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Preparation of (±)-5,6,7-Trioxygenated Dihydroflavonols and Evaluation of their Superoxide Radical Scavenging Activity

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Chinese Chemical Letters 2006年第4期17卷 449-452页

作者： Jing Xu GONG Yu Bin FENG Feng WANG Yan Guang WANG Hai Bo LI yi hang wu Xiao Jiang HAO Xiu Mei wu Hua BAI Joachim STOECKIGT Yu ZHAO Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310031 The Key Laboratory of Chemistry of Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550022 Zhejiang Hisun Naturelite Pharmaceutical R＆D Co. Ltd. Hangzhou 310007 Lehrstuhl für Pharmazeutische Biologie Institut für Pharmazie Johannes-Gutenberg Universiaet Mainz D-55099 Mainz Germany

The synthesis of （±）-5, 6, 7-trioxygenated dihydroflavonols was carried out. All synthetic compounds were passed through superoxide radical scavenging activity in vitro. Compounds 1 e and 1 g exhibited significant ... 详细信息

关键词： Dihydroflavonol (±)-5,6,7-trioxygenated-dihydroflavonols total synthesis antioxidant,superoxide radical scavenging.

Predicting Quantum Many-Body Dynamics with Transferable Neural Net works

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Chinese Physics Letters 2020年第1期37卷 101-104页

作者： Ze-Wang Zhang Shuo Yang yi-hang wu Chen-Xi Liu yi-Min Han Ching-Hua Lee Zheng Sun Guang-Jie Li Xiao Zhang School of Physics Sun Yat-sen UniversityGuangzhou 510275 State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084 Department of Physics National University of Singapore117542Singapore Institute of High Performance Computing 138632Singapore

Advanced machine learning(ML)approaches such as transfer learning have seldom been applied to approximate quantum many-body *** we demonstrate that a simple recurrent unit(SRU)based efficient and transferable sequence learning framework is capable of learning and accurately predicting the time evolution of the one-dimensional(ID)Ising model with simultaneous transverse and parallel magnetic fields,as quantitatively corroborated by relative entropy measurements between the predicted and exact state *** a cost of constant computational complexity,a larger many-body state evolution is predicted in an autoregressive way from just one initial state,without any guidance or knowledge of any *** work paves the way for future applications of advanced ML methods in quantum many-body dynamics with knowledge only from a smaller system.

关键词： quantum exact entropy

Synthesis and Antioxidant Properties of Novel Silybin Analogues

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Chinese Chemical Letters 2006年第4期17卷 465-468页

作者： Jing Xu GONG Lin Jia WENG Feng WANG Yu Bin FENG Chang Xin ZHOU Hai Bo LI yi hang wu Xiao Jiang HAO Xiu Mei wu Hua BAI Joachim STOECKIGT Yu ZHAO Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310031 The Key Laboratory of Chemistry of Natural Products of Guizhou Province Chinese Academy of Sciences Guiyang 550022 Zhejiang Hisun Naturelite Pharmaceutical R＆D Co. Ltd. Hangzhou 310007 Lehrstuhl für Pharmazeutische Biologie Institut für Pharmazie Johannes-Gutenberg Universitaet Mainz D-55099 Mainz Germany

Eight novel silybin analogues （7a-h） were synthesized and their antioxidant properties including the capability of scavenging superoxide anion free radicals and the inhibitory effect on DPPH free radicals were dete... 详细信息

关键词： Silybin analogues synthesis antioxidant DPPH inhibition superoxide anion free radical scavenging.

Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties

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Chinese Chemical Letters 2009年第9期20卷 1030-1033页

作者： Ke Xin Huang Jing Xu Gong Wei Xiong Lei Xiang Yang Feng Wang Qiao Feng Tao yi hang wu Xiao Kun Li Joachim Stockigt Yu Zhao Jia Qu Key Laboratory of Southern Zhejiang TCM R&D Pharmacy School of Wenzhou Medical College Wenzhou 325035 China Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

Twelve 23-esterified silybin derivatives with different patterns of substituents such as aromatic and aliphatic groups （1-12） were designed and synthesized. The antioxidative properties of these compounds were evaluated. The modifed silybin analogues exhibited improved inhibitory effects against rat liver homogenate lipid peroxidation compared to silybin, with exception of the trimethoxylated ester （5） and the aliphatic one （9）. Compounds 3, 5, 7, 8 and 11 displayed their protective properties on DNA cleavage in a dose-dependent manner. 2009 Xiao Kun Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Silybin derivatives Antioxidant Lipid peroxidation DNA cleavage

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun yi Yao Liu yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

Tuning the interfacial reaction environment via pH-dependent and induced ions to understand C–N bonds coupling performance in NO3- integrated CO2 reduction to carbon and nitrogen compounds over dual Cu-based N-doped carbon catalyst

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Journal of Energy Chemistry 2025年第1期100卷 273-285页

作者： Tianhang Zhou Chen Shen Zhenghao wu Xingying Lan yi Xiao College of Carbon Neutrality Future Technology State Key Laboratory of Heavy Oil Processing China University of Petroleum (Beijing) Institute of Materials Science TU Darmstadt Department of Chemistry Xi'an Jiaotong-Liverpool University Department of Mechanical and Mechatronics Engineering and Waterloo Institute of Nanotechnology University of Waterloo Waterloo

Dual atomic catalysts （DAC）,particularly copper （Cu2）-based nitrogen （N） doped graphene,show great potential to effectively convert CO2and nitrate （NO3-） into important industrial chemicals such as ethylene,glycol,acetamide,and urea through an efficient catalytical process that involves C–C and C–N ***,the origin of the coupling activity remained unclear,which substantially hinders the rational design of Cu-based catalysts for the N-integrated CO2reduction reaction （CO2RR）.To address this challenge,this work performed advanced density functional theory calculations incorporating explicit solvation based on a Cu2-based N-doped carbon (Cu2N6C10) catalyst for *** calculations are aimed to gain insight into the reaction mechanisms for the synthesis of ethylene,acetamide,and urea via coupling in the interfacial reaction *** to the sluggishness of CO2,the formation of a solvation electric layer by anions （F-,Cl-,Br-,and I-） and cations (Na+,Mg2+,K+,and Ca2+) leads to electron transfer towards the Cu *** process significantly accelerates the reduction of *** results reveal that*CO intermediates play a pivotal role in N-integrated ***,the Cu2-based N-doped carbon catalyst examined in this study has demonstrated the most potential for C–N coupling to *** findings reveal that through the process of a condensation reaction between*CO and NH2OH for urea synthesis,*NO3-is reduced to*NH3,and*CO2to*CCO at dual Cu atom *** dual-site reduction facilitates the synthesis of acetamide through a nucleophilic reaction between NH3and the ketene ***,we found that the I-and Mg2+ions,influenced by pH,were highly effective for acetamide and ammonia synthesis,except when F-and Ca2+were ***,the mechanisms of C–N bond formation were investigated via ab-initio molecular dynamics simulations,and we found that adjusting the micro-environment can change the dominant side reaction,shift

关键词： pH-dependent micro-environments C–N coupling Dual Cu-based nitrogen carbon catalysts Explicit solvation model Ion stabilizer AIMD

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： yi Ji Chaoyi Yang Xuerui Pang yibing Yan Yue wu Zhi Geng Wenjie Hu Panpan Hu Xingqi wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang wu yi-Sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

可见光OFDM中调制与载波数综合自适应研究

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光通信技术 2016年第10期40卷 33-36页

作者：蔡彦博刘羿辰吴航张斯琪梁逸曦张准华南师范大学信息光电子科技学院广州510006

提出了一种在可见光OFDM通信中的自适应方法。描述了自适应可见光OFDM系统的设计原理,介绍了系统的自适应方法,并依次对可见光OFDM系统中子载波数目的自适应性能、系统的调制方式和子载波数目相结合的自适应性能进行了仿真分析。

关键词： OFDM 可见光通信子载波数综合自适应子带分组传输速率