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Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats

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Acta Pharmacologica Sinica 2019年第8期40卷 1106-1118页

作者： Kai-jing Zhao yang Chen Shi-jin Hong yi-ting yang Jiong Xu Han-yu yang Liang Zhu Ming Liu Qiu-shi Xie Xian-ge Tang ting-ting yang Ya-qian Zhou Li Liu Xiao-dong Liu Center of Drug Metabolism and Pharmacokinetics School of PharmacyChina Pharmaceutical University

Cinnamic acid and its analogues(pyragrel and ozagrel)undergo chain-shortened(β-oxidative)and reductive metabolism on acyl side *** this study,we characterized the β-oxidative and reductive metabolism on acyl side chain of cinnamic acid and its analogues using primary rat hepatocytes,hepatic mitochondrial,and microsomal systems.A compartmental model including parent compounds and metabolites was developed to characterize in vivo β-oxidative and reductive metabolism following an intravenous dose of parent compounds to *** fitted total in vivo clearance values were further compared with the in vitro values predicted by the well-stirred *** showed that hepatic microsomal CYP450s did not catalyze β-oxidative or reductive metabolism of the three *** to β-oxidation of fatty acids,β-oxidative metabolism on their acyl side chain occurred mainly in mitochondria,which was highly dependent on ATP,CoA and NAD~+.Fatty acids and NADH inhibited the β-oxidative *** metabolism occurred in both mitochondria and *** in mitochondria was ATP-,CoA-,and NAD(P)H-dependent and reversible,which was suppressed by enoyl reductase inhibitor *** in microsomes was ATP-,CoA-,and NADPH-dependent but little affected by *** plasma concentrations of β-oxidative metabolites and reductive metabolites were successfully fitted using the compartmental *** estimated total in vivo clearance values were consistent with those predicted from hepatocytes and organelles,implicating significance of in vitro *** findings demonstrate the roles of hepatic mitochondria and microsomes in β-oxidative and reductive metabolism on acyl side chain of cinnamic acid and its analogues along with their metabolic characteristics.

关键词： antiplatelet drug cinnamic acid pyragrel ozagrel drug metabolism hepatocytes mitochondria microsomes pharmacokinetics in vitro-in vivo correlation

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Characterizing receiver clock behaviors onboard Low Earth Orbiters:A case study of GRACE satellites

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Geodesy and Geodynamics 2019年第4期10卷 276-281页

作者： Tzu-Pang Tseng C.K.Shum ting-yi yang Geoscience Australia Jerrabomberra Ave&Hindmarsh DriveSymonstonACT2609Australia Division of Geodetic Science School of Earth SciencesThe Ohio State University125 South Oval MallColumbusOH43210USA Institute of Geodesy and Geophysics Chinese Academy of SciencesWuhanHubei430077China

Accurate estimation of clocks, for example for the Gravity Recovery And Climate Experiment(GRACE)twin-satellites, is a critical part of precise orbit determination(POD) that ensures temporal gravity inversion. Characterizing the periodic variations of the receiver clocks is critical for precise clock modeling and prediction. In this study, the receiver clock is estimated using two different POD procedure: kinematic and reduced-dynamic approaches. Choices and the number of orbital parameters estimated in POD process affect the clock estimates, e.g., there are 8895 and 34,560 total parameters in the reduced-dynamic and kinematic approaches, respectively. In the both cases, the periodic variations of GRACE receiver clock are mainly dominated by the GPS orbit period, as well as once-(1-pr) and twiceper-revolution(2-pr) effects. Here the 1-pr effect is coupled with the relativistic effect, resulting in a difficulty to separate both signals. The clock amplitudes caused by the GPS orbit period, 1-pr and 2-pr are about 0.1, 0.03 and 0.01 ns, respectively. The GPS orbit period is almost one order magnitude larger than the 1-and 2-pr effect. The 0.1-ns amplitude of the 12-h periodic variation is equivalent to a 3-cm error in range. Such a systematic error should be considered in the receiver clock modeling for both the improvement of positioning accuracy and the reduction of number of unknown parameters, if the precise point positioning(PPP) technique is used for the orbit determination of the GRACE.

关键词： GPS GRACE Precision orbit determination Clock modeling

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Tenebrio molitor Gram-negative-binding protein 3 (TmGNBP3)is essential for inducing downstream antifungal Tenecin 1 gene expression against infection with Beauveria bassiana JEF-007

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Insect Science 2018年第6期25卷 969-977页

作者： yi-ting yang Mi Rong Lee Se Jin Lee Sihyeon Kim Yu-Shin Nai Jae Su Kim Department of Agricultural Biology Chonbuk National UniversityKorea Department of Biotechnology and Animal Science National llan UniversityllanTaiwanChina plant Medical Research Center College of Agricultural and Life SciencesChonbuk National UniversityJenojuKorea

The Toll signaling pathway is responsible for defense against both Grampositive bacteria and ***-negative binding protein 3(GNBP3)has a strong affinity for the fungal cell wall component,β-1,3-glucan,which can activate the prophenoloxidase (proPO)cascade and induce the Toll signaling *** differentiation factor 88 (MyD88)is an intracellular adaptor protein involved in the Toll signaling *** this study,we monitored the response of 5 key genes (TmGNBP3,TmMyD88,and Tenecin 1,2, and 3)in the Toll pathway of the mealworm Tenebrio molitor immune system against the fungus Beauveria bassiana JEF-007 using ***3,Tenecin 1,and Tenecin 2 were significantly upregulated after fungal *** better understand the roles of the Toll signaling pathway in the mealworm immune system,TmGNBP3and TmMyD88 were knocked down by RNAi *** gene expression levels decreased at 2 d postknockdown and were dramatically reduced at 6 d post-dsRNA ***, mealworms were compromised by *** JEF-007at 6d post-dsRNA injection. Silencing of TmMyD88 and TmGNBP3 resulted in reduced resistance of tilde host to fun- gal ***,reducing TmGNBP3 levels obviously downregulated Tenecin 1 and Tenecin 2expression levels,whereas silencing TmMyD88 expression resulted in de- creased Tenecin 2 *** results indicate that TmGNBP3 is essential to induce downstream antifungal peptide Tenecin i expression against *** JEF-007.

关键词： Beauveria bassiana RNAi Tenebrio molitor TmGNBP3 TmMyD88

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Atmospheric chemistry of 2-nitrobenzaldehyde:Initiated by photo-excitation,OH-oxidation,and small TiO_(2) clusters adsorption catalysis

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Journal of Environmental Sciences 2024年第5期139卷 123-137页

作者： Feng-yang Bai Xiang-Huan Liu ting-ting Meng Zhou Yu yi-Chen Wang Shuang Ni Zhen Zhao Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034China

The fate of 2-nitrobenzaldehyde(2-NBA)is of interest in atmospheric chemistry as it is a semi-volatile organic compound with high *** study presents a quantum chemical study of the gas-phase reactions of 2-NBA photo-excitation and OH-oxidation in the absence and presence of small TiO_(2) *** further understand the unknown photolysis mechanism,the photo-reaction pathways of ground singlet state and the lying excited triplet state of 2-NBA were investigated including the initial and subsequent reactions of proton transfer,direct CO,NO_(2),and HCO elimination routes in the presence of O_(2) and ***,the OH-mediated degradation of 2-NBA proceeded via five H-extraction and six OH-addition channels by indirect mechanism,which follows a succession of reaction steps initiated by the formation of weakly stable intermediate *** H-extraction from the-CHO group was the dominant pathway with a negative activation energy of-1.22 kcal/*** calculated rate coefficients at 200–600 K were close to the experimental data in literature within 308-352 K,and the kinetic negative temperature independence was found in both experimental literature and computational ***,2-NBA was favored to be captured onto small TiO_(2) clusters via six adsorption configurations formed via various combination of three types of bonds of Ti…O,Ti…C,and O…H between the molecularly adsorbed 2-NBA and TiO_(2) *** indicted that the chemisorptions of aldehyde oxygen have largest *** results suggested adsorption conformations have a respectable impact on the catalysis *** study is significant for understanding the atmospheric chemistry of 2-nitrobenzaldehyde.

关键词： 2-nitrobenzaldehyde OH radical oxidation Rate coefficient Photolysis mechanism Adsorption catalysis

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Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motility

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Asian Journal of Andrology 2023年第5期25卷 608-615页

作者： yi-ting yang Bin Yan Yu-Hua Li Li-Na Guo Wei-Wei Wang Li-Jie Liu He-Guo Yu Hua Diao NHC Key Laboratory of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies) School of Basic Medical SciencesFudan UniversityShanghai 200032China Reproductive Medicine Centre Zhongshan HospitalFudan UniversityShanghai 200032China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Urology Huashan HospitalFudan UniversityShanghai 200040China

Phosphodiesterase(PDE)inhibitors can improve sperm motility in patients with ***,the most commonly reported nonselective PDE inhibitor pentoxifylline and PDE5 inhibitor sildenafil have the disadvantages of requiring a high concentration and destroying sperm *** examined the PDE10A inhibitor PF-2545920 to compare its ability to promote sperm motility with that of pentoxifylline and *** seminal plasma was discarded,several semen samples were subjected to four treatments(control,PF-2545920,pentoxifylline,and sildenafil)to evaluate their ability to affect motility,viability,and spontaneous acrosome *** calcium and adenosine triphosphate(ATP),mitochondrial membrane potential,and penetration through viscous medium were assessed by flow cytometry,luciferase,and hyaluronic acid after treatment with *** analyses were performed using the analysis of variance statistical ***-2545920 elevated the percentage of motile spermatozoa compared to the control,pentoxifylline,and sildenafil groups at 10μmol l^(-1)(Pting ability(Ptingthe spermmotility.

关键词： pentoxifylline phosphodiesterase 10A sildenafil sperm motility spontaneous acrosome reaction

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Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1711-1725页

作者： yingting Wu Jiaqi Xin Xinyu Li ting yang yi Liu Yongsheng Zhao Wen Xie Mengxi Jiang Department of Pharmacology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Department of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261USA Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China

Drug repurposing offers an efficient approach to therapeutic *** this study,our bioinformatic analysis first predicted an association between obesity and lansoprazole(LPZ),a commonly prescribed drug for gastrointestinal *** went on to show that LPZ treatment increased energy expenditure and alleviated the high-fat diet-induced obesity,insulin resistance,and hepatic stea-tosis in *** with LPZ elicited thermogenic gene expression and mitochondrial respiration in primary adipocytes,and induced cold tolerance in cold-exposed mice,suggesting the activity of LPZ in promoting adipose thermogenesis and energy ***,LPZ is an efficient inhibitor of adipose phosphocholine phosphatase 1(PHOSPHOI)and produces metabolic benefits in a PHOS-PHO1-dependent *** results suggested that LPZ may stimulate adipose thermogenesis by inhi-biting the conversion of 2-arachidonoylglycerol-lysophosphatidic acid(2-AG-LPA)to 2-arachidonoylglycerol(2-AG)and reduce the activity of the thermogenic-suppressive cannabinoid recep-tor *** summary,we have uncovered a novel therapeutic indication and mechanism of LPZ in managing obesity and its related metabolic syndrome,and identified a potential metabolic basis by which LPZ improves energy metabolism.

关键词： Lansoprazole Proton pump inhibitors Adipose thermogenesis Energy expenditure Metabolic syndrome PHOSPHO1 inhibitor Cannabinoid receptor signaling Drug repurposing

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Effect of post rolling stress on phase transformation behavior of microalloyed dual phase steel

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Journal of Iron and Steel Research International 2024年第3期31卷 688-699页

作者： Wen-quan Sun Sheng-yi Yong Tie-heng Yuan ting-song yang An-rui He Chao Liu Rui-chun Guo National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing 100083China

The slow phase transformation of microalloyed dual phase steel makes the nonuniform stress and temperature fields during the post rolling cooling process have a significant impact on the phase transformation *** the relatively slow phase transformation of DP780 steel within the microalloyed dual phase steel series,the influence of stress on the phase transformation behavior of DP780 steel was *** quantify the nonuniform thermal and stress conditions in the steel coil,a thermo-mechanical coupled finite element model of the hot-rolled strip cooling process was *** on the simulation data,DP780 steel was chosen as the research material,and Gleeble 3500 thermal simulation equipment was used for experimental *** thermal expansion curves were analyzed through regression to establish the dynamic model of DP780 steel phase transformation under ***,metallographic analysis was conducted to determine phase transformation type and grain size of DP780 *** results confirmed that the stress promotes the occurrence of semi-diffusion-type bainite ***,an appropriate level of stress facilitates the growth of bainitic grains,while the increased stress inhibits the growth of ferritic grains.

关键词： Microalloyed dual phase steel Stress Bainitic transformation Grain Finite element method

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Quality of life after pancreatic surgery

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World Journal of Gastroenterology 2024年第8期30卷 943-955页

作者： Shi-Zhen Li ting-ting Zhen yi Wu Min Wang ting-ting Qin Hang Zhang Ren-yi Qin Department of Biliary-Pancreatic Surgery Affiliated Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Pancreatic surgery is challenging owing to the anatomical characteristics of the *** attention has been paid to changes in quality of life(QOL)after pancreatic *** To summarize and analyze current research results on QOL after pancreatic *** A systematic search of the literature available on PubMed and EMBASE was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** studies were identified by screening the references of retrieved *** on patients’QOL after pancreatic surgery published after January 1,2012,were *** included prospective and retrospective studies on patients'QOL after several types of pancreatic *** results of these primary studies were summarized *** A total of 45 articles were included in the study,of which 13 were related to pancreaticoduodenectomy(PD),seven to duodenum-preserving pancreatic head resection(DPPHR),nine to distal pancreatectomy(DP),two to central pancre-atectomy(CP),and 14 to total pancreatectomy(TP).Some studies showed that 3-6 months were needed for QOL recovery after PD,whereas others showed that 6-12 months was more *** TP and PD had similar influences on QOL,patients needed longer to recover to preoperative or baseline levels after *** QOL was better after DPPHR than ***,the superiority of the QOL between patients who underwent CP and PD remains *** decrease in exocrine and endocrine functions postoperatively was the main factor affecting the *** invasive surgery could improve patients’QOL in the early Core Tip:This review summarizes and analyzes current research results on quality of life(QOL)after pancreatic *** article covers the discussion and analysis of the QOL of various pancreatic *** kind of surgical procedure has better QOL is *** long-term benefits on QOL of minimally invasive su

关键词： Quality of life Pancreaticoduodenectomy Duodenum-preserving pancreatic head resection Distal pancreatectomy Central pancreatectomy Total pancreatectomy

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Copper-coated Porous Polyimide as Ultralight and Safe Current Collectors for Advanced LIBs

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Chinese Journal of Polymer Science 2024年第4期42卷 521-531页

作者： Cun-Sheng Liu Jun-Qi Hu ting-ting Mao Song-yi Liao Ru-Ming Feng yi-Dong Liu Yong-Gang Min School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China College of Chemistry and Chemical Engineering Zhongkai University of Agriculture and EngineeringGuangzhou510225China Shanwei Branch of Advanced Energy Science and Technology Guangdong Laboratory Shanwei516600China

Metallic copper is widely used as current collector(CC) for graphite anode of lithium-ion batteries(LIBs) due to its high electrical conductivity and electrochemical stability. However, the large volume density of commercial copper foil(~8.9 g·cm^(-3)) limits the increase of energy density of battery. Here, copper-coated porous polyimide(Cu@PPI) was prepared by vacuum evaporation as collector for the graphite anode. The sandwich structure connects the copper metal on both sides of the collector with excellent electrical conductivity. Compared to commercial Cu foil, Cu@PPI has lighter mass(≤3.9 mg for disc of 12 mm diameter versus 9.9 mg of ~10 μm Cu foil) and lower volume density(≤3.3 g·cm^(-3)). In addition, the porous structure allows of better adhesion of reactive substances and electrochemical properties than pure Cu foils. It is estimated that the energy density of Cu@PPI should be much higher than that of Cu foil. This strategy should be applicable for other current collectors.

关键词： Copper-coated Vacuum evaporation Porous polyimide(PPI) Current collector(CC) LIBs

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Chinese Journal of Electronics 2024年第3期33卷 672-682页

作者： yi ZHANG Kai ZHANG ting CUI PLA SSF Information Engineering University

Related-key model is a favourable approach to improve attacks on block ciphers with a simple key ***,to the best of our knowledge,there are a few results in which zero-correlation linear attacks take advantage of the related-key *** ascribe this phenomenon to the lack of consideration of the key input in zerocorrelation linear *** on the linear key schedule of a block cipher,we generalize the zero-correlation linear attack by using a related-key ***,we propose the creation of generalized linear hulls(GLHs)when the key input is involved;moreover,we indicate the links between GLHs and conventional linear hulls(CLHs).Then,we prove that the existence of zero-correlation GLHs is completely determined by the corresponding CLHs and the linear key *** addition,we introduce a method to construct zero-correlation GLHs by CLHs and transform them into an integral *** correctness is verified by applying it to SIMON16/16,a SIMON-like toy *** on our method,we find 12/13/14/15/15/17/20/22-round related-key zero-correlation linear distinguishers of SIMON32/64,SIMON48/72,SIMON48/96,SIMON64/96,SIMON64/128,SIMON96/144,SIMON128/192 and SIMON 128/256,*** far as we know,these distinguishers are one,two,or three rounds longer than current best zero-correlation linear distinguishers of SIMON.

关键词： Schedules Ciphers Analytical models Toy manufacturing industry Force Linear approximation Transforms

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