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Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model

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Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 653-658页

作者： Sung Min Woo Woo Rin Choi Dooly Jang Chun Sik Yi Hae Lim kim Kyung Hyeon kim Jong Tae kim Won hee Choi Seung hee Jang Min Jeung kim Ji Hyang Wee yeon Ki kim Bao Le Interdisciplinary Program of Biomodulation Myongji UniversityYonginGyeonggi 17058Republic of Korea Center for Nutraceutical and Pharmaceutical Materials Myongji UniversityYonginGyeonggi 17058Republic of Korea Teazen Co. B-606 Acrotower230 Sinim-daeroDongan-guAnyang-siGyeonggi-do 14067Republic of Korea Department of Food Science&Biotechnology Shin Ansan UniversityAnsanGyeonggi 15435Republic of Korea' Division of Bioscience and Bioinformatics Myongji UniversityYonginGyeonggi 17058Republic of Korea Department of Biotechnology Chonnam National UniversityYeosuChonnam 59626Republic of Korea

Objective: To investigate the effects of a herb complex extract(HCE) prepared from Cornus officinalis Sieb. Et Zucc., Eriobotrya japonica Lindley, and olive leaves on immune response of mouse spleen NK cells in vitro and in vivo analysis. Methods: The activity of natural killer(NK) cells was measured in splenocytes and YAC-1 cells. Mice were immunosuppressed using cyclophosphamide(5 mg/kg body weight). Three different doses of HCE(200, 400, and 800 mg/kg body weight) and red ginseng extract(800 mg/kg body weight) which was used as standard immunomodulatory herb were administered orally for 4 weeks. The body weight, dietary, water intake, organs(liver, thymus, and spleen) weight, completed blood count, and cytokines(tumor necrosis factor alpha, interferon gamma, and interleukin-2) production was measured. Results: At the maximum concentration of HCE, the activity of NK cells was increased by 48.5%. HCE increased liver, spleen, and thymus weights without altering numbers of white blood cells, lymphocytes, and neutrophils in a cyclophosphamide-induced immunosuppression rat model. However, HCE recovered the inhibited cytokine expression; HCE(800 mg/kg) increased cytokines levels. The results indicate the immune enhancement potential of this HCE. Conclusion: The HCE enhances immunity by increasing NK cell activity, regulating cytokine levels, and maintaining spleen weight. Therefore, it may be used as a potential immunity enhancer.

关键词： Immune system enhancement Cyclophosphamide Cornus officinalis Sieb Et Zucc Eriobotrya japonica Lindley Olive leaves

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Potential Alzheimer’s disease therapeutic nano-platform: Discovery of amyloid-beta plaque disaggregating agent and brain-targeted delivery system using porous silicon nanoparticles

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Bioactive Materials 2023年第6期24卷 497-506页

作者： Jaehoon kim Hyeji Um Na hee kim Dokyoung kim Department of Biomedical Science Graduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute Kyung Hee UniversitySeoul02447Republic of Korea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversitySeoul02447Republic of Korea Center for Converging Humanities Kyung Hee UniversitySeoul02447Republic of Korea KHU-KIST Department of Converging Science and Technology Kyung Hee UniversitySeoul02447Republic of Korea UC San Diego Materials Research Science and Engineering Center 9500 Gilman Drive La JollaCA92093USA

There has been a lot of basic and clinical research on Alzheimer’s disease(AD)over the last 100 years,but its mechanisms and treatments have not been fully *** some controversies,the amyloid-beta hypothesis is one of the most widely accepted causes of *** this study,we disclose a new amyloid-beta plaque disaggregating agent and an AD brain-targeted delivery system using porous silicon nanoparticles(pSiNPs)as a therapeutic nano-platform to overcome *** hypothesized that the negatively charged sulfonic acid functional group could disaggregate plaques and construct a chemical *** a result of the in vitro assay of amyloid plaques and library screening,we confirmed that 6-amino-2-naphthalenesulfonic acid(ANA)showed the highest efficacy for plaque disaggregation as a hit *** confirm the targeted delivery of ANA to the AD brain,a nano-platform was created using porous silicon nanoparticles(pSiNPs)with ANA loaded into the pore of pSiNPs and biotin-polyethylene glycol(PEG)surface *** resulting nano-formulation,named Biotin-CaCl2-ANA-pSiNPs(BCAP),delivered a large amount of ANA to the AD brain and ameliorated memory impairment of the AD mouse model through the disaggregation of amyloid plaques in the *** study presents a new bioactive small molecule for amyloid plaque disaggregation and its promising therapeutic nano-platform for AD brain-targeted delivery.

关键词： Alzheimer’s disease Plaques disaggregation Nanotherapeutics Brain-targeted drug delivery Porous silicon nanoparticles

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HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis

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Plant Communications 2023年第4期4卷 225-239页

作者： Gyeongik Ahn hee Jin Park Song Yi Jeong Gyeong-Im Shin Myung Geun Ji Joon-Yung Cha Jeongsik kim Min Gab kim Dae-Jin Yun Woe-yeon kim Research Institute of Life Science Institute of Agricultural and Life ScienceGyeongsang National UniversityJinju 52828Republic of Korea Division of Applied Life Science(BK21 Four) Plant Biological Rhythm Research CenterPlant Molecular Biology and Biotechnology Research CenterGraduate School of Gyeongsang National UniversityJinju 52828Republic of Korea Department of Biological Sciences College of Natural SciencesChonnam National UniversityGwangju 61186Republic of Korea Faculty of Science Education and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National UniversityJeju 63243Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Science PMBBRCGyeongsang National UniversityJinju 52828Republic of Korea Institute of Glocal Disease Control Konkuk UniversitySeoul 05029Republic of Korea Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China

Flowering is the primary stage of the plant developmental transition and is tightly regulated by environmental factors such as light and ***,the mechanisms by which temperature signals are integrated into the photoperiodic flowering pathway are still poorly ***,we demonstrate that HOS15,which is known as a GI transcriptional repressor in the photoperiodic flowering pathway,controls flowering time in response to low ambient *** 16℃,the hos15 mutant exhibits an early flowering phenotype,and HOS15 acts upstream of photoperiodic flowering genes(GI,CO,and FT).GI protein abundance is increased in the hos15 mutant and is insensitive to the proteasome inhibitor ***,the hos15 mutant has a defect in low ambient temperature-mediated GI degradation,and HOS15 interacts with COP1,an E3 ubiquitin ligase for GI *** analyses of the hos15 cop1 double mutant revealed that repression of flowering by HOS15 is dependent on COP1 at 16℃.However,the HOS15-COP1 interaction was attenuated at 16℃,and GI protein abundance was additively increased in the hos15 cop1 double mutant,indicating that HOS15 acts independently of COP1 in GI turnover at low ambient *** study proposes that HOS15 controls GI abundance through multiple modes as an E3 ubiquitin ligase and transcriptional repressor to coordinate appropriate flowering time in response to ambient environmental conditions such as temperature and day length.

关键词： Arabidopsis flowering response low ambient temperature HOS15 GIGANTEA

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Insights into the changes in the surface properties of goethite with Ni in the lattice in the presence of salicylhydroxamic acid:Experimental and density functional theory studies

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 665-677页

作者： Levie Mweene Gilsang Hong hee-Eun Jeong hee-won Kang Hyunjung kim Department of Earth Resources and Environmental Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea

Comparative experiments and theoretical analysis of the surface chemistry changes of goethite(GT)and goethite containing Ni(GTN)in the lattice in the presence of salicylhydroxamic acid(SA)were *** was revealed that in the presence of 100 g·t^(-1)of SA,the flotation recovery of GTN and GT increased with increasing pH,achieving a maximum recovery of 98.9%for both minerals at p H 8.3 and decreasing beyond that pH,with GTN having a slightly higher recovery than GT,except at pH *** was further confirmed by the higher complexation energies of GTN···SA(-883.87 kJ·mol^(-1))compared with GT···SA(-604.23 kJ·mol^(-1))resulting from covalent,closed-shell,and conventional hydrogen *** higher adsorption of SA onto GTN relative to GT was due to the formation of aπ-hole in GTN,thereby promoting a higher interaction of the collector with the ***,the presence of Ni in the GT lattice improves and decreases the adsorption and desorption of SA onto and from the mineral,respectively,compared with those onto and from GT.

关键词： nickel goethite adsorption salicylhydroxamic acid recovery

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Body-centered-cubic martensite and the role on room-temperature tensile properties in Si-added SiVCrMnFeCo high-entropy alloys

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Journal of Materials Science & Technology 2021年第17期76卷 222-230页

作者： Yong hee Jo Junha Yang Won-Mi Choi Kyung-yeon Doh Donghwa Lee Hyoung Seop kim Byeong-Joo Lee Seok Su Sohn Sunghak Lee Center for High Entropy Alloys Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering Division of Advanced Materials SciencePohang University of Science and TechnologyPohang 37673South Korea Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841South Korea

We present a new class of metastable high-entropy alloys(HEAs),triggering deformation-induced martensitic transformation(DIMT)from face-centered-cubic(FCC)to body-centered-cubic(BCC),i.e.,*** the ab-initio calculation based on 1 st order axial interaction model and combined with the Gibbs free energy calculation,the addition of Si is considered as a critical element which enables to reduce the intrinsic stacking fault energy(ISFE)in Si_xV_((9-x))Cr_(10)Mn_5 Fe_(46)Co_(30)(x=2,4,and 7 at.%)alloy *** ISFE decreases from-30.4 to-35.5 mJ/m^(2)as the Si content increases from 2 to 7 at.%,which well corresponds to the reduced phase stability of FCC against *** BCC-DIMT occurs in all the alloys via intermediate HCP martensite,and the HCP martensite provides nucleation sites of BCC ***,the transformation rate enhances as the Si content increases in an earlier deformation ra ***,the BCC-DIMT is also affected by the phase stability of FCC against BCC,and the stability is the highest at the Si content of 7 at.%.Thus,the 7Si alloy presents the moderate transformation rate in the later deformation *** to the well-controlled transformation rate and consequent strain-ha rdening rate,the 7Si alloy possesses the superior combination of strength and ductility beyond 1 GPa of tensile strength at room *** results suggest that the Si addition can be a favorable candidate in various metastable HEAs for the further property improvement.

关键词： High-entropy alloy(HEA) Deformation-induced martensitic transformation(DIMT) Phase stability Stacking fault energy(SFE)

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Genome-wide DNA methylation profiling reveals candidate biomarkers and probable molecular mechanism of metabolic syndrome

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Genes & Diseases 2022年第4期9卷 833-836页

作者： Su-Jin Baek Hyo-Jeong Ban Sang-Min Park Soo yeon kim Siwoo Lee hee-Jeong Jin KM Data Division Korea Institute of Oriental Medicine1672 Yuseong-daeroYuseong-guDaejeon 34054Republic of Korea

Although aberrant DNA methylation changes are significantly associated with the pathogenesis of many diseases,little is known about the molecular mechanisms underlying interactions between DNA methylation and gene expression in metabolic syndrome(MetS).The aim of this study was to identify biomarkers and molecular mechanisms regulated by DNA methylation in *** profiled genome-wide DNA methylation using the Infinium MethylationEPIC BeadChIP and characterized the transcriptome by RNA sequencing in our study population comprised of subjects with MetS(n=11)and controls(n=9).

关键词： diseases pathogenesis EPIC

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S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis

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Bone Research 2019年第4期7卷 424-436页

作者： Haemin kim Bongjun kim Sang Il kim Hyung Joon kim Brian YRyu Junho Chung Zang hee Lee Hong-hee kim Department of Cell and Developmental Biology BK21 Program and DRISeoul National UniversitySeoulKorea Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea Cancer Research Institute Seoul National University College of MedicineSeoulKorea Department of Cancer Biology Seoul National University College of MedicineSeoulKorea Department of Oral Physiology BK21 PLUS Projectand Dental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanKorea Interdisciplinary Program in Bioinformatics Seoul National University College of Natural SciencesSeoulKorea Department of Biomedical Sciences Seoul National University Graduate SchoolSeoulKorea

Bone destruction induced by breast cancer metastasis causes severe complications,including death,in breast cancer *** between cancer cells and skeletal cells in metastatic bone microenvironments is a principal element that drives tumor progression and ***-derived factors play fundamental roles in this form of *** identify soluble factors released from cancer cells in bone metastasis,we established a highly bone-metastatic subline of MDA-MB-231 breast cancer *** subline(mtMDA)showed a markedly elevated ability to secrete S100A4 protein,which directly stimulated osteoclast formation via surface receptor *** S100A4 stimulated osteoclastogenesis in vitro and bone loss in *** medium from mtMDA cells in which S100A4 was knocked down had a reduced ability to stimulate ***,the S100A4 knockdown cells elicited less bone destruction in mice than the control knockdown *** addition,administration of an anti-S100A4 monoclonal antibody(mAb)that we developed attenuated the stimulation of osteoclastogenesis and bone loss by mtMDA in *** together,our results suggest that S100A4 released from breast cancer cells is an important player in the osteolysis caused by breast cancer bone metastasis.

关键词： S100A4 breast metastatic

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Laparoscopic gastric bypass vs sleeve gastrectomy in obese Korean patients

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World Journal of Gastroenterology 2015年第44期21卷 12612-12619页

作者： Ji yeon Park Yong Jin kim Department of Surgery Soonchunhyang University Seoul Hospital Department of Surgery National Cancer Center Goyang-si

AIM: To compare the mid-term outcomes of lapa-roscopic sleeve gastrectomy(LSG) and laparoscopic Roux-en-Y gastric bypass(LRYGB) in obese Korean patients. METHODS: All consecutive patients who underwent either LSG or LRYGB with primary to treat morbid obesity between January 2011 and December 2012 were retrospectively reviewed. Patients with a body mass index(BMI) ≥ 30 kg/m2 with inadequately controlled obesity-related comorbidities(e.g., diabetes, obstructive sleep apnea, hypertension, or obesityrelated arthropathy) or BMI ≥ 35 kg/m2 were considered for bariatric surgery according to the International Federation for the Surgery of Obesity-Asia Pacific Chapter Consensus statements in 2011. The decision regarding the procedure type was made on an individual basis following extensive discussion with the patient about the specific risks associated with each procedure. All operative procedures were performed laparoscopically by a single surgeon experienced in upper gastrointestinal surgeries. Baseline demographics, perioperative surgical outcomes, and postoperative anthropometric data from a prospectively established database were thoroughly reviewed and compared between the two surgical ***: One hundred four patients underwent LSG, and 236 underwent LRYGB. Preoperative BMI in the LSG group was significantly higher than that of the LRYGB group(38.6 kg/m2 vs 37.2 kg/m2, P = 0.024). Patients with diabetes were more prevalent in the LRYGB group(18.3% vs 35.6%, P = 0.001). Operating time and hospital stay were significantly shorter in the LSG group compared with the LRYGB group(100 min vs 130 min, P < 0.001; 1 d vs 2 d, P = 0.003), but the incidence of perioperative complications was similar between the groups(P = 0.351). The mean percentage of excess weight loss(%EWL) was 71.2% for LRYGB, while it was 63.5% for LSG, at mean follow-up periods of 18.0 and 21.0 mo, respectively(P = 0.073). The %EWL at 1, 3, 6, 12, 18, 24, and 36 mo was equivalentbetween the grou

关键词： Morbid obesity Bariatric surgery Rouxen-Y gastric

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Early experience of the compression anastomosis ring (CAR^(TM) 27) in left-sided colon resection

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World Journal of Gastroenterology 2011年第43期17卷 4787-4792页

作者： Jung-yeon Lee Jin-hee Woo Hong-Jo Choi Ki-Jae Park Young-Hoon Roh Ki-Han kim Hak-Yoon Lee Department of Surgery Dong-A University Medical Center

AIM:To evaluate clinical validity of the compression anastomosis ring(CARTM27) anastomosis in left-sided colonic resection. METHODS:A non-randomized prospective data collection was performed for patients undergoing an elective left-sided colon resection,followed by an anastomosis using the CARTM27 between November 2009 and January *** criteria of the use of the CARTM27 were anastomoses between the colon and at or above the intraperitoneal *** primary short-term clinical endpoint,rate of anastomotic leakage,and other clinical outcomes,including intraand postoperative complications,length of operation time and hospital stay,and the ring elimination time were evaluated. RESULTS:A total of 79 patients(male,43;median age,64 years) underwent an elective left-sided colon resection,followed by an anastomosis using *** was performed laparoscopically in 70 patients,in whom two patients converted to open procedure(2.9%) .There was no surgical *** an intraoperative complication,total disruption of the anastomosis occurred by premature enforced tension on the proximal segment of the anastomosis in one *** ring was removed and another new CARTM27 anastomosis was *** patient with sigmoid colon cancer showed postoperative anastomotic leakage after 6 d postoperatively and temporary diverting ileostomy was *** date of expulsion of the ring could not be recorded because most patients were not aware that the ring had been *** patients manifested clinical symptoms of anastomotic stricture. CONCLUSION:Short-term evaluation of the CARTM27 anastomosis in elective left colectomy suggested it to be a safe and efficacious alternative to the standard hand-sewn or stapling technique.

关键词： Compression anastomosis Colon Anastomotic leakage CARTM27

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PopFlow:a novel flow management scheme for SDN switch of multiple flow tables based on flow popularity

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Frontiers of Computer Science 2020年第6期14卷 111-122页

作者： Cheng WANG Kyung Tae kim hee Yong YOUN College of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon 16419Korea College of Software Sungkyunkwan UniversitySuwon 16419Korea

Pipeline processing is applied to mutiple flow tables(MFT)in the switch of software-defined network(SDN)to increase the throughput of the ***,the processing time of each flow increases as the size or number of flow tables gets *** this paper we propose a novel approach called PopFlow where a table keeping popular flow entries is located up front in the pipeline,and an express path is provided for the flow matching the table.A Markov model is employed for the selection of popular entries considering the match latency and match frequency,and Queuing theory is used to model the flow processing time of the existing MFT-based schemes and the proposed *** simulation reveals that the proposed scheme substantially reduces the flow processing time compared to the existing schemes,and the diference gets more significant as the flow arrival rate increases.

关键词： edge computing SDN pipeline processing PopFlow match frequency and latency markov model-based prediction

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