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Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota

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World Journal of Gastroenterology 2025年第7期31卷 110-129页

作者： yi-tong Qiu Xin-yi Luo Ya-Feng Deng Xue Zheng Jian-Guo Qiu Lin-Sheng Zhang Xiao-Qi Huang Xue-Bao Zheng Hai-Yang Huang School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 525000Guangdong ProvinceChina Druggability Research Team Dongguan Institute of Guangzhou University of Chinese MedicineDongguan 523808Guangdong ProvinceChina Institute of Traditional Chinese Medicine Dongguan Hospital of Traditional Chinese MedicineDongguan 523000Guangdong ProvinceChina

BACKGROUND Modified Pulsatilla decoction(PD),a PD with licorice and ejiao,is a classic Traditional Chinese Medicine formula with significant efficacy in treating intestinal mucositis(IM)induced by tumor ***,its specific molecular and biological mechanisms remain *** To investigate the therapeutic effect and mechanism of modified PD in *** This study used an IM mouse model established using 5-fluorouracil injections to investigate the effects of the modified PD(3,6,and 12 g/kg)in *** primary chemical components of the modified PD were identified using liquid chromatography-mass *** weight loss,diarrhea scores,intestinal length,histopathological scores,and inflammatory cytokine levels were measured to evaluate the effects of the modified PD in *** on the TLR4/MyD88/NF-κB pathway were evaluated using western blot *** intestinal microbiota was characterized using Illumina NovaSeq *** The results showed that modified PD significantly improved weight loss and diarrhea and shortened the intestines in IM ***,modified PD suppressed the TLR4/MyD88/NF-κB pathway and downregulated the expression of reactive oxygen species,lipopolysaccharides,and pro-inflammatory cytokines(IL-1β,TNF-α,IFN-γ,IL-6,IL-8,and IL-17),while increasing the expression of the anti-inflammatory cytokine ***,modified PD protected the intestinal mucosal barrier by increasing the expression of tight junction proteins(occludin-1,claudin-1,and ZO-1)and ***,16S rDNA sequencing revealed that modified PD improved intestinal *** Our research offers new insights into the potential mechanism of modified PD in alleviating IM and provides experimental evidence supporting its pharmaceutical application in clinical IM treatment.

关键词： Modified Pulsatilla decoction Intestinal mucositis Oxidative stress Gut microbiota,TLR4/MyD88/NF-κB pathway Inflammatory response

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北京因地制宜发展新质生产力的观察与思考

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中国科技论坛 2025年第1期 1-8页

作者：伊彤北京市科学技术研究院创新发展战略研究所北京100089

当前,发展新质生产力是新发展阶段推进高质量发展的需要,也是中国经济抢抓机遇、占领产业制高点的必然要求。各地发展新质生产力应立足地方实际、直面地方问题,以实现汇聚地方力量、激发地方活力的效果。本文在对因地制宜发展新质生产... 详细信息

当前,发展新质生产力是新发展阶段推进高质量发展的需要,也是中国经济抢抓机遇、占领产业制高点的必然要求。各地发展新质生产力应立足地方实际、直面地方问题,以实现汇聚地方力量、激发地方活力的效果。本文在对因地制宜发展新质生产力进行理论研究的基础上,重点围绕北京市近年来因地制宜推动新质生产力发展的做法进行归纳阐述,并从提升战略科技力量的协同攻关能力、促进科技创新与产业创新的深度融合、优化区域创新空间布局、完善区域创新政策体系等方面提出思考与建议。

关键词：因地制宜新质生产力北京

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纹状体D2型中等多棘神经元Erk信号通路:运动改善帕金森病的重要途径

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生物化学与生物物理进展 2025年第1期52卷 61-71页

作者：高博赖一宁葛一彤陈巍河北师范大学体育学院石家庄050024 河北师范大学河北省人体运动生物信息测评重点实验室石家庄050024

帕金森病(PD)是一种神经退行性疾病,其核心特征是黑质致密部多巴胺能神经元的退行性凋亡,导致纹状体多巴胺(DA)水平的持续下降,主要表现为静止性震颤、肌强直和运动迟缓等运动功能障碍。纹状体作为皮层下调控躯体运动的重要中枢,其功能... 详细信息

帕金森病(PD)是一种神经退行性疾病,其核心特征是黑质致密部多巴胺能神经元的退行性凋亡,导致纹状体多巴胺(DA)水平的持续下降,主要表现为静止性震颤、肌强直和运动迟缓等运动功能障碍。纹状体作为皮层下调控躯体运动的重要中枢,其功能受多条信号通路的精细调控。中等多棘神经元(MSNs)是纹状体内的主要神经元,其中表达多巴胺2型受体的MSNs(D2-MSNs)的功能异常与PD的运动障碍密切相关。PD患者中,纹状体细胞外信号调节激酶/丝裂原活化蛋白激酶(Erk/MAPK)信号通路活性发生改变,进而影响D2-MSNs的功能活动,引发基底神经节运动功能调节障碍。运动干预作为PD的潜在治疗策略,已被证明可以通过抑制Erk/MAPK信号通路调控D2-MSNs功能活动。然而,Erk/MAPK信号通路在D2-MSNs运动依赖可塑性中的作用,以及对PD运动功能障碍改善的具体调控机制仍不明确。本文综述了纹状体Erk/MAPK信号通路在PD运动防治中的作用及其生物学机制,旨在为PD治疗新靶点的发现提供科学依据。

关键词：纹状体运动控制 Erk/MAPK通路帕金森病

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虾青素对饲料组胺胁迫下美洲鳗鲡幼鱼肠道健康的影响

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水生生物学报 2025年第2期49卷 85-94页

作者：郭怡彤彭志闰徐一闯翟少伟集美大学水产学院鳗鲡现代产业技术教育部工程研究中心厦门361021

为研究虾青素对饲料组胺胁迫下美洲鳗鲡幼鱼(Anguilla rostrata)肠道健康的影响,以初始质量为(25.01±0.17)g的美洲鳗鲡为研究对象,随机分为对照组(Control组),高组胺饲料组(H组,组胺实测水平为661.86 mg/kg)及其基础上添加4 mg/kg(H+As... 详细信息

为研究虾青素对饲料组胺胁迫下美洲鳗鲡幼鱼(Anguilla rostrata)肠道健康的影响,以初始质量为(25.01±0.17)g的美洲鳗鲡为研究对象,随机分为对照组(Control组),高组胺饲料组(H组,组胺实测水平为661.86 mg/kg)及其基础上添加4 mg/kg(H+Ast 4组)、8 mg/kg(H+Ast 8组)虾青素的实验组。在养殖10周后,测定血清二胺氧化酶活性和D-乳酸水平、肠道抗氧化能力、肠道组织形态及炎症因子基因表达量等指标。添加4和8 mg/kg虾青素均可降低投喂高组胺饲料美洲鳗鲡幼鱼的血清二胺氧化酶活性和D-乳酸水平(P<0.05);降低肠道丙二醛水平(P<0.05),提高肠道超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性(P<0.05);增加肠道绒毛长度和肌层厚度(P<0.05);降低肠道组胺H1受体、NF-κB、IL-6、TNF-α基因表达量(P<0.05),提高IFN-γ基因表达量(P<0.05)。结果表明,添加4 mg/kg虾青素即可缓解饲料组胺对美洲鳗鲡幼鱼肠道健康的损害,为缓解鳗鲡饲料源胁迫提供技术参考。

关键词：虾青素饲料组胺肠道健康美洲鳗鲡

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Hollow cerium nanoparticles synthesized by one-step method for multienzyme activity to reduce colitis in mice

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World Journal of Gastroenterology 2025年第5期31卷 94-104页

作者： Lin Mi Kai Zhang Jian-Xia Ma Jian-Feng Yao yi-Li tong Zhi-Jun Bao Department of General Medicine Huadong HospitalFudan UniversityShanghai 200040China Department of Gastroenterology Huadong HospitalFudan UniversityShanghai 200040China

BACKGROUND Inflammatory bowel disease(IBD)is a common chronic intestinal inflammatory *** oxidative stress is a treatment target for *** oxide(CeO2)nanomaterials as nanozymes with antioxidant activity are potential drugs for the treatment of *** To synthesize hollow cerium(H-CeO2)nanoparticles by one-step method and to validate the therapeutic efficacy of H-CeO2 in *** H-CeO2 was synthesized by one-step method and examined its characterization and nanoenzymatic ***,we constructed dextran sulfate so-dium(DSS)-induced colitis in mice to observe the effects of H-CeO2 on colonic *** effects of H-CeO2 on colon inflammation and reactive oxygen species(ROS)levels in IBD mice were detected by hematoxylin and eosin staining and dichlorofluorescein diacetate staining,***,the biological sa-fety of H-CeO2 on mice was evaluated by hematoxylin and eosin staining,blood routine,and blood *** H-CeO2 nanoparticles prepared by the one-step method were uniform,monodi-sperse and hollow.H-CeO2 had a good ability to scavenge ROS,∙OH and∙OOH.H-CeO2 reduced DSS-induced decreases in body weight and colon length,colonic epithelial damage,inflammatory infiltration,and ROS accumulation.H-CeO2 administration reduced the disease activity index of DSS-induced animals from about 8 to 5.H-CeO2 had no significant effect on body weight,total platelet count,hemoglobin,white blood cell,and red blood cell counts in healthy *** significant damage to major organs was observed in healthy mice following H-CeO2 *** The one-step synthesis of H-CeO2 nanomaterials had good antioxidant activity,biosafety,and inhibited deve-lopment of DSS-induced IBD in mice by scavenging ROS.

关键词： Inflammatory bowel disease Nanozymes Hollow cerium nanoparticles One-step method Cerium oxide biosafety

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Synthesis, Structure and Geometrical Calculation of a Novel Co-crystal of {[4-Bromo-2-(benzimidazol-2-yl)phenolato][2-(1-butylbenzimidazol-2-yl)phenolato]zinc(Ⅱ)] and Bis[μ-2-(1-butylbenzimidazol-2-yl)phenolato]-1κN^3:2κO;1κO:2κN^3-bis{[2-(1-butylbe

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Chinese Journal of Structural Chemistry 2007年第2期26卷 143-148页

作者： tong yi-Ping Department of Chemistry Hanshan Normal University Chaozhou 521041 China

The title compound has been synthesized and characterized crystallographicaUy. It is a co-crystal consisting of two different neutral zinc（H） complexes with Hbpbm （Hbpbm = 4- bromo-2-（benzimidazol-2-yl）phenol） and Hnpbm （Hnpbm = 2-（1-butylbenzimidazol-2-yl）phenol）. One is a monomeric mixed-ligand complex of [Zn（bpbm）（npbm）] 1 and the other a dimer of [Zn2（npbm）4] 2 with their ratio of 2：1. Thus the overall formula for the title compound is 21.2. Adjacent 1 and 2 are connected to each other by intermolecular hydrogen bonding interactions in the lattice. The crystal data： monoclinic, space group P21/c, a = 15.0141（12）, b = 20.9941（17）, c = 18.4686（15） A, β = 97.445（2）°, V = 5772.4（8） A^3, Mr= 2429.68, Z = 2, Dc = 1.398 g/cm^3,μ = 1.579 -1 mm , F（000） = 2504, R = 0.0637 and wR = 0.1771 for 6464 observed reflections （I 〉 2σ（I））. The geometrical structure for 1 has also been theoretically optimized and compared with the experimental one.

关键词： zinc complex co-crystal structure 4-bromo-2-(1-butylbenzimidazol-2-yl)phenol 2-(1-butylbenzimidazol-2-yl)phenol

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Data-driven glass-forming ability criterion for bulk amorphous metals with data augmentation

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Journal of Materials Science & Technology 2022年第26期121卷 99-104页

作者： Jie Xiong tong-yi Zhang School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518000China Hong Kong University of Science and Technology(Guangzhou) Guangzhou 511400China Material Genome Institute Shanghai UniversityShanghai 200444China

A data augmentation technique is employed in the current work on a training dataset of 610 bulk metallic glasses(BMGs),which are randomly selected from 762 collected *** ensemble machine learning(ML)model is developed on augmented training dataset and tested by the rest 152 *** result shows that ML model has the ability to predict the maximal diameter Dmaxof BMGs more accurate than all reported ML *** addition,the novel ML model gives the glass forming ability(GFA)rules:average atomic radius ranging from 140 pm to 165 pm,the value of TT/(T-T)(T-T)being higher than 2.5,the entropy of mixing being higher than 10 J/K/mol,and the enthalpy of mixing ranging from-32 k J/mol to-26 k J/*** model is interpretative,thereby deepening the understanding of GFA.

关键词： Materials informatics Glass-forming ability Data augmentation Model interpretation Meta-ensemble model

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The Generalized L_p-Mixed Affine Surface Area

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Acta Mathematica Sinica,English Series 2015年第11期31卷 1775-1788页

作者： tong yi MA College of Mathematics and Statistics Hexi University

Abstract In this article, we put forward the concept of the （i,j）-type Lp-mixed alpine surface area, such that the notion of Lp-affine surface area which be shown by Lutwak is its special cases. Furthermore, applying this concept, the Minkowski inequality for the （i, -p）-type Lp-mixed affine surface area and the extensions of the well-known Lp-Petty atone projection inequality are established, respectively. Besides, we give an affirmative answer for the generalized Lp-Winterniz monotonicity problem.

关键词： Convex body star body i-th Lp-mixed curvature function i-th Lp-mixed curvature im-age (i j)-type Lp-mixed affine surface area

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ITO thin films prepared by electron beam evaporation with End-Hall ion source assisted without heating to the substrate

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光学精密工程 2005年第4期13卷 397-402页

作者： GAO Jin-song XU ying WANG Xiao-yi WANG tong-tong Optical Technology and Research Center Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun 130022 China

ITO （indium oxide doped with tin） thin films were deposited on glass substrates by using ITO pellet with a composition of w（In2O3）=90% and w（SnO2）=10% by electron beam evaporated with End-Hall ion source assisted without extra heating. The rate of deposition and flow rate of oxygen were measured and changed to obtain the best properties of ITO thin films. Furthermore, the post annealing process was done in vacuum at different annealing temperatures for 2 h and at 400℃ for different keeping time, respectively. The relation between optical, electrical properties and structure was discussed in detail.

关键词： ITO 薄膜电子束离子源

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Grain boundary segregation and relaxation in nano-grained polycrystalline alloys

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Science China(Physics,Mechanics & Astronomy) 2021年第2期64卷 72-90页

作者： tong-yi Zhang ying-Xin Gao Sheng Sun Materials Genome Institute Shanghai UniversityShanghai200444China

The present study carries out systematic thermodynamics analysis of Grain Boundary(GB)segregation and relaxation in NanoGrained(NG)polycrystalline *** segregation and relaxation is an internal process towards thermodynamic equilibrium,which occurs naturally in NG alloys without any applied loads,causes deformation and generates internal *** analysis comprehensively investigates the multiple coupling effects among chemical concentrations and mechanical stresses in GBs and grains.A hybrid approach of eigenstress and eigenstrain is developed herein to solve the multiple coupling *** analysis results indicate that the GB stress and grain stress induced by GB segregation and relaxation can be extremely high in NG alloys,reaching the GPa level,which play an important role in the thermal stability of NG alloys,especially via the coupling terms between stress and *** present theoretic analysis proposes a novel criterion of thermal stability for NG alloys,which is determined by the difference in molar free energy between a NG alloy and its reference single crystal with the same nominal chemical *** the difference at a temperature is negative or zero,the NG alloy is thermal stable at that temperature,otherwise unstable.

关键词： nano-grained alloys thermal stability grain boundary segregation eigenstress eigenstrain

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