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Structural basis of DNA binding by the NAC transcription factor ORE1,a master regulator of plant senescence

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Plant Communications 2023年第3期4卷 139-150页

作者： Inseop Chun Hyo Jung kim Sunghyun Hong yeon-Gil kim Min-Sung kim Department of Life Sciences Pohang University of Science and Technology(POSTECH)PohangGyeongbukRepublic of Korea Center for Plant Aging Research Institute for Basic ScienceDaeguRepublic of Korea Center for Genome Engineering Institute for Basic ScienceDaejeonRepublic of Korea Pohang Accelerator Laboratory Pohang University of Science and TechnologyPohangRepublic of Korea

Plants use sophisticated mechanisms of gene expression to control senescence in response to environmental stress or ***1(Arabidopsis thaliana NAC092)is a master regulator of senescence that belongs to the plant-specific NAC transcription factor protein ***1 has been reported to bind to multiple DNA targets to orchestrate leaf senescence,yet the mechanistic basis for recognition of the cognate gene sequence remains ***,we report the crystal structure of the ORE1-NAC domain alone and its DNA-binding *** structure of DNA-bound ORE1-NAC revealed the molecular basis for nucleobase recognition and phosphate backbone *** showthat local versatility in the DNA-binding site,in combination with domain flexibility of the ORE-NAC homodimer,is crucial for the maintenance of binding to intrinsically flexible *** results provide a platformfor understanding other plant-specific NAC protein-DNA interactions as well as insight into the structural basis of NAC regulators in plants of agronomic and scientific importance.

关键词： NAC transcription factor crystal structure DNA complex senescence regulator

Effects of the Syzygium aromaticum L. extract on antioxidation and inhibition of matrix metalloproteinase in human dermal fibroblast

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Asian Pacific Journal of Tropical Biomedicine 2019年第2期9卷 53-59页

作者： Da Eun kim yeon Sil Hwang Bo Yoon Chang Dae Sung kim Hyoung Kwon Cho Sung yeon kim Institute of Pharmaceutical Research and Development College of PharmacyWonkwang University Hanpoong Pharm.CO. Ltd

Objective: To investigate cosmetic potential of Syzygium aromaticum L.(S. aromaticum L.) and to determine its antioxidant and anti-wrinkling effects. Methods: Using highperformance liquid chromatography, eugenol component was quantitated. The antioxidant activity of S. aromaticum L. was analyzed by 2,2-diphenyl-1-picrylhydrazyl radical scavenging and superoxide dismutase like activities. To determine cell viability, elastase and matrix metalloproteinase-1(MMP-1) activity, human dermal fibroblasts(HS68) were treated with S. aromaticum L. The inhibitory effect of S. aromaticum L. on tumor necrosis factor alpha induced MMPs expression in HS68 was analyzed by realtime-PCR. Results: The eugenol content was confirmed in S. aromaticum L. S. aromaticum L. was observed to have high 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and superoxide dismutase like activity. S. aromaticum L. had no cytotoxicity against the HS68 and dose-dependently increased elastase inhibition. Moreover, S. aromaticum L. significantly decreased MMP-1 content and inhibited gene levels of MMP-1, MMP-2, MMP-3 and MMP-9. Conclusions: The findings suggest that S. aromaticum L. has great potential as a cosmeceutical ingredient with antioxidant and antiwrinkling effects.

关键词： Syzygium aromaticum L Antioxidant Anti-aging Elastase Matrix metalloproteinase-1

Effect of an oxygen-free atmosphere during heating on anthocyanin,organic acid,and color of strawberry puree

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Food Bioscience 2022年第6期50卷 695-703页

作者： Ah-Na kim Kyo-yeon Lee Chae-yeon Han Hyun-Jin kim Sung-Gil Choi Division of Applied Life Science Gyeongsang National UniversityJinju52828South Korea Research Group of Safety Distribution Korea Food Research InstituteWanju-gun55365Republic of Korea Division of Food Science and Technology (Institute of Agriculture and Life Sciences) Gyeongsang National UniversityJinju52828South Korea

Strawberries were ground and heated under oxygen-free condition using a specially designed device,and compared with the berries processed at atmospheric *** complete inactivation of oxidative enzymes and microorganisms were found in both *** heating without oxygen led to higher concentrations of anthocyanins and organic acids than with oxygen,resulting in higher redness and antioxidant ***,the greatest effect of anaerobic condition was observed in delphinidin-3-glycoside and ascorbic acid which are the most sensitive to oxidation in presence of ***,some nutrients which are low dependence on oxygen were degraded regardless of insufficient *** was considered that anaerobic condition may inhibit the deterioration related to only oxidation,not non-oxidative reaction during *** results implicated that dissolved oxygen in tissues may cause continuous oxidative *** summary,oxygen-free condition can confer better oxidative stability of antioxidants and color during heating of berry products.

关键词： Thermal processing Oxygen Vacuum Anthocyanin Strawberry Oxidation

Impact of nonalcoholic fatty liver disease on the risk of gallbladder polyps in lean and non-obese individuals:A cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 573-578页

作者： Nam hee kim Ji Hun Kang Hong Joo kim Division of Gastroenterology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea Department of Radiology Hanyang University Guri HospitalHanyang University College of MedicineGuriKorea

Background:The association between non-obese or lean nonalcoholic fatty liver disease(NAFLD)and gallbladder polyps(GBPs)has not yet been *** aimed to determine whether NAFLD is an independent risk factor for the development of GBPs,even in non-obese and lean ***:We analyzed a cohort of 331208 asymptomatic adults who underwent abdominal ultrasonography(US).The risk of GBP development was evaluated according to the obesity and NAFLD ***:The overall prevalence of NAFLD and GBPs≥5 mm was 28.5%and 2.9%,*** prevalence of NAFLD among 160276 lean,77676 overweight and 93256 obese participants was 8.2%,31.2%,and 61.1%,*** with NAFLD had a significantly higher incidence of GBPs with a size of≥5 mm[adjusted odds ratio(OR)=1.18;95%confidence interval(CI):1.11–1.25].A higher body mass index and its categories were also significantly associated with an increased risk of GBPs≥5 ***,risk of GBPs≥5 mm was significantly increased even in NAFLD individuals who are not obese(lean:adjusted OR=1.36,95%CI:1.19-1.54;overweight:adjusted OR=1.14,95%CI:1.03–1.26,respectively).Conclusions:Non-obese/lean NAFLD is an independent risk factor for GBP development,suggesting that NAFLD may play an important role in the pathogenesis of GBPs regardless of the obesity ***,a more thorough evaluation for GBPs may be necessary when hepatic steatosis is detected on abdominal US,even in non-obese or lean individuals.

关键词： Nonalcoholic fatty liver disease Non-obese Lean Gallbladder polyps

Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain

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Neural Regeneration Research 2015年第7期10卷 1101-1106页

作者： Ho-Sung Lee Dai-In Kang Seung Zhoo Yoon yeon hee Ryu Inhyung Lee Hoon-Gi kim Byung-Cheon Lee Ki Bog Lee Ki Primo Research Laboratory Division of Electrical Engineering KAIST Institute for Information Technology Convergence Korea Advanced Institute of Science and Technology (KAIST) Nadi Primo Research Institute Graduate School of Integrative Medicine Sun Moon University Pharmacopuncture Medical Research Center Korean Pharmacopuncture Institute Department of Anesthesiology and Pain Medicine College of Medicine Korea University Acupuncture Moxibustion & Meridian Research Group Medical Research Division Korea Institute of Oriental Medicine Department of Veterinary Surgery College of Veterinary Medicine Seoul National University Faculty of Liberal Education Seoul National University Korea Atomic Energy Research Institute

With chromium-hematoxylin staining, we found evidence for the existence of novel age-dependent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-weekold rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-dependent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increasing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix.

关键词： nerve regeneration dura mater chromium-hematoxylin staining fascia primo vascular system brain hormone neural regeneration

Surface properties of Al-doped ZnO thin film before and after CF_4/Ar plasma etching

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Plasma Science and Technology 2022年第7期24卷 194-200页

作者： Young-hee JOO Gwan-Ha kim Doo-Seung UM Chang-Il kim School of Electrical and Electronics Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Semiconductor Materials and Applications Korea PolytechnicSeongnam 13122Republic of Korea Department of Electrical Engineering Sejong UniversitySeoul 05006Republic of Korea

Al-doped ZnO(AZO) is considered as an alternative to transparent conductive oxide *** and achieving a stable surface are important challenges in the development and optimization of dry etching processes, which must be overcome for the application of AZO in various devices. Therefore, in this study, the etch rate and surface properties of an AZO thin film after plasma etching using the adaptive coupled plasma system were investigated. The fastest etch rate was achieved with a CF_(4)/Ar ratio of 50:50 sccm. Regardless of the ratio of CF_(4) to Ar,the transmittance of the film in the visible region exceeded 80%. X-ray photoelectron spectroscopy analysis of the AZO thin film confirmed that metal-F bonding persists on the surface after plasma etching. It was also shown that F eliminates O vacancies. Consequently, the work function and bandgap energy increased as the ratio of CF-4 increased. This study not only provides information on the effect of plasma on AZO thin film, but identifies the cause of changes in the device characteristics during device fabrication.

关键词： Al-doped ZnO plasma etching F-based plasma surface characteristics X-ray photoelectron spectroscopy ultraviolet photoelectron spectroscopy

Prospective comparison of prophylactic antibiotic use between intravenous moxifloxacin and ceftriaxone for high-risk patients with post-ERCP cholangitis

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 512-518页

作者： Nam hee kim Hong Joo kim Ki Bae Bang Department of Internal Medicine Sungkyunkwan University Kangbuk Samsung Hospital Department of Internal Medicine Dankook University Hospital

BACKGROUND: The use of prophylactic antibiotics before endoscopic retrograde cholangiopancreatography(ERCP) is recommended by all major international gastroenterological societies, especially in the presence of an obstructed biliary system. This study compared the occurrence rate of post-procedural complications, including cholangitis and septicemia between prophylactic intravenous moxifloxacin and ceftriaxone in patients with bile duct obstruction scheduled for therapeutic ***: From November 2013 to July 2015, 86 consecutive patients with biliary obstruction with one or more factors predicting benefits of antibiotic prophylaxis prior to ERCP were included in the current randomized open-label non-inferiority trial(Clinical *** identifier NCT02098486). Intravenous moxifloxacin(400 mg/day) or ceftriaxone(2 g/day)were given 90 minutes before ERCP, and were administered for more than 3 days if the patient developed symptoms and signs of cholangitis or septicemia. Recalcitrant cholangitis was defined as persistence of cholangitis for more than 5 days after ERCP or recurrence of cholangitis within 30 days after ***: Recalcitrant cholangitis occurred in 1(2.3%) and 2(4.8%) patients receiving intravenous moxifloxacin and ceftriaxone group, respectively(P=0.612). Septicemia was noted in1(2.3%) and 1(2.4%) patient in intravenous moxifloxacin and ceftriaxone group, respectively(P=1.0). The mean hospital stay was also not significantly different between the moxifloxacin and ceftriaxone groups(8.8±7.2 vs 9.1±9.4 days, P=0.867). Antibiotic resistance of the isolated pathogens by in vitro activity assay was noted in 1(2.3%) and 2(4.8%) patients in the moxifloxacin and ceftriaxone group, respectively(P=0.612). CONCLUSION: Intravenous moxifloxacin is not inferior to intravenous ceftriaxone for the prophylactic treatment of post-ERCP cholangitis and cholangitis-associated morbidity.

关键词： endoscopic retrograde cholangiopancreatography cholangitis moxifloxacin ceftriaxone recalcitrant cholangitis

Determining node duty cycle using Q-learning and linear regression for WSN

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Frontiers of Computer Science 2021年第1期15卷 17-23页

作者： Han Yao HUANG Kyung Tae kim hee Yong YOUN College of Software Sungkyunkwan UniversitySuwon 440-746Korea

Wireless sensor network(WSN)is effective for monitoring the target environment,which consists of a large number of sensor nodes of limited *** efficient medium access control(MAC)protocol is thus imperative to maximize the energy efficiency and performance of *** most existing MAC protocols are based on the scheduling of sleep and active period of the nodes,and do not consider the relationship between the load condition and *** this paper a novel scheme is proposed to properly determine the duty cycle of the WSN nodes according to the load,which employs the Q-leaming technique and function approximation with linear *** allows low-latency energy-efficient scheduling for a wide range of traffic conditions,and effectively overcomes the limitation of Q-learning with the problem of continuous state-action ***3 simulation reveals that the proposed scheme significantly improves the throughput,latency,and energy efficiency compared to the existing fully active scheme and S-MAC.

关键词： wireless sensor network media access control duty-cycle scheduling Q-leaming linear regression

Evaluation of recurrence in gastric carcinoma: Comparison of contrast-enhanced computed tomography and positron emission tomography/computed tomography

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World Journal of Gastroenterology 2017年第35期23卷 6448-6456页

作者： Jong Hyeon kim Suk hee Heo Jin Woong kim Sang Soo Shin Jung Jun Min Seong Young Kwon Yong yeon Jeong Heoung Keun Kang Department of Radiology Chonnam National University Medical SchoolChonnam National University Hwasun Hospital Department of Radiology Chonnam National University Medical SchoolChonnam National University Hospital Department of Nuclear Medicine Chonnam National University Medical SchoolChonnam National University Hwasun Hostpital

AIM To compare the value of contrast-enhanced abdominal computed tomography(CT) and fluorodeoxyglucose(FDG) positron emission tomography/computed tomography(PET/CT) for detecting gastric carcinoma *** We retrospectively examined data from 2475 patients who underwent both contrast-enhanced abdominal CT and FDG PET/CT for the surveillance of gastric carcinoma curative resection. Patients had an interval of less than 1 mo between their CT and PET/CT scans. Sixty patients who had recurrence were enrolled. Among 1896 patients who did not have recurrence, 60 were selected by simple random sampling. All CT and PET/CT images were reviewed retrospectively by two reviewers blinded to all clinical and pathologic information except curative resection due to gastric carcinoma. RESULTS The pathological stage of the recurrence group was statistically significantly higher than that of the control group(P < 0.001). In the 60 patients who had recurrence, there were 79 recurrent lesions. Fortyfour patients had only one location of recurrence, 13 patients had two locations, and 3 patients had three. In the detection of patient-based overall recurrence, no statistically significant differences existed between the two modalities(P = 0.096). However, for peritoneal carcinomatosis, CT had a statistically significantly higher sensitivity compared to PET/CT(96% vs 50%, P = 0.001). Adenocarcinoma was the most common type of gastric carcinoma. On the pathology-based analysis, CT also had a statistically significantly higher sensitivity compared to PET/CT(98% vs 80%, P = 0.035).CONCLUSION Contrast-enhanced CT was superior to PET/CT in the detection of peritoneal carcinomatosis and pathologic type of adenocarcinoma.

关键词： Gastric carcinoma Surgery Contrastenhanced abdominal computed tomography Fluorodeoxyglucose positron emission tomograph/computed tomography Surveillance Recurrence