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Assessments on slope instabilities triggered by engineering excavations near a small settlement(Turkey)

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Journal of Mountain Science 2018年第1期15卷 114-129页

作者： TUnCAY ergün Department of Geological Engineering Hacettepe University

In this study,the mechanisms of slope instabilities triggered by engineering excavations at location of a planned tunnel portal in the northwest region of Turkey were assessed,and stability of the current slopes which has impacts on safety of a settlement(village)and agricultural fields was *** the first stage of the study,in order to identify the geological units and structural properties of the sedimentary rocks in the area,to clarify the mechanisms of instabilities and to characterize discontinuity and rock mass properties field works were *** this content,geotechnical boreholes,geophysical explorations between the boreholes,line surveys to explore discontinuity properties,preparation of slope profiles using topographical techniques and sampling of rock blocks and discontinuity planes were *** the second stage,laboratory tests were carried out on the samples to determine the geomechnical properties of the slope forming materials and ***,back analyses of the instabilities were made to assess the responsible shear strength parameters of the geological units during failures by considering laboratory shear test results *** on the backanalyses of the failures,the strength properties of the slope debris were estimated,and it has been clarified that the residual shear strength properties are the factors controlling slip mechanism along the *** the stability analyses,it is understood that a further instability along the mass or bedding planes in the failed and redesigned area are not expected,if the current slope geometry is not ***,safety factor calculated for the slope in the debris is 1.1 which is well below the recommended value in the *** minimum safety factor for currently stable slopes which were cut at the eastern part of the failed area is 1.22 which is also less than that suggested in *** remedial measures such as mini-pile or slope flattening are suggested af

关键词： Slope instability Back-analysis Remedial measures

Mechanical Properties of Epoxy Composite Materials Produced with Different Ceramic Powders

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Journal of Materials Science and Chemical Engineering 2019年第12期7卷 1-8页

作者： yelda akcin ergün Department of Metallurgical and Material Engineering Faculty of TechnologyAfyon Kocatepe UniversityAfyonkarahisarTurkey

In this study, production and mechanical properties of polymer composite materials obtained by using Al2O3, SiO2, MgO and TiO2 hard ceramic fillers were studied. Epoxy resin was used as the matrix material, and four different ceramic powders were mechanically mixed into the resin at 3% and 5% as reinforcement. The mechanical properties of the polymer composite materials were then characterized. For this purpose, flexural modulus and flexural strength of composite materials were determined by using three point bending test and impact toughness of the materials were determined by Charpy impact test. In addition, the hardness values of the samples were determined by Shore D hardness test.

关键词： Polymer Composite Epoxy Ceramic Powders Mechanical Properties

nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Surface Pencil with a Common Line of Curvature in Minkowski 3-Space

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Acta Mathematica Sinica,English Series 2014年第12期30卷 2103-2118页

作者： Evren ergn ergin BAYRAM Emin KASAP Ondokuz Mayis University arsamba Chamber of Commerce Vocational School Ondokuz Mayis University Faculty of Arts and SciencesMathematics Department

In this paper, we analyze the problem of constructing a surface pencil from a given spacelie （timelike） line of curvature. Using the Frenet frame of the given line of curvature in Minkowski 3-space, we express the surface pencil as a linear combination of this frame and derive the necessary and sufficient conditions for the coefficients to satisfy the line of curvature requirement. We illustrate this method by presenting some examples.

关键词： Minkowski space line of curvature surface pencil

Is Li-ESWT effective in diabetic patients with severe erectile dysfunction?

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Asian Journal of Andrology 2022年第5期24卷 521-524页

作者： Müslüm ergün Osman akyüz Department of Urology School of MedicineAtlas UniversityIstanbul 34200Turkey

noninvasive low-intensity extracorporeal shockwave treatment(Li-ESWT)has been widely used to treat erection *** is no clear information regarding either the selection of patients for the treatment or the treatment *** this study,we aimed to investigate the efficacy of extracorporeal shockwave therapy in diabetic patients with severe erectile dysfunction(International Index of Erectile Function-5[IIEF-5]scores of 5 to 7).Sixty-three diabetes mellitus patients with erectile dysfunction having IIEF-5 scores of 5 to 7 and not showing a recovery of potency despite phosphodiesterase type 5 inhibitor therapy for the past 6 months were included in the *** patients were evaluated based on their IIEF-5 scores and Erection Hardness Scale *** IIEF-5 score(mean±standard deviation[s.d.])increased from 5.29±1.67 to 5.56±1.85,with a difference of 0.27±0.18(P>0.05).The Erection Hardness Scale scores(mean±s.d.),on the other hand,increased from 1.46±0.50 to 1.48±0.50,with a difference of 0.02±0(P>0.05).In conclusion,the response to phosphodiesterase type 5 inhibitors did not change after extracorporeal shockwave treatment in diabetes mellitus patients with severe erectile dysfunction(IIEF-5 scores of 5 to 7).

关键词： diabetes mellitus International Index of Erectile Function-5 score low-intensity extracorporeal shockwave treatment severe erectile dysfunction

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(akT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/akT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/akT/connexin 43,and notch/PI3K/akT *** targeting the inactivation of the PI3K/akT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/akT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

Fair-news: Digital Journalism Model to Prevent Information Pollution and Manipulation

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Computers, Materials & Continua 2023年第6期75卷 6059-6082页

作者： Savas Takan Duygu ergün Gökmen Katipoglu Department of Artificial Intelligence and Data Engineering Ankara UniversityAnkara06830Turkey Faculty of Fine Arts Design&Architecture Fine Arts and Elective CoursesAtılım UniversityAnkara06830Turkey Department of Computer Engineering Kafkas UniversityKars36100Turkey

As digital data circulation increases,information pollution and manipulation in journalism have become more *** this study,a new digital journalism model is designed to contribute to the solution of the main current problems,such as information pollution,manipulation,and account-ability in digital *** model uses blockchain technology due to its transparency,immutability,and ***,it is tough to provide the mechanisms necessary for journalism,such as updating one piece of information,instantly updating all other information affected by the updated information,establishing logical relationships between news,making quick comparisons,sorting and indexing news,and keeping the changing informa-tion about the news in the system,with the blockchain data *** this reason,in our study,we have developed a new data structure that provides both the immutability,transparency and traceability properties of the blockchain and can support the communication mechanisms necessary for *** functionality of our proposed data structure is demonstrated in terms of communication mechanisms such as mutability,context,consistency,and reliability through example ***,our data structure is compared with the data structure of blockchain technology in terms of time,space,and maintenance ***,while the model size increases linearly in blockchain,the model’s size remains approximately constant since the structure we developed is *** this way,maintenance costs are *** our model also has an indexing mechanism,it reduces the linear time search complexity to logarithmic *** a result,the data structure we developed is found to have higher performance than blockchain in the journalism *** future studies,it is planned to test all aspects of the model with a pilot application,eliminate its shortcomings,and develop a holistic approach to the root causes of the problems in the journalism

关键词： Digital journalism data structure news-sharing platform verification mechanism distributed ledger new media information pollution and manipulation