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Hematopoietic aging:Cellular,molecular,and related mechanisms

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Chinese Medical Journal 2024年第11期137卷 1303-1312页

作者： Li ye Chuan Tian ye Li Hang Pan Jinxiu hu Liping Shu Xinghua Pan The Stem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan ProvinceKunming Key Laboratory of Stem Cell and Regenerative MedicineBasic Medical Laboratory920th Hospital of Joint Logistics Support ForcePLAKunmingYunnan 650032China Department of Immunology of School of Basic Medicine of Guizhou Medical University National and Local Joint Engineering Laboratory of Cell Engineering Biomedical TechnologyKey Laboratory of Regenerative Medicine of Guizhou ProvinceState Key Laboratory of Efficacy and Utilization of Medicinal Plants Co-constructed by Province and MinistryKey Laboratory of Translational Research of Adult Stem Cell of Chinese Academy of Medical SciencesGuiyangGuizhou 550025China

Aging is accompanied by significant inhibition of hematopoietic and immune system function and disruption of bone marrow ***-related alterations in the inflammatory response,immunity,and stem cell niches are at the root of hematopoietic *** the molecular mechanisms underlying hematopoietic and bone marrow aging can aid the clinical treatment of aging-related *** particular,it is unknown how the niche reprograms hematopoietic stem cells(HSCs)in an age-dependent manner to maintain normal hematopoiesis in elderly ***,specific inhibitors and blood exchange methods have been shown to reshape the hematopoietic niche and reverse hematopoietic ***,we present the latest scientific discoveries related to hematopoietic aging and hematopoietic system rejuvenation,discuss the relationships between hematopoietic niche aging and HSC aging,and describe related studies on stem cell-mediated regulation of hematopoietic aging,aiming to provide new ideas for further study.

关键词： Stem cells Hematopoietic stem cell Niche Hematopoietic aging

Toughening ultrastrong low-density steel by textured δ-ferrite lamellas

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Defence Technology（防务技术） 2024年第2期32卷 405-411页

作者： Bin hu Guosen zhu Guohui Shen Zheng Wang Qinghua Wen Xiao Shen Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingXue Yuan Rd.30Beijing 100083China Shougang Research Institute of Technology Yangzhuang Street 69Beijing 100043China Steel Institute RWTH Aachen UniversityIntzestraße 152072AachenGermany

By both the Charpy V-notched impact and the projectile tests, we here investigated the dynamic fracture behavior of a recently developed ultrastrong lightweight steel comprising a hierarchical martensitic matrix, dispersed ultra-fine-retained austenite grains and oriented δ-ferrite lamellas, the latter being due to high Al and Si contents employed for low-density design. This steel shows a superior combination of specific ultimate tensile strength and impact toughness to other ultrastrong steels and has successfully arrested a real steel-cored bullet shot. These are attributed to the densely textured δ-ferrite lamellas that can deflect the propagating cracks until they are trapped and enclosed besides austenite-to-martensite transformation crack closure, leading to more energy consumed before failure. These results suggest a new pathway for toughening ultrastrong lightweight steels.

关键词： Ultrastrong and light steel d-Ferrite lamellas Crack propagation Toughness

Ultracompact silicon on-chip polarization controller

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Photonics Research 2024年第2期12卷 183-193页

作者： WEIKE ZHAO YINGYING PENG MINGYU zhu RUORAN LIU XIAOLONG hu YAOCHENG SHI DAOXIN DAI State Key Laboratory for Modern Optical Instrumentation Center for Optical&Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityZijingang CampusHangzhou 310058China School of Precision Instrument and Optoelectronic Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Optoelectronic Information Science and Technology Ministry of EducationTianjin 300072China Ningbo Research Institute Zhejiang UniversityNingbo 315100China

On-chip polarization controllers are extremely important for various optical *** this paper,a compact and robust silicon-based on-chip polarization controller is proposed and demonstrated by integrating a special polarization converter and phase *** special polarization converter consists of a 1×1 Mach–Zehnder interferometer with two polarization-dependent mode converters at the input/output *** light with an arbitrary state of polarization(SOP)is launched into the chip,the TE_(0)and TM_(0)modes are simultaneously *** polarization extinction ratio(PER)and the phase difference for the TE_(0)∕TM_(0)modes are tuned by controlling the first phase shifter,the polarization converter,and the second phase *** a result,one can reconstruct the light SOP at the output *** fabricated polarization controller,as compact as~150μm×700μm,exhibits an excess loss of less than 1 dB and a record PER range of>54 dB for arbitrary input light beams in the wavelength range of 1530–1620 nm.

关键词： polarization SOP interferometer

Study on Image Recognition Algorithm for Residual Snow and Ice on Photovoltaic Modules

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Energy Engineering 2024年第4期121卷 895-911页

作者： Yongcan zhu JiawenWang ye Zhang Long Zhao Botao Jiang Xinbo huang College of Electronics and Information Xi’an Polytechnic UniversityXi’an710048China Xi’an Key Laboratory of Interconnected Sensing and Intelligent Diagnosis for Electrical Equipment Xi’an710048China

The accumulation of snow and ice on PV modules can have a detrimental impact on power generation,leading to reduced efficiency for prolonged ***,it becomes imperative to develop an intelligent system capable of accurately assessing the extent of snow and ice coverage on PV *** address this issue,the article proposes an innovative ice and snow recognition algorithm that effectively segments the ice and snow areas within the collected ***,the algorithm incorporates an analysis of the morphological characteristics of ice and snow coverage on PV modules,allowing for the establishment of a residual ice and snow recognition *** process utilizes both the external ellipse method and the pixel statistical method to refine the identification *** effectiveness of the proposed algorithm is validated through extensive testing with isolated and continuous snow area *** results demonstrate the algorithm’s accuracy and reliability in identifying and quantifying residual snow and ice on PV *** conclusion,this research presents a valuable method for accurately detecting and quantifying snow and ice coverage on PV *** breakthrough is of utmost significance for PV power plants,as it enables predictions of power generation efficiency and facilitates efficient PV maintenance during the challenging winter conditions characterized by snow and *** proactively managing snow and ice coverage,PV power plants can optimize energy production and minimize downtime,ensuring a sustainable and reliable renewable energy supply.

关键词： Photovoltaic(PV)module residual snow and ice snow detection feature extraction image processing

A Low Cost, Green Sustainable and Biodegradable Biomass-based Fluorine-free Water and Oil Repellent

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Chinese Journal of Polymer Science 2024年第4期42卷 480-491页

作者： Zhi-Wei Shen Shu-Feng hu Chen Zeng Wei-Qing Kong Mei-Fang zhu State Key Laboratory for Modification of Chemical Fibers&Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China State Key Laboratory of Pulp and Paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510630China

With the global ban on plastics intensifying, the substitution of plastic with paper has garnered increasing attention. However, the inadequate water and oil repellency of pulp molding hinders its practical applications. Currently, the common method to enhance the oil and water repellency of pulp molding is by adding fluorinated water and oil repellents. Nevertheless, fluorinated compounds are environmentally and physiologically harmful. Therefore, the development of fluorine-free, water and oil repellent alternatives is crucial. In this study, chitosan and stearic acid were utilized as the first and second layers of the oil and water repellent coatings, respectively. The coated samples exhibited favorable water repellency, with a water contact angle of 116.4°, and excellent oil repellency, achieving a 12/12 rating on the kit scale. Importantly, the samples did not exhibit any leakage after being soaked in hot water and hot oil at 95±5℃ for 30 min, demonstrating remarkable performance as a barrier against hot water and oil. Moreover, the coated samples displayed outstanding mechanical properties, thermal stability, biodegradability, and recyclability. The approach presented in this study is simple, cost-effective, environmentally friendly, and represents a promising technique for producing fluoride-free, oil-and water-resistant pulp molding products.

关键词： Biomass Fluoride-free Oil-andwater-resistant Plasticfree

Cortical activity in patients with high-functioning ischemic stroke during the Purdue Pegboard Test:insights into bimanual coordinated fine motor skills with functional near-infrared spectroscopy

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Neural Regeneration Research 2024年第5期19卷 1098-1104页

作者： Siyun Chen Mengchai Mao Guangyue zhu Yufeng Chen Yuqi Qiu Bin ye Dongsheng Xu The Second Rehabilitation Hospital of Shanghai ShanghaiChina College of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina School of Statistics East China Normal UniversityShanghaiChina The Third Rehabilitation Hospital of Shanghai ShanghaiChina Tongji University ShanghaiChina Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine ShanghaiChina

After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional *** arm training has been proposed as a promising intervention to address these ***,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted *** address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and ***-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand *** found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly ***,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test ***,the observed neural response patterns varied depending on the specific *** the unaffected hand task,the differences were primarily observed in the ipsilesional *** contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,*** significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual *** study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural resp

关键词： bilateral arm training bimanual coordination cortical activity fine motor dexterity functional near-infrared spectroscopy(fNIRS) high-functioning Purdue Pegboard Test stroke

High-chromium vanadium-titanium magnetite all-pellet integrated burden optimization and softening-melting behavior based on flux pellets

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 498-507页

作者： Bojian Chen Tao Jiang Jing Wen Guangdong Yang Tangxia Yu Fengxiang zhu Peng hu School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China Liaoning Key Laboratory for Metallurgical Sensor and Technology Shenyang 110819China State key laboratory of vanadium and titanium resources comprehensive utilization Panzhihua 617000China

High-chromium vanadium-titanium magnetite(HVTM)is a crucial polymetallic-associated resource to be *** allpellet operation is a blast furnace trend that aims to reduce carbon dioxide emissions in the *** referencing the production data of vanadium-titanium magnetite blast furnaces,this study explored the softening-melting behavior of high-chromium vanadium-titanium magnetite and obtained the optimal integrated burden based on flux *** results show that the burden with a composition of 70wt%flux pellets and 30wt%acid pellets exhibits the best softening-melting *** comparison to that of the single burden,the softening-melting characteristic temperature of this burden composition was *** melting interval first increased from 307 to 362℃and then decreased to 282℃.The maximum pressure drop(ΔPmax)decreased from 26.76 to 19.01 *** permeability index(S)dropped from 4643.5 to 2446.8 kPa·℃.The softening-melting properties of the integrated burden were apparently *** acid pellets played a role in withstanding load during the softening *** flux pellets in the integrated burden exhibited a higher slag melting point,which increased the melting temperature during the melting *** slag homogeneity and the TiC produced by over-reduction led to the gas permeability deterioration of the single *** segregation of the flux and acid pellets in the HVTM proportion and basicity mainly led to the better softening-melting properties of the integrated burden.

关键词： high-chromium vanadium-titanium magnetite softening-melting properties all pellets integrated burden flux pellets

Failure behavior and strength model of blocky rock mass with and without rockbolts

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International Journal of Mining Science and Technology 2024年第6期34卷 747-762页

作者： Chun zhu Xiansen Xing Manchao He Zhicheng Tang Feng Xiong Zuyang ye Chaoshui Xu School of Earth Sciences and Engineering Hohai UniversityNanjing 210024China Key Laboratory of Water Management and Water Security for yellow River Basin Ministry of Water Resources(under construction)Zhengzhou 450003China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and TechnologyBeijing 10083China Faculty of Engineering China University of GeosciencesWuhan 430074China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China School of Resource and Environmental Engineering Wuhan University of Science and TechnologyWuhan 430081China School of Chemical Engineering Faculty of SciencesEngineering and TechnologyThe University of AdelaideAdeliade 5005Australia

To better understand the failure behaviours and strength of bolt-reinforced blocky rocks,large scale extensive laboratory experiments are carried out on blocky rock-like specimens with and without rockbolt *** results show that both shear failure and tensile failure along joint surfaces are observed but the shear failure is a main controlling factor for the peak strength of the rock mass with and without *** rockbolts are necked and shear deformation simultaneously happens in bolt reinforced rock *** the joint dip angle increases,the joint shear failure becomes more *** number of rockbolts has a significant impact on the peak strain and uniaxial compressive strength(UCS),but little influence on the deformation modulus of the rock *** the Winkler beam model to represent the rockbolt behaviours,an analytical model for the prediction of the strength of boltreinforced blocky rocks is *** agreement between the UCS values predicted by proposed model and obtained from experiments suggest an encouraging performance of the proposed *** addition,the performance of the proposed model is further assessed using published results in the literature,indicating the proposed model can be used effectively in the prediction of UCS of bolt-reinforced blocky rocks.

关键词： Blocky rock mass Rockbolt ground support Uniaxial compression test Failure mechanism Uniaxial compressive strength model

Research Progress on the Association between Schizophrenia and Toxoplasma gondii Infection

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Biomedical and Environmental Sciences 2024年第6期37卷 647-660页

作者： Yiting zhu Xiaohui Yang Miaoru Chen Yu hu Yunfeng Chang Xiang Wu Department of Forensic Medicine Science Xiangya School of Basic MedicineCentral South UniversityChangsha 410013HunanChina Nursing Department The Third Xiangya Hospital of Central South UniversityChangsha 410013HunanChina Department of Basic Medicine Science Xiangya School of Basic MedicineCentral South UniversityChangsha 410013HunanChina Department of Parasitology Xiangya School of Basic MedicineCentral South UniversityChangsha 410013HunanChina

Toxoplasma gondii(*** or Tg),is an obligatory intracellular parasite with humans as its intermediate *** recent years,significant correlations between *** infection and schizophrenia have been reported,including the possible mediating ***,mechanisms and hypotheses focus on central neurotransmitters,immunity,neuroinflammation,and epigenetics;however,the exact underlying mechanisms remain *** this article,we review the studies related to *** infection and schizophrenia,particularly the latest research *** on dopamine(DA)and other neurotransmitters,the blood-brain barrier,inflammatory factors,disease heterogeneity,and other confounders is also *** addition,we also summarized the results of some new epidemiological investigations.

关键词： Toxoplasma gondii Schizophrenia Neurotransmitters Neuroinflammation Immunity Epigenetics