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Improvement of radiative recombination rate in deep ultraviolet laser diodes with step-like quantum barrier and aluminum-content graded electron blocking layer

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Chinese Physics B 2020年第1期29卷 412-416页

作者： yi-fu wang Mussaab I Niass Fang wang Yu-Huai Liu National Center of International Joint Research for Electronic Materials and Systems Zhengzhou UniversityZhengzhou 450001China International Joint Laboratory of Electronic Materials and Systems Zhengzhou UniversityZhengzhou 450001China School of Information Engineering Zhengzhou UniversityZhengzhou 450001China

The design of the active region structures,including the modifications of structures of the quantum barrier(QB)and electron blocking layer(EBL),in the deep ultraviolet(DUV)Al Ga N laser diode(LD)is investigated numerically with the Crosslight *** analyses focus on electron and hole injection efficiency,electron leakage,hole diffusion,and radiative recombination *** with the reference QB structure,the step-like QB structure provides high radiative recombination and maximum output ***,a comparative study is conducted on the performance characteristics with four different *** the EBL with different Al mole fraction layers,the higher Al-content Al Ga N EBL layer is located closely to the active region,leading the electron current leakage to lower,the carrier injection efficiency to increase,and the radiative recombination rate to improve.

关键词： radiative recombination rate step-like quantum barrier aluminum-content-graded EBL

Reduction of Electron Leakage in a Deep Ultraviolet Nitride Laser Diode with a Double-Tapered Electron Blocking Layer

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Chinese Physics Letters 2019年第5期36卷 67-70页

作者： yi-fu wang Mussaab I.Niass Fang wang Yu-Huai Liu National Joint Research Center for Electronic Materials and Systems Zhengzhou UniversityZhengzhou 450001 International Joint Laboratory of Electronic Materials and Systems Zhengzhou UniversityZhengzhou 450001

A double-tapered AlGaN electron blocking layer (EBL) is proposed to apply in a deep ultraviolet semiconductor laser diode. Compared with the inverse double-tapered EBL, the laser with the double-tapered EBL shows a higher slope efficiency, which indicates that effective enhancement in the transportation of electrons and holes is achieved. Particularly, comparisons among the double-tapered EBL, the inverse double-tapered EBL, the singletapered EBL and the inverse single-tapered EBL show that the double-tapered EBL has the best performance in terms of current leakage.

关键词： EBL AlGaN Reduction of Electron Leakage in a Deep Ultraviolet Nitride Laser Diode with a Double-Tapered Electron Blocking Layer

Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang yi-fu wang Jie Zheng yi-Ming Lei Zhong-Yuan Chen yi Guo Ya-Jie Guo Bing-Qian Guo Yu-Fang Lv Hong-Hong wang Juan-Juan Xie yi-Xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-Hua Jiang Zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model

Elevated Circulating Levels of Osteopontin Are Associated with Metastasisin Advanced Non-Small Cell Lung Cancer

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Chinese Journal of Cancer Research 2011年第1期23卷 64-68页

作者： Yong Liang Hui Li Bin Hu Xing Chen Jin-bai Miao Tong Li Bin You Qi-rui Chen yi-li fu Yang wang Sheng-cai Hou Department of Thoracic Surgery and Central Laboratory Beijing Key Laboratory of Respiratory and CirculationBeijing Chao-Yang HospitalBeijing Institute of Respiratory MedicineCapital Medical UniversityBeijing 100020China

Objective：To investigate the relationship between postoperative metastasis and circulating levels of osteopontin in non-small cell lung cancer（NSCLC）.Methods：The expression of osteopontin mRNA were detected with RT-PCR *** circulating levels of osteopontin were measured through ELASA in 46 NSCLC cases that had not been received any anti-cancer treatment at the time of *** tissues from fifteen patients with benign pulmonary diseases were studied as control ***：The overall median mRNA expression level of osteopontin was approximately 70-fold higher in tumor tissues than in matched normal lung tissues（P0.001）.Over-expression of osteopontin mRNA was significantly associated with clinical stage（P=0.009）.Advanced disease states had higher circulating level of osteopontin（stage I＋II versus stage III＋VI）.In multivariate analysis,stage was the only independent factor influencing circulating levels of *** patients were followed up for 12 months,2 of the 46 patients with both osteopontin mRNA expression and elevated plasma osteopontin levels had local recurrence and 10 had distant *** was a significant difference in the osteopontin levels between metastasis group and non-metastasis ***：Preoperative plasma levels of osteopontin are significantly associated with post-operative metastasis in advanced NSCLC.

关键词： Osteopontin Non-small cell lung cancer Metastasis Prognosis

Hydrogen sulfide facilitates carotid sinus baroreceptor activity in anesthetized male rats

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Chinese Medical Journal 2007年第15期120卷 1343-1347页

作者： XIAO Lin WU Yu-ming wang Ru LIU yi-xian wang fu-wei HE Rui-rong Department of Physiology Institute of Basic Medicine Hebei Medical Univesity Shijiazhuang 050017 China

Background It has been reported that hydrogen sulfide （H2S） could relax vascular smooth muscle by direct activation of KATP channels and hyperpolarization of the membrane potential. Recently, our study has shown that H2S facilitated carotid baroreflex. This study was conducted to investigate the effect of H2S on carotid baroreceptor activity （CBA）. Methods The functional curve of carotid baroreceptor （FCCB） was constructed and the functional parameters of carotid baroreceptor were measured by recording sinus nerve afferent discharge in anesthetized male rats with perfused isolated carotid sinus. Results H2S （derived from NariS） 25, 50 and 100 pmol/L facilitated CBA, which shifted FCCB to the left and upward. There was a marked increase in peak slope （PS） and peak integral value of carotid sinus nerve charge （PIV） in a concentration-dependent manner. Pretreatment with glibenclamide （20 pmol/L）, a KATP channel blocker, the above effects of H2S on CBA were abolished. Pretreatment with Bay K8644 （an agonist of calcium channels, 500 nmol/L） eliminated the role of H2S on CBA. An inhibitor of cystathionine y-lyase （CSE）, DL-propargylglycine （PPG, 200 pmol/L） inhibited CBA in male rats and shifted FCCB to the right and downward. Conclusions Our results suggest that exogenous H2S exerts a facilitatory role on isolated CBA through opening KATP channels and further closing the calcium channels in vascular smooth muscle. Endogenous H2S may activate CBA in vivo.

关键词： hydrogen sulfide potassium channels glibenclamide baroreceptors Bay K8644

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双特性抗体技术演进与作用模式的研究进展

中国新药杂志 2017年第20期26卷 2431-2438页

作者：吕一甫王志明沈阳药科大学药学院沈阳110000 华北制药集团新药研究开发有限责任公司抗体药物研制国家重点实验室石家庄050015

双特异性抗体(Bs Ab)融合2种单抗的特异性,能够同时与不同的抗原或抗原表位结合,这种特殊的作用机制使其成为引人注目的治疗药物。经过多年的研究与发展,第一个双特异性抗体于2009年进入市场,另一个于2014年上市,还有众多双特异性抗体... 详细信息

双特异性抗体(Bs Ab)融合2种单抗的特异性,能够同时与不同的抗原或抗原表位结合,这种特殊的作用机制使其成为引人注目的治疗药物。经过多年的研究与发展,第一个双特异性抗体于2009年进入市场,另一个于2014年上市,还有众多双特异性抗体处于临床试验阶段。自然状态下不存在双特异性抗体,只能通过特殊方法进行制备。随着生命科学基础与应用研究的飞速发展,双特异性抗体的分子模式与制备技术在不断的演进,作用机制也在不断创新,应用范围更从肿瘤与炎症疾病,拓展到了遗传疾病。双特异性抗体有望成为未来抗体药物中的重要一员。

关键词：双特异抗体基因工程抗体 Fc区 T细胞信号传导

First principles calculation of electronic structure, chemical bonding and elastic properties of ultra-incompressible Re_2P

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Transactions of Nonferrous Metals Society of China 2013年第11期23卷 3400-3404页

作者：王一夫夏庆林余燕湖南师范大学数学与计算机科学学院高性能计算与随机信息处理省部共建教育部重点实验室长沙410081 中南大学物理与电子学院长沙410083

The electronic structures, chemical bonding and elastic properties of the Co2P-type structure phase ultra-incompressible Re2P （orthorhombic phase） were investigated by density-functional theory （DFT） within generalized gradient approximation （GGA）. The calculated energy band structures show that the orthorhombic structure phase Re2P is metallic material. The density of state （DOS） and the partial density of state （PDOS） calculations show that the DOS near the Fermi level is mainly from the Re-5d state. Population analysis suggests that the chemical bonding in Re2P has predominantly covalent character with mixed covalent-ionic character. Basic physical properties, such as lattice constant, bulk modulus, shear modulus, and elastic constants Cij, were calculated. The elastic modulus and Poisson ratio were also predicted. The results show that the Co2P-type structure phase Re2P is mechanically stable and behaves in a brittle manner.

关键词： Re2P first principles electronic structures chemical bonding elastic properties

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu yi-Hua wang yi-Xin Liu Lu Xu Lin fu Ning yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

First principles calculation on ternary stannide phase narrow band gap semiconductor Na_2MgSn

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Transactions of Nonferrous Metals Society of China 2014年第6期24卷 1853-1858页

作者：王一夫夏庆林潘留仙余燕湖南师范大学数学与计算机科学学院高性能计算与随机信息处理省部共建教育部重点实验室长沙410081 中南大学物理与电子学院长沙410083 湖南涉外经济学院电气与信息工程学院长沙410205

The electronic structures,chemical bonding,elastic and optical properties of the ternary stannide phase Na2MgSn were investigated by using density-fimctional theory（DFT） within generalized gradient approximation（GGA）.The calculated energy band structures show that Na2MgSn is an indirect semiconductor material with a narrow band gap 0.126 *** density of state（DOS）and the partial density of state（PDOS） calculations show that the DOS near the Fermi level is mainly from the Na 2p,Mg 3p and Sn5 p *** analysis suggests that there are strongly bonded Mg-Sn honeycomb layers in *** physical properties,such as lattice constant,bulk modulus,shear modulus,elastic constants c（ij） were *** elastic modulus E and Poisson ratio v were also *** results show that Na2MgSn is mechanically stable soft material and behaves in a brittle *** analysis of all optical functions reveals that Na2MgSn is a better dielectric material,and reflectivity spectra show that Na2MgSn promise as good coating materials in the energy regions 6.24-10.49 eV.

关键词： stannide phase Na2MgSn first principles electronic structures chemical bonding elastic properties optical properties