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Transcriptomic analyses of humans and mice provide insights into depression

Zoological Research 2020年第6期41卷 632-643页

作者： Hui-Juan Li Xi Su Lu-Wen zhang chu-yi zhang Lu Wang Wen-Qiang Li Yong-Feng Yang Lu-Xian Lv Ming Li Xiao Xiao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Henan Mental Hospital Second Affiliated Hospital of Xin xiang Medical UniversityXinxiangHenan 453002China Henan Key Lab of Biological Psychiatry International Joint Research Laboratory for Psychiatry and Neuroscience of HenanXinxiang Medical UniversityXinxiangHenan 453002China Henan Province People's Hospital ZhengzhouHenan 450003China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

Accumulating studies have been conducted to identify risk genes and relevant biological mechanisms underlying major depressive disorder(MDD).In particular,transcriptomic analyses in brain regions engaged in cognitive and emotional processes,e.g.,the dorsolateral prefrontal cortex(DLPFC),have provided essential *** on three independent DLPFC RNA-seq datasets of 79 MDD patients and 75 healthy controls,we performed differential expression analyses using two alternative approaches for *** also conducted transcriptomic analyses in mice undergoing chronic variable stress(CVS)and chronic social defeat stress(CSDS).We identified 12 differentially expressed genes(DEGs)through both analytical methods in MDD patients,the majority of which were also dysregulated in stressed ***,the mRNA level of the immediate early gene FOS(Fos proto-oncogene)was significantly decreased in both MDD patients and CVS-exposed mice,and CSDSsusceptible mice exhibited a greater reduction in Fos expression compared to resilient *** findings suggest the potential key roles of this gene in the pathogenesis of MDD related to stress *** transcriptomes in the DLPFC of MDD patients might be,at least partially,the result of stress exposure,supporting that stress is a primary risk factor for MDD.

关键词： Major depressive disorder Stressed mice Dorsolateral prefrontal cortex Transcriptomic analysis FOS

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A study on the mechanism of acupuncture treatment of acne based on immune inflammation

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TMR Non-Drug Therapy 2023年第1期6卷 8-13页

作者： chu-yi zhang Rui Jin yi-Jun Feng Zhen Zhou Graduate school Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Traditional Chinese Medicine Tianjin Children's HospitalTianjin 300134China Department of Acupuncture and Moxibustion Second Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China

Acne is a chronic inflammatory skin disease involving hair follicle sebaceous glands,which is characterized by acne,papules,pustules,nodules,cysts and so *** disorder of immune inflammation is the key link.A variety of factors participate in the immune inflammatory response of acne and interact with each other,leading to the occurrence and development of acne *** can regulate the immune and inflammatory response through many links and improve the skin *** study explains potential mechanisms of acupuncture in the treatment of acne by regulating the body's immune inflammatory response,in order to provide new ideas.

关键词： acupuncture acne immunity inflammatory reaction mechanism

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Bibliometric and visual analysis of limb spasm after stroke based on Citespace software

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Medical Data Mining 2022年第1期5卷 21-27页

作者： Rui Jin Bing-Quan Wang Lian-yi Hu yi-Jun Feng chu-yi zhang yin-Tao zhang Xin-Ju Li Tianjin University of Chinese Medicine Tianjin 301617China

Background:To apply CiteSpace software to the hotspot,trend and cutting-edge dynamics of limb spasm after stroke in nearly 20 ***:From 2000 to 2018,spasming literature in the Web of Science database were searched,and cooperative analysis of authors'national institutions was conducted by using CiteSpace software,keyword analysis and cluster analysis,citation analysis of authors'literature journals,and visual ***:2005 articles were retrieved,and the number of articles increased year by year,and the country with the most articles was the United *** analysis shows that mechanistic research and clinical treatment of spasticity are research hotspots in this *** most posts are Northwestern Univ and Univ ***:Through the CiteSpace software analysis of spasticity literature,it is found that the research focus is embodied in the nerve regeneration technology and the standardized clinical study of botulinum toxin type A application,which has certain reference significance for the future research direction of spasticity.

关键词： limb spasm after stroke CiteSpace bibliometry visual analysis.

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Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue Tang Mansheng chu Quan Shi Zhen zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

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Research progress of traditional Chinese medicine monomers in intervening colorectal cancer by regulating MAPK signaling pathway

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Cancer Advances 2022年第14期5卷 1-8页

作者： Shuang Li Chen-Chen Zhao chu-yi zhang Jing-Xuan Li Wang Gao Graduate School of Tianjin University of Traditional Chinese Medicine Tianjin 301617China Department of Oncology Second Affliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine National Clinical Research for Chinese Medicine Acupuncture and MoxibustionTianjin 300193China Department of Gastroenterology Second Affliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China.

The incidence rate and mortality rate of colorectal cancer in China are increasing year by *** effective therapeutic strategies and interventions,especially exploring“highly effective and low toxic”drugs to prevent“inflammation-cancer”transformation,treat primary tumors,prevent tumor metastasis and reduce the toxicity and increase efficiency of existing therapies has become a hot topic of domestic and foreign *** advantage of traditional Chinese medicine in the treatment of colorectal cancer is to reduce the postoperative recurrence rate,improve patients’symptoms and the quality of life of“tumor survivors”and prolong the survival *** paper summarizes the tumor treatment strategies and research prospects of traditional Chinese medicine targeting mitogen activated protein kinase by sorting out the mechanism of traditional Chinese medicine extracts or effective components intervening colorectal cancer by regulating mitogen activated protein kinase signal pathway in tumor cells in recent years.

关键词： traditional Chinese medicine monomer mitogen activated protein kinase colorectal cancer research progress

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Numerical Study of Flow and Heat Transfer Characteristics of Shell-and-Tube Molten Salt Electric Heater with Circularly Perforated Baffles

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Journal of Thermal Science 2025年第1期34卷 24-33页

作者： LIN Yongjie zhang Cancan WU Yuting zhang yi LU Yuanwei Key Laboratory of Heat Transfer and Energy Conversion National User-Side Energy Storage Innovation Research and Development CenterBeijing University of Technology

Numerical simulations of the flow and heat transfer characteristics of four shell-and-tube molten salt electric heaters with different perforation rates was ***-and-tube electric heaters have the same geometry and tube arrangement,and all of them use single segmental baffles,but there exist four different baffle openings（φ）,i.e.,0%,2.52%,4.06%,and 6.31%.The results indicated that the reasonable baffle opening could significantly reduce the shell-side pressure drop,effectively decreasing the shell-side flow dead zone *** can eliminate the local high-temperature phenomenon on the surface of electric heating tubes,but the heat transfer coefficient is slightly *** perforated schemes significantly reduce shell-side pressure drop compared to the baseline solution without open *** particular,the φ=6.31% scheme exhibits the optimal performance among all the schemes,with a maximum reduction of up to 50.50% in shell-side pressure drop relative to the unopened holes *** heat transfer coefficient is the highest for φ=0%,exhibiting a range of5.26% to 5.73%,5.14% to 5.99%,and 7.31% to 8.54% higher than φ=2.52%,4.06%,and 6.31%,respectively,within the calculated *** composite index h/（Δp）1/3was higher for all open-hole solutions than that for the unopened-hole *** best overall performance was for φ=6.31%,which improved the composite index by15.29% to 17.18% over the unopened-hole solution.

关键词： molten salt electric heater perforated baffles heat transfer

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Nano high-entropy oxide cathode with enhanced stability for direct borohydride fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 309-316页

作者： Lei zhang Lingfeng Kuang Lianke zhang Wen chu Haiying Qin Jing zhang Junjing He Hualiang Ni Hongzhong Chi New Energy Materials Research Center College of Materials and Environmental Engineering Hangzhou Dianzi University School of Materials Science and Engineering Zhejiang University Key Laboratory of MEMS of Ministry of Education School of Integrated Circuits Southeast University

High-entropy materials have become high-activity electrocatalysis owing to their high-entropy effect and multiple active ***,we synthesize a series of carbon-supported nano high-entropy oxides（HEOs/C）,specifically （PtFeCoNiCu）O/C,using a carbothermal shock （CTS） method for application as a cathode catalyst in direct borohydride fuel cells （DBFCs）.The microstructure of the prepared catalysts was characterized by X-ray photoelectron spectroscopy,X-ray absorption fine structure,and transmission electron *** prepared （PtFeCoNiCu）O/C,with particle sizes ranging from 2 to 4 nm,demonstrates 3.94 transferred electrons towards the oxygen reduction reaction in an alkaline environment,resulting in a minimal H2O2yield of 2.6%.Additionally,it exhibits a Tafel slope of 61 mV dec-1,surpassing that of commercial Pt/C (82 mV dec-1).Furthermore,after 40,000 cycles of cyclic voltammetry（CV） testing,the half-wave potential of （PtFeCoNiCu）O/C shows a positive shift of 3 mV,with no notable decline in the limiting current *** （PtFeCoNiCu）O/C is used as a cathode catalyst in DBFCs,the DBFC achieves a maximum power density of 441 mW cm-2at 60°C and sustains a cell voltage of approximately 0.73 V after 52 h at 30°*** findings confirm that HEO/C is a promising cathode catalyst for DBFCs.

关键词： Direct borohydride fuel cells (DBFC)

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Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期68卷 152-156页

作者： Lihua zhang Lingjing Chen Huatian Shi Yue Wei Gui Chen Tai-chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

关键词： photocatalysis noble metal-free CO2 reduction formate cobalt hydride

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To explore the research progress of acupuncture in the treatment of stroke based on the function of intestinal flora

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Microenvironment & Microecology Research 2022年第4期4卷 1-6页

作者： yi-Jun Feng Rui Jin Bing-Quan Wang Dong-Jian Hu Yue-Qiao Ren Jun Wu yin-Tao zhang chu-yi zhang Zhen Zhou Graduate school Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Traditional Chinese Medicine Tianjin Children's HospitalTianjin 300134China Department of Acupuncture and Moxibustion Second Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China

Gut microbiota is a microecosystem composed of microbes in the gut,and each microbiota participates in maintaining various functions of the human body by achieving ecological *** number and structure of gut microbiota change after stroke,which causes a series of reactions and aggravates brain *** can promote the recovery of nerve function by correcting the disorder of intestinal *** study illustrates multiple potential mechanisms of acupuncture in the treatment of stroke by interfering with gut microbiota,aiming to provide new ideas for the prevention and treatment of stroke.

关键词： acupuncture gut microbiota stroke the gut-brain axis review

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Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan zhang yi Yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

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