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Role of the Alleviating Aβ Toxicity in the Anti-AD Effect of Brown Wolfberry

Food Science and Human Wellness 2024年

作者： Miaosi Zhang Rui Liu Ran Yang Jilite Wang Xiaozhi Liu Baorui Li ye.Zhang Hao Wang State Key Laboratory of Food Nutrition and Safety， Tianjin University of Science and Technology (TUST) Department of Agriculture， Hetao College Tianjin Key Laboratory of Epigenetic for Organ Development of Preterm Infants， Tianjin Fifth Central Hospital High Altitude Characteristic Medical Research Institute， Huangnan Tibetan Autonomous Prefecture People's Hospital Institute of Food & Nutrition Science and Technology， Shandong Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Key Laboratory of Novel Food Resources Processing， Ministry of Agriculture and Rural Affairs/Shandong Engineering Research Center of Food for Special Medical Purpose

Wolfberry (Lycium barbarum L.) is a medicinal herb with anti-aging and neuroprotective effects. The purpose of this study was to explore the enhanced neuroprotective effects of wolfberry water extract (rw)， and brown wolfberry water extract (BBW). The reduced percentage of reducing sugar in BBW was shown to be 62.8%， 64.3%， 39.8%， and 11.6% for glucose， fructose， maltose， and lactose compared to those of rw， as well as free amino acids. And the contents of total phenols and total flavonoids were increased by 62.0% and 33.1%. Melanoidins (1% ± 0.05%) were first isolated from BBW. rw and BBW increased anti-stress abilities (oxidative stress: 24.2% vs 35.7%， and heat stress: 10.9% vs 19.1%) while decreasing the ROS levels in vivo. rw and BBW reduced the rate of paralysis and odor cognitive deficits. At the same time， rw and BBW reduced the number of fluorescent spots of Aβ::GFP. The rw and BBW activated autophagy by upregulating the gene levels (bec-1， lgg-1， lgg-2， unc-51， vps-34， atg-5， atg-18， and sqst-1). Additionally， BBW promoted the nuclear-cytoplasmic ratio of DAF-16::GFP and fluorescence intensity of SOD-3::GFP by 39.4 fold and 1.16 fold. This study laid a new insight for exploring the Maillard reaction in improving the anti-AD activity of wolfberry.

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日本对非洲农业技术转移的发展、模式与反思——以日本对撒哈拉以南非洲国家水稻技术转移为例

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中国农村经济 2024年第2期 155-174页

作者：马红坤金晔毛世平山东师范大学经济学院中国农业科学院农业经济与发展研究所

本文以日本对撒哈拉以南非洲国家水稻技术转移为例,系统探究日本官方发展援助对非农业技术转移的发展、模式并进行深刻反思,进而凝练出对中国完善对非洲农业技术转移机制的启示。研究发现,自20世纪60年代始,日本基于履行国际责任、开发... 详细信息

本文以日本对撒哈拉以南非洲国家水稻技术转移为例,系统探究日本官方发展援助对非农业技术转移的发展、模式并进行深刻反思,进而凝练出对中国完善对非洲农业技术转移机制的启示。研究发现,自20世纪60年代始,日本基于履行国际责任、开发非洲资源与市场、获取国际社会信任和话语权、推动实施“海外农业战略”等综合考量,不断推动对非洲农业技术转移。为此,日本着眼水稻生产经营链条的每个环节,向撒哈拉以南非洲国家开展以编制产业发展规划、灌溉水稻栽培、新品种推广、收获后加工以及增强受援国自主创新能力为典型模式的水稻综合技术转移。总体来看,日本官方发展援助农业技术转移取得了一定成效,但可持续性尚有不足。日本官方发展援助对非洲农业技术转移的经验和教训,在实现双方技术优势和真实需求有效衔接、变革非洲农耕模式和农耕理念、拓展技术转移视野以开展综合技术转移、提升技术转移的可持续性等方面对中国具有启示意义。

关键词：农业技术转移非洲水稻官方发展援助(ODA) 日本

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加载环形等离子体束的圆柱波导中慢等离子体波高频特性的数值研究

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强激光与粒子束 2024年第4期36卷 215-221页

作者：杨温渊董志伟董烨周前红北京应用物理与计算数学研究所北京100094

等离子体相对论微波发生器(PRMG)可以产生宽带高功率微波输出,同时又具有良好的频率可调谐性,因此在雷达、通信、电子对抗和物体探测等诸多领域均具有良好的应用前景。PRMG通常采用加载环形等离子体束的圆柱波导作为其波束互作用区,工... 详细信息

等离子体相对论微波发生器(PRMG)可以产生宽带高功率微波输出,同时又具有良好的频率可调谐性,因此在雷达、通信、电子对抗和物体探测等诸多领域均具有良好的应用前景。PRMG通常采用加载环形等离子体束的圆柱波导作为其波束互作用区,工作模式为慢等离子体波TM_(01)模(下称P-TM_(01)模)。P-TM_(01)模的色散特性及其变化规律对PRMG输出性能有着重要影响。利用全电磁粒子模拟程序对加载环形等离子体束的圆柱波导中P-TM_(01)模的色散特性和场分布进行了粒子模拟和分析,获得等离子体束密度n_(p)、径向厚度Δr_(p)和径向位置r_(p)以及外加引导磁场强度B_(z)和波导半径r_(w)等参数对P-TM_(01)模的色散特性和场分布的影响规律。主要研究结果包括:(1)一定范围内,n_(p)和Δr_(p)的变化对色散特性影响较大,r_(p),B_(z)和r_(w)的变化对色散特性影响较小。值得关注的是,由于波导中环形等离子体束的存在,随着波导半径r_(w)的增加,相同纵向波数k_(z)对应的P-TM_(01)模的频率没有降低而是略有提高。因此,在实际应用时,可以适当加大波导径向尺寸以提高器件功率容量;适当降低磁场,则有利于提高器件的紧凑性。(2)P-TM_(01)模的纵向电场的方向不随径向位置变化,径向电场的方向在等离子体束内外两侧相反,外侧的场分布与同轴波导中TEM模相似。(3)主要物理参数变化时,场分布基本特点不会改变。但随着纵向模式数N和k_(z)相应增加,电场能量向等离子体束收拢,不利于波束相互作用和电磁场的耦合输出。因此为了PRMG的高效运行,束波互作用的共振点最好落在k_(z)相对较小的区域。上述研究结果对PRMG的设计和优化具有一定的理论参考价值。

关键词：等离子体相对论微波发生器慢等离子体波色散特性场分布粒子模拟

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A massless scalar field in Robertson-Walker spacetimes:Adiabatic regularization and Green’s function

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Chinese Physics C 2020年第9期44卷 194-209页

作者： Yang Zhang Bo Wang Xuan ye Department of Astronomy CAS Key Laboratory for Researches in Galaxies and CosmologySchool of Astronomy and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China

We study adiabatic regularization of a coupling massless scalar field in general spatially flat Robertson-Walker(rw)*** the conformal coupling,the 2nd-order regularized power spectrum and 4th-order regularized stress tensor are zero,and no trace anomaly exists in general rw *** is a new result that exceeds those found in de Sitter *** the minimal coupling,the regularized spectra are also zero in the radiationdominant and matter-dominant stages,as well as in de Sitter *** vanishing of these adiabatically regularized spectra is further confirmed by direct regularization of the Green's *** a general coupling and general rw spacetimes,the regularized spectra can be negative under the conventional *** a higher order of regularization,the spectra will generally become positive,but will also acquire IR divergence,which is inevitable for a massless *** avoid the IR divergence,the inside-horizon regularization is *** these procedures,nonnegative UV-and IR-convergent power spectrum and spectral energy density will eventually be achieved.

关键词： quantum fields in curved spacetimes inflationary universe mathematical and relativistic aspects of cosmology

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Research of Power Take-off System for “Sharp Eagle Ⅱ” Wave Energy Converter

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China Ocean Engineering 2019年第5期33卷 618-627页

作者： ye.Yin WANG Kun-lin YOU Ya-ge SHENG Song-wei Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640 China Key Laboratory of Renewable Energy Chinese Academy of Sciences Guangzhou 510640 China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640 China

The " Sharp Eagle” device is a wave energy converter of a hinged double floating body. The wave-absorbing floating body hinges on the semi-submerged floating body structure. Under the action of wave, the wave-absorbing floating body rotates around the hinge point, and the wave energy can be converted into kinetic energy. In this paper, the power take-off system of " Sharp Eagle Ⅱ” wave energy converter (the second generation of " Sharp Eagle”) was studied, which adopts the hydraulic type power take-off system. The 0-1 power generation mode was applied in this system to make the " Sharp Eagle Ⅱ” operate under various wave conditions. The principle of power generation was introduced in detail, and the power take-off system was simulated. Three groups of different movement period inputs were used to simulate three kinds of wave conditions, and the simulation results were obtained under three different working conditions. In addition, the prototype of " Sharp Eagle Ⅱ” wave energy converter was tested on land and in real sea conditions. The experimental data have been collected, and the experimental data and simulation results were compared and validated. This work has laid a foundation for the design and application of the following " Sharp Eagle” series of devices.

关键词： Sharp Eagle Wave Energy Converter power take-off power generation mode hydraulic system

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Optical rogue wave in random fiber laser

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Photonics Research 2020年第1期8卷 1-7页

作者： JIANGMING XU JIAN WU JUN ye.JIAXIN SONG BAICHENG YAO HANWEI ZHANG JINYONG LENG WEILI ZHANG PU ZHOU YUNJIANG RAO College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Fiber Optics Research Centre Key Laboratory of Optical Fiber Sensing&Communications(Ministry of Education)University of Electronic Science&Technology of ChinaChengdu 611731China

The famous demonstration of optical rogue waves(rws),a powerful tool to reveal the fundamental physics in different laser scenarios,opened a flourishing time for temporal *** fiber laser(RFL)has likewise attracted wide attention due to its great potential in multidisciplinary demonstrations and promising ***,owing to the distinctive cavity-free structure,it is a scientific challenge to achieve temporal localized rws in RFLs,whose feedback arises from multiple scattering in disordered ***,we report the exploration of rw in the highly skewed,transient intensity of an incoherently pumped RFL for the first time,to our knowledge,and unfold the involved kinetics *** corresponding frequency domain measurements demonstrate that the rw event arises from a crucial sustained stimulated Brillouin scattering process with intrinsic stochastic *** investigation highlights a novel path to fully understanding the complex physics,such as photon propagation and localization,in disordered media.

关键词： fiber scattering pumped

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Relationship between Renying pulse augmentation index and Cunkou pulse condition in different blood pressure groups

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Journal of Traditional Chinese Medicine 2014年第3期34卷 279-285页

作者： Jiewei Luo Xingyu Zheng Zijing Hu Jing Wu Shichao Wei Zhencheng ye.Weiji Chen Ning Lin Jianwei Li Department of Traditional Chinese Medicine Fujian Provincial Hospital Fujian Medical University Department of Ultrasonic Diagnosis Fujian Provincial Hospital

OBJECTIVE： To explore the relationship between Renying pulse （carotid） augmentation index （AI） and Cunkou pulse condition in different blood pres- sure groups, and the clinical significance of Reny- ing and Cunkou pulse parameters to reflect vascu- lar function. METHODS： Eighty-six patients with essential hyper- tension （EH） and 52 individuals with normal blood pressure （control group） between and January 2012 were included September 2010 this study. Reny- ing pulse AI was examined by a new diagnostic tool （ALOKA ProSound Alpha 10） --wave intensity （Wl） that is calculated as the product of the deriva- tives of the simultaneously recorded blood pres- sure changes （dP/dt） and blood-flow-velocity changes （dU/dt）, while Cunkou pulse condition was detected by DDMX-100 Pulse Apparatus inboth EH and control groups. A multifactorial corre- lation analysis was performed for data analysis. RESULTS： After adjusting for potential confound- ing variables, in the EH group, AI was positively cor- related with ts, w2/t （rts=0.225, P〈0.05; rw2/t=0.230, P〈 0.05） and negatively correlated with hs, hs/hl and w2 （rhs=- 0.393,P〈0.01 ;rhs/l=- 0.444, P〈0.01 ;rw2=- 0.389, P〈0.01）. In the control group, AI was positively cor- related with t3, t4, ts and w, （rt3=0.595, P〈0.01; r,4= 0.292, P〈0.05; rt5=0.318, P〈0.05; rw1=0.541, P〈0.01） and negatively correlated with h1, h2, h3, Ad and A （rh1= - 0.368, P〈0.05; rh2= - 0.330, P〈0.05; rh3= - 0.327, P〈 0.05; rAd=- 0.322, P〈0.05; rA=- 0.410, P〈0.01）. In the total sample group （EH plus control group, n= 138）, AI was positively correlated with t, ts, w1 and w, （rt=0.257, P〈0.01; rt5=0.266, P〈0.01; rw1=0.184, P〈 0.05; rw/t=0.210, P〈0.05） and negatively correlated with hs, hs/hl, w2 and Ad （rhs= - 0.230, P〈0.01; rh5/h1= - 0.218, P〈0.05; rw2= - 0.267, P〈0.01; rAd= - 0.246, P〈0.01）. Multiple linear regression analysis was car- ried out to model the relationship （F=7.887, P〈 0.001）.CONCLUSION： Renying pulse AI can effectively pre- dict arterial stiffness

关键词： Ultrasonography Hypertension, essen-tial Cunkou pulse diagnosis Renying pulse Aug-mentation index Wave intensity

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DRG支付背景下临床科室超支情况分析及管理策略——以某三级综合医院心血管内科为例

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广西医学 2024年第6期46卷 889-894页

作者：叶娟金卉曾冠玉何青何彬婵蒋丽萍陈密思广西医科大学第二附属医院医疗保险科广西南宁市530007

目的分析临床科室疾病诊断相关分组(DRG)结算病例超支的影响因素,为科室精细化管理提供思路。方法选取2022年某三级综合医院心血管内科1495例DRG结算病例的医保结算信息、病案信息及费用信息,使用单因素分析及多因素Logistic回归模型分... 详细信息

目的分析临床科室疾病诊断相关分组(DRG)结算病例超支的影响因素,为科室精细化管理提供思路。方法选取2022年某三级综合医院心血管内科1495例DRG结算病例的医保结算信息、病案信息及费用信息,使用单因素分析及多因素Logistic回归模型分析DRG结算病例超支的影响因素。结果单因素分析结果显示,结余病例组和超支病例组在年龄、住院天数、医保类型、病例类型、疾病严重程度、治疗操作类型、相对权重(rw),以及药品占比、耗材占比、检查检验占比、医疗服务占比方面的差异具有统计学意义(Prw≥2是DRG结算病例超支的保护因素(P<0.05)。结论临床科室可从主动适应医保规则,落实临床路径管理,加强医疗成本控制,兼顾学科高质量发展等方面持续改进,促进DRG精细化管理,助力医院可持续发展。

关键词：疾病诊断相关分组结算病例超支影响因素运营管理临床科室

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浅谈对构建我国农地信托之基础——信托财产的认识

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改革与战略 2011年第5期27卷 65-67页

作者：叶朋江苏科技大学人文社科学院江苏镇江212003

目前,国内对农地承包经营权信托制度的研究略显不足,尤其对信托财产——农地承包经营权研究甚少。文章认为,农地承包经营权具有合法性、流通性,能成为信托财产;农地承包经营权作为信托财产的权利应该归属委托人而不是受托人;农地承包经... 详细信息

目前,国内对农地承包经营权信托制度的研究略显不足,尤其对信托财产——农地承包经营权研究甚少。文章认为,农地承包经营权具有合法性、流通性,能成为信托财产;农地承包经营权作为信托财产的权利应该归属委托人而不是受托人;农地承包经营权作为信托财产之独立性是指与委托人其他的与信托事务无关的财产相独立。

关键词：承包经营权信托信托财产

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Crystal Structure of (γ-CH_3C_5H_4N)_2Zn(S_2C_2(CN)_2)and the Second Harmonic Effect

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Chinese Journal of Structural Chemistry 1997年第1期16卷 32-35页

作者： ye.Ning WU Bai-Chang CHEN Qi-Xian WANG Shou-Bai QIN Jing-Gui(Fujian institute of Research on the Structure of Matter,Chinese Academy of Sciences, Fuzhou, 350002) Fujian Inst. Res. Struct. of Matter Chinese Academy of Sciences Fuzhou 350002 China

The title compound (γ-CH3C5H4N)2Zn(S2C2 (CN )2 ) crystallizes in theorthorhombic system, space group C2221, with a= 10. 069 (2), b= 14. 629 (4), c=11. 923(4) A, V= 1756. 2(3) A3, Dc= 1. 48g/cm3, Z=4, Mr= 391.81. λ(MoKa)= 0. 71069 A, μ= 16. 6 cm--l, F(000) = 800, final R= 0. 055 and rw= 0. 066 for.1481 observed reflections with I≥3σ(I). In the (γ-CH3C5H4N)2Zn(S2C2(CN)2 ) complex, Zn2+ is coordinated by two nitrogen atoms from two 4--methylpyridine ligands andtwo sulfur atoms from maleonitriledithiol ligand. The powder tests show a frequencydoubling effect 2. 4 times as great as KH2PO4, which is in consistency with theoreticalcalculations

关键词： crystal structure zinc complex nonlinear optical effect

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