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Role of glucose metabolism and signaling pathways at different stages of ovarian folliculogenesis

Reproductive and Developmental Medicine 2024年第2期8卷 111-120页

作者： Dan Mo Zhong-Hong Zeng Xin Sui Rong Li yi-hua yang Guangxi Reproductive Medical Center the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases Nanning 530021China Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology/National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital)Beijing 100191China

The female ovaries are critical for follicle growth and development in the process known as"folliculogenesis".This complex process is regulated by various factors,among which the microenvironment around follicles appears to be *** to previous studies,folliculogenesis is an energy-demanding *** fact,well-balanced follicular energy metabolism is associated with ovarian function and female ***,glucose metabolism has been widely described as the main source of energy during ***,the follicular glucose metabolism profiles change dynamically during follicular *** abnormalities during folliculogenesis are associated with aging,primary ovarian insufficiency,and polycystic ovary syndrome,thereby leading to subfertility and infertility in *** signaling pathways in follicles appear to form a link between glucose metabolism and ***,a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental *** review aimed to describe variations in glucose metabolism at different stages of folliculogenesis,provide new insights into glucose metabolic disorder-related diseases,and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis:phosphatidylinositol 3-kinase,protein kinase B(PI3K-PKB/AKT),and AMP-activated protein kinase(AMPK)signaling pathways.

关键词： Folliculogenesis Glucose metabolism Glycolysis Oxidative phosphorylation Signaling pathway

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The First Total Synthesis of Saurufuran B

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Chinese Chemical Letters 2006年第10期17卷 1287-1289页

作者： yi hua yang Yu Lin LI State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University Lanzhou 730000

First total synthesis of saurufuran B 1, a furanoditerpene, from （E, E）-farnesol 2 and citraconic anhydride 3 through thirteen steps is described. Our work involves two key steps：（1） High regioselective alkylation of 2-（tert-butyldimethylsiloxy）-4-methylfuran 6 with aUylic iodides 5 in the presence of silver wifluoroacetate and （2） Conversion of substituted 7-1actone 7 into furan derivative 8.

关键词： Saurufuran B first total synthesis furanoditerpene regioselective alkylation.

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Genetic analysis and molecular detection of resistance to chlorpyrifos mediated by the A216S substitution in acetylcholinesterase-1 in the plant bug Apolygus lucorum

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Insect Science 2020年第6期27卷 1224-1232页

作者： Kai-Ran Zuo yi-hua yang yi-Dong Wu Shu-Wen Wu College of Plant Protection Nanjing Agricultural UniversityNanjingChina

The green plant bug Apolygus lucorum is a major pest of Bacillus thuringiensis cotton in ***,we reported that chlorpyrifos resistance in a laboratory-selected strain of ***(BZ-R)is associated with the homozygosis of an allele in the ace-1 gene encoding an alanine to serine substitution at position 216 of *** we describe the results of crosses between the resistant BZ-R strain(41-fold to chlorpyrifos)and the unselected susceptible BZ-S strain homozygous for the wild type alanine allele at position *** to chlorpyrifos was inherited as a semi-dominant trait mainly controlled by a single autosomal gene and co-segregates strongly but not completely with the serine substitution in *** bioassays and enzyme assays showed that minor contributions to resistance are also made by enhanced cytochrome P450 and carboxylesterase activities.A survey of 25 field populations from five Chinese provinces showed strong positive correlations between 50%lethal concentration against chlorpyrifos and S216 allele and genotype frequencies,although the most tolerant populations still only show 40%-50%S216 allele *** results above provide important information for designing effective resistance monitoring and management strategies for *** in China.

关键词： acetylcholinesterase-1 Apolygus lucorum chlorpyrifos resistance inheritance

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Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the diamondback moth, Plutella xylostella

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Insect Science 2016年第1期23卷 50-58页

作者： Xing-Liang Wang Wen Su Jian-Heng Zhang yi-hua yang Ke Dong yi-Dong Wu College ofPlantProtection NanjingAgricultural University Nanjing China Department of Entomology Genetics and Neuroscience Programs Michigan State University East Lansing MI USA

Indoxacarb and metaflumizone belong to a relatively new class of sodium channel blocker insecticides （SCBIs）. Due to intensive use of indoxacarb, field-evolved indoxacarb resistance has been reported in several lepidopteran pests, including the dia- mondback moth Plutella xylostella, a serious pest of cruciferous crops. In particular, the BY 12 population of P. xylostella, collected from Baiyun, Guangdong Province of China in 2012, was 750-fold more resistant to indoxacarb and 70-fold more resistant to metaflu- mizone compared with the susceptible Roth strain. Comparison of complementary DNA sequences encoding the sodium channel genes of Roth and BY12 revealed two point mu- tations （F1845Y and V1848I） in the sixth segment of domain IV of the PxNav protein in the BY population. Both mutations are located within a highly conserved sequence region that is predicted to be involved in the binding sites of local anesthetics and SCBIs based on mammalian sodium channels. A significant correlation was observed among 10 field-collected populations between the mutant allele （Y 1845 or I 1848） frequencies （1.7% to 52.5%） and resistance levels to both indoxacarb （34- to 870-fold） and metaflumizone （1- to 70-fold）. The two mutations were never found to co-exist in the same allele of PxNav, suggesting that they arose independently. This is the first time that sodium channel muta- tions have been associated with high levels of resistance to SCBIs. F 1845Y and V 1848I are molecular markers for resistance monitoring in the diamondback moth and possibly other insect pest species.

关键词： indoxacarb metaflumizone mutation Plutellaxylostella resistance sodium channel

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Knockout of three aminopeptidase N genes does not affect susceptibility of Helicoverpa armigera larvae to Bacillus thuringiensis Cry1A and Cry2A toxins

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Insect Science 2020年第3期27卷 440-448页

作者： Jing Wang Ya-Yun Zuo Ling-Li Li Hui Wang Shao-Yan Liu yi-hua yang yi-Dong Wu College of Plant Protection Nanjing Agricultural UniversityNanjingChina

Bacillus thuringiensis(Bt)insecticidal toxins have been globally utilized for control of agricultural insects through spraying or transgenic *** of Bt toxins to special receptors on midgut epithelial cells of target insects is a key step in the mode of *** studies suggested aminopeptidase N1(APN1)as a receptor or putative receptor in several lepidopteran insects including Helicoverpa armigera through evidence from RNA interefence‐based gene silencing *** the current study we tested the role of APNs in the mode of action of Bt toxins using clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR‐associated protein 9‐mediated gene *** APN genes(HaAPN1,HaAPN2 and HaAPN5)were individually knocked out in a susceptible strain(SCD)of *** to establish three homozygous knockout *** in vitro binding studies indicated binding of Cry1Ac or Cry2Ab to midgut brush border membrane vesicles was not obviously affected by APN *** results showed that none of the three knockouts had significant changes in susceptibility to Cry1A or Cry2A toxins when compared with the SCD *** suggests that the three HaAPN genes we tested may not be critical in the mode of action of Cry1A or Cry2A toxins in ***.

关键词： aminopeptidase N Bacillus thuringiensis CRISPR/Cas9 Helicoverpa armigera receptor

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Global Zero-relaxation Limit Problem of the Electro-diffusion Model Arising in Electro-Hydrodynamics

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 241-268页

作者： Ming-hua yang Si-ming huang Jin-yi Sun Department of Mathematics Jiangxi University of Finance and EconomicsNanchang330032China School of Public Administration Guangdong University of Foreign StudiesGuangzhou510006China College of Mathematics and Statistics Northwest Normal UniversityLanzhou730070China

In this paper,we study a global zero-relaxation limit problem of the electro-diffusion model arising in electro-hydrodynamics which is the coupled Planck-Nernst-Poisson and Navier-Stokes *** is,the paper deals with a singular limit problem of{u^(∈)_(t)+u^(∈)·▽u^(∈)-Δu^(∈)+▽P^(∈)=Δφ^(∈)▽φ^(∈),in R^(3)×(0,∞),▽·u^(∈)=0,in R^(3)×(0,∞),n^(∈)_(t)+u^(∈)·▽n^(∈)-Δn^(∈)=-▽·(n^(∈)▽φ^(∈)),in R^(3)×(0,∞),ct+u^(∈)·▽c^(∈)-Δc^(∈)=▽·(c^(∈)▽φ^(∈)),in R^(3)×(0,∞),∈^(-1)φ^(∈)_(t)=Δφ^(∈)-n^(∈)+c^(∈),in R^(3)×(0,∞),(u^(∈),n^(∈),c^(∈),φ^(∈))|t=0=(u0,n0,c0,φ0),in R^(3) involving with a positive,large parameter^(∈).The present work show a case that(u^(∈),n^(∈),c^(∈))stabilizes to(u^(∞),n∞,c∞):=(u,n,c)uniformly with respect to the time variable as^(∈)→+∞with respect to the strong topology in a certain Fourier-Herz space.

关键词： fourier-Herz space littlewood-Paley decomposition stability limit dissipative system

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Knockin of the G275E mutation of the nicotinic acetylcholine receptor (nAChR) α6 confers high levels of resistance to spinosyns in Spodoptera exigua

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Insect Science 2022年第2期29卷 478-486页

作者： Ya-Yun Zuo Yu-Xin Xue Ze-Yu Wang Xuan Ren Ahmed A.A.Aioub yi-Dong Wu yi-hua yang Zhao-Nong Hu Institute of Pesticide Science College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi712100 China College of Plant Protection Nanjing Agricultural UniversityNanjing210095 China Key Laboratory of Crop Pest Integrated Pest Management on the Loess Plateau of Ministry of Agriculture College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi712100 China Key Laboratory for Botanical Pesticide R&D of Shaanxi Province YanglingShaanxi712100 China Plant Protection Department Faculty of AgricultureZagazig UniversityZagazig44511 Egypt

Spinosyns,including spinosad and spinetoram,act on the insect central nervous system,gradually paralyzing or destroying the target *** resistance is associated with loss-of-function mutations in the nicotinic acetylcholine receptor(nAChR)α6 subunit in a number of agricultural *** gene editing,nAChRα6 has been verified as a target for spinosyns in five insect ***,a point mutation(G275E)in exon 9 of nAChRα6 was identified in spinosad-resistant strains of Thrips palmi and Tuta *** date,no in vivo functional evidence has been obtained to support that this mutation is involved in spinosyn resistance in lepidopteran *** this study,the G275E mutation was introduced into the nAChR of Spodoptera exigua using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene-editing *** transcriptase-polymerase chain reaction and sequencing confirmed that this mutation was present in exon 9 of the nAChR transcripts in the edited 275E *** results of bioassays showed that the 275E strain was highly resistant to spinosad(230-fold)and spinetoram(792-fold)compared to the unedited background strain,directly confirming that the G275E mutation of the nAChRα6 subunit confers high levels of spinosyn resistance in *** analysis showed that the resistance trait is autosomal and incompletely *** study employs a reverse genetics approach to validate the functional role played by the G275E mutation in nAChRα6 of *** in spinosyns resistance and provides another example of the use of CRISPR/Cas9 gene-editing technology to confirm the role played by candidate target site mutations in insecticide resistance.

关键词： beet armyworm CRISPR G275E mutation nicotinic acetylcholine recep・tor spinosyns insecticides target resistance

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Identification of the ryanodine receptor mutation I4743M and its contribution to diamide insecticide resistance in Spodoptera exigua (Lepidoptera: Noctuidae)

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Insect Science 2020年第4期27卷 791-800页

作者： Ya-Yun Zuo huan-huan Ma Wen-Jie Lu Xing-Liang Wang Shu-Wen Wu Ralf Nauen yi-Dong Wu yi-hua yang College of Plant Protection Nanjing Agricultural UniversityNanjingChina Bayer CropScience R&D Pest ControlMonheimGermany

Insect ryanodine receptors(RyRs)are the targets of diamide *** point mutations G4946E and I4790M(numbering according to Plutella xylostella,PxRyR)in the transmembrane domain of the insect RyRs associated with diamide resistance have so far been identified in three lepidopteran pests,***,Tuta absoluta and Chilo *** this study,we identified one of the known RyR target site resistance mutations(I4790M)in a field-collected population of Spodoptera *** field-collected WF population of *** exhibited 154 fold resistance to chlorantraniliprole when compared with the susceptible WH-S *** the transmembrane domains of *** RyR(SeRyR)revealed that the resistant WF strain was homozygous for the 14743M mutation(corresponding to I4790M in PxRyR),whereas the G4900E allele(corresponding to G4946E of PxRyR)was not *** 4743M allele was introgressed into the susceptible WH-S strain by crossing WF with WH-S,followed by three rounds of backcrossing with *** introgressed strain 4743M was homozygous for the mutant 4743M allele and shared about 94%of its genetic background with that of the recipient WH-S *** with WH-S,the near-isogenic 4743M strain showed moderate levels of resistance to chlorantraniliprole(21 fold),cyantraniliprole(25 fold)and flubendiamide(22 fold),suggesting that the I4743M mutation confers medium levels of resistance to all three *** analysis showed diamide resistance in the 4743M strain was inherited as an autosomal and recessive *** from this study have direct implications for the design of appropriate resistance monitoring and management practices to sustainably control ***.

关键词： beet armyworm diamide insecticides point mutation resistance ryanodine receptor

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On the Performances of Estimating Stellar Atmospheric Parameters from CSST Broad-band Photometry

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Research in Astronomy and Astrophysics 2024年第4期24卷 161-173页

作者： Rui-Feng Shi yang huang Xin-yi Li hua-Wei Zhang School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China South-Western Institute for Astronomy Research Yunnan UniversityKunming 650500China CAS Key Lab of Optical Astronomy Key Laboratory of Space Astronomy and TechnologyNational Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics and Electronic Engineering Qilu Normal UniversityJinan 250200China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

Deriving atmospheric parameters of a large sample of stars is of vital importance to understand the formation and evolution of the Milky *** surveys,especially those with near-ultraviolet filters,can offer accurate measurements of stellar parameters,with the precision comparable to that from low/medium resolution *** this study,we explore the capability of measuring stellar atmospheric parameters from Chinese Space Station Telescope(CSST)broad-band photometry(particularly in the near-ultraviolet bands),based on synthetic colors derived from model *** find that colors from the optical and near-ultraviolet filter systems adopted by CSST show significant sensitivities to the stellar atmospheric parameters,especially the *** to our mock data tests,the precision of the photometric metallicity is quite high,with typical values of0.17 and 0.20 dex for dwarf and giant stars,*** precision of the effective temperature estimated from broad-band colors are within 50 K.

关键词： methods:data analysis stars:abundances surveys

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Effects of changing the control ovarian stimulation protocol in patients without a transplantable embryo in the previous in vitro fertilization/intracytoplasmic sperm injection cycle

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Reproductive and Developmental Medicine 2023年第4期7卷 218-223页

作者： Shan-Jia yi yi-hua yang yin Bi Zhong-Hong Zeng Xi Wang Mu-Jun Li Wen-Hong Ma Guangxi Reproductive Medical Center The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Reproductive Medicine Center Affiliated Hospital of Guilin Medical UniversityGuilin 541001China Reproductive Medicine Center Liuzhou Maternity and Child Healthcare Hospital Liuzhou 545001China

Objective:Some patients fail to obtain an embryo for transplantation during previousin vitro fertilization(IVF)or intracytoplasmic sperm injection(ICSI)cycles,and require multiple reproductive *** study aimed to evaluate whether changing the control ovarian stimulation(COS)protocol during the subsequent stimulation cycle could improve laboratory and clinical outcomes in these ***:Patients without a transplantable embryo(TE)in the previous IVF/ICSI cycles were recruited during their second *** were classified into two groups according to their first cycle protocol:Group A,patients treated with a gonadotropinreleasing hormone agonist(GnRH-a),and Group B,patients treated with a gonadotropin-releasing hormone antagonist(GnRH-ant).The study group included patients whose stimulation protocols were changed,whereas the control group consisted of patients who used the same stimulation protocol in the second *** then compared the numbers of oocytes collected(OC)and TE,the incidence of non-TE,the pregnancy rate(PR),and the live birth rate(LBR).Results:In Group A,the numbers of OC and TE were significantly lower(6.0±4.7vs.9.4±6.4,2.3±2.2vs.4.5±3.8,P<0.05)in the study group compared with those in the control *** Group B,the numbers of OC and TE were higher(7.0±5.5vs.4.0±4.3,3.5±3.4vs.1.8±2.1,P<0.05)in the study *** was a significant increase in the incidence of non-TE(adjusted odds ratio(AOR)=2.12,95%CI:1.04–4.69)of the study group in Group A but not in Group *** significant differences in the PR or LBR were found between the study and control groups in either Group A or ***:Changing the COS protocol from GnRH-ant to GnRH-a or continuing the GnRH-a protocol can improve laboratory outcomes in patients with no TE in the previous IVF/ICSI cycle.

关键词： GnRH agonist GnRH antagonist Transplantable embryo Pregnancy rate Live birth rate

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