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Unbiased Diffusion to Escape Complex Geometries: is Reduction to Effective One-Dimensional Description Adequate to Assess narrow Escape Times?

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Applied Mathematics 2014年第8期5卷 1218-1225页

作者： Yoshua chávez Guillermo chacón-Acosta Marco-Vinicio Vázquez Leonardo Dagdug Applied Mathematics and Systems Department Universidad Autónoma Metropolitana-Cuajimalpa México DF México chemistry Department Universidad Autónoma Metropolitana-Iztapalapa México DF México Physics Department Universidad Autónoma Metropolitana-Iztapalapa México DF México

This study is devoted to unbiased diffusion of point Brownian particles inside a tube of varying cross-section (see Figure 1). An expression for the mean survival time, , of the particles inside the tube is obtained in terms of the bulk diffusion constant, D0 and the system’s geometrical parameters, namely, the tube’s axial semi-length, L, the minor radius, , and the slope of the tube’s wall, . Our expression for correctly retrieves the limit behavior of the system under several conditions. We ran Monte Carlo numerical simulations to compute the mean survival time by averaging the survival time of 5 × 104 trajectories, with time step t = 10-6, D0 = 1, and L = 1. The simulations show good agreement with our model. When the geometrical parameters of this system are varied while keeping constant the tube’s enclosed volume, it resembles the problems of narrow Escape Time (J. chem. Phys. 116(22), 9574 (2007)). A previous study on the use of the reduction to effective one-dimension technique (J. Mod. Phys. 2, 284 (2011)) in complex geometries has shown excellent agreement between the theoretical model and numerical simulations. However, in this particular system, the general assumptions of the Hill problem are seemingly inapplicable. The expression obtained shows good agreement with our simulations when 0 ≤ ≤ 1, but fails when grows larger. On the other hand, some errors are found when 0, but the expression holds reasonably well for a broad range of values of . These comparisons between simulations and theoretical predictions, and the expressions obtained for , are the main results of this work.

关键词： Component Formatting Style Styling insert

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characteristics of ionospheric scintillation climatology over indian low-latitude region during the 24th solar maximum period

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Geodesy and Geodynamics 2019年第2期10卷 110-117页

作者： K.Sahithi M.Sridhar Sarat K.Kotamraju K.ch.Sri Kavya G.Sivavaraprasad D.Venkata Ratnam ch.Deepthi Department of Electronics and Communication Engineering Koneru Lakshamaiah Education Foundation

The amplitude and phase of L-band satellite signals are fluctuated randomly due to small scale electron density irregularity structures in the ionosphere which result in fleeting variations, known as 'ionospheric scintillations'. The Global navigation Satellite System(GnSS) is a profound remote sensing tool to monitor, model and forecast the ionospheric weather conditions. in this paper, the GnSS amplitude scintillation data has been analyzed during the year 2013 at Bengaluru(12.9°n, 77.59°E) and Lucknow(26.8467°n, 80.9462°E) stations to reinforce climatology of ionospheric scintillation over indian low-latitude region. The probability of scintillation occurrence and their variations over equatorial and Equatorial ionization Anomaly(EiA) regions in india are analyzed during various geomagnetic quiet and disturbed days, months and seasons. The annual occurrence of amplitude scintillations are mapped with the function of local time. it is observed from the experimental results that the probability of scintillations occurrences is higher over EiA region than over the equatorial region. The probability of scintillations is higher during March equinox and December solstice, and lowest during June *** of scintillations is intense during post-sunset period. The maximum percentage of scintillation occurrences at the two stations are recorded in november. Moreover, the highest percentage of scintillation occurrences took place on storm day(March 17, 2013) at the two stations. This work would be helpful for understanding the features of GnSS amplitude scintillations over Southern and northern indian regions. Moreover, these kinds of investigations are helpful for developing new algorithms to nowcast and forecast ionospheric scintillations over indian Sub-continent.

关键词： GnSS ionospheric scintillations indian low-latitude region

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Study nanostructure of a Biomaterial with Medicine Therapeutic Activity

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Microscopy Research 2016年第2期4卷 32-38页

作者： Marilú chávez-Castillo Martha Lilia Domínguez-Patiño Rosa María Melgoza-Alemán Centro de investigación en ingeniería y Ciencias Aplicadas Universidad Autónoma del Estado de Morelos Cuernavaca México Facultad de Ciencias Químicas e ingeniería Universidad Autónoma del Estado de Morelos Cuernavaca México

in Mexico, the medicinal plants have been for used since ancient times and still continue to use by rural populations to treat conditions such as infectious diseases (skin, gastrointestinal or respiratory), metabolics, inflammatory problems, among others. This work includes a proposal that initiates the study and development of new biomaterials or vehicles with therapeutic application. The nanomolecular interaction of the organic extract of a plant (EOV) Distictis buccinatoria (dc) with different materials inert supports of inorganic type (bentonite, gel) determining their and combined anti-inflammatory activity is studied individually [1] [2]. The importance of the characterization of biomaterials by scanning electron microscopy (SEM) is ability to analyze the structure on the surface of materials (organic, inorganic and biological) in the micro and nanometrics levels in order to correlate it with the sample surface properties such as roughness, interfacial phenomena, etc. With this technique we can also perform the chemical analysis at different levels (micro and nano) for information on the nature and composition of the materials [3] [4]. The biomaterial shows that higher anti-inflammatory activity is to be generated through the combination of EOV-gel, the nanostructure interaction SEM shows integrated particles agglome-rated form and porous due to the presence of EOV and some flat areas indicated the gel preponderance situation generated by the low interaction between materials of organic type and polar type (gel).

关键词： Biomaterials nanomolecular Anti-inflamatory Vehicles

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Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors

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World Journal of Gastroenterology 2005年第40期11卷 6373-6380页

作者： Yen-Shen Lu Huang-ch.n Lien Pei-Yen yeh Kun-Huei yeh Min-Liang Kuo Sung-Hsin Kuo Ann-Lii ch.ng Department ofOncology National Taiwan University Hospital Graduate Instituteof Clinical Medicine National Taiwan University College ofMedicine Taipei Taiwan China Departments of Pathology National TaiwanUniversity Hospital Taipei Taiwan China Department of Oncology National Taiwan UniversityHospital Taipei Taiwan Department of Oncology and Departments of InternalMedicine National Taiwan University Hospital Departments ofInternal Medicine and Medical Research Far Eastern MemorialHospital Taipei Taiwan China Department of Oncology and Department ofInternal Medicine National Taiwan University Hospital TaipeiTaiwan China

AiM： To determine how glucocorticoids （GCs） may affect the growth and chemosensitivity of common carcinoma cells. METHODS： The effect of dexamethasone （DEX） on growth and chemosensitivity was assessed in 14 carcinoma cell lines. The function of GC receptors （GR） was assessed by MMTV reporter assay. Overexpression of GR was done by in vitro transfection and expression of a GR-expressing vector. immunohistochemical stain of tissues and ceils were done by PA1-511A, an anti-GR monodonal antibody. RESULTS： DEX inhibited cell growth of four （MCF-7, MCF- 7/MXR1, MCF-7/TPT300, and HeLa）, increased cisplatin cytoxicity of one （SiHa）, and decreased dsplatin cytotoxicity of two （H460 and Hep3B） cell lines. The GR content of the seven cell lines affected by DEX was significantly higher than those of the seven cell lines unaffected by DEX （5.2±2.5×10^4 sites/cell vs1.3±1.4×10^4 sites/cell, P= 0.005）. Only two DEX-unresponsive cell lines {nPC-TW01 and nPC- TW04） oontained high GR amounts in the range （1.9-8.1×10^4 sites/cell） of the seven DEX-responsive cell lines. The GR function of nPC-TW01 and nPC-TW04, however, was foundto be impaired. The importance of high cellular amount of GR in mediating DEX susceptibility of the cells was further exemplified by GR dose-dependent drug resistance to cisplatin of AGS, a cell line with low GR content and was unaffected by DEX before transfection of GR-expressing vector. immunohistochemical studies of human cancer tissues showed that 5 of the 45 （11.1%） breast cancer and 43 of the 85 （50.6%） non-small cell lung cancer had high GR contents at the ranges of the GC-responsive carcinoma cell lines. COnCLUSiOn： The growth and chemosensitivity of human carcinomas with high GR contents may be affected by GC. However, in light of the heterogeneous and even contradictive effects of GC on these cells, routine examination of GR contents of human carcinoma tissues may not be clinically useful until other markers that help predict the ultimate effect of

关键词： Glucocorticoids Glucocorticoid receptor Carcinoma Cell growth chemosensitivility Drug resistance

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Retroperitoneal epithelioid sarcoma: A case report

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World Journal of Gastrointestinal Endoscopy 2017年第12期9卷 579-582页

作者： JoséA Coronado Migueláchávez Martín A Manrique Jony Cerna Ana L Trejo Division of Gastrointestinal Endoscopy Hospital Juarez de Mexico Division of Anatomic Pahology Hospital Juarez de Mexico

Epithelioid sarcoma(ES), a mesenchymatous malign neoformation, is often diagnosed in later stages and associated with high recurrence index, metastasis and mortality. We report a case of a 65 years old male, with history of abdominal pain and upper gastrointestinal bleeding. Endoscopy demonstrated a posterior duodenal wall perforation communicating with a solid retroperitoneal neoformation. Endoscopic biopsy was performed, with a final report of ES. The patient was submitted for surgical palliation due to the tumor's unresectability. Retroperitoneal ES is an extremely rare condition with limited reports in the literature where guidelines for its optimal treatment are not well established.

关键词： Epithelioid sarcoma Retroperitoneal Mesenchymatous neoformation Duodenal perforation Endoscopy

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对《消费经济》的展望与期望——庆祝《消费经济》创刊20周年

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消费经济 2006年第2期22卷 3-4页

作者：何炼成西北大学经济管理学院

在我国著名消费经济学家尹世杰教授的亲手领导和指导下，《消费经济》杂志迎来了20周年华诞，可喜可贺。作为贵刊的忠实读者与作者，谨对贵刊的创建者和指导者表示崇高的敬意，并对贵刊全体工作人员表示诚挚的感谢。

关键词：消费经济创刊20周年期望展望经济学家工作人员尹世杰指导者

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基于人均GDP的上海房地需求分析

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消费经济 2005年第2期21卷 52-54页

作者：陈鹏程复旦大学管理学院上海200433

目前上海市房地产需求处于数量和质量并重的发展阶段,本文以上海市人均GDP为基础,采用上海市1985-2003年的历史数据,建立了上海市人均住房面积与人均GDP的回归模型,利用这一回归模型对上海市2020年前的主要年份住房需求进行了预测。

关键词：上海房地产业人均GDP 房地产需求房地产市场

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论消费者权益案中的举证责任配置

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消费经济 2005年第2期21卷 72-74页

作者：谌小永湖南省怀化市委党校湖南怀化418008

与商品生产经营者相比,消费者在保护消费者权益过程中发生的经济关系中处于弱势地位,因而在侵权诉讼中配置举证责任时应向消费者倾斜,即消费者只需负责举证受损害的事实证据,其他举证责任则应由商品生产经营者负责。

关键词：消费者权益举证责任配置《消费者权益保护法》中国维权工作侵权行为产品质量

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Research on a Dispersed networked CAD/CAM System of Motorcycle

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厦门大学学报（自然科学版） 2002年第S1期41卷 167-168页

作者： WAnG Xian-kun (Dept. of Mech.nical Engineering, Fuzhou University, Fuzhou 350002, ch ina)

in order to improve competitive ability of market, mo torcycle enterprises, special the small and middle sized ones must use iT to org anize social resource and adopt effective production mode, namely the dispersed networked design and manufacturing (DnDM), which was put forward and proved to b e one of vitality production modes in recent years. in responding to the new pro duction mode of VMCE, a dispersed networked CAD/CAM system (DnCADMS) of motorcyc le products should be developed. The objective of this paper is to investigate a new design and manufacturing mode and technical environment of motorcycle produ ction based on the concept of the DnDM for the small and meddle sized motorcycle enterprises. Because there are various CAx software systems, including differen t kinds of isolated CD, CAD, CAE, CAPP, CAM, PDM, and so on, are used at differe nt stages of the life period of motorcycle products under heterogeneous environm ents, to build a DnCADMS of motorcycle with high performance, some key issues, n amely the architecture of the DnCADMS, the integration of the isolated CAx softw are systems (CAxs), the data communication and exch.nge between these isolated s ystems and the data share problem under the dispersed heterogeneous database env ironment, should be solved well. For this, the idea we propose is the combinatio n of Web, CORBA, STEP and Java, which provides an effective mech.nism to support the integration of isolated CAxs, and support communication and interoperabilit y among CAx systems. Each isolated CAx has been encapsulated respectively by a c ontainer, which is implemented by the ORBs and the iDL of the COBRA technology s tandard, and managed by the application index server. Each container is connecte d with the others by a local network or intranet/Extranet/internet and communica tes through network. For exch.nging design and manufacturing information and kno wledge via a local network or the internet, a commmerical product data translato r has

关键词： dispersed networked CAD/CAM PDM motorcycle We b CORBA

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Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration

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international Journal of Oral Science 2023年第2期15卷 185-203页

作者： Milos Marinkovic Olivia n.Tran Hanzhou Wang Parveez Abdul-Azees David D.Dean Xiao-Dong ch.n chih-Ko yeh Department of Comprehensive Dentistry University of Texas Health Science Center at San AntonioTXUSA Research Service South Texas Veterans Health Care SystemTXUSA Department of Biomedical Engineering University of Texas at San AntonioTXUSA Geriatric Research Education and Clinical CenterSouth Texas Veterans Health Care SystemTXUSA

Salivary gland(SG)dysfunction,due to radiotherapy,disease,or aging,is a clinical manifestation that has the potential to cause severe oral and/or systemic diseases and compromise quality of ***,the standard-of-care for this condition remains palliative.A variety of approaches have been employed to restore saliva production,but they have largely failed due to damage to both secretory cells and the extracellular matrix(niche).

关键词： salivary clinical diseases

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