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Labeled Network Stack: A High-Concurrency and Low-Tail Latency Cloud Server Framework for Massive IoT Devices

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Journal of Computer Science & Technology 2020年第1期35卷 179-193页

作者： Wen-Li Zhang Ke Liu yi-fan shen Ya-Zhu Lan Hui Song Ming-Yu Chen Yuan-Fei Chen State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of Sciences Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Peng Cheng Laboratory Shenzhen 518000China Zhongke Zhicheng Electronic Technology Company Limited Jining 272000China

Internet of Things(IoT)applications have massive client connections to cloud servers,and the number of networked IoT devices is remarkably *** services require both low-tail latency and high concurrency in *** study aims to determine whether an order of magnitude improvement is possible in tail latency and concurrency in mainstream systems by proposing a hardware-software codesigned labeled network stack(LNS)for future *** key innovation is a cross-layered payload labeling mechanism that distinguishes different requests by payload across the full network stack,including application,TCP/IP,and Ethernet *** type of design enables prioritized data packet processing and forwarding along the full datapath,such that latency-insensitive requests cannot significantly interfere with high-priority *** build a prototype datacenter server to evaluate the LNS design against a commercial X86 server and the mTCP research,using a cloud-supported IoT application *** results show that the LNS design can provide an order of magnitude improvement in tail latency and concurrency.A single datacenter server node can support over 2 million concurrent long-living connections for IoT devices as a 99-percentile tail latency of 50 ms is *** addition,the hardware-software codesign approach remarkably reduces the labeling and prioritization overhead and constrains the interference of high-priority requests to low-priority requests.

关键词： tail latency high concurrency network stack cloud server Internet of Things(IoT)service

Growth and structural characteristics of metastableβ-In2Se3 thin films on H-terminated Si(111)substrates by molecular beam epitaxy

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Chinese Physics B 2020年第5期29卷 429-434页

作者： yi-fan shen Xi-Bo yin Chao-fan Xu Jing He Jun-Ye Li Han-Dong Li Xiao-Hong Zhu Xiao-Bin Niu College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054China

Epitaxial growth and structural characteristics of metastableβ-In2Se3 thin films on H-terminated Si(111)substrates are *** In2Se3 thin films grown below theβ-to-αphase transition temperature(453 K)are characterized to be strainedβ-In2Se3 mixed with significantγ-In2Se3 *** pure-phased single-crystallineβ-In2Se3 can be reproducibly achieved by in situ annealing the as-deposited poly-crystalline In2Se3 within the phase equilibrium temperature window ofβ-*** is suggeted that the observedγ-to-βphase transition triggered by quite a low annealing temperature should be a rather lowered phase transition barrier of the epitaxy-stabilized In2Se3 thin-film system at a state far from thermodynamic equilibrium.

关键词： In2Se3 molecular beam epitaxy single-crystalline annealing and quench phase transition

Role of interleukin-8 in the progression of estrogen receptor-negative breast cancer

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Chinese Medical Journal 2007年第20期120卷 1766-1772页

作者： YAO Chen LIN ying YE Cai-sheng BI Jiong ZHU yi-fan WANG shen-ming Division of Breast Surgery Department of Surgery First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 China

Background Estrogen receptor （ER） is a very important biomarker of breast cancer. ER deletion has been consistently associated with tumor progression, recurrence, metastasis and poor prognosis, but the biological mechanism is still unclear. ER negative breast cancer expresses high levels of interleukin-8 （IL-8）. ER expression can downregulate IL-8 promotor activity. As a multifunctional cytokine, IL-8 has many important biological activities in tumor genesis and development. With the goal of investigating the role of IL-8 in ER-negative breast cancer progression, we applied RNA interference technology to specifically knockdown the IL-8 expression in ER-negative breast cancer cell line MDA-MB-231.Methods Interfering pRNA-IL-8 and the control was transfected into ER（-） MDA-MB-231. The proliferation, cell apotosis, and invasive ability were recorded in transfected, untransfected and negative transfected cells. These cells were injected into nude mice to assess tumorigenicity, proliferation, metastasis and microvessel density （MVD）.Results In vitro, decreased expression of IL-8 was associated with reduced cell invasion （P〈0.001）, but had no effect on cell proliferation （P〉0.05）. In vivo, neutrophils infiltration was significantly inhibited in pRNA-IL-8 transfected cells compared with untransfected and negatively transfected cells （P=0.001, P〈0.001）. Less metastasis was found in transfected cells compared with negatively transfected cells （0% vs 80%, P=0.048）. Nevertheless, we observed less MVD in transfected cells compared with control in nude mice （P〈0.001）.Conclusions IL-8 inhibits ER-negative breast cancer cell growth and promotes its metastasis in vivo, which may be correlated with neutrophils infiltration induced by IL-8.

关键词： breast cancer interleukin-8 estrogen receptor RNA interference

湿热环境对Sikaflex-265铝合金粘接接头失效强度的影响

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吉林大学学报（工学版） 2018年第5期48卷 1331-1338页

作者：那景新浦磊鑫范以撒沈传亮吉林大学汽车仿真与控制国家重点试验室长春130022

为了研究湿热环境对车辆上粘接结构机械性能的影响,本文选取4个温度点和5个湿度点进行组合,对单搭接接头进行了试验测试。通过对试验数据进行统计分析,获得了接头平均失效强度随温度和湿度的变化规律。利用响应面分析判断湿热环境对接... 详细信息

为了研究湿热环境对车辆上粘接结构机械性能的影响,本文选取4个温度点和5个湿度点进行组合,对单搭接接头进行了试验测试。通过对试验数据进行统计分析,获得了接头平均失效强度随温度和湿度的变化规律。利用响应面分析判断湿热环境对接头失效强度影响的显著性,并获得了环境因素对试验结果影响的合理数学模型。研究结果表明:接头平均失效强度在一定湿度水平下随温度增加呈指数衰减,在一定温度水平下随着湿度增加呈二次多项式衰减,且温度对接头平均失效强度的影响更加显著。

关键词：车辆工程粘接技术湿热环境强度预测响应面分析

Arachidonic acid is a bidirectional regulator of mTOR complexes through short-term activation and long-term inhibition in estrogen receptor positive breast cancer cells

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Arachidonic acid is a bidirectional regulator of mTOR comple...

Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： yi-fan shen Wen-Di Chu ying-Ji Chen Yu Jiang Yu-Long Zhang Department of bioengineering College of ChemistryChemical Engineering and BiotechnologyDonghua University Department of Molecular Pharmacology and Chemical Biology School of MedicineUniversity of Pittsburgh

Arachidonic acid(AA) is a polyunsaturated fatty acid that plays a key role in mediating some of tumorigenesis,especially for estrogen receptor(ER) positive breast *** studies have demonstrated that mTORC1 and mTORC2 siganling acted as strong activators in breast cancer ***,the mechanisms how AA regulates mTOR activity remain *** the present study,we found that AA exhibited both positive and negative effects on mTORC1 and mTORC2 activity,depending on the treatment *** short-term treatment,AA served as a strong downstream effector of estrogen receptor,activating mTOR activity at early *** the contrary,the classic PI3 K-Akt pathway was responsible for the late stage activation of mTOR under estrogen *** with prolonged treatment of AA and depleted estrogen,both mTORC1 and mTORC2 activities drastically reduced via ***,AA-induced mTOR degradation mechanism was be blocked by additional ***,down-regulating mTOR kinase activity protected the abrogation of ER enhanced AA-induced mTOR ***,we identified the three lipoxygenase-derived AA metabolites-5-HETE,12-HETE and 15-HETE,the downstream effector of AA,induced mTOR *** a novel cancer cell death control mechanism involving the synergetic effects of estrogen,it is an intriguing interplay between AA and mTOR activity with distinct *** strategy of targeting on AA might carry a lot of hope on anti-breast cancer.

关键词： arachidonic acid(AA) breast cancer mammalian target of rapamycin(mTOR) estrogen AA metabolites

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： yi-Qing shen Qiu-Wan Wei yi-Ren Tian Yun-Zhi Ling Min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru shen Zheng Song Dinggang fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

Bowel preparation before colonoscopy: Consequences, mechanisms, and treatment of intestinal dysbiosis

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World Journal of Gastroenterology 2025年第2期31卷 13-26页

作者： Ze-Long Zheng Qing-fan Zheng Li-Qiang Wang yi Liu Department of Gastroenterology(Endoscopy Center) China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

The term“gut microbiota”primarily refers to the ecological community of various microorganisms in the gut,which constitutes the largest microbial community in the human *** adequate bowel preparation can improve the results of colonoscopy,it may interfere with the gut *** preparation for colonoscopy can lead to transient changes in the gut microbiota,potentially affecting an individual’s health,especially in vulnerable populations,such as patients with inflammatory bowel ***,measures such as oral pro-biotics may ameliorate these adverse *** focused on the bowel prepa-ration-induced changes in the gut microbiota and host health status,hypothesized the factors influencing these changes,and attempted to identify measures that may reduce dysbiosis,thereby providing more information for individualized bowel preparation for colonoscopy in the future.

关键词： Bowel preparation Colonoscopy Microbiota Inflammatory bowel disease Probiotics

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大面积有机太阳能电池的研究进展

中国科学：化学 2022年第11期52卷 2001-2026页

作者：沈伊凡刘耀虎张建齐魏志祥国家纳米科学中心中国科学院纳米系统与多级次制造重点实验室北京100190 中国科学院大学中丹学院北京100049 中国科学院前沿科学与教育局北京100864

近年来,有机太阳能电池发展十分迅速,小面积器件的光电转化率已经突破19%,然而大面积器件的研究远远滞后.深入研究有机光伏大面积器件中的关键基础问题、开发大面积印刷制备方法,对推动有机太阳能电池的工业化应用具有重要意义,是未来... 详细信息

近年来,有机太阳能电池发展十分迅速,小面积器件的光电转化率已经突破19%,然而大面积器件的研究远远滞后.深入研究有机光伏大面积器件中的关键基础问题、开发大面积印刷制备方法,对推动有机太阳能电池的工业化应用具有重要意义,是未来有机太阳能电池的发展的热点和难点方向.相较于小面积器件,大面积器件对活性层材料的膜厚容忍度、透明电极的电阻、器件的加工方式等都有较高的要求,如何制备高效、稳定的刚性/柔性大面积器件仍是一个挑战.本综述着眼于刚性基底与柔性基底大面积器件中使用的材料、器件的涂布工艺、阳极/阴极传输层及电极材料的开发等方面,系统总结了近年来领域内的代表成果,并对未来高性能大面积有机太阳能器件的发展进行了展望.

关键词：有机太阳能电池大面积器件涂布工艺

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