Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development
作者机构：Department of EndocrinologyPeking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of EndocrinologyZhujiang Hospital of Southern Medical UniversityGuangzhou 510282Guangdong ProvinceChina
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2023年第14卷第11期
页 面：1621-1631页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the Shenzhen Science and Technology Innovation Committee Projects,No.JCYJ20170816105416349 Shenzhen High-level Hospital Construction Fund Shenzhen Key Medical Discipline Construction Fund,No.SZXK010
主 题：Diabetes mellitus Obesity Noncoding RNA Epigenetic regulation Insulin resistance
摘 要：Diabetes mellitus(DM)and obesity have become two of the most prevalent and challenging diseases worldwide,with increasing incidence and serious *** studies have shown that noncoding RNA(ncRNA)and epigenetic regulation play crucial roles in the pathogenesis of DM complicated by *** of the involvement of ncRNA and epigenetic regulation in the pathogenesis of diabetes with obesity has opened new avenues of *** these mechanisms with small molecules or RNA-based therapies may provide a more precise and effective approach to diabetes treatment than traditional *** this review,we discuss the molecular mechanisms of ncRNA and epigenetic regulation and their potential therapeutic targets,and the research prospects for DM complicated with obesity.
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