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石羊河上游径流量与气象要素关联性分析

科学技术与工程 2024年第13期24卷 5278-5285页

作者：徐亦凡董增川倪晓宽邵逸卿孟金玉李瑶河海大学水文水资源学院南京210098

气象因子是驱动径流演变的重要因素,运用交叉小波方法分析了石羊河上游4条典型支流的径流量与气象要素之间的共振周期规律,揭示了不同时域、频域上相关性的程度变化和异常情况,对现有相关性研究进行了补充。结果表明:西大河水库站与大...

气象因子是驱动径流演变的重要因素,运用交叉小波方法分析了石羊河上游4条典型支流的径流量与气象要素之间的共振周期规律,揭示了不同时域、频域上相关性的程度变化和异常情况,对现有相关性研究进行了补充。结果表明:西大河水库站与大靖峡水库站径流量总体呈上升趋势,而南营水库站与古浪站呈下降趋势,径流量与降水量的周期规律及相关性最显著,其次是最高气温,最低气温最差,共振周期范围为2~8 a。通过与现有成果的对比分析,表明该方法对探究气象因子突变性、水文气象要素相关性及其时频变化有重要的指导意义,石羊河流域在针对性补水时应优先考虑从降水环节出发,实施人工增雨作业。

关键词：石羊河流域周期性交叉小波变换相关性

Novel sutureless transplantation for primary pterygium associated with cysts

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 280-283页

作者： yi shao, Jing-Lin yi Department of Ophthalmology the First Affiliated Hospital of Nanchang University Nanchang 330006 Jiangxi Province China Department of Science education the First Affiliated Hospital of Nanchang University Nanchang 330006 Jiangxi Province China Department of Endocrinology the Third Hospital of Nanchang the Affiliated Nanchang Hospital of Southern Medical University Nanchang 330009 Jiangxi Province China Laboratory of Neurobiology University of California·Irvine Irvine California 92697 USA

AIM: To evaluate the efficacy and safety of a novel sutureless AMT (amniotic membrane transplantation) or CAT (conjunctivolimbal autograft transplantation) using fibrin glue for reconstructing corneoconjunctival surfaces for primary pterygium associated with cysts. METHODS: A prospective descriptive study was made of the period 1 January 2006-1 May 2009. Nine patients with primary pterygium associated with cysts underwent pterygium and cyst excision followed by sutureless AMT or CAT using fibrin glue. RESULTS: During a mean follow-up of 8.00 +/- 0.67 months, all eyes maintained a smooth and stable corneal epithelial surface without recurrent erosion or persistent epithelial defect. The limbal donor site showed the presence of mild depressions without the formation of pseudopterygium. All eyes have good tear secretion function, tear film stability and ocular motility. CONCLUSION: Sutureless transplantation using fibrin glue is safe and effective for restoring a stable corneoconjunctival epithelium in primary pterygium associated with cysts.

关键词： sutureless pterygium cyst AMT CAT

重楼皂苷Ⅶ调控ROS诱导膀胱癌细胞凋亡和自噬

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中国药理学通报 2024年第4期40卷 799-800页

作者：杨凡邵轶群贾默然聂伟东王田田彭煜上海中医药大学附属岳阳中西医结合医院上海200080

膀胱癌(bladder cancer,BC)是世界上最常见的一种泌尿生殖系统恶性肿瘤^([1])。目前,BC的治疗包括根治性膀胱切除术、放疗和化疗。然而,约有5%的患者在诊断时有远处转移。晚期或转移性BC的治愈效果差、预后差,接受一线铂类化疗的患者1...

膀胱癌(bladder cancer,BC)是世界上最常见的一种泌尿生殖系统恶性肿瘤^([1])。目前,BC的治疗包括根治性膀胱切除术、放疗和化疗。然而,约有5%的患者在诊断时有远处转移。晚期或转移性BC的治愈效果差、预后差,接受一线铂类化疗的患者1年总生存率仅为36%^([2])。因此,迫切需要有效抑制BC而又有较低毒副作用的药物。

关键词：重楼皂苷Ⅶ 活性氧膀胱癌自噬

Evaluation of novel decellularizing corneal stroma for cornea tissue engineering applications

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 415-418页

作者： yi shao, Lu Yang Department of Ophthalmology the First Affiliated Hospital of Nanchang University Nanchang 330006 Jiangxi Province China Department of Endocrinology the Third Hospital of Nanchang the Affiliated Nanchang Hospital of Southern Medical University Nanchang 330009 Jiangxi Province China Department of Physiology Endocrinology Institute of Oklahoma University Oklahoma City OK 73104-5020 USA Department of Ophthalmology the First Affiliated Hospital of Nanhua University Hengyang 421001 Hunan Province China

AIM:To develop a new decellularization method depended upon the natural corneal structure and to harvest an ideal scaffold with good biocompatibilities for corneal ***:The acellular cornea matrix (ACM) were prepared from de-epithelium fresh porcine corneas (DFPCs) by incubation with 100% fresh human sera and additional electrophoresis at 4℃. Human corneal epithelial cells (HCEs) were used for the cytotoxicity tests of ACM. ACM were implanted into the Enhanced Green Fluorecence Protein (eGFP) transgenic mouse anterior chamber for evaluation of ***:HE and GSIB4 results showed fresh porcine cornea matrix with 100% human sera and electrophoresis could entirely decellularize stromal cell without reducing its transparency. ACM has no cytotoxic effect ex vivo. Animal test showed there was no rejection for one month after ***:These results provide a decellularizing approach for the study of corneal tissue engineering and had the broader implications for the field of biological tissue engineering in other engineered organ or tissue matrix.

关键词： cornea human sera electrophoresis tissue engineering decellularization biocompatibility

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OCT图像多教师知识蒸馏超分辨率重建

光电工程 2024年第7期51卷 95-106页

作者：陈明惠芦焱琦杨文逸王援柱邵怡上海理工大学健康科学与工程学院上海介入医疗器械工程技术研究中心教育部医学光学工程中心上海200093 上海瑞柯恩激光技术有限公司上海200120 上海市第一人民医院上海200080

光学相干断层成像(OCT)广泛应用于眼科诊断与辅助治疗,但其成像质量不可避免地受到散斑噪声和运动伪影影响。本文提出了一种针对OCT超分辨率任务的多教师知识蒸馏网络MK-OCT,使用不同优势的教师网络训练平衡、轻量级和高效的学生网络。M...

光学相干断层成像(OCT)广泛应用于眼科诊断与辅助治疗,但其成像质量不可避免地受到散斑噪声和运动伪影影响。本文提出了一种针对OCT超分辨率任务的多教师知识蒸馏网络MK-OCT,使用不同优势的教师网络训练平衡、轻量级和高效的学生网络。MK-OCT中高效通道蒸馏方法ECD的使用也使得模型能够更好地保留视网膜图像的纹理信息,满足临床需要。实验结果表明,与经典超分辨率网络相比,本文所提模型在重建精度和感知质量两个方面均表现优异,模型尺寸更小,计算量更少。

关键词：医学图像光学相干断层图像超分辨率知识蒸馏对比学习

The expression and distribution of α-Gal gene in various species ocular surface tissue

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International Journal of Ophthalmology(English edition) 2012年第5期5卷 543-548页

作者： yi shao, Qiu-Ping Liu Department of Ophthalmology the First Affiliated Hospital of Nanchang University Nanchang 330006 Jiangxi Province China Department of Endocrinology the Third Hospital of Nanchang the Affiliated Nanchang Hospital of Southern Medical University Nanchang 330009 Jiangxi Province China Cullen Eye Institute of Baylor Universit Houston Texas 77030 USA

AIM: To examine the α-Gal gene expression and distribution in the different species/genus and developing phase animal ocular surface ***: α-Gal binding assay were carried out on various animal eye sections. Photograph, slit-lamp observation on various eye showed normal corneal ***: A strong α-Gal expression in invertebrates and some vertebrates ocular tissue, but no α-Gal binding in birds, fish and mammal. α-Gal expression change in the development of mice ocular surface tissue (except sclera) and display genus dependency in the different murine ocular surface ***: This study identified specific α-Gal epitopes binding area in the ocular surface of several species and may solve the problem that naive ocular surface may be used as natural α-Gal gene knockout model/high risk immunologic rejection model or ocular surface scaffold material.

关键词： α-Gal xenotransplantation animal ocular surface tissue engineering

Optimal Reinsurance and Investment Strategy with Delay in Heston’s SV Model

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Journal of the Operations Research Society of China 2021年第2期9卷 245-271页

作者： Chun-Xiang A Ai-Lin Gu yi shao School of Mathematics and Statistics Zhaoqing UniversityZhaoqing 526061GuangdongChina School of Applied Mathematics Guangdong University of TechnologyGuangzhou 510520China

In this paper,we consider an optimal investment and proportional reinsurance problem with delay,in which the insurer’s surplus process is described by a jump-diffusion *** insurer can buy proportional reinsurance to transfer part of the insurance claims *** addition to reinsurance,she also can invests her surplus in a financial market,which is consisted of a risk-free asset and a risky asset described by Heston’s stochastic volatility(SV)*** the performance-related capital flow,the insurer’s wealth process is modeled by a stochastic differential delay *** insurer’s target is to find the optimal investment and proportional reinsurance strategy to maximize the expected exponential utility of combined terminal *** explicitly derive the optimal strategy and the value ***,we provide some numerical examples to illustrate our results.

关键词： Proportional reinsurance Stochastic differential delay equation(SDDE) Heston’s stochastic volatility(SV)model Hamilton–Jacobi–Bellman(HJB)equation

AIDS Research and Its Role in China's AIDS Prevention and Control Policies

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Virologica Sinica 2007年第6期22卷 421-425页

作者： yi-ming shao State Key Laboratory for Infectious Diseases Prevention and Control National Center for AIDS / STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China

By the end of 2005,the estimated number of HIV infected people in China was 650,000. The seriousness of the epidemic calls for effective control measures to tackle the problems in order to avoid the tragedy in Africa from happening in China. "Prevention First" is the cornerstone of the country's health policy. On 2003 World AIDS Day,Premier Jiabao Wen announced a new national AIDS control policy,"Four Frees and One Care". This policy clearly shows that the Chinese government has once again taken full responsibility to solve public health problems and has profound impact far beyond the AIDS field. In early 2006,the central government put scientific and technology innovation as a national priority and set the target to build an innovative China by year 2020. Since then,the government has been increasing investment in science and technology with major emphasis on both infectious diseases control and new drug research and development. For the first time,development of 100 new drugs and control of major infectious diseases (AIDS,HBV,TB and other emerging infectious diseases) have been selected as national key scientific projects. China's best minds in related fields will be pooled to work together in order to remove the technical barriers blocking efficient control of the major infectious disease in China. Knowledge on molecular epidemiology,immunology,pathogenesis,HAART,as well as HIVDR strains will certainly provide urgently needed scientific information for China's AIDS control program. Only evidence-based strategy from good research will provide long-term effective control of AIDS.

关键词： AIDS Prevention Control

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中小学生课业负担实证研究

河北大学成人教育学院学报 2024年第2期26卷 114-124页

作者：陈星宇王少义吉林外国语大学教育学院吉林长春130117

当前,我国中小学生课业负担过重的问题广受关注。结合CEPS (2014-2015),2022年课业负担数据以及2014年课业负担数据进行统计得出:第一,因家庭教育投资倾向而存在课业负担的显著差异,故需依据家庭教育投资倾向分类讨论减负效果;第二,2014...

当前,我国中小学生课业负担过重的问题广受关注。结合CEPS (2014-2015),2022年课业负担数据以及2014年课业负担数据进行统计得出:第一,因家庭教育投资倾向而存在课业负担的显著差异,故需依据家庭教育投资倾向分类讨论减负效果;第二,2014年3至9年级的课后作业时间均显著短于《中小学学生近视眼防控方案》标准,而2022年3至9年级(除8年级外)所有学生的课后作业时间均显著长于《中小学学生近视眼防控方案》标准;第三,与2014年相比,2022年3至9年级大部分学生课后作业时间显著增加,部分群体作业后劳累程度显著增加。这需要精确定位目标群体,分类讨论减负对策;课内课外两手抓,减少学生课后作业时间;首要关注3年级“提分增负”现象,降低3年级课业负担。

关键词：义务教育课业负担减负