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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin li Jian Xiang Lu Qiu Xiaohan chen yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong liu Dan Xiao Zhaoyu Jin Panpan li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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KNOWLEDGE AND BEHAVIOR OF SEXUAliTY AND CONTRACEPTION AMONG PREGNANT TEENAGERS:A QUESTIONNAIRE SURVEY IN SHANGHAI

KNOWLEDGE AND BEHAVIOR OF SEXUALITY AND CONTRACEPTION AMONG ...

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The 5th International Conference on Reproductive Endocrinology

作者： Xu Jie-shuang chen yi cheng li-nan Shanghai Institute of Family Planning Technical Instruction International Peace Maternal and Child Health Hospital Shanghai China

＜正＞Objectives:To study the knowledge and behavior of sexuality and contraception among pregnant teenagers and find the way of changing risky sexual behavior and prevention of teenage pregnancy. Methods:A total of 124 pregnant teenagers filed a self-administrated questionnaire anonymously in Shanghai International Peace MCH Hospital from Jan,2004-Jun,2004.

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河西走廊文化翻译传播研究

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兰州文理学院学报（社会科学版） 2024年第2期40卷 23-30页

作者：曹进陈怡莉西北师范大学国别与区域研究院甘肃兰州730070

从洛特曼文化符号学的角度出发,探析文本的三个功能在河西走廊文化翻译传播过程中产生的影响,并探索河西走廊文化国际表达的有效路径。研究发现,文本的信息记忆功能指导译者在翻译中还原原文的历史信息,通过重构文化联想的空间来引发读... 详细信息

从洛特曼文化符号学的角度出发,探析文本的三个功能在河西走廊文化翻译传播过程中产生的影响,并探索河西走廊文化国际表达的有效路径。研究发现,文本的信息记忆功能指导译者在翻译中还原原文的历史信息,通过重构文化联想的空间来引发读者的共鸣;信息传递功能引导译者采取迂回婉转的方式转换原文,消除文化不匀质现象,实现最大化的信息等值传递;文本的信息生成功能解决两种语言文化空缺或概念空缺的现象。

关键词：河西走廊文化符号学文本功能

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某院小儿尿路感染常见细菌菌群分布及耐药谱分析

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中国卫生检验杂志 2014年第12期24卷 1797-1799页

作者：陈怡丽黄汉张丹丹中山大学附属第一医院医学检验部广东广州510080 广东医学院医学检验学院广东湛江524000

目的了解近年来小儿尿路感染病原菌的构成和药敏试验,指导临床用药。方法分析2008年-2013年中山大学附属第一医院尿培养阳性的尿路感染住院患儿致病菌分布和耐药情况。结果小儿尿路感染的病原菌仍以革兰阴性杆菌为主,占75.0%。大肠埃希... 详细信息

目的了解近年来小儿尿路感染病原菌的构成和药敏试验,指导临床用药。方法分析2008年-2013年中山大学附属第一医院尿培养阳性的尿路感染住院患儿致病菌分布和耐药情况。结果小儿尿路感染的病原菌仍以革兰阴性杆菌为主,占75.0%。大肠埃希菌的检出率最高,占25.9%,其次为肺炎克雷伯杆菌(19.3%)及屎肠球菌(15.1%)。尿培养阳性的标本主要来自小儿外科,占59.4%,主要原因为儿科外科病区的患儿大部分为复杂性尿路感染。革兰阴性杆菌最敏感的药物是亚胺培南、哌拉西林/他唑巴坦及阿米卡星;耐药率最高的是氨苄西林、头孢唑林及复方新诺明;其中55株大肠埃希菌中有19株产超广谱β-内酰胺酶(ESBLs)阳性(35.0%),肺炎克雷伯菌的ESBL阳性率为24.4%(10/41)。结论目前小儿尿路感染仍以大肠埃希菌为主,耐药菌株不断增加,临床治疗应参考药敏结果合理选用抗菌药。

关键词：儿童尿路感染致病菌耐药性

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen Menghua li Weiwei Guo Shuolong Yuan liangwei Xu Chang lin Xi Shi Wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu chen liping li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang yi Teng Qianru li Changfa Xia Wanqing chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrendlimited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin chen Jinghong Xu Bin Jiang Lei li Yawei li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

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当归炮制品9种化学成分的比较研究

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中药新药与临床药理 2017年第1期28卷 88-92页

作者：陶益陈西李伟东蔡宝昌南京中医药大学中药炮制重点实验室江苏南京210023

目的比较当归生品、酒品、炭品及土炒品的质控指标及主要化学成分的差异。方法按照《中国药典》(2015版)标准,测定当归不同炮制品的水分、总灰分、酸不溶性灰分、醇溶性浸出物及阿魏酸含量,考察HPLC方法的线性、精密度、稳定性、重复性... 详细信息

目的比较当归生品、酒品、炭品及土炒品的质控指标及主要化学成分的差异。方法按照《中国药典》(2015版)标准,测定当归不同炮制品的水分、总灰分、酸不溶性灰分、醇溶性浸出物及阿魏酸含量,考察HPLC方法的线性、精密度、稳定性、重复性及加样回收率。同时采用HPLC-Q-TOF/MS法鉴定当归不同炮制品的9种主要化学成分,并用HPLC法比较各当归炮制品中9种主要化学成分相对含量的差异。结果各当归炮制品的水分、总灰分、醇溶性浸出物测定结果均符合《中国药典》(2015版)的要求。生当归和酒当归的阿魏酸含量分别为0.061%和0.050%,符合《中国药典》(2015版)要求。运用高分辨质谱鉴定了9个主要化学成分,分别为邻苯二甲酸、阿魏酸、肉桂酸、洋川芎内酯I、洋川芎内酯A、(E)-藁苯内酯、(Z)-藁苯内酯、新当归内酯、欧当归内酯A。结论当归酒炙后挥发油成分含量降低,可能有助于舒缓子宫的兴奋,使子宫收缩平缓,发挥稳定的活血通经作用;当归土炒后挥发油成分含量降低,土炒缓和油润而不滑肠作用可能与此有关。当归炮制后挥发油成分含量下降,与传统炮制理论吻合。

关键词：当归炮制生当归酒当归当归炭土炒当归高效液相-质谱联用法

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A gradient solid electrolyte interphase with high li+conductivity induced by bisfluoroacetamide additive for stable lithium metal batteries

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Nano Research 2023年第6期16卷 8425-8432页

作者： Zhaoyang Sun Ziyue Wen yi chen Yue Ma Jinxiang Zhang Yuejiao li li li Renjie chen Beijing Key Laboratory of Environmental Science and Engineering School of Material Science&EngineeringBeijing Institute of TechnologyBeijing 100081China Institute of Advanced Technology Beijing Institute of TechnologyJinan 250300China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081China

Stable li metal anodes have become the driving factor for high-energy-density battery ***,uncontrolled growth of li dendrite hinders the application of rechargeable li metal batteries(LMBs).Here,a multifunctional electrolyte additive bisfluoroacetamide(BFA)was proposed to facilitate high-performance *** uniform and dense deposition of li^(+) was achieved due to the reduced nucleation and plateau overpotential by the addition of ***,X-ray photoelectron spectroscopy(XPS)tests reveal a gradient solid electrolyte interface(SEI)structure on the li metal *** voltammetry(CV)curves at different sweep speeds prove the formation of pseudocapacitance at the electrode-electrolyte interface,which accelerates the li+transport rate and protects the electrode *** low activation energy also indicates the ability of rapid li^(+) transportation in electrolyte ***,the li||li symmetric cells with 1.0 wt.%BFA electrolyte exhibit good cycling performance at 0.5 mA·cm^(−2)for over 2000 h,and li||liNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622)full cells maintain a high capacity for 200 cycles at 1 C rate.

关键词： electrolytes additives solid electrolyte interphase li dendrites li metal batteries

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