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Influence of the Acoustic Liner in Large Eddy Simulation of Longitudinal Thermoacoustic Instability in a Model Annular Combustor

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Journal of Thermal Science 2024年第2期33卷 710-724页

作者： MENG Sheng ZHANG Man gao yi AECC Commercial Aircraft Engine Co. Ltd.Shanghai200241China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China

Although extensive efforts have been made to dampen the thermoacoustic instability,successfully controlling the pressure oscillations in modern gas turbines or aeroengines remains *** influence of the acoustic liner on the longitudinal thermoacoustic mode in a model annular combustor is investigated by Large Eddy Simulation(LES) in this *** result of the self-excited longitudinal thermoacoustic instability without the liner agrees well with the frequency and acoustic analysis of the pressure mode based on experimental *** different bias flow velocities of the liner located downstream of the combustor are then *** results reveal that the existence of the liner influences not only the acoustic field but also the flow *** the bias velocity is large,it leads to intense turbulence-induced fluctuations,and the pressure oscillation is modulated *** shows that the weak coupling between flow and pressure oscillations plays a significant role in the onset of the intermittency of a thermoacoustic *** on the dynamic analysis of the thermoacoustic system with the acoustic liner,this intermittency is caused by the influence of the flow field on the flame-acoustic ***,a low-order modeling method based on Van der Pol(VdP) oscillator with additive stochastic forcing is conducted to reproduce the evolving dynamics of the thermoacoustic *** the numerical cases demonstrated in this work are relatively simpler than those in a practical combustion system,the results are helpful for us to understand the effect of the acoustic liner and show the attractive potential to apply this device to suppress thermoacoustic instability.

关键词： thermoacoustic instability acoustic liner Large Eddy Simulation low-order modeling

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The study of intelligent algorithm in particle identification of heavy-ion collisions at low and intermediate energies

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Nuclear Science and Techniques 2024年第2期35卷 170-182页

作者： gao-yi Cheng Qian-Min Su Xi-Guang Cao Guo-Qiang Zhang School of Electronic and Electrical Engineering Shanghai University of Engineering ScienceShanghai 201620China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

Traditional particle identification methods face timeconsuming,experience-dependent,and poor repeatability challenges in heavy-ion collisions at low and intermediate *** urgently need solutions to the dilemma of traditional particle identification *** study explores the possibility of applying intelligent learning algorithms to the particle identification of heavy-ion collisions at low and intermediate *** intelligent algorithms,including XgBoost and TabNet,were selected to test datasets from the neutron ion multi-detector for reaction-oriented dynamics(NIMROD-ISiS)and Geant4 ***-based machine learning algorithms and deep learning algorithms *** show excellent performance and generalization *** additional data features besides energy deposition can improve the algorithm’s performance when the data distribution is *** learning algorithms can be applied to solve the particle identification problem in heavy-ion collisions at low and intermediate energies.

关键词： Heavy-ion collisions at low and intermediate energies Machine learning Ensemble learning algorithm Particle identification Data imbalance

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Fully umbilical cord-derived adhesive materials enable to recruit and segregate immune cells for the reversal of acute liver failure

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Engineered Regeneration 2024年第1期5卷 70-79页

作者： Xiao yi Feng Chen Kunjie gao Huayan Li Yuan Xie Shao Li Jiajun Zhang Qing Peng Weijie Zhou Shutao Wang Jun-Bing Fan yi gao Research Centre for Artificial Organ and Tissue Engineering&Institute of Regenerative Medicine Department of Hepatobiliary Surgery II Zhujiang Hospital Cancer Research InstituteSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong Province 510515P R China Department of Gynecology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510515P R China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science CAS Center for Excellence in NanoscienceTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190P R China Department of Hepato-Biliary-Pancreatic and Hernia Surgery The First People’s Hospital of ZhaoqingZhaoqingGuangdong 526000P R China Department of Pathology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515P R China

Inflammatory cytokine storms can trigger disease exacerbation and even death and have reached a consensus in the clinical treatment of acute organ ***,the existing strategies remain a great challenge to efficiently suppress inflammatory cytokine storms for promoting organ repair and ***,fully human umbilical cord(UC)-derived adhesive materials(UCAM)that integrate decellularized extracellular matrix(ECM)nanofiber hydrogel and homologous mesenchymal stem cells(MSCs)are demonstrated to greatly suppress inflammatory cytokine storms,demonstrating high efficacy in treating acute liver failure(ALF)in rats with 90%*** UC-derived adhesive materials have the capacity to secrete a significant quantity of cytokines by MSCs to recruit activated immune cells to migrate into their ECM nanofiber networks,segregating them away from the infection area and thereby greatly suppressing the inflammatory cytokine *** expected,the UC-derived adhesive materials can significantly promote hepatocyte proliferation to achieve functional recovery and regeneration of the liver,significantly improving the survival rate in *** fully human UC-derived adhesive materials provide a new avenue in suppressing inflammatory cytokine storms for promoting organ regeneration that would be really utility in clinical organ transplantation-related treatment.

关键词： Interfacial adhesive materials Extracellular matrix nanofibers Hydrogel Mesenchymal stem cells Acute liver failure

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Enhanced Sampling Simulations on Transition-Metal-Catalyzed Organic Reactions:Zirconocene-Catalyzed Propylene Polymerization and Sharpless Epoxidation

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CCS Chemistry 2024年第4期6卷 964-975页

作者： Xu Han Tian-Yu Sun yi Isaac Yang Jun Zhang Jing Qiu Zhaoping Xiong Nan Qiao Yun-Dong Wu yi Qin gao Institute of Theoretical and Computational Chemistry College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871 Shenzhen Bay Laboratory Shenzhen 518132 Changping Laboratory Beijing 102200 Laboratory of Health Intelligence Huawei Cloud Computing Technologies Co.Ltd.Guizhou 550025

The bond breaking and forming in chemical reactions is a typical rare event,which is one of the difficult problems in molecular dynamics *** enhanced sampling methods have been developed to extend the time scale covered by molecular ***,the difficulties of obtaining appropriate collective variables from complicated reaction pathways and a controlled sampling over the desired phase space remain as ***,we use MetaITS,which combines metadynamics and integrated tempered sampling,to increase the sampling efficiency for chemical *** with collective variables obtained by harmonic linear discriminant analysis can efficiently decrease the main energy barrier of chemical ***,integrated tempered sampling can enhance the exploration of other degrees of *** this study,we applied the MetaITS method to two transition-metal-catalyzed organic reactions with complicated reaction *** simulated here a zirconocene-catalyzed propylene polymerization to investigate the regioselectivity and temperature *** also studied a Sharpless epoxidation reaction,for which both chiral products are observed through simulation.

关键词： molecular dynamics enhanced sampling metadynamics integrated tempering sampling propylene polymerization Sharpless epoxidation

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Early gastric composite tumor comprising signet-ring cell carcinoma and mucosa-associated lymphoid tissue lymphoma:A case report

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World Journal of Gastroenterology 2024年第38期30卷 4232-4238页

作者： yi-Fan Jia Fei-Fan Chen Li Yang Yun-Xia Ye yi-Zhu gao Wen-Yan Zhang Jin-Lin Yang Department of Gastroenterology and Hepatology University of Oxford Huaxi Joint Centre for Gastrointestinal CancerFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pathology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Emergency West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Composite tumors are neoplasms comprising two distinct,yet intermingling,cell *** paper reports a rare phenomenon where early gastric signet-ring cell carcinoma(SRCC)and gastric mucosa-associated lymphoid tissue(MALT)lymphoma coexist within the same *** SUMMARY A 40-year-old woman presented to the West China Hospital for examination,which revealed a whitish,shallow,and uneven mucosal lesion in the *** lesion was diagnosed as a poorly differentiated adenocarcinoma,including SRCC with atypical lymphoid hyperplasia associated with Helicobacter pylori infection,based on histopathological examination of the biopsy *** lesion was excised using segmental ***,histological exami-nation of the surgical specimen confirmed that it was a poorly differentiated gastric adenocarcinoma with features of SRCC and MALT *** two entities were stage I and coexisted in the same *** It is uncommon for gastric SRCC and MALT lymphoma to coexist without distinct *** resection is effective for these lesions.

关键词： Gastric cancer Composite tumors Early stage Signet-ring cell carcinoma Mucosa-associated lymphoid tissue lymphoma Case report

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Review on thermal management technologies for electronics in spacecraft environment

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Energy Storage and Saving 2024年第3期3卷 153-189页

作者： yi-gao Lv Yao-Ting Wang Tong Meng Qiu-Wang Wang Wen-Xiao Chu Key Laboratory of Thermo-fluid Science and Engineering Ministry of EducationXi’an Jiaotong UniversityXi’an710049China Xi’an Institute of Space Radio Technology Xi’an710100China

Due to the rapid development of the space industry,ever higher demands are being made for the optimization and improvement of spacecraft thermal management *** control technology has become one of the key bottlenecks that restrict the level of spacecraft *** this paper,the thermal management technologies(TMTs)for spacecraft electronics are reviewed according to the different heat transfer processes,including heat acquisition,heat transport,and heat *** researches on efficient heat acquisition include the utilization of high thermal conductance materials,the development of novel package structure based on micro-/nanoelectromechanical system(MEMS/NEMS)technologies,and advanced near-junction microfluidic cooling *** the heat transport process,various heat pipes and mechanical pumped fluid loops(MPFLs)are widely implemented to transport heat from heat generation components to the ultimate heat *** heat pipes are divided into two categories based on their structure layout,i.e.,separated heat pipes and unseparated heat *** merits and demerits of these heat pipes and MPFLs(including the single-phase MPFL and the two-phase MPFL)are discussed and summarized *** terms of the heat rejection for spacecraft,thermal radiators are normally the sole option due to the unique space *** meet the requirements of large heat dissipation power and fluctuated thermal environment,research efforts on the radiators mainly focus on the development of deployable radiators,variable emissivity radiators,and the combination with other *** to the fluctuated characteristics of the heat power of internal electronics and the outer thermal environment,the phase change materials(PCMs)exhibit great advantages in this scenario and have attracted a lot of research *** review aims to serve as a reference guide for the development of thermal management system in the future spacecraft.

关键词： Thermal management Electronics Spacecraft Heat pipe Mechanically pumped fluid loop Radiator Phase change material

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传统和机器学习策略在基于结构虚拟筛选中的应用

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Chinese Journal of Chemical Physics 2024年第2期37卷 177-191,I0101,I0102页

作者：张宏高毅勤昌平实验室北京102200 北京大学化学与分子工程学院北京100871 北京大学生物医学前沿创新中心北京100871

计算机辅助药物发现和人工智能驱动药物设计在制药行业中是减少时间和经济成本的重要策略.其中具有代表性的方法包括虚拟筛选、蛋白质-配体相互作用评估、药物药代动力学性质预测以及药物设计.通常来说,虚拟筛选是药物发现的第一步,其... 详细信息

计算机辅助药物发现和人工智能驱动药物设计在制药行业中是减少时间和经济成本的重要策略.其中具有代表性的方法包括虚拟筛选、蛋白质-配体相互作用评估、药物药代动力学性质预测以及药物设计.通常来说,虚拟筛选是药物发现的第一步,其主要目标是识别和发现潜在的先导化合物的候选物.在过去的几十年里,已经开发了多种传统的和基于机器学习的方法来提高虚拟筛选的准确性和速度.本综述总结了传统和机器学习方法在基于结构的虚拟筛选中的应用,讨赖性较弱,且分布非常冷并在j=1处达到峰值,但(0,1,0)振动态的转论了它们的性能、优势和局限性等方面.

关键词：分子对接机器学习基于结构的虚拟筛选计算机辅助药物发现人工智能驱动药物设计

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关于“民族国家”问题的若干思考

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历史教学（上半月） 2024年第3期 3-10页

作者：高毅北京大学历史学系

“民族国家”是“现代化”事业的必备平台,而“民族国家”的建设又须臾离不开“现代化”进程的推动,民族国家的基本特征是“政治统一、独立自主”,随着资本主义经济勃兴于西方,“民族意识”也迅速发展了起来,从而催生出欧洲最早的一批... 详细信息

“民族国家”是“现代化”事业的必备平台,而“民族国家”的建设又须臾离不开“现代化”进程的推动,民族国家的基本特征是“政治统一、独立自主”,随着资本主义经济勃兴于西方,“民族意识”也迅速发展了起来,从而催生出欧洲最早的一批民族国家,而“民族国家建设”,实际体现的正是人类社会谋求和平的一种努力,一般有两个发展阶段:第一阶段是在世袭王权的领导下建立一种统一、独立的国家,第二阶段是用民权取代王权,即实现国家政权的民主化。由于世界民族文化近乎无限的多样性,我们在“民族国家”问题上需要在坚持有关共性和个性的辩证分析的同时,引入一些比较历史分析。

关键词：民族国家现代化民权王权

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Marginal zone lymphoma with severe rashes: A case report

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World Journal of Clinical Cases 2024年第3期12卷 565-574页

作者： Si-Jun Bai Ye Geng yi-Nan gao Cai-Xia Zhang Qian Mi Chen Zhang Jia-Ling Yang Si-Jie He Zhen-yingYan Jian-Xia He Department of Hematology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial *** SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent ***-line treatment with rituximab combined with zanubrutinib had poor ***,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes *** For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be *** approach may provide a new perspective in the treatment of MZL.

关键词： Marginal zone lymphoma Mucosa-associated lymphoid tissue Extranodal marginal zone lymphoma Primary cutaneous marginal zone lymphoma Rituximab,Obinutuzumab Zanubrutinib Case report

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旋转导弹横向喷流干扰特性数值模拟

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兵工学报 2024年第1期45卷 105-121页

作者：雷娟棉高毅勇政北京理工大学宇航学院北京100081 空间物理重点实验室北京100076

为研究超声速来流条件下旋转导弹横向喷流干扰流场结构及喷流干扰对导弹气动特性的影响和机理,使用基于雷诺平均非定常N-S方程和滑移网格技术的非定常数值方法对旋转导弹横向喷流干扰流场进行模拟。研究旋转对导弹横向喷流控制效果的影... 详细信息

为研究超声速来流条件下旋转导弹横向喷流干扰流场结构及喷流干扰对导弹气动特性的影响和机理,使用基于雷诺平均非定常N-S方程和滑移网格技术的非定常数值方法对旋转导弹横向喷流干扰流场进行模拟。研究旋转对导弹横向喷流控制效果的影响,给出不同条件下导弹的气动特性变化规律,分析了横向喷流对旋转导弹气动特性的影响。研究结果表明:旋转会导致导弹横向喷流控制力发生偏转,偏转方向与旋转方向相反,偏转角度随着转速增加而增加;在小攻角下,喷流干扰效应产生的附加侧向力和偏航力矩系数的瞬时值比旋转马格努斯效应产生的侧向力和偏航力矩系数的瞬时值大一个数量级,随着攻角增大,旋转马格努斯效应引起的侧向力和偏航力矩系数占全弹的比例增大,喷流引起的附加侧向力和偏航力矩量值减小;旋转导弹横向喷流控制扇面内气动系数随滚转角变化具有很强的非定常性,当喷流控制扇面角度不大时,时均侧向气动特性与对称面处滚转角下的瞬时值侧向气动特性比较接近,不同扇面角度内有喷流的时均侧向力系数和偏航力矩系数远大于无喷流时。

关键词：旋转导弹横向喷流喷流干扰侧向力数值模拟

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