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World Journal of Gastroenterology 2004年第8期10卷 1098-1102页

作者： Wei-HuaFu lu-HuaWang Zong-MeiZhou Jian-RongDai yi-MinHu lu-JunZhao DepartmentofRadiationOncology CancerInstitute(Hospital)PekingUnionMedicalCollegeChineseAcademyofMedicalSciencesBeijing10021China

AIM:To compare intensity-modulated radiotherapy (IMRT) with conformal radiotherapy (CRT) by investigating the dose profiles of primary tumors,electively treated regions,and the doses to organs at risk. METHODS:CRT and IMRT plans were designed for five patients with upper esophageal *** each patient, target volumes for primary lesions (67.2 Gy) and electively treated regions (50.4 Gy) were *** experienced planner manually designed one CRT *** IMRT plans were generated with the same dose-volume constraints,but with different beam *** including dose distributions,dose volume histograms (DVHs) and conformity index were compared. RESULTS:The plans with three intensity-modulated beams were discarded because the doses to spinal cord were lager than the tolerable dose 45Gy,and the dose on areas near the skin was up to *** the number of intensity beams increased to five,IMRT plans were better than CRT plans in terms of the dose conformity and homogeneity of targets and the dose to *** dose distributions changed little when the beam number increased from five to seven and nine. CONCluSION:IMRT is superior to CRT for the treatment of upper esophageal carcinoma with simultaneous integrated boost (SIB).Five equispaced coplanar intensity-modulated beams can produce desirable dose *** primary tumor can get higher equivalent dose by SIB technique. The SIB-IMRT technique shortens the total treatment time, and is an easier,more efficient,and perhaps a less error- prone way in delivering IMRT.

关键词：上食管癌放射疗法等角增强调节技术综合治疗影像学检查

Basic fibroblast growth factor increases the numbe of endogenous neural stem cells and inhibits the expression of amino methyl isoxazole propionic acid receptors in amyotrophic lateral sclerosis mice

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Neural Regeneration Research 2012年第10期7卷 761-765页

作者： Weihui Huang Dawei Zang yi lu Ping Jiang Department of Neurology Tianjin First Center Hospital Tianjin Medical University Tianjin 300192 China

This study aimed to investigate the number of amino methyl isoxazole propionic acid （AMPA） receptors and production of endogenous neural stem cells in the SOD1 G93AG1H transgenic mouse model of amyotrophic lateral sclerosis, at postnatal day 60 following administration of basic fibroblast growth factor （FGF-2）. A radioligand binding assay and immunohistochemistry were used to estimate the number of AMPA receptors and endogenous neural stem cells respectively. Results showed that the number of AMPA receptors and endogenous neural stem cells in the brain stem and sensorimotor cortex were significantly increased, while motor function was significantly decreased at postnatal days 90 and 120. After administration of FGF-2 into mice, numbers of endogenous neural stem cells increased, while expression of AMPA receptors decreased, whilst motor functions were recovered. At postnatal day 120, the number of AMPA receptors was negatively correlated with the number of endogenous neural stem cells in model mice and FGF-2-treated mice. Our experimental findings indicate that FGF-2 can inhibit AMPA receptors and increase the number of endogenous neural stem cells, thus repairing neural injury in amyotrophic lateral sclerosis mice.

关键词： amino methyl isoxazole propionic acid receptor amyotrophic lateral sclerosis basic fibroblast growth factor endogenous neural stem cells

Inference on Varying-Coefficient Partially Linear Regression Model

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Acta Mathematicae Applicatae Sinica 2015年第1期31卷 139-156页

作者： Jing-yan FENG Ri-quan ZHANG yi-qiang lu Department of Mathematics Shanxi Datong University Department of Statistics East China Normal University Institute of Electronic Technology the PLA Information Engineering University

The varying-coefficient partially linear regression model is proposed by combining nonparametric and varying-coefficient regression procedures. Wong, et al. （2008） proposed the model and gave its estimation by the local linear method. In this paper its inference is addressed. Based on these estimates, the generalized like- lihood ratio test is established. Under the null hypotheses the normalized test statistic follows a x2-distribution asymptotically, with the scale constant and the degrees of freedom being independent of the nuisance param- eters. This is the Wilks phenomenon. Furthermore its asymptotic power is also derived, which achieves the optimal rate of convergence for nonparametric hypotheses testing. A simulation and a real example are used to evaluate the performances of the testing procedures empirically.

关键词： asymptotic normality varying-coefficient partially linear regression model generalized likelihoodratio test Wilks phenomenon xi-distribution.

2-D FluID SIMULATION OF DUAL-FREQUENCY CAPACITIVELY COUPLED PLASMA

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Journal of Hydrodynamics 2009年第6期21卷 814-819页

作者： lu yi-jia YAN Da-qiang CHEN Yao-song LTCS and College of Engineering Peking University Beijing 100871 China

Dual-frequency aegon discharge at 100 m Torr is modeled with a 2-D fluid model in this study. The plate gap of the system is 20 ram, and discharges are modeled at High Frequency （HF） 40 MHz, 60 MHz, 80 MHz, Low Frequency （LF） 2 MHz, 5 MHz, 10 MHz, low-frequency voltage 50 V, 75 V, 100 V and high-frequency voltage 200 V, respectively. The spatial distribution of electron density and ion density and the periodic evolution of instantaneous electric potential in bulk plasma and sheath are discussed. The numerical results show that plasma density increases with HFs and LFs and LF voltage, while HFs has more effect on the density. It is concluded that improving the ratio of HFs/LFs and increasing LF voltages is a method to gain high density and high ion bombardment energy simultaneously based on the analysis of electric potential distribution.

关键词： dual frequency CCP discharge 2-D fluid model

Ab initio Study of Anharmonic Force Field and Spectroscopic Constants for Germanium Dichloride

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Chinese Journal of Chemical Physics 2016年第6期29卷 657-662,I0001页

作者： Wei-xiu Pang Yun-bin Sun Jian-jun Zhao yi lu KeyLaboratoryofMagnetismandMaEneticMaterialsatUniversitiesofInnerMongoliaAutonomousRegion DepartmentofPhysicsBaotouNormalUniversityBaotou014030China

Ab initio study of the equilibrium structure, spectroscopy constants, and anharmonic force field for several isotopomers of germanium dichloride （70GeCl2, 72GECl2, and 76GeCl2） have been carried out at the MP2 and CCSD（T） levels of theory using cc-pVTZ basis set. The cal- culated geometries, rotational constants, vibration-rotation interaction constants, harmonic frequencies, anharmonic constants, quartic and sextic centrifugal distortion constants, cubic and quartic force constants are compared with experimental data. For small mass differences of the Ge isotopes, the isotopic effects for germanium dichloride are much weaker. The agreements are satisfactory for these two methods, but the deviations of CCSD（T） results are slightly larger than that of MP2, because of CCSD（T）＇s inadequate treatment of electron correlation in hypervalent Cl atom.

关键词： Anharmonic force field Spectroscopic constants Germanium dichloride

Primary isolated central nervous system acute lymphoblastic leukemia with BCR-ABL1 rearrangement:A case report

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World Journal of Clinical Cases 2022年第13期10卷 4242-4248页

作者： Yan Chen Quan-yi lu Jing-Yuan lu Xiu-Li Hong Department of Hematology Zhongshan Hospital of Xiamen UniversityXiamen 361000Fujian ProvinceChina

BACKGROUND BCR-ABL1 fusion gene is associated with a poor prognosis and a high incidence in central nervous system(CNS)*** invasion which detected at the initial diagnosis is commonly with bone marrow *** is uncommon for the leukemia cells to be located primarily in the CNS without bone marrow *** SUMMARY We here report the rare initial presentation of CNS-restricted BCR-ABL-positive acute lymphoblastic leukemia in a 30-year-old female patient who clinically manifested with leukemic meningitis,with no involvement in peripheral blood or bone *** of abnormal phenotypes of blast cells,and BCR-ABL1 rearrangement in the cerebrospinal fluid alone established the diagnosis of primary CNS-isolated acute lymphocytic *** patient received a combination of intrathecal therapy and high-dose *** the benefits of the treatments were short-lived and she experienced *** Flow cytometry in combination with molecular genetic analysis improved diagnostic *** approaches that may enhance the efficacy of the existing therapies and cure CNS leukemia are required.

关键词： Acute lymphoblastic leukemia BCR-ABL1 Diagnosis Primary central nervous system leukemia Treatment Case report

The Great Opening up and the Roadmap for the Future： The Story of China＇s International Trade

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China & World Economy 2018年第2期26卷 68-93页

作者： Yan Du yi lu Lecturer Business School Sichuan Agricultural University China (corresponding author) Professor School of Economics and Management Tsinghua University China

The astonishing surge in China＇s international trade is the result of comprehensive economic reforms in the 1980s and 1990s. Trade was further bolstered by China＇s accession to the World Trade Organization （WTO） in 2001. We examine several aspects of China＇s international trade that might help to explain its surprisingly fast growth and its ever-growing role in the global economy. A large number of studies have analyzed how trade liberalization, the WTO accession in particular, has profoundly changed the Chinese economy. We survey notable contributions to this literature that analyze the effects of trade liberalization on Chinese firms, individuals and households. Meanwhile, China ＂s exports have had various effects on importing countries and the enormous growth of China＇s exports is seen by some observers as posing a threat to China ＂s trading partners. Therefore, we discuss the emerging literature on the effects of China ＂s spectacular export growth on consumers, labor markets, innovation, media and politics in foreign countries. Given the new domestic and external circumstances, the Chinese Government is determined to push for the formation of a new trade structure characterized by broad opening up to transform China into a strong trading powerhouse.

关键词： China intemational trade opening up reform

Increasing Anthropogenic Mercury Pollution over the Last 200 Years Revealed by Lagoonal Sediments from Hainan Island,South China

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Chinese Geographical Science 2023年第6期33卷 1127-1140页

作者： LI Yanting XUE Jibin CHEN Jingqiang lu yi MA Xinlu School of Geographical Sciences South China Normal UniversityGuangzhou510631China

The toxic heavy metal mercury(Hg)has significantly enhanced the global Hg cycle influenced by human activities over the last *** this study,we presented a high-resolution Hg deposition history between∼1780 and 2015 AD in a sediment core from Xincun Lagoon,located in the southeastern Hainan Island,South China,and analyzed it in conjunction with geochemical elements,grain-size distribution,organic matter,and HYSPLIT backward trajectory *** objective was to investigate the influencing factors affecting historical Hg deposition in relatively remote regions and assess the extent of the effects of natural background and human *** results showed that the Hg in the sediment was deposited primarily through atmospheric deposition,which was closely related to regional and even global human *** Hg contamination increased gradually from the 1830s to 1850s,possibly due to Hg emissions from Opium Wars I and II occurring in southeastern *** broad peaks of anthropogenic Hg were observed during the 1910s to 1950s and in the 1980s,likely associated with the two world wars and modern Chinese *** addition,a further sharp increase in anthropogenic Hg from the mid-1970s to the present occurred,likely originating from the intense industrial activities in China triggered by the reform and opening-up policy of China in 1978 and some countries in Southeast Asia.

关键词： Mercury deposition pollution history anthropogenic impact Xincun Lagoon Hainan,China

Application of total keratometry in ten intraocular lens power calculation formulas in highly myopic eyes

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Eye and Vision 2024年第2期10卷 22-30页

作者： Ling Wei Kaiwen Cheng Wenwen He Xiangjia Zhu yi lu Department of Ophthalmology and Eye Institute Eye and ENT Hospital of Fudan UniversityShanghai 200031China Key Laboratory of Myopia(Fudan University)Key Laboratory of MyopiaShanghai Key Laboratory of Visual Impairment and Restoration National Health CommissionChinese Academy of Medical ScienceShanghai 200031China State Key Laboratory of Medical Neurobiology Fudan UniversityShanghai 200031China

Background:The accuracy of using total keratometry(TK)value in recent IOL power calculation formulas in highly myopic eyes remained ***:Highly myopic patients who underwent uneventful cataract surgery were prospectively enrolled in this prospective comparative *** one month postoperatively,standard deviation(SD)of the prediction errors(PEs),mean and median absolute error(MedAE)of 103 highly myopic eyes were back-calculated and compared among ten formulas,including XGboost,RBF 3.0,Kane,Barrett Universal II,Emmetropia Verifying Optical 2.0,Cooke K6,Haigis,SRK/T,and Wang-Koch modifications of Haigis and SRK/T formulas,using either TK or standard keratometry(K)***:In highly myopic eyes,despite good agreement between TK and K(P>0.05),larger differences between the two were associated with smaller central corneal thickness(Plue,the XGboost calculator was comparable with the RBF 3.0 formula(P>0.05),which both presented smaller MedAEs than others(all P0.05),and statistically larger percentages than the other eight formulas(Plusions:Highly myopic eyes with thinner corneas tend to have larger differences between TK and *** XGboost enhancement calculator and RBF 3.0 formula using TK showed the most promising outcomes in highly myopic eyes.

关键词： High myopia Total keratometry Cataract surgery IOL power calculation

Chemoselective hydrogenation of α,β-unsaturated aldehydes with modified Pd/C catalyst

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Chinese Chemical Letters 2012年第7期23卷 773-776页

作者： Wen Qiang Du Ze Ming Rong Yan Liang Yong Wang Xin yi lu yi Fan Wang Lian Hai lu State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian 116024China

Selective hydrogenation of α, β-unsaturated aldehydes with modified Pd/C catalyst was *** reduction of C=O bond could be efficiently inhibited by the addition of carbonates,and high selectivity to the corresponding saturated aldehydes was achieved under mild *** protocol provides an alternative for efficient preparation of saturated aldehydes.

关键词： Pd/C catalyst α,β-Unsaturatcd aldehydes Hydrogenation Selectivity