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Individualized treatment of breast cancer with chronic renal failure: A case report and review of literature

World Journal of Clinical Cases 2021年第33期9卷 10345-10354页

作者： Jie-Hui Cai Jie-Hua Zheng xiao-Qi Lin Wei-Xun Lin Juan Zou Yao-Kun chen Zhi-Yang Li ye-xi chen Department of General Surgery The Second Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Breast Disease Research Center The Medical Research Institute of Shantou Doctoral AssociationShantou 515041Guangdong ProvinceChina

BACKGROUND Studies have shown that patients with chronic renal failure(CRF)are more likely to suffer from breast cancer and other malignant *** our knowledge,CRF can reduce drug excretion,thereby increase drug exposure and lead to increased toxicity,which will limit drug treatment and lead to tumor ***,there are few successful reports on the combination of docetaxel,trastuzumab,and pertuzumab(THP)as a neoadjuvant treatment regimen for breast cancer patients with *** SUMMARY We report a breast cancer(cT2N2M0,Her-2+/HR-)patient with *** was a clinical stage IIIA tumor on the left *** patient had suffered from uremia for 2 years,and her heart function was *** on the pathological type,molecular type,and clinical stage of breast cancer,and the patient’s renal function,the clinician analyzed the pharmacological and pharmacokinetic characteristics of the antitumor drugs after consulting the relevant literature,and prescribed the neoadjuvant regimen of THP(docetaxel 80 mg/m²,trastuzumab 8 mg/kg for the first dose,and 6 mg/kg for the maintenance dose with pertuzumab 840 mg for the first dose and 420 mg for the maintenance dose),once every 3 wk,for a total of 6 *** neoadjuvant treatment had a good effect,and the patient then underwent surgery which was *** CRF is not a contraindication for systemic treatment and surgery of breast *** THP regimen without dose adjustment may be a safe and effective neoadjuvant treatment for HER-2 positive breast cancer patients with CRF.

关键词： Breast cancer Chronic renal failure Neoadjuvant treatment Dose adjustment Pertuzumab Case report

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Nomogram for predicting overall survival in Chinese triple-negative breast cancer patients after surgery

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World Journal of Clinical Cases 2022年第31期10卷 11338-11348页

作者： Wei-Xun Lin Yan-Na xie Yao-Kun chen Jie-Hui Cai Juan Zou Jie-Hua Zheng Yi-Yuan Liu Zhi-Yang Li ye-xi chen Department of Thyroid Breast and Hernia SurgeryThe Second Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND There are few nomograms for the prognosis of Chinese patients with triplenegative breast cancer(TNBC).AIM To construct and validate a nomogram for overall survival(OS)of Chinese TNBC patients after *** This study used the data of SEER*stat 8.3.5 and selected Chinese patients with TNBC operated on between 2010 and *** and multivariate Cox proportional hazard regression models were *** identified variables were integrated to form a predictive nomogram and risk stratification model;it was assessed with C-indexes and calibration *** The median and maximal OS of the 336 patients was 39 and 83 mo,*** multivariate analysis showed that age(P=0.043),marital status(P=0.040),tumor localization(P=0.030),grade(P=0.035),T classification(P=0.012),and N classification(P=0.002)were independent prognostic *** six variables were combined to construct a 1-,3-and 5-year OS *** C-indexes of the nomogram to predict OS were 0.766 and compared to the seventh edition staging system,which was higher(0.766 vs 0.707,P<0.001).In order to categorize patients into different prognostic groups,a risk stratification model was *** was a significant difference between the Kaplan–Meier curves of the entire cohort and each disease stage according to the *** The nomogram provided prognostic superiority over the traditional tumor,node and metastasis *** could help clinicians make individual OS or risk predictions for Chinese TNBC patients after surgery.

关键词： Triple-negative breast cancer Chinese nomogram Risk stratification Overall survival

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Follicular carcinoma of the thyroid with a single metastatic lesion in the lumbar spine:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9493-9501页

作者： Yao-Kun chen Yu-Chun chen Wei-Xun Lin Jie-Hua Zheng Yi-Yuan Liu Juan Zou Jie-Hui Cai Ze-Qi Ji Ling-Zhi chen Zhi-Yang Li ye-xi chen Department of Thyroid Breast and Hernia SurgeryThe Second Affiliated Hospital of Shantou University Medical CollegeShantou 515000Guangdong ProvinceChina Department of Bone Joint and Spine SurgeryThe Second Affiliated Hospital of Shantou University Medical CollegeShantou 515000Guangdong ProvinceChina

BACKGROUND The bone is the second most common site of thyroid cancer metastasis,after the *** options for bone metastasis of thyroid cancer include surgery,radioiodine therapy(RAIT),external radiation therapy,thyroid-stimulating hormone(TSH)inhibition,bisphosphonates,and small-molecule targeted *** most cases,thyroid carcinoma is found in the thyroid tissue;reports of follicular thyroid carcinoma with a single metastasis to the lumbar spine are *** SUMMARY We report a case of bone metastasis as the only clinical manifestation of thyroid *** patient was a 67-year-old woman with lumbar pain for 7 years and aggravation with intermittent claudication who had previously undergone partial thyroidectomy of a benign thyroid *** abnormal nodules were found in the bilateral thyroid ***,imaging studies were consistent with a spinal tumor,and the lesion was diagnosed as a metastatic follicular carcinoma of thyroid *** adopted a multidisciplinary collaboration and comprehensive treatment *** patient underwent lumbar spine surgery,total resection of the thyroid,postoperative TSH suppression therapy,and *** were no complications associated with the operation,and the patient had good postoperative *** has experienced no *** Follicular thyroid carcinoma is associated with early hematogenous metastasis,and the bone is a typical site of *** bone metastasis is not a contraindication to medical procedures,and providing the appropriate therapy can result in better outcomes and quality of life for these patients.

关键词： Case report Thyroid carcinoma Lumbar spine Metastasis Surgery

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PINN for solving forward and inverse problems involving integrable two-dimensional nonlocal equations

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Communications in Theoretical Physics 2025年第2期77卷 15-22页

作者： xi chen Wei-Qi Peng School of Mathematics China University of Mining and Technology School of Mathematical Sciences Ocean University of China

In this paper, the physics informed neural network(PINN) deep learning method is applied to solve two-dimensional nonlocal equations, including the partial reverse space y-nonlocal Mel'nikov equation, the partial reverse space-time nonlocal Mel'nikov equation and the nonlocal twodimensional nonlinear Schr?dinger(NLS) equation. By the PINN method, we successfully derive a data-driven two soliton solution, lump solution and rogue wave solution. Numerical simulation results indicate that the error range between the data-driven solution and the exact solution is relatively small, which verifies the effectiveness of the PINN deep learning method for solving high dimensional nonlocal equations. Moreover, the parameter discovery of the partial reverse space-time nonlocal Mel'nikov equation is analysed in terms of its soliton solution for the first time.

关键词： two dimensional nonlocal equations PINN soliton solution rogue wave inverse problems

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Unintentional emissions of polychlorinated naphthalenes in China:Sources,composition,and historical trends

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Journal of Environmental Sciences 2025年第2期148卷 221-229页

作者： ye Huang Lin Huang Ying Li Nazupar Sidikjan Yunshan Zhang Yan chen Yangmin chen ye Li Wei Du Long chen YanWu Shanshan Zhang Jing Yang Wenjun Meng Guofeng Shen Min Liu Shu Tao Key Laboratory of Geographic Information Science of the Ministry of Education School of Geographic SciencesEast China Normal UniversityShanghai 200241China Yunnan Provincial Key Laboratory of Soil Carbon Sequestration and Pollution Control Faculty of Environmental Science&EngineeringKunming University of Science&TechnologyKunming 650500China Laboratory of Earth Surface Processes College of Urban and Environmental SciencePeking UniversityBeijing 100871China

Polychlorinated naphthalenes(PCNs)are detrimental to human health and the *** the commercial production of PCNs banned,unintentional releases have emerged as a significant environmental ***,relevant information is still *** this study,provincial emissions for eight PCNs homologues from 37 sources in the Chinese mainland during the period of 1960-2019 were estimated based on a source-specific and time-varying emission factor *** results showed that the total PCNs emissions in 2019 reached 757.0 kg with Hebei ranked at the top among all the provinces and iron&steel industry as the biggest ***-chlorinated PCNs comprised 90%of emissions by mass,while highly chlorinated PCNs dominated in terms of toxicity,highlighting divergent priorities for mitigating emissions and safeguarding human *** emissions showed an overall upward trend from 1960 to 2019 driven by emission increase from iron&steel industry in terms of source,and from North China and East China in terms of geographic ***-capita emissions followed an inverted U-shaped environmental Kuznets curvewhile emission intensities decreased with increasing per-capita Gross Domestic Product(GDP)following a nearly linear pattern when log-transformed.

关键词： PCNs Emission inventory Emission factor Composition profile Emission intensity Chinese mainland

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Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： Kedong Zhu Hualong Wang Keqiang ye Guiqin chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C

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Thermal effects on the strain rate-dependent behavior of highly compacted GMZ01 bentonite

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 453-464页

作者： Pengju Qin Weimin ye Qiong Wang Yonggui chen College of Civil Engineering Taiyuan University of TechnologyTaiyuan030024China Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai200092China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai200092China

Investigation of thermal effects on the strain rate-dependent properties of compacted bentonite is crucial for the long-term safety assessment of deep geological repository for disposal of high-level radioactive *** the present work,cylindrical GMZ01 bentonite specimens were compacted with suction-controlled by the vapor equilibrium ***,a series of temperature-and suction-controlled stepwise constant rate of strain(CRS)tests was performed and the rate-dependent compressibility behavior of the highly compacted GMZ01 bentonite was *** plastic compressibility parameterλ,the elastic compressibility parameterκ,the yield stress p0,as well as the viscous parameterαwere *** indicate thatλ,κandαdecrease and p0 increases as suction *** heating,parametersλ,αand p0 *** is also found that p0 increases linearly with increasing CRS in a double-logarithm *** on the experimental results,a viscosity parameterα(s,T)was fitted to capture the effects of suction s and temperature T on the relationship between yield stress and strain ***,an elastic-thermo-viscoplastic model for unsaturated soils was developed to describe the thermal effects on the rate-dependent behavior of highly compacted GMZ01 *** showed that the calculated results agreed well to the measured ones.

关键词： Highly compacted bentonite Rate-dependent behavior Constant rate of strain Temperature Elastic-thermo-viscoplastic model

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Long-term trends and response of wet ammonia deposition to changes in anthropogenic emissions in the Pearl River delta of China

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Journal of Environmental Sciences 2025年第5期151卷 373-386页

作者： Mingyue Li Lyumeng ye Ming Chang Weihua chen Shuidi He Buqing Zhong Xuemei Wang Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Institute for Environmental and Climate ResearchJinan UniversityGuangzhou 511443China South China Institute of Environmental Sciences The Ministry of Ecology and Environment of PRCGuangzhou 510530China Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China

The Pearl River Delta(PRD)region has been identified as a significant hotspot of wet ammonium ***,the absence of long-term monitoring data in the area hinders the comprehension of the historical trends and changes in wet NH_(4)^(+)-N deposition in response to emissions,which interferes with the ability to make effective *** study has analyzed the long-term trends of wet NH_(4)^(+)-N deposition flux and has quantified the effect of anthropogenic emissions and meteorological factors at a typical urban site and a typical forest site in the PRD region from 2009 to *** revealed a significant decreasing trend in wet NH_(4)^(+)-N flux in both the typical urban and forest areas of the PRD region,at-6.2%/year(pyear(pyears compared to meteorological *** conditions dominated the interannual fluctuations in wet NH_(4)^(+)-N deposition with an absolute contribution of 46%–52%,while anthropogenic emissions change alone explained 10%–31%.NH_(3)emissions have the greatest impact on the urban area among anthropogenic emission factors,while SO_(2)emissions have the greatest impact on the forest ***,precipitation was identified as the primary meteorological driver for both *** findings also imply that the benefits of NH_(3)emissions reductions might not immediately emerge due to interference from weather-related factors.

关键词： Long-term trends Inter-annual variation Wet ammonium deposition Anthropogenic emission change Meteorological condition The Pearl River Delta region

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Large-scale Preparation of Black CeO_(x) with Stable Oxygen Vacancies

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Chemical Research in Chinese Universities 2025年第1期41卷 40-47页

作者： PENG Huan JIANG Mengmeng ye Jinfeng WANG Lei DING Shunmin chen Chao College of Materials and Chemical Engineering Pingxiang UniversityPingxiang337055P.R.China Key Laboratory of Jiangxi Province for Environment and Energy Catalysis College of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031P.R.China

Oxygen vacancy in ceria is a crucial regulation factor for modifying *** reduced oxygen vacancy will undergo rapid recombination and deactivation due to the imbalance perturbation of active oxygen species,thereby restricting their larger-scale *** this work,we proposed a strategy to stabilize oxygen vacancy in four black CeO_(x)(Si)(0

关键词： Black CeO_(x) Oxygen vacancy Ce-O_(v)-Si Stabilization Quartz sand

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Spatiotemporal evolution of Ediacaran-Cambrian(ca.551–523 Ma)sponges in South China and their simulated contributions to marine oxygenation

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Science China Earth Sciences 2025年第2期68卷 549-563页

作者： Yan ye Lei ZHANG Can chen Shan CHANG Yuhao YI Qinglai FENG State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China School of Earth Science China University of GeosciencesWuhan 430074China Department of Geology Lund UniversityLund 22362Sweden Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu 610059China Second Geological Brigade of Hubei Geological Bureau Enshi 445000China College of Urban and Environmental Sciences Hubei Normal UniversityHuangshi 435002China Exploration and Development Research Institute SINOPEC Jianghan Oilfield CompanyWuhan 430223China

The origin and evolution of sponges have attracted interest,not only because they are among the most basal metazoans,but also because they act as important ecological engineers in the *** research suggested that sponge groups diversified quickly during the Cambrian Series 2,while Terreneuvian sponge fossils are conspicuously rare and poorly ***,an increasing number of sponge spicules have been reported from the Ediacaran-Cambrian(E-C,ca.551–523 Ma)transitional carbonates/cherts worldwide,particularly in South China,which calls for updated *** oxygenation has been widely proposed to play a critical role in organismal evolution,but its relationship with sponges is unclear and falls into a“chicken-egg”*** this study,we summarize reported sponge spicule distributions from five E-C sections in South China to investigate the early evolutionary pattern of siliceous *** to current stratigraphic correlation,monaxons first appear in the late Ediacaran in the intrashelf basin-slope area,and then potentially expand to the continental shelf and deep basin in the lower *** these sections,the abundance,size,and diversity of monaxons increase upwards,followed by the appearance of diaxons,triaxons and then *** the uncertain affinity of the sponge fossils,it is possible that siliceous hexactinellids evolved later than siliceous demosponges,given that the earliest spicule assemblages are exclusively composed of monaxons,which commonly form bundles comparable to modern *** geochemical data from the Sifangjing section,Guizhou Province and the Yanziqiao section,Hunan Province,South China show that the appearance of sponges usually corresponds to anoxic *** addition,we applied the recently proposed Biological Pump,Oxygen and Phosphorus(BPOP)model to trace the evolution of oceanic oxygen concentrations with the radiation of *** results indicate that the possible contribution o

关键词： Cambrian Sponge Oxygenation Silicon concentration Box model

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