x=0.5,0.6,0.7,0.8,0.9).The introduction of pressure not only revolutionized the morphology of the electrocatalysts,but also enhanced the activity of oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)in alkaline ***_(0.6)Co_(0.4)-P exhibits superior OER and HER performances in 1.0 mol·L^(-1)KOH solution with overpotentials of 364 and 346 mV at 10 mA·cm^(-2),which are 28 and 5 mV lower than unpressurized Fe0.6Co0.4.

关键词： Metal-organic frameworks(MOFs) Carbon nanotubes(CNTs) Bifunctional Pressurizing Oxygen evolution reaction(OER) Hydrogen evolution reaction(HER)