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Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development

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World Journal of Diabetes 2023年第11期14卷 1621-1631页

作者： yi-chen guo Hao-Di Cao Xiao-Fen Lian Pei-Xian Wu Fan Zhang Hua Zhang Dong-Hui Lu Department of Endocrinology Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Endocrinology Zhujiang Hospital of Southern Medical UniversityGuangzhou 510282Guangdong ProvinceChina

Diabetes mellitus(DM)and obesity have become two of the most prevalent and challenging diseases worldwide,with increasing incidence and serious *** studies have shown that noncoding RNA(ncRNA)and epigenetic regulation play crucial roles in the pathogenesis of DM complicated by *** of the involvement of ncRNA and epigenetic regulation in the pathogenesis of diabetes with obesity has opened new avenues of *** these mechanisms with small molecules or RNA-based therapies may provide a more precise and effective approach to diabetes treatment than traditional *** this review,we discuss the molecular mechanisms of ncRNA and epigenetic regulation and their potential therapeutic targets,and the research prospects for DM complicated with obesity.

关键词： Diabetes mellitus Obesity Noncoding RNA Epigenetic regulation Insulin resistance

Studies on Material Cycling in Evergreen Broad-Leaved Forest Ecosystem in Hangzhou: Ⅰ. Precipitation Distribution

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Pedosphere 1993年第3期3卷 221-230页

作者： JIANG QIU-yi, HE LI-MING, YU yi-WU, chen guo-RUI and SHI DE-FAZhejiang Forestry College, Lin’an. Zhejiang 311300 (China)

Through the long-term plot studies on the precipitation distribution in the evergreen broad-leaved forest ecosystem in Hangzhou for two years, it was indicated that the pattern of precipitation distribution included larger amounts of penetration water and stemflow and a lower amount of interception water. The results revealed that the main factors to infulence the percentages of penetration and stemflow were the air temperature and the leaf area of the forest. The quantity of seepage through the litter layer was much larger than that through the soil layers which decreased sharply with soil depth. The output of water from the ecosystem by surface runoff and deep infiltration through the soil was much lower, only being 5.20 percent of the rainfall, while the water evapotranspiration loss was as large as more than 90 percent of it. The losses by the soil evaporation and plant evapotranspiration were the largest part of output in this forest ecosystem.

关键词： ecosystem evergreen broad-leaved forest rainfall water balance

Furfural residues from straw become complex fertilizer by addition method

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Journal of Environmental Sciences 2000年第2期12卷 74-77页

作者： LIU Jun\|feng,yi Ping\|gui,chen An\|guo (Department of Chemical Engineering, Xiangtan Polytechnic University, Xiangtan 411201, China)

The additives such as phosphoric acid, calcium phosphate, calcium super phosphate, calcium over super phosphate, calcium carbonate, sodium hydrosulphite, etc. were used to produce furfural from the straw by hydrolysis with sulfuric acid. The effect of amount of the additives, the content of the added substance and the conditions of distillation on the acidity of the residues were studied. The experiment results showed that the all residues became neutral complex fertilizer, and the productivity of furfural increases under the following conditions: sulfuric acid concentration is 20% (by weight), the ratio of liquid to solid is 3∶1—4∶1 (by weight), the ratio of the additives to straw is suitable.

关键词： straw furfural residues complex fertilizer CLC number: X712 Document code: A

Study on the effect and mechanism of Swertia mussotii Franch. in the treatment of primary biliary cholangitis based on bioinformatics and in vitro experiments

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Traditional Medicine Research 2024年第3期9卷 32-42页

作者： Xing-Fang Zhang Meng-Meng Yang yi-chen guo Meng-Yuan Wang Hong-Xia Yang Ming Zhang Cen Li Li-Xin Wei Hong-Tao Bi Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation Northwest Institute of Plateau BiologyChinese Academy of ScienceXining 810008China Medical College Qinghai UniversityXining 810001China College of Eco-Environmental Engineering Qinghai UniversityXining 810016China CAS Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001China

Background:Primary biliary cholangitis(PBC)is a chronic biliary autoimmune liver disease characterized by intrahepatic *** mussotii Franch.(SMF)is a Tibetan medicine with hepatoprotective and anti-inflammatory *** this study,the therapeutic effect and potential mechanisms of SMF on PBC were investigated by bioinformatics analysis and in vitro experimental validation,with the aim of promoting the progress of SMF and PBC ***:We first explored the therapeutic effects and key targets of SMF on PBC using a network pharmacology approach,further screened the core targets using the GSE79850 dataset,and finally validated the results using molecular docking techniques and in vitro ***:By bioinformatics analysis,we identified core targets of SMF for PBC treatment(STAT3,JAK2,TNF-α,and IL-1β)and important signaling pathways:JAK-STAT,TNF,and *** molecular docking results showed that the significant components of SMF had good binding properties to the core *** vitro experiments showed that SMF extracts improved the extent of epithelial-mesenchymal transition in human intrahepatic biliary epithelial cells and had a significant reversal effect on epithelial-mesenchymal transition process markers and potential targets in ***:SMF may exert its therapeutic effects on PBC by acting on important targets such as STAT3,JAK2,TNF-α,IL-1β,Vimentin,and E-cadherin and the pathways in which they are involved.

关键词： Swertia mussotii Franch. primary biliary cholangitis bioinformatics in vitro experiments

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun Wen-Biao Han yi-Yang guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

Analysis of Micromechanical Properties at the Interface of Pre-wet SBS Modified Asphalt Mixture Based on Molecular Simulation Technology

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 103-113页

作者： chen Wuxing chen Shuang YU Yan ZHANG Jiangyi XU Haiyang guo Wei School of Mines China University of Mining and TechnologyXuzhou 221000China College of Construction Engineering Jilin Uni-versityChangchun 130026China

The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and *** effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics *** diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are *** simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are *** concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more *** to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after *** to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.

关键词： pre-wet oil-stone interface interface interaction interface mechanics molecular dynamics simulation

Alterations of ATPase activity and erythrocyte oxygen consumption in patients with liver-blood deficiency syndrome

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World Journal of Gastroenterology 1997年第3期3卷 52-53页

作者： SHI Lin Jie 1, LIU Jun Fan 2, ZHANG Zi Qiang 1, LU yi Qin 2, SHU yi Gang 3, chen guo Lin 1, XIN Zhi Hua 1 and XU Jin Yao 2

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ＡｌｔｅｒａｔｉｏｎｓｏｆＡＴＰａｓｅａｃｔｉｖｉｔｙａｎｄｅｒｙｔｈｒｏｃｙｔｅｏｘｙｇｅｎｃｏｎｓｕｍｐｔｉｏｎｉｎｐａｔｉｅｎｔｓｗｉｔｈｌｉｖｅｒｂｌｏｏｄｄｅｆｉｃｉｅｎｃｙｓｙｎｄｒｏｍｅＳＨＩＬｉｎＪｉｅ１，ＬＩＵＪｕｎＦａｎ２...

关键词： erythrocytes cell membrane oxygen consumption adenosinetriphosphatase liver blood deficiency syndrome anemia,iron deficiency anemia, aplastic

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中国城市化对城乡平衡增长的影响

经济理论与经济管理 2016年第3期36卷 72-85页

作者：陈义国徐骏湖北经济学院金融学院 430205 浙江财经大学中国政府管制研究院

正确处理城市化进程中的城乡发展关系是一个关系到社会稳定的问题。本文通过建模分析城乡割裂和流动两种状态下的城乡经济发展状况,发现城市化通过知识、劳动和资本三方面的流动作用促进城乡间的平衡增长,而政府的投资偏向和价格干预行... 详细信息

正确处理城市化进程中的城乡发展关系是一个关系到社会稳定的问题。本文通过建模分析城乡割裂和流动两种状态下的城乡经济发展状况,发现城市化通过知识、劳动和资本三方面的流动作用促进城乡间的平衡增长,而政府的投资偏向和价格干预行为能够加剧割裂状态下的城乡发展不平衡和抵消城市化对城乡平衡发展的促进作用,利用中国省际面板数据的实证分析也验证了这一结论。因此在继续推进城市化的同时,要注重政府投资的平衡和减少对产品市场的价格干预,这样才能早日实现城乡的平衡发展。

关键词：城市化平衡增长农村工业化

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu Jiaxin Ren yingying Sun Zhen-Ni guo yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents