Preparation of (±)-5,6,7-Trioxygenated Dihydroflavonols and Evaluation of their Superoxide Radical Scavenging Activity
Preparation of (±)-5,6,7-Trioxygenated Dihydroflavonols and Evaluation of their Superoxide Radical Scavenging Activity作者机构：Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310031 The Key Laboratory of Chemistry of Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550022 Zhejiang Hisun Naturelite Pharmaceutical R＆D Co. Ltd. Hangzhou 310007 Lehrstuhl für Pharmazeutische Biologie Institut für Pharmazie Johannes-Gutenberg Universiaet Mainz D-55099 Mainz Germany
出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)
年 卷 期：2006年第17卷第4期
页 面：449-452页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 100701[医学-药物化学] 10[医学]
基 金：面向21世纪教育振兴行动计划(985计划)(CSC 3067)
主 题：Dihydroflavonol (±)-5,6,7-trioxygenated-dihydroflavonols total synthesis antioxidant,superoxide radical scavenging.
摘 要：The synthesis of （±）-5, 6, 7-trioxygenated dihydroflavonols was carried out. All synthetic compounds were passed through superoxide radical scavenging activity in vitro. Compounds 1 e and 1 g exhibited significant bioactivity with the inhibitory rates of 68.1% and 80.9% at 40 μg/mL, respectively.
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