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Fully umbilical cord-derived adhesive materials enable to recruit and segregate immune cells for the reversal of acute liver failure

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Engineered Regeneration 2024年第1期5卷 70-79页

作者： Xiao yi Feng Chen Kunjie Gao Huayan Li Yuan Xie Shao Li Jiajun Zhang Qing Peng Weijie Zhou Shutao wang Jun-Bing fan yi Gao Research Centre for Artificial Organ and Tissue Engineering&Institute of Regenerative Medicine Department of Hepatobiliary Surgery II Zhujiang Hospital Cancer Research InstituteSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong Province 510515P R China Department of Gynecology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510515P R China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science CAS Center for Excellence in NanoscienceTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190P R China Department of Hepato-Biliary-Pancreatic and Hernia Surgery The First People’s Hospital of ZhaoqingZhaoqingGuangdong 526000P R China Department of Pathology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515P R China

Inflammatory cytokine storms can trigger disease exacerbation and even death and have reached a consensus in the clinical treatment of acute organ ***,the existing strategies remain a great challenge to efficiently suppress inflammatory cytokine storms for promoting organ repair and ***,fully human umbilical cord(UC)-derived adhesive materials(UCAM)that integrate decellularized extracellular matrix(ECM)nanofiber hydrogel and homologous mesenchymal stem cells(MSCs)are demonstrated to greatly suppress inflammatory cytokine storms,demonstrating high efficacy in treating acute liver failure(ALF)in rats with 90%*** UC-derived adhesive materials have the capacity to secrete a significant quantity of cytokines by MSCs to recruit activated immune cells to migrate into their ECM nanofiber networks,segregating them away from the infection area and thereby greatly suppressing the inflammatory cytokine *** expected,the UC-derived adhesive materials can significantly promote hepatocyte proliferation to achieve functional recovery and regeneration of the liver,significantly improving the survival rate in *** fully human UC-derived adhesive materials provide a new avenue in suppressing inflammatory cytokine storms for promoting organ regeneration that would be really utility in clinical organ transplantation-related treatment.

关键词： Interfacial adhesive materials Extracellular matrix nanofibers Hydrogel Mesenchymal stem cells Acute liver failure

Non-adiabatic holonomic quantum operations in continuous variable systems

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 12-19页

作者： Hao-Long Zhang yi-Hao Kang fan Wu Zhen-Biao Yang Shi-Biao Zheng Fujian Key Laboratory of Quantum Information and Quantum Optics College of Physics and Information EngineeringFuzhou UniversityFuzhou 350116China

Quantum operations by utilizing the underlying geometric phases produced in physical systems are favoured due to their potential *** a system in a non-degenerate eigenstate undergoes an adiabatically cyclic evolution dominated by its Hamiltonian,it will get a geometric phase,referred to as the Berry *** a non-adiabatically cyclic evolution produces an Aharonov-Anandan geometric *** two types of Abelian geometric phases are extended to the non-Abelian cases,where the phase factors become matrix-valued and the transformations associated with different loops are *** and non-Abelian(holonomic)operations are prevalent in discrete variable systems,whose limited(say,two)energy levels,form the *** their developments in continuous systems have also been investigated,mainly due to that,bosonic modes(in,such as,cat states)with large Hilbert spaces,provide potential advantages in fault-tolerant quantum *** we propose a feasible scheme to realize non-adiabatic holonomic quantum logic operations in continuous variable systems with cat *** construct arbitrary single-qubit(two-qubit)gates with the combination of single-and two-photon drivings applied to a Kerr Parametric Oscillator(KPO)(the coupled KPOs).Our scheme relaxes the requirements of the previously proposed quantum geometric operation strategies in continuous variable systems,providing an effective way for quantum control.

关键词： cat qubit continuous variable systems non-Abelian

Siliceous mesocellular foam supported Cu catalysts for promoting non-thermal plasma activated CO_(2) hydrogenation toward methanol synthesis

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 55-65页

作者： yi Chen Shaowei Chen Yan Shao Cui Quan Ningbo Gao Xiaolei fan Huanhao Chen State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 211816China School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Chemical Engineering School of EngineeringThe University of ManchesterManchester M139PLUK Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048China Institute of Wenzhou Zhejiang UniversityWenzhou 325006China

Electrified non-thermal plasma (NTP) catalytic hydrogenation is the promising alternative to the thermal counterparts, being able to be operated under mild conditions and compatible with green electricity/hydrogen. Rational design of the catalysts for such NTP-catalytic systems is one of the keys to improve the process efficiency. Here, we present the development of siliceous mesocellular foam (MCF) supported Cu catalysts for NTP-catalytic CO_(2) hydrogenation to methanol. The findings show that the pristine MCF support with high specific surface area and large mesopore of 784 m2·g−1 and ~8.5 nm could promote the plasma discharging and the diffusion of species through its framework, outperforming other control porous materials (viz., silicalite-1, SiO_(2), and SBA-15). Compared to the NTP system employing the bare MCF, the inclusion of Cu and Zn in MCF (i.e., Cu1Zn1/MCF) promoted the methanol formation of the NTP-catalytic system with a higher space-time yield of methanol at ~275 μmol·g_(cat)^(−1)·h^(−1) and a lower energy consumption of 26.4 kJ^(−1)·mmol_(CH_(3)OH)^(-1) (conversely, ~225 μmol·g_(cat)^(−1)·h^(−1) and ~71 kJ^(−1)·mmol_(CH_(3)OH)^(-1), respectively, for the bare MCF system at 10.1 kV). The findings suggest that inclusion of active metal sites (especially Zn species) could stabilize the CO_(2)/CO-related intermediates to facilitate the surface reaction toward methanol formation.

关键词： non-thermal plasma(NTP)catalysis Cu catalyst CO_(2)hydrogenation methanol siliceous mesocellular foam(MCF)

Black holes as the source of dark energy:A stringent test with high-redshift JWST AGNs

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 181-188页

作者： Lei Lei Lei Zu Guan-Wen Yuan Zhao-Qiang Shen yi-ying wang Yuan-Zhu wang Zhen-Bo Su Wen-Ke Ren Shao-Peng Tang Hao Zhou Chi Zhang Zhi-Ping Jin Lei Feng yi-Zhong fan Da-Ming Wei Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China

Studies have proposed that there is evidence for cosmological coupling of black holes(BHs)with an index of k≈3;hence,BHs serve as the astrophysical source of dark ***,the data sample is limited for the redshifts of≤*** recent years,the James Webb Space Telescope(JWST)has detected many high-redshift active galactic nuclei(AGNs)and *** the JWST NIRSpec-/NIRCam-resolved AGNs,three are determined to be in early-type host galaxies with a redshift of z~***,their M_(*)and MBH are in tension with the predicted cosmological coupling of black holes with k=3 at a confidence level of~2σ,which challenges the hypothesis that BHs serve as the origin of dark *** work on high-redshift AGNs using the JWST will further assess such a hypothesis by identifying more early-type host galaxies in the higher mass range.

关键词： dark energy supermassive black hole active galactic nuclei James Webb Space Telescope

Flexible and Stretchable Electrodes for In Vivo Electrophysiological and Electrochemical Monitoring

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Chinese Journal of Chemistry 2024年第13期42卷 1523-1545页

作者： Kai-Kai Sheng yi-Fei Lu Wen-Ting fan Yan-Ling Liu College of Chemistry and Molecular Sciences Wuhan University WuhanHubei 430072China Core Facilty of Wuhan University WuhanHubei 430072China

In vivo monitoring of bioelectrical and biochemical signals with implanted electrodes has received great interest over the past ***,this faces huge challenges because of the severe mechanical mismatch between conventional rigid electrodes and soft biological *** recent years,the emergence of flexible and stretchable electrodes offers seamless and conformable biological-electronic interfaces and has demonstrated significant advantages for in vivo electrochemical and electrophysiological *** review first summarizes the strategies for electrode fabrication from the point of substrate and conductive ***,recent progress in electrode functionalization for improved performance is ***,the advances of flexible and stretchable electrodes in exploring bioelectrical and biochemical signals are ***,we present some challenges and perspectives ranging from electrode fabrication to application.

关键词： Flexible electrodes Conductive materials Stretchable structures Electrode functionalization In vivo monitoring Biochemical signals Bioelectrical signals

Development and validation of a nomogram to predict allograft survival after pediatric liver transplantation

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World Journal of Pediatrics 2024年第3期20卷 239-249页

作者： Guang-Xiang Gu Shu-Ting Pan yi-Chen fan Chen Chen Qiang Xia Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineNo.160 Pujian RoadPudong New DistrictShanghai 200128China Department of Liver Transplantation Sun Yet-Sen Memorial HospitalSun Yat-Sen UniversityNo.107 Yanjiang West RoadGuangzhou 510080China Clinical Center for Investigation Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina

Background Liver transplantation is the main treatment for cholestatic liver disease and some metabolic liver diseases in ***,no accurate prediction model to determine the survival probability of grafts prior to surgery *** study aimed to develop an effective prognostic model for allograft survival after pediatric liver *** This retrospective cohort study included 2032 patients who underwent pediatric liver transplantation between January 1,2006,and January 1,2020.A nomogram was developed using Cox regression and validated based on bootstrap *** and discriminatory accuracies were determined using the concordance index and visualized using calibration curves;net benefits were calculated for model *** online Shiny application was developed for easy access to the *** Multivariable analysis demonstrated that preoperative diagnosis,recipient age,body weight,graft type,preoperative total bilirubin,interleukin-1β,portal venous blood flow direction,spleen thickness,and the presence of heart disease and cholangitis were independent factors for survival,all of which were selected in the *** of the nomogram indicated that the 1-,3-,and 5-year predicted survival rates agreed with the actual survival *** concordance indices for graft survival at 1,3,and 5 years were 0.776,0.757,and 0.753,respectively,which were significantly higher than those of the Pediatric End-Stage Liver Disease and Child-Pugh scoring *** allograft dysfunction risk of a recipient could be easily predicted using the following URL:https://***/ASPELT/l Conclusion The allograft survival after pediatric liver transplantation(ASPELT)score model can effectively predict the graft survival rate after liver transplantation in children,providing a simple and convenient evaluation method for clinicians and patients.

关键词： Allograft survival Nomogram Pediatric liver transplantation

β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu yi-Rong Jiang Xuan-Qi Zheng Huan wang Hao Liu Hong wang Hui-Jie Leng Dong-Wei fan Wan-Qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

The Synthesis and Solubility of a Wholly Aromatic Polyamide Containing para-and meta-Substituted Phenylene Rings

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The Synthesis and Solubility of a Wholly Aromatic Polyamide ...

Comparative Analysis of Noise Margin between Pure SET-SET and Hybrid SET-PMOS Inverters

2012 China Functional Materials Technology and Industry Forum

作者： yi-fan wang Jun-Sun Li-xing Dai College of Chemistry Chemical Engineering and Materials ScienceSoochow University

A series of wholly aromatic polyamides(aramid) containing para-and meta-substituted phenylene rings was copolymerized via phosphorylation method with different ratio of 4-aminobenzoic acid and 3-aminobenzoic *** inherent viscosities(η) of products were 0.52-0.99 dL/*** chain structure of the polymers was characterized by Fourier transform infrared spectroscopy(FT-IR) and Raman *** differential scanning calorimetry(DSC) was also performed to investigate the chain transformation behavior of *** increasing the content of meta-substituted phenylene rings in macromolecular chain,the solubility of the polymers was improved obviously without appreciable loss for their original thermal property.

关键词： Aromatic Polyamide Aramid Copolymerization Solubility

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Chinese Journal of Electronics 2024年

作者： fan ZHANG yi LIU yibo wang Minghu WU Sheng HU Youli DONG Hubei Key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of Technology School of Electrical and Electronic Engineering Hubei University of Technology

Single-electron transistor（SET） is considered as one of the promising candidates for future electronic devices due to its advantages of low power consumption and high integration. The comparative analysis of SETbased inverters, especially the noise margin, is carried out. Pure SET-SET and hybrid SET with p type metal oxide semiconductor（SET-PMOS） inverters are designed for investigation. The effects of SET supply voltage, junction resistance and junction capacitance on noise tolerance and power consumption of inverters are studied. For hybrid SET-PMOS inverters, the noise margin for a logic high（NMH） is less than 60 mV under various conditions, which may become the bottleneck of its application. For pure SET-SET inverters, both NMH and the noise margin for a logic low（NML） could reach 300 mV at a supply voltage of 0.8 V. The minimum power consumption of pure SETSET and hybrid SET-PMOS inverters is 2.85 nW and 58 nW, respectively. The pure SET-SET inverters have greater noise tolerance and lower power consumption, which is more conducive to large-scale integration. When junction capacitance CJ= 0.0273 aF and junction resistance V, the NMH and NML are not significantly affected by the junction resistance and the noise margin fluctuates at 300mV.

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