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天然气化工—C1化学与化工 2002年第3期27卷 43-48页

作者：莫若飞蒋毅郑林程极源曾忠义王华明中国科学院成都有机化学研究所成都610041

综述了催化裂解法制氢的机理、方法、影响因素以及甲烷催化裂解和催化剂再生的匹配与循环。

关键词：催化裂解研究进展甲烷氢气制备催化剂再生循环

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组合墙梁的试验研究

西安建筑科技大学学报(自然科学版) 1985年第1期 55-76页

作者：易文宗王庆霖西安冶金建筑学院建工系

前言墙梁在房屋建筑中有着广泛的应用,例如底层商店上层为住宅房屋的墙梁承重结构,支承墙砌体的基础梁、连系梁等,但是由于对墙梁在荷载作用下的工作性能,破坏情况了解不足,到目前为止尚无统一合理的设计计算方法,多年来人们采用Б.Н... 详细信息

前言墙梁在房屋建筑中有着广泛的应用,例如底层商店上层为住宅房屋的墙梁承重结构,支承墙砌体的基础梁、连系梁等,但是由于对墙梁在荷载作用下的工作性能,破坏情况了解不足,到目前为止尚无统一合理的设计计算方法,多年来人们采用Б.Н热莫契金法。把墙体看作半无限的弹性地基,把托梁当作弹陀地基梁来计算,而设有考虑墙体的承载能力,近年来由于城市建筑的需要,国内不少单位对墙梁进行了试验实测探讨墙梁的组合作

关键词：墙梁墙体压应变承载能力开洞斜裂缝剪切破坏试验研究

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燃油隧道窑烘窑方法的改进与探讨

山东冶金 2001年第1期23卷 3-4页

作者：王忠义王民业山东第二耐火材料厂山东王村255311

采用火箱车燃重油法对 111m粘土隧道窑进行烘窑 ,解决了硅质内衬的裂纹和掉角、掉片问题 ,而且减少了热量损失 ,操作简便。

关键词：烘窑隧道窑控制温度内衬粘土重油燃油裂纹

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG wang YUANHONG PENG MENG CHEN LIN zhong LUJI HUANG FU CHENG XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： Yu-Mei wang Mei-Xia Tao Kai-Ming Mo Xu Chen Shu-Hua zhong Elena S Shubina Guo-Hong Ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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基于PLC的磁导航AGV路径跟踪模糊控制研究

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装备制造技术 2018年第7期 207-210页

作者：林义忠张勤望翔广西大学机械工程学院广西南宁530004

由于AGV具有非线性和非完整约束特性,导致很难对其建立精确的数学模型,用传统的控制方法进行控制会产生严重的滞后,造成轨迹跟踪时会产生较大的偏差且不能及时纠正,对AGV导航精度造成很大影响。而模糊控制是一种非线性控制方法,可以有... 详细信息

由于AGV具有非线性和非完整约束特性,导致很难对其建立精确的数学模型,用传统的控制方法进行控制会产生严重的滞后,造成轨迹跟踪时会产生较大的偏差且不能及时纠正,对AGV导航精度造成很大影响。而模糊控制是一种非线性控制方法,可以有效改善这种情况。设计了用于AGV路径跟踪的模糊控制器,并阐述了此模糊控制器在西门子PLC上的实现方法。经现场实测,运用此模糊控制器的AGV有良好的导航精度,纠偏迅速。

关键词：磁导航AGV 模糊控制 PLC 路径跟踪

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang Jun-Zhao Xiao yi-Fan wang Tian-Yu Wei Jia-Wei Jiang Ye wang Qian Peng Liang yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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“大、小、重、慢”疾病定义与全科医生“4善”定位的探讨

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中国全科医学 2025年第1期28卷 125-128页

作者：李敏王仲清华大学附属北京清华长庚医院临床医学院全科医学系北京市102218 北京清华长庚医院全科与健康医学部北京市102218

随着我国医药卫生体制的深度改革,特别是分级诊疗制度的推进,全科医生在基层医疗保健体系中的角色日益重要。全科医生不仅是居民健康的第一道防线,更是常见疾病预防、诊断、治疗及健康教育的关键执行者。国家对全科医生提出了“小病善... 详细信息

随着我国医药卫生体制的深度改革,特别是分级诊疗制度的推进,全科医生在基层医疗保健体系中的角色日益重要。全科医生不仅是居民健康的第一道防线,更是常见疾病预防、诊断、治疗及健康教育的关键执行者。国家对全科医生提出了“小病善治、大病善识、重病善转、慢病善管”的临床定位。本文通过问答形式,分析“小、大、重、慢”疾病的分类与全科医生的“4善”定位,探讨全科医生在新医改时代下的重要职能及挑战。访谈者认为虽然分级诊疗制度旨在优化医疗资源配置,但在实践中仍面临“大、小、重、慢”疾病分类的模糊性和基层医疗资源的不均衡分配等问题。全科医生在这个体系中扮演着至关重要的角色,其需要具备综合的临床诊疗能力,并与专科医生共同制定临床判断标准和诊疗标准。为了应对这些挑战并充分发挥全科医生在现代医疗体系中的作用,迫切需要对全科医学教育和实践进行进一步改革与优化,同时强化全科医生的角色定位,以确保在提升医疗服务质量和效率的同时,实现公平和可持续的健康保障体系。

关键词：全科医学全科医生分级诊疗医疗体系改革疾病分类医疗资源优化

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新时代高校师德失范行为惩戒的法治化构造

黑龙江高教研究 2025年第1期43卷 15-21页

作者：王羿程中国人民公安大学北京100038

高校师德失范行为惩戒既是新时代师德师风建设的核心部分,更是推进教育治理现代化的关键命题。当前高校师德失范行为惩戒面临两个方面困境:一是制度层面的供给不足;二是在实施机制中存在参与通道不畅、教师权利的实效性救济困难等问题... 详细信息

高校师德失范行为惩戒既是新时代师德师风建设的核心部分,更是推进教育治理现代化的关键命题。当前高校师德失范行为惩戒面临两个方面困境:一是制度层面的供给不足;二是在实施机制中存在参与通道不畅、教师权利的实效性救济困难等问题。应当明确,法治既是新时代教育治理现代化的基本目标与重要内容,也是高校教育治理现代化的基本路径,更是高校进行师德失范行为惩戒必须遵循的基本模式。通过法治化的建构路径,于静态维度准确界定惩戒的启动条件,划定惩戒的适用范围;于动态维度畅通多元主体的利益诉求表达通道。进而,在实践维度强化高校自主化、专业化实施师德失范行为惩戒的能力,在中国式现代化的时代格局下,有力推进高校教育治理现代化。

关键词：教育治理现代化师德失范行为惩戒制度困境法治化建构阶层化构造

Short-term Photovoltaic Power Prediction Based on Feature Optimization and Hybrid Improved Grey Wolf Algorithm-optimized BiLSTM Network

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Dianwang Jishu/Power System Technology 2025年第1期49卷 209-222页

作者： Zhao, Ruyi wang, Xiaohui Zheng, Bihuang Li, Daoxing Gao, yi Guo, Pengtian China Electric Power Research Institute Haidian District Beijing 100192 China Economic and Technological Research Institute State Grid Tianjin Electric Power Company Hedong District Tianjin 300171 China

To address the challenges posed by strong noise interference in photovoltaic (PV) sequences and the issues of low accuracy and poor generalization of a single model in PV power prediction, we propose a short-term PV power prediction method. This method uses feature optimization and a hybrid improved Grey Wolf algorithm to optimize the BiLSTM network. Firstly, the mutual information algorithm is employed for variable selection in input data to eliminate redundant variables. Subsequently, the Complementary Ensemble Empirical Mode Decomposition and an improved wavelet threshold algorithm are applied to the selected data for feature reconstruction to reduce noise interference in the data and optimize input variable features. Finally, the standard Grey Wolf Optimizer algorithm underwent hybrid optimization by integrating improved Tent chaotic mapping, nonlinear decreasing factors, dynamic weight strategies, and the differential evolution algorithm. This process aimed to ascertain the optimal hyperparameter combination for the BiLSTM network. The attention mechanism was also employed to extract key temporal information from the data, developing a novel short-term photovoltaic power prediction model. Simulation experiments demonstrate that, compared to the least squares support vector machine, long short-term memory network, and bidirectional long short-term memory neural network, the proposed model achieves an average reduction of 12.45%, 7.95%, and 5.37% in root mean square error under various weather conditions such as sunny, cloudy, overcast, and rainy, showcasing excellent predictive performance, good generalization ability, and promising engineering application value. © 2025 Power System Technology Press. All rights reserved.

关键词： Mean square error