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Network Pharmacology-Based Dissection of the Bioactive Compounds and Pharmacological Mechanisms of yiqi Fumai Lyophilized Injection for the Treatment of Heart Failure

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 75-82页

作者： Yu-Xi Huang Jing-Jing fan lu-lu Xu Rong Yu yi Kuang Yue Chai Rui Zheng Xiao-Yu Zhang Hong-Cai Shang Xue Qiao Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina Key Laboratory of Chinese Internal Medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina Yunnan Baiyao International Medical Research Center Peking UniversityBeijingChina Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Peking UniversityBeijingChina

Objective:yiqi Fumai Lyophilized Injection(YQFM),a Chinese medicine injection,has been widely used for the treatment of cardiovascular diseases,especially heart failure(HF).However,bioactive compounds and underlying mechanisms of YQFM in treating HF remain poorly *** and Methods:Network pharmacology was employed to investigate the bioactive compounds and mechanisms of YQFM.A compound-target network was constructed to screen bioactive compounds based on contribution index ***,an adriamycin-induced HF rat model was established to evaluate the cardio-protective effects of YQFM by hematoxylin and eosin staining and enzyme-linked immunosorbent ***:Network pharmacology indicated that YQFM may alleviate HF through 36 compounds and 109 ***,ginsenosides Rb1,Rg1,Re,Rf,Rb2,Rh1,schisandrin,and ginsenoside Rc were indicated as the top contributors of YQFM in treating *** was predicted to act on multiple targets such as vascular endothelial growth factor A,interleukin-2(IL-2),IL-6,and IL-1β,as well as to regulate signaling pathways such as hypoxia-inducible factor 1,tumor necrosis factor,VEGF,and *** pharmacological study suggested that YQFM could attenuate cardiac injury and up-regulate plasma concentrations of VEGFR-1 and NO in HF *** Rb1,as the major contributor from network pharmacology analysis,also showed a cardioprotective effect and up-regulation of VEGFR-1 in ***:Ginsenosides and schisandrin were predicted as the most important contributors to the cardioprotective effect of *** Rb1 was proved to alleviate HF and increase the plasma concentration of VEGFR-1.

关键词： Contribution index heart failure network pharmacology traditional Chinese medicine yiqi fumai lyophilized injection

Gut microbiota in gastrointestinal diseases:Insights and therapeutic strategies

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World Journal of Gastroenterology 2024年第39期30卷 4329-4332页

作者： lu Jiang Jian-Gao fan Department of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

Considering the bidirectional crosstalk along the gut-liver axis,gut-derived microorganisms and metabolites can be released into the liver,potentially leading to liver *** this editorial,we comment on several studies published in the recent issue of the World Journal of *** focus specifically on the roles of gut microbiota in selected gastrointestinal(GI)diseases that are prevalent,such as inflammatory bowel disease,metabolic dysfunction-associated steatotic liver disease,and hepatitis B virus-related portal *** the past few decades,findings from both preclinical and clinical studies have indicated an association between compositional and metabolic changes in the gut microbiota and the pathogenesis of the aforementioned GI ***,studies elucidating the mechanisms underlying the host-microbiota interactions remain *** purpose of this editorial is to summarize current findings and provide insights regarding the context-specific roles of gut ***,the discovery of microbiome-based biomarkers may facilitate disease diagnosis and the development of personalized medicine.

关键词： Gut microbiota Inflammatory bowel disease Metabolic dysfunction-associated steatotic liver disease Hepatitis B virus Portal hypertension

The enhanced mechanical properties of SiC nanowires/Ba_(0.75)Sr_(0.25)Al_(2)Si_(2)O_(8) ceramics with embedded SiO_(2) interface

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Journal of Advanced Ceramics 2024年第7期13卷 933-941页

作者： Xin Li Xiaomeng fan Haojie luo Xiaoke lu Jimei Xue fang Ye Yongsheng Liu Science and Technology on Thermostructural Composite Materials Laboratory Northwestern Polytechnical UniversityXi’an 710072China Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an 710049China

In this work,low-softening-temperature and low-modulus SiO_(2) was introduced as an embedded interface between SiC nanowires(SiCnws)and a Ba_(x)Sr_(1−x)Al_(2)Si_(2)O_(8) ceramic matrix to enhance strength and toughness of the *** the sintering process,molten SiO_(2) enhances the flowability of the ceramic powders and modifies the dispersion of *** strengthening effect of SiCnws was fully realized,and the flexural strength of the optimized ceramics reached 193±16 MPa,which represents an increase of 52.6%.After the formation of the embedded SiO_(2) interface with a low modulus,cracks can deflect along the SiCnws surface,which is consistent with the criterion of He and *** can effectively extend the crack propagation path,and the fracture toughness(K_(IC))is thus improved by 94.0%,reaching 3.1±0.5 MPa·m^(1/2).

关键词： multiphase ceramics SiO_(2) interface densification mechanical properties

Development and validation of a nomogram to predict allograft survival after pediatric liver transplantation

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World Journal of Pediatrics 2024年第3期20卷 239-249页

作者： Guang-Xiang Gu Shu-Ting Pan yi-Chen fan Chen Chen Qiang Xia Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineNo.160 Pujian RoadPudong New DistrictShanghai 200128China Department of Liver Transplantation Sun Yet-Sen Memorial HospitalSun Yat-Sen UniversityNo.107 Yanjiang West RoadGuangzhou 510080China Clinical Center for Investigation Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina

Background Liver transplantation is the main treatment for cholestatic liver disease and some metabolic liver diseases in ***,no accurate prediction model to determine the survival probability of grafts prior to surgery *** study aimed to develop an effective prognostic model for allograft survival after pediatric liver *** This retrospective cohort study included 2032 patients who underwent pediatric liver transplantation between January 1,2006,and January 1,2020.A nomogram was developed using Cox regression and validated based on bootstrap *** and discriminatory accuracies were determined using the concordance index and visualized using calibration curves;net benefits were calculated for model *** online Shiny application was developed for easy access to the *** Multivariable analysis demonstrated that preoperative diagnosis,recipient age,body weight,graft type,preoperative total bilirubin,interleukin-1β,portal venous blood flow direction,spleen thickness,and the presence of heart disease and cholangitis were independent factors for survival,all of which were selected in the *** of the nomogram indicated that the 1-,3-,and 5-year predicted survival rates agreed with the actual survival *** concordance indices for graft survival at 1,3,and 5 years were 0.776,0.757,and 0.753,respectively,which were significantly higher than those of the Pediatric End-Stage Liver Disease and Child-Pugh scoring *** allograft dysfunction risk of a recipient could be easily predicted using the following URL:https://***/ASPELT/l Conclusion The allograft survival after pediatric liver transplantation(ASPELT)score model can effectively predict the graft survival rate after liver transplantation in children,providing a simple and convenient evaluation method for clinicians and patients.

关键词： Allograft survival Nomogram Pediatric liver transplantation

Mothers’challenges and experiences of children with cerebral palsy:a qualitative meta-synthesis

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Frontiers of Nursing 2024年第2期11卷 169-179页

作者： Meng-Yun Peng yi-Fu lu Department of Nursing Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhouJiangsu 215123China Department of Nursing Graduate School of Health SciencesOkayama UniversityOkayama 7008588Japan Department of Anesthesiology and Resuscitology Okayama UniversityOkayama 7008588Japan

Objective:To examine what challenges and experiences a mother faces in caring for children with cerebral palsy(CP).As the main caregiver of children with CP,mothers are under multiple *** though mothers’challenges and experiences of children with CP will affect their quality of life and the rehabilitation of the children,little is known about their challenges and experiences during the whole ***:A qualitative meta-synthesis was conducted to extract and analyze qualitative research from the PubMed,CINAHL,PsycINFO,Web of Science,Ovid and MEDLINE *** articles were selected and analyzed using thematic ***:From 2522 screened abstracts,84 texts were reviewed,and 13 studies met the inclusion ***’challenges and experiences of children with CP include 4 themes,both positive and ***:The mothers of children with CP suffer from physical burden,as well as psychological pressure,in the care experience;social and healthcare support are their main *** to help them face the difficulties and adapt to the role of caregivers as soon as possible should target multiple aspects in order to maximize effectiveness,to promote the healthy growth of children with CP.

关键词： challenges children with cerebral palsy experience meta-synthesis mothers

Antibacterial performance of cationic quaternary phosphonium-modified chitosan polymer in water

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Chinese Chemical Letters 2024年第9期35卷 326-330页

作者： Jinjie lu Qikai Liu Yuting Zhang yi Zhou Yanbo Zhou State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and TechnologyShanghai 200237China

Microbial contamination in water has emerged as a critical concern and thus developing biocide materials for controlling microbial contamination is *** all pathogenic bacteria in water is difficult when using traditional water treatment ***,these bacteria can easily reproduce during pipeline *** this work,a facile and effective chitosan derivative biocide denoted as PCC was developed by grafting with quaternary phosphonium salt(QPS).PCC became positively charged with a wide range of p H and demonstrated antibacterial activity up to 95%and 100%against Escherichia coli and Staphylococcus aureus as model pathogens,*** grafting of QPS may disrupt the cell membrane and lead to bacterial inactivation,as demonstrated by the scanning electron microscopy image and the concentration of intracellular substance *** assay results indicate that PCC achieved good biocompatibility with negligible in vitro *** findings introduce a promising approach for bacterial decontamination due to its low cytotoxicity and high biocidal activity.

关键词： Chitosan Quaternary phosphonium salt Antibacterial performance Antibacterial mechanism Morphology change

Effect of Rare-Earth Element Substitution in Superconducting R_(3)Ni_(2)O_(7) under Pressure

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Chinese Physics Letters 2024年第8期41卷 77-81页

作者： Zhiming Pan Chen lu fan Yang Congjun Wu Institute for Theoretical Sciences Westlake UniversityHangzhou 310024China New Cornerstone Science Laboratory Department of PhysicsSchool of ScienceWestlake UniversityHangzhou 310024China School of Physics Beijing Institute of TechnologyBeijing 100081China Key Laboratory for Quantum Materials of Zhejiang Province School of ScienceWestlake UniversityHangzhou 310024China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Recently,high temperature(T_(c)≈80 K)superconductivity(SC)has been discovered in La_(3)Ni_(2)O_(7)(LNO)under *** raises the question of whether the superconducting transition temperature T_(c) could be further enhanced under suitable *** possible route for achieving higher T_(c) is element *** SC could appear in the Fmmm phase of rare-earth(RE)R_(3)Ni_(2)O_(7)(RNO,R=RE element)material series under suitable *** electronic properties in the RNO materials are dominated by the Ni 3d orbitals in the bilayer NiO_(2) *** the strong coupling limit,the SC could be fully characterized by a bilayer single 3d_(x^(2)−y^(2))-orbital t–J‖–J⊥ *** RE element substitution from La to other RE element,the lattice constant of the Fmmm RNO material decreases,and the resultant electronic hopping integral increases,leading to stronger superexchanges between the 3d_(x^(2)−y^(2)) *** on the slave-boson mean-field theory,we explore the pairing nature and the evolution of T_(c) in RNO materials under ***,it is found that the element substitution does not alter the pairing nature,i.e.,the inter-layer s-wave pairing is always favored in the superconducting RNO under ***,the T_(c) increases from La to Sm,and a nearly doubled T_(c) could be realized in SmNO under *** work provides evidence for possible higher T_(c) R_(3)Ni_(2)O_(7) materials,which may be realized in further experiments.

关键词： element substitution Rare

Versatile MXene Gels Assisted by Brief and Low‑Strength Centrifugation

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Nano-Micro Letters 2024年第5期16卷 231-247页

作者： Weiyan Yu yi Yang Yunjing Wang lulin Hu Jingcheng Hao lu Xu Weimin Liu State Key Laboratory of Solid lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264006People’s Republic of China Key Laboratory of Colloid and Interface Chemistry and Key Laboratory of Special Aggregated Materials Shandong UniversityJinan 250100People’s Republic of China

Due to the mutual repulsion between their hydrophilic surface terminations and the high surface energy facilitating their ran-dom restacking,2D MXene nanosheets usually cannot self-assemble into 3D macroscopic gels with various applications in the absence of proper linking *** this work,a rapid spontaneous gelation of Ti3C2Tx MXene with a very low dispersion concentration of 0.5 mg mL^(-1) into multifunctional architectures under moderate centrifugation is *** as-prepared MXene gels exhibit reconfigurable internal structures and tunable rheological,tribological,electrochemical,infrared-emissive and photothermal-conversion properties based on the pH-induced changes in the surface chemistry of Ti_(3)C_(2)T_(x) *** adopting a gel with optimized pH value,high lubrication,exceptional specific capacitances(~635 and~408 F g^(-1) at 5 and 100 mV s^(-1),respectively),long-term capacitance retention(~96.7%after 10,000 cycles)and high-precision screen-or extrusion-printing into different high-resolution anticounterfeiting patterns can be achieved,thus displaying extensive potential applications in the fields of semi-solid lubrication,control-lable devices,supercapacitors,information encryption and infrared camouflaging.

关键词： MXene Centrifugation-assisted rapid gelation lubrication Supercapacitor Anti-counterfeiting applications

Pt nanoclusters modified porous g-C_(3)N_(4)nanosheets to significantly enhance hydrogen production by photocatalytic water reforming of methanol

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Chinese Journal of Chemical Engineering 2024年第2期66卷 40-50页

作者： yi-Fei Liang Jin-Rong lu Shang-Kun Tian Wen-Quan Cui Li Liu Hebei Provincial Key Laboratory of Environmental Photocatalytic and Electrocatalytic Materials College of Chemical EngineeringNorth China University of Science and TechnologyTangshan 063210China

For the use of green hydrogen energy,it is crucial to have efficient photocatalytic activity for hydrogen generation by water reforming of methanol under mild *** attention has been paid to gC_(3)N_(4)as a promising photocatalyst for the generation of *** improve the separation of photogenerated charge,porous nanosheet g-C_(3)N_(4)was modified with Pt nanoclusters(Pt/g-C_(3)N_(4))through impregnation and following photo-induced *** catalyst showed excellent photocatalytic activity of water reforming of methanol fo r hydrogen production with a 17.12 mmol·g^(-1)·h^(-1)rate at room temperature,which was 311 times higher than that of the unmodified g-C_(3)N_(4).The strong interactions of Pt-N in Pt/g-C_(3)N_(4)constructed effective electron transfer channels to promote the separation of photogenerated electrons and holes *** addition,in-situ infrared spectroscopy was used to investigate the intermediates of the hydrogen production reaction,which proved that methanol and water eventually turn into H_(2)and CO_(2)via formaldehyde and *** study provides insights for understanding the photocatalytic hydrogen production in the water reforming of methanol.

关键词： Water reforming of methanol Photocatalysis g-C_(3)N_(4) Pt nanoclusters Hydrogen production