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Improving constraint onΩ_(m)from SDSS using marked correlation functions

Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 207-224页

作者： Limin Lai Jiacheng Ding Xiaolin Luo yizhao Yang Zihan Wang Keshi Liu Guanfu Liu Xin Wang yi zheng Zhaoyu Li Le Zhang Xiao-Dong Li School of Physics and Astronomy Sun Yat-sen University Zhuhai CampusZhuhai 519082China Department of Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Department of Astronomy Tsinghua UniversityBeijing 100084China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area SYSUZhuhai 519082China Peng cheng Laboratory Shenzhen 518000China

Large-scale structure(LSS)surveys will increasingly provide stringent constraints on our cosmological ***,the density-marked correlation function(MCF)has been introduced,offering an easily computable density-correlation *** have demonstrated that MCFs offer additional,independent constraints on cosmological models beyond the standard two-point correlation(2PCF).In this study,we apply MCFs for the first time to SDSS CMASS data,aiming to investigate the statistical information regarding clustering and anisotropy properties in the Universe and assess the performance of various weighting schemes in MCFs,and finally obtain constraints onΩ_(m).Upon analyzing the CMASS data,we observe that,by combining different weights(α=[-0.2,0,0.2,0.6]),the MCFs provide a tight and independent constraint on the cosmological parameterΩ_(m),yieldingΩ_(m)=0.293±0.006 at the 1σlevel,which represents a significant reduction in the statistical error by a factor of 3.4 compared to that from *** constraint is consistent with recent findings from the small-scale clustering of BOSS galaxies(Zhai et ***.J.948,99(2023))within the 1σ***,we also find that our estimate is lower than the Planck measurements by about 2.6σ,indicating the potential presence of new physics beyond the standard cosmological model if all the systematics are fully *** method outlined in this study can be extended to other surveys and datasets,allowing for the constraint of other cosmological ***,it serves as a valuable tool for forthcoming emulator analysis on the Chinese Space Station Telescope(CSST).

关键词： large scale structure of universe dark energy cosmological parameters marked weighted correlation function

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Prediction of pathological complete response and prognosis in locally advanced rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2520-2530页

作者： yi-Jun Xu Dan Tao Song-Bing Qin Xiao-Yan Xu Kai-Wen Yang Zhong-Xu Xing Ju-ying Zhou Yang jiao Li-Li Wang Department of Radiation Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Radiation Oncology The Fourth Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina School of Radiation Medicine and Protection Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGROUND Colorectal cancer is currently the third most common malignant tumor and the second leading cause of cancer-related death *** chemoradiotherapy(nCRT)is standard for locally advanced rectal cancer(LARC).Except for pathological examination after resection,it is not known exactly whether LARC patients have achieved pathological complete response(pCR)before *** date,there are no clear clinical indicators that can predict the efficacy of nCRT and patient *** To investigate the indicators that can predict pCR and long-term outcomes following nCRT in patients with *** Clinical data of 128 LARC patients admitted to our hospital between September 2013 and November 2022 were retrospectively *** were categorized into pCR and non-pCR *** analysis(using the χ^(2) test or Fisher’s exact test)and logistic multivariate regression analysis were used to study clinical predictors affecting *** 5-year disease-free survival(DFS)and overall survival(OS)rates were calculated using Kaplan-Meier analysis,and differences in survival curves were assessed with the log-rank *** Univariate analysis showed that pretreatment carcinoembryonic antigen(CEA)level,lymphocyte-monocyte ratio(LMR),time interval between neoadjuvant therapy completion and total mesorectal excision,and tumor size were correlated with *** results showed that CEA≤5 ng/mL(P=0.039),LMR>2.73(P=0.023),and time interval>10 wk(P=0.039)were independent predictors for *** analysis demonstrated that patients in the pCR group had significantly higher 5-year DFS rates(94.7%vs 59.7%,P=0.002)and 5-year OS rates(95.8%vs 80.1%,P=0.019)compared to the non-pCR *** deposits(TDs)were significantly correlated with shorter DFS(P=0.002)and OS(P<0.001).CONCLUSION Pretreatment CEA,LMR,and time interval contribute to predicting nCRT efficacy in LARC *** pCR demonstrates longer DFS and *** correlate with poor pr

关键词： Locally advanced rectal cancer Neoadjuvant chemoradiotherapy Pathological complete response Carcinoembryonic antigen Inflammation-related markers Tumor deposit Prognosis

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Endoscopic polidocanol foam sclerobanding for the treatment of grade Ⅱ-Ⅲ internal hemorrhoids:A prospective,multi-center,randomized study

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World Journal of Gastroenterology 2024年第38期30卷 3326-3335页

作者： Chun-ying Qu Fei-Yu Zhang yi Zhang Ming-Ming Li zheng-Hong Li Mei-Hong Cai Lei-Ming Xu Feng Shen Wen Wang Wu-Lian Lin Feng-Yu Gao Hao Zhang Guang-Yu chen Department of Gastroenterology&Endoscopy Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Gastroenterology The 900th Hospital of the People’s Liberation Army Joint Service Support ForceFuzhou 350025Fujian ProvinceChina Department of Endoscopy Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014Shandong ProvinceChina Department of Endoscopy Baoshan People’s Hospital of Yunnan ProvinceBaoshan 678000Yunnan ProvinceChina Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

BACKGROUND Endoscopic rubber band ligation(ERBL)is a nonsurgical technique for the treatment of symptomatic internal hemorrhoids but is limited by recurrence and post-procedural *** To evaluate satisfaction,long-term recurrence,and post-procedural pain in managing internal hemorrhoids using a combination of polidocanol foam sclerotherapy and *** This was a prospective,multicenter,randomized study.A total of 195 consecutive patients diagnosed with grade II-III internal hemorrhoids were enrolled from four tertiary hospitals and randomly divided into a cap-assisted endoscopic polidocanol foam sclerobanding(EFSB)or an ERBL *** patients were followed-up for 12 ***-based severity and post-procedural pain were assessed using a hemorrhoid severity score(HSS)and a visual analog scale(VAS).Continuous variables were reported as medians and interquartile *** One hundred and ninety-five patients were enrolled,with 98 in the EFSB *** was lower in the EFSB group than in the ERBL group at 8 weeks[4.0(3.0-5.0)vs 5.0(4.0-6.0),P=0.003]and 12-month[2.0(1.0-3.0)vs 3.0(2.0-3.0),P<0.001]of *** prolapse recurrence rate was lower in the EFSB group at 12 months(11.2%vs 21.6%,P=0.038).Multiple linear regression analysis demonstrated that EFSB treatment[B=-0.915,95%confidence interval(CI):−1.301 to−0.530,P=0.001]and rubber band number(B=0.843,95%CI:0.595-1.092,P<0.001)were negatively and independently associated with the VAS score 24 hours *** median VAS was lower in the EFSB group than in the ERBL[2.0(1.0-3.0)vs 3.0(2.0-4.0),P<0.001].CONCLUSION Cap-assisted EFSB provided long-term satisfaction and effective relief from the recurrence of prolapse and pain 24 hours post-procedure.

关键词： Internal hemorrhoids Endoscopic therapy Polidocanol foam Sclerotherapy Rubber band ligation Sclerobanding

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全国统一电力市场演进过程下省间-省内市场出清及定价模型

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电工技术学报 2024年第7期39卷 2116-2131页

作者：陈熠王晗严正冯凯刘子杰电力传输与功率变换控制教育部重点实验室上海交通大学上海200240 上海非碳基能源转换与利用研究院上海交通大学上海200240 中国电力科学研究院有限公司南京210037

为了促进电力资源在省间的余缺互济和在全国范围内的优化配置,我国正有序推进电力市场改革,逐步实现省间-省内市场的耦合和全国统一市场的演进。根据省间-省内市场耦合程度的不同,该文将演进过程划分为三个阶段:分层阶段、松耦合阶段和... 详细信息

为了促进电力资源在省间的余缺互济和在全国范围内的优化配置,我国正有序推进电力市场改革,逐步实现省间-省内市场的耦合和全国统一市场的演进。根据省间-省内市场耦合程度的不同,该文将演进过程划分为三个阶段:分层阶段、松耦合阶段和紧耦合阶段。进一步考虑跨区、跨省以及省内输电的输电费回收问题,跨区直流输电线路与区域内交流输电线路按照传输电量收费,省内线路按照用户负荷用电量收费。构建了面向不同输电费收取方式的出清模型与定价机制,分层阶段采用顺序出清,松耦合阶段采用双层迭代出清,紧耦合阶段采用统一出清,定价机制均采用节点电价定价机制。最后,利用IEEE 39节点和118节点系统进行仿真计算,验证了出清模型和定价机制的有效性,并分析了输电费对出清和定价结果的影响。

关键词：省间-省内电力市场输电费出清模型定价模型松耦合阶段

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Potential application of Nardostachyos Radix et Rhizoma-Rhubarb for the treatment of diabetic kidney disease based on network pharmacology and cell culture experimental verification

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World Journal of Diabetes 2024年第3期15卷 530-551页

作者： Meng-ying Che Ling Yuan jiao Min Duo-Jie Xu Dou-Dou Lu Wen-Jing Liu Kai-Li Wang Yan-Yan Wang yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Endocrinology Yinchuan Hospital of Traditional Chinese MedicineYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic kidney disease(DKD)is one of the serious complications of diabetes mellitus,and the existing treatments cannot meet the needs of today's *** Chinese medicine has been validated for its efficacy in DKD after many years of clinical ***,the specific mechanism by which it works is still *** the molecular mechanism of the Nardostachyos Radix et Rhizoma-rhubarb drug pair(NRDP)for the treatment of DKD will provide a new way of thinking for the research and development of new *** To investigate the mechanism of the NRDP in DKD by network pharmacology combined with molecular docking,and then verify the initial findings by in vitro *** The Traditional Chinese Medicine Systems Pharmacology(TCMSP)database was used to screen active ingredient targets of *** for DKD were obtained based on the Genecards,OMIM,and TTD *** VENNY 2.1 database was used to obtain DKD and NRDP intersection targets and their Venn diagram,and Cytoscape 3.9.0 was used to build a"drug-component-target-disease"*** String database was used to construct protein interaction *** Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and Gene Ontology analysis were performed based on the DAVID *** selecting the targets and the active ingredients,Autodock software was used to perform molecular *** experimental validation using renal tubular epithelial cells(TCMK-1),we used the Cell Counting Kit-8 assay to detect the effect of NRDP on cell viability,with glucose solution used to mimic a hyperglycemic *** cytometry was used to detect the cell cycle progression and *** blot was used to detect the protein expression of STAT3,p-STAT3,BAX,BCL-2,Caspase9,and *** A total of 10 active ingredients and 85 targets with 111 disease-related signaling pathways were obtained for *** analysis of KEGG pathways was performed to determ

关键词： Nardostachyos Radix et Rhizoma-rhubarb Diabetic kidney disease Molecular docking Network pharmacology Experimental validation

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Chirality discerning and monitoring in a metal cladding optofluidic chip

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Chinese Optics Letters 2024年第8期22卷 52-57页

作者： Qiheng Wei Xueqian Wang Hongrui Shan yi Lai He Li Hailang Dai Xianfeng chen State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Head and Neck Surgery and Department of Traditional Chinese Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

The metabolic process of chiral drugs plays a significant role in clinics and in research on ***,we experimentally demonstrate by all-optical means that the chiral molecules can be quickly discriminated and monitored with the ultrahighorder modes excited in a metal cladding optofluidic chip,achieving over 5 times sensitivity with a low-dosage *** show that the varying concentration of the chiral drugs can be monitored both in cell and animal experiments,presenting a significant difference between chiral enantiomers at the optimal function time and the effect of the *** our knowledge,this approach provides a new way to achieve important chiral discrimination for the pharmacokinetics and the pharmacodynamics and may present opportunities in indicating the health status of humans.

关键词： chiral detection ultrahigh-order guided modes metal cladding optofluidic chip high sensitivity circularly polarized light

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Gamma/Hadron Separation Method for the HADAR Experiment

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Research in Astronomy and Astrophysics 2024年第3期24卷 70-74页

作者： Yang-Zhao Ren Tian-Lu chen You-Liang Feng Dan-Zeng Luo-Bu yi-Qing Guo cheng Liu Qi Gao Mao-Yuan Liu Xiang-Li Qian Ya-Ping Wang Zi-Hao Zhang Xin-Long Li Qing-Yuan Hou Heng-jiao Liu Qing-Qian Zhou Shan-Jie Shu The Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences School of Intelligent Engineering Shandong Management University

Ground-based arrays of imaging atmospheric Cherenkov telescopes(IACTs)are the most sensitiveγ-ray detectors for energies of approximately 100 Ge V and *** such IACT is the High Altitude Detection of Astronomical Radiation(HADAR)experiment,which uses a large aperture refractive water lens system to capture atmospheric Cherenkov photons(i.e.,the imaging atmospheric Cherenkov technique).The telescope array has a low threshold energy and large field of view,and can continuously scan the area of the sky being observed,which is conducive to monitoring and promptly responding to transient *** process ofγ-hadron separation is essential in very-high-energy(>30 Ge V)γ-ray astronomy and is a key factor for the successful utilization of *** this study,Monte Carlo simulations were carried out to model the response of cosmic rays within the HADAR *** analyzing the Hillas parameters and the distance between the event core and the telescope,the distinction between air showers initiated byγ-rays and those initiated by cosmic rays was ***,a Quality Factor was introduced to assess the telescope’s ability to suppress the background and to provide a more effective characterization of its performance.

关键词： astroparticle physics-telescopes-methods data analysis

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Achieving an ion-homogenizing and corrosion-resisting interface through nitro-coordination chemistry for stable zinc metal anodes

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Journal of Energy Chemistry 2024年第7期94卷 10-18页

作者： Jizhen Wang Long jiao Qiaoyun Liu Wei Xin Yechen Lei Tian Zhang Leixin Yang Dengkun Shu Shuo Yang Kaihua Li chenyang Li Chao yi Hongyuan Bai Yuchao Ma Huan Li Wenjun Zhang Bowen'cheng schoolof Light Industry Science and Engineering State Key Laboratory of Biobased Fiber Manufacturing TechnologyTianjin Key Laboratory of Pulp and PaperChina Light Industry Key Laboratory of Papermaking and BiorefineryTianjin University of Science&TechnologyTianjin 300457China Department of Materials Science and Engineering &Center of Super-Diamond and Advanced FilmsCity University of Hong Kong83 Tat Chee AvenueHong Kong 999077China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia

Suppression of uncontrollable dendrite growth and water-induced side reactions of Zn metal anodes is crucial for achieving long-lasting cycling stability and facilitating the practical implementations of aqueous Zn-metal *** address these challenges,we report in this study a functional nitro-cellulose interfacial layer(NCIL)on the surface of Zn anodes enlightened by a nitro-coordination chemistry *** NCIL exhibits strong zincophilicity and superior coordination capability with Zn^(2+)due to the highly electronegative and highly nucleophilic nature of the nitro functional *** characteristic facilitates a rapid Zn-ion desolvation process and homogeneous Zn plating,effectively preventing H_(2) evolution and dendrite ***,the negatively charged surface of NCIL acts as a shield,repelling SO_(4)^(2-)anions and inhibiting corrosive reactions on the Zn ***,reversible and stable Zn plating/stripping is achieved for over 5100 h at a current density of 1 mA cm^(-2),which is nearly 30 times longer than that of bare Zn ***,the Zn/V_(2)O_(5) full cells with the functional interface layer deliver a high-capacity retention of 80.3%for over 10,000 cycles at 5 A g^(-1).This research offers valuable insights for the rational development of advanced protective interface layers in order to achieve ultra-long-lifeZnmetal batteries.

关键词： Zinc metal anode Nitro-cellulose interfacial layer Coordination capability Dendrite-free deposition Long-term cycling

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避免近期偏好的自学习掩码分区增量学习

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软件学报 2024年第7期35卷 3428-3453页

作者：姚红革邬子逸马姣姣石俊程嗣怡陈游喻钧姜虹西安工业大学计算机科学与工程学院陕西西安710021 空军工程大学航空工程学院陕西西安710051

遗忘是人工神经网络在增量学习中的最大问题,被称为“灾难性遗忘”.而人类可以持续地获取新知识,并能保存大部分经常用到的旧知识.人类的这种能持续“增量学习”而很少遗忘是与人脑具有分区学习结构和记忆回放能力相关的.为模拟人脑的... 详细信息

遗忘是人工神经网络在增量学习中的最大问题,被称为“灾难性遗忘”.而人类可以持续地获取新知识,并能保存大部分经常用到的旧知识.人类的这种能持续“增量学习”而很少遗忘是与人脑具有分区学习结构和记忆回放能力相关的.为模拟人脑的这种结构和能力,提出一种“避免近期偏好的自学习掩码分区增量学习方法”简称ASPIL.它包含“区域隔离”和“区域集成”两阶段,二者交替迭代实现持续的增量学习.首先,提出“BN稀疏区域隔离”方法,将新的学习过程与现有知识隔离,避免干扰现有知识;对于“区域集成”,提出自学习掩码(SLM)和双分支融合(GBF)方法.其中SLM准确提取新知识,并提高网络对新知识的适应性,而GBF将新旧知识融合,以达到建立统一的、高精度的认知的目的;训练时,为确保进一步兼顾旧知识,避免对新知识的偏好,提出间隔损失正则项来避免“近期偏好”问题.为评估以上所提出方法的效用,在增量学习标准数据集CIFAR-100和miniImageNet上系统地进行消融实验,并与最新的一系列知名方法进行比较.实验结果表明,所提方法提高了人工神经网络的记忆能力,与最新知名方法相比识别率平均提升5.27%以上.

关键词：增量学习灾难性遗忘持续学习自学习掩码近期偏好区域隔离

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Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma

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Chinese Chemical Letters 2024年第5期35卷 344-350页

作者： Ke Gong Jinghan Liao Jiangtao Lin Quan Wang Zhihua Wu Liting Wang Jiali Zhang yi Dong Yourong Duan Jianhua chen State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200032China Department of Ultrasound Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Department of Oncology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The platinum-based chemotherapy is a routine strategy for the treatment of ovarian cancer,while it is prone to chemoresistance in clinical,which hinders the ***,it is urgently needed to elucidate the underlying mechanism of drug resistance and form the appropriate *** sequencing results showed that cisplatin(DDP)resistant ovarian cancer overexpressed BTB and CNC homology 1(BACH1),and up-regulated the“don’t eat me”signal *** identified that hemin,a BACH1 inhibitor,could effectively down-regulate BACH1 and simultaneously inhibit ***,hemin has a synergistic effect with *** designed a pH-responsive nanoparticle(H/D@FA-CaP-NPs)in which folic acid(FA)ensured targeting of ovarian cancer cells,while hemin inhibited BACH1 as well as down-regulated CD47,achieving the promotion of apoptosis of tumor cells and inducing phagocytosis of tumors by ***,hemin has a synergistic effect with DDP to promote apoptosis of tumor ***,hemin and DDP was encapsulated within hydrophobic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine(DSPE)to form a tight core,and hydrophilic polyethylene glycol 2000(PEG2000)and calcium phosphate(CaP)formed the outside shell,and FA was modified on the surface of *** terms of function,(a)FA enhanced the active targeting of nanoparticles to tumors;(b)NPs targeted mitochondria to induce reactive oxygen species(ROS)production;(c)hemin encapsulated in nanoparticles could specifically target BACH1,thereby down regulating CD47;(d)hemin had a synergistic effect with DDP,thus augmenting the ***,mitochondria-targeted nanoparticles H/D@FA-CaP-NPs promoted tumor apoptosis and mobilized phagocytosis to treat tumor,providing a novel scheme for clinical treatment of cisplatin-resistant ovarian carcinoma.

关键词： Cisplatin-resistant Hemin BACH1 CD47 Phagocytosis ROS Synergistic effect

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