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Journal of Magnesium and Alloys 2019年第4期7卷 648-660页

作者： Jong Un Lee ye Jin kim Sang-Hoon kim Jeong Hun Lee Min-Seong kim Shi-Hoon Choi Byoung Gi Moon Young Min kim Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Ulsan Regional Division Korea Institute of Industrial TechnologyUlsan 44413Republic of Korea Department of Printed Electronics Engineering Sunchon National UniversitySuncheonJeonnam 57922Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study,the texture of a rolled Mg alloy is effectively modified through the application of precompression and subsequent annealing treatment,leading to a remarkable improvement in the bending formability of the alloy at room *** induces lattice reorientation through{10-12}twinning,and annealing treatment reduces the stored strain energy of the precompressed material,which results in the formation of a stable grain structure with two dominant texture *** an increase in precompression,the tensile strain in the outer region of the bending samples is accommodated to a greater extent due to more pronounced{10-12}twinning and basal *** a result,the bending formability of the material at room temperature improves with greater *** variation in microstructure,texture,and bending behavior in relation to the degree of precompression is discussed in detail.

关键词： Magnesium Bending Formability Twinning Texture

Spatial Control of Lithium Deposition by Controlling the Lithiophilicity with Copper(Ⅰ)Oxide Boundaries

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Energy & Environmental Materials 2023年第5期6卷 183-191页

作者： Ju ye kim Oh B.Chae Gukbo kim Woo-Bin Jung Sungho Choi Do Youb kim San Moon Jungdon Suk Yongku Kang Mihye Wu Hee-Tae Jung Department of Chemical and Biomolecular Engineering(BK-21 four)and Institute for Nanocentury Korea Advanced Institute of Science and Technology(KAIST)DaejeonKorea Chemical&Process Technology Division Korea Research Institute of Chemical TechnologyDaejeon 34114Korea School of Engineering Brown UniversityProvidence 02912USA Department of Chemistry University of Rhode IslandKingston 02881USA School of Engineering and Applied Sciences Harvard UniversityCambridge 02138USA Advanced Materials Division Korea Research Institute of Chemical TechnologyDaejeon 34114Korea

Spatial control of lithium deposition is the most important issue in lithium-metal batteries because of the considerable control of lithium dendrite suppression via the uniform distribution of Li^(+)*** seed materials are crucial for the behavior of lithium deposition,in-depth studies on their physical and chemical control have not been ***,we describe a new design of seed structure comprising a wrinkled Cu/graphene substrate surrounded by copper(Ⅰ)oxide(Cu_(2)O)on a graphene grain boundary over a large area,which is fabricated by the oxidation of the Cu surface via graphene boundary defects by using chemical vapor deposition(CVD).Scanning and transmission electron microscopy results reveal that Cu_(2)O on the graphene boundary can render a preferential reaction with lithium during the first deposition and assist in the uniform deposition of lithium by preventing the agglomeration of lithium clusters during the second *** two-step process is attributed to the degree of selectivity due to the difference in lithium affinity,which allows long-term electrochemical stability and a high rate capability via boundary *** study highlights the significance of the boundary effect,which can open new avenues for the formation of a large family of seed structures in lithium-metal batteries.

关键词： Cu_(2)O boundary dendrite-free lithium deposition lithium-metal battery lithium spatial control seed boundary effect

CRISPR/Cas9-mediated gene editing to confer turnip mosaic virus (TuMV) resistance in Chinese cabbage (Brassica rapa)

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Horticulture Research 2023年第6期10卷 135-143页

作者： ye-Rin Lee Muhammad Irfan Siddique Do-Sun kim Eun Su Lee Koeun Han Sang-Gyu kim Hye-Eun Lee Vegetable Research Division National Institute of Horticultural and Herbal ScienceRural Development AdministrationWanju55365Republic of Korea Department of Horticultural Sciences North Carolina State University Mountain Horticultural Crops ResearchExtension Center 455 Research DriveMills RiverNC 28759USA Department of Biological Sciences Korea Advanced Institute for Science and TechnologyDaejeon34141Republic of Korea

Genome editing approaches,particularly the CRISPR/Cas9 technology,are becoming state-of-the-art for trait development in numerous breeding *** advances in improving plant traits are enabled by this influential tool,especially for disease resistance,compared to traditional *** of the potyviruses,the turnip mosaic virus(TuMV),is the most widespread and damaging virus that infects Brassica *** generated the targeted mutation at the eIF(iso)4E gene in the TuMV-susceptible cultivar“Seoul”using CRISPR/Cas9 to develop TuMV-resistant Chinese *** detected several heritable indel mutations in the edited T0 plants and developed T1 through generational *** was indicated in the sequence analysis of the eIF(iso)4E-edited T1 plants that the mutations were transferred to succeeding *** edited T1 plants conferred resistance to *** was shown with ELISA analysis the lack of accumulation of viral ***,we found a strong negative correlation(r=-0.938)between TuMV resistance and the genome editing frequency of eIF(iso)***,it was revealed in this study that CRISPR/Cas9 technique can expedite the breeding process to improve traits in Chinese cabbage plants.

关键词： CRISPR/Cas9 TuMV breeding

Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling

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Cellular & Molecular Immunology 2022年第12期19卷 1373-1391页

作者： Hee Ja kim Kyungwon Yang Kiyoon kim ye‐Ji Lee Sieun Lee Sung Yong Ahn Young‐Ho Ahn Jihee Lee Kang Department of Physiology College of MedicineEwha Womans UniversitySeoul07804Korea Inflammation-Cancer Microenvironment Research Center College of MedicineEwha Womans UniversitySeoul07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul07804Korea

The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and ***-associated fibroblasts(CAFs)play a crucial role in promoting these events through paracrine ***,we demonstrate that conditioned medium(CM)from lung CAFs exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and *** exposure of CAFs to apoptotic 344SQ cells(ApoSQ)inhibited CAF migration and invasion and the expression of CAF activation *** secretion of Wnt‐induced signaling protein 1(WISP-1)by CAFs exposed to ApoSQ was required for these antimigratory and anti-invasive *** inhibition of Notch1 activation or siRNA-mediated Notch1 silencing prevented WISP-1 production by CAFs and reversed the antimigratory and anti-invasive *** expression of the Notch ligand delta-like protein 1 on the surface of ultraviolet-irradiated apoptotic lung cancer cells triggered Notch1-WISP-1 *** receptor brain-specific angiogenesis inhibitor 1(BAI1)-Rac1 signaling,which facilitated efferocytosis by CAFs,participated in crosstalk with Notch1 signaling for optimal production of *** addition,a single injection of ApoSQ enhanced WISP-1 production,suppressed the expression of CAF activation markers in isolated Thy1^(+)CAFs,and inhibited lung metastasis in syngeneic immunocompetent mice via Notch1 *** with CM from CAFs exposed to ApoSQ suppressed tumor growth and lung metastasis,whereas treatment with WISP-1-immunodepleted CM from CAFs exposed to ApoSQ reversed the antitumorigenic and antimetastatic ***,treatment with CM from CAFs exposed to apoptotic lung cancer cells could be therapeutically applied to suppress CAF activation,thereby preventing cancer progression and metastasis.

关键词： CAFs Apoptotic lung cancer cells Notch1 WiSP-1 Efferocytosis Migration Invasion Metastasis

Effect of organic mineral supplementation in reducing oxidative stress in Holstein calves during short‑term heat stress and recovery conditions

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Journal of Animal Science and Biotechnology 2024年第2期15卷 812-825页

作者： A-Rang Son Seon-Ho kim Mahfuzul Islam Michelle Miguel ye Pyae Naing Sang-Suk Lee Ruminant Nutrition and Anaerobe Laboratory Department of Animal Science and TechnologySunchon National UniversitySuncheon 57922Korea Department of Microbiology and Parasitology Sher-e-Bangla Agricultural UniversityDhaka 1207Bangladesh

Background This study investigated the effects of inorganic and organic minerals on physiological responses,oxidative stress reduction,and rumen microbiota in Holstein bull calves(123.81±9.76 kg;5 months old)during short-term heat stress(HS)and recovery *** Holstein calves were randomly assigned to four treatment groups:no mineral supplementation(Con),inorganic minerals(IM),organic minerals(OM),and high-concentration organic minerals(HOM)and two thermal environments(HS and recovery)using 4×2 factorial arrangement in a crossover design of four periods of 35 *** were maintained in a temperature-controlled *** experimental period consisted of 14 d of HS,14 d of recovery condititon,and a 7-d washing *** Body temperature and respiration rate were higher in HS than in the recovery conditions(Psol was 20.26 ng/mL in the HOM group,which was 5.60 ng/mL lower than in the control group(P0.05).The principal coordinate analysis represented that the overall rumen microbiota was not influenced by mineral supplementation;however,temperature-induced microbial structure shifts were indicated(PERMANOVA:P<0.05).At the phylum level,Firmicutes and Actinobacteria decreased,whereas Fibrobacteres,Spirochaetes,and Tenericutes increased(P<0.05),under HS *** genus Treponema increased under HS conditions,while Christensenella was higher in recovery conditions(P<0.05).Conc

关键词： Antioxidant status Heat stress Holstein bull calves Organic mineral supplementation Oxidative stress

HRNetO:Human Action Recognition Using Unified Deep Features Optimization Framework

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Computers, Materials & Continua 2023年第4期75卷 1089-1105页

作者： Tehseen Ahsan Sohail Khalid Shaheryar Najam Muhammad Attique Khan ye Jin kim Byoungchol Chang Department of Electrical Engineering Riphah International UniversityPeshawar Rdnear Hajj ComplexI-14IslamabadIslamabad Capital Territory46000Pakistan Departmnt of Computer Science HITEC UniversityTaxila47080Pakistan Department of Computer Science Hanyang UniversitySeoul04763Korea Center for Computational Social Science Hanyang UniversitySeoul04763Korea

Human action recognition(HAR)attempts to understand a subject’sbehavior and assign a label to each action *** is more appealingbecause it has a wide range of applications in computer vision,such asvideo surveillance and smart *** attempts have been made in theliterature to develop an effective and robust framework for ***,theprocess remains difficult and may result in reduced accuracy due to severalchallenges,such as similarity among actions,extraction of essential features,and reduction of irrelevant *** this work,we proposed an end-toendframework using deep learning and an improved tree seed optimizationalgorithm for accurate *** proposed design consists of a *** the first step,frame preprocessing is *** the second step,two pre-trained deep learning models are fine-tuned and trained throughdeep transfer learning using preprocessed video *** the next step,deeplearning features of both fine-tuned models are fused using a new ParallelStandard Deviation Padding Max Value *** fused features arefurther optimized using an improved tree seed algorithm,and select the bestfeatures are finally classified by using the machine learning *** was carried out on five publicly available datasets,including UTInteraction,Weizmann,KTH,Hollywood,and IXAMS,and achieved higheraccuracy than previous techniques.

关键词： Action recognition features fusion deep learning features selection

Highly impermeable and flexible silica encapsulation films synthesized by sol-gel process

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Nano Research 2022年第8期15卷 7476-7483页

作者： Si-Hoon kim Gyeong-Seok Hwang Donghwan Koo Dong-Hyun Seo ye-Pil Kwon Hansuek Lee Hyesung Park Eun-chae Jeon Ju-Young kim School of Materials Science and Engineering University of UlsanTechno saneop-ro 55beon-gil 12Ulsan 44776Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)UNIST-gil 50Ulsan 44919Republic of Korea Department of Physics Korea Advanced Institute of Science and Technology(KAIST)Daehak-ro 291Deajeon 34141Republic of Korea Graduate School of Semiconductor Materials and Devices Ulsan National Institute of Science and Technology(UNIST)UNIST-gil 50Ulsan 44919Republic of Korea

Silica thin films synthesized sol–gel process are proposed as flexible encapsulation materials.A sol–gel process provides a dense and stable amorphous silica structure,yielding an extremely high elastic deformation limit of 4.9%and extremely low water vapor transmission rate(WVTR)of 2.90×10^(−4)g/(m^(2)∙day)at 60℃and relative humidity of 85%.The WVTR is not degraded by cyclic bending deformations for the bending radius corresponding to a tensile strain of 3.3%in the silica encapsulation film,implying that the silica thin film is robust against the formation of pinhole-type defects by cyclic bending *** organic solar cells encapsulated with the silica films operate without degradation in power conversion efficiency for 50,000 bending cycles for a bending radius of 6 mm.

关键词： silica thin film sol-gel flexible encapsulation mechanical reliability flexible organic solar cell

Annexin A10 expression in colorectal cancers with emphasis on the serrated neoplasia pathway

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World Journal of Gastroenterology 2015年第33期21卷 9749-9757页

作者： Jeong Mo Bae Jung Ho kim ye-Young Rhee Nam-Yun Cho Tae-You kim Gyeong Hoon Kang Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of Medicine Department of Pathology Seoul National University College of Medicine Department of Internal Medicine Seoul National University College of Medicine

AIM: To validate the utility of Annexin A10 as a surrogate marker of the serrated neoplasia pathway in invasive colorectal cancers(CRCs).METHODS: A total of 1133 primary CRC patients who underwent surgical resection at Seoul National University Hospital between January 2004 and December 2007 were *** of Annexin A10 was evaluated by immunohistochemistry using tissue microarray and paired to our findings on clinicopathologic and molecular characteristics of each *** G island methylator phenotype was determined by Methy Light assay and microsatellite instability was determined by high performance liquid *** and BRAF mutation status was evaluated by direct sequencing and allele-specific *** and stage-specific survival analyses were performed to reveal the prognostic value of Annexin A10 ***: Annexin A10 expression was observed in 66(5.8%) of the 1133 *** A10 expression was more commonly found in females and was associated with proximal location,ulcerative gross type,advanced T category,N category and TNM *** with Annexin A10 expression showed an absence of luminal necrosis,luminal serration and mucin *** with Annexin A10 expression were associated with Cp G island methylator phenotype,microsatellite instability and BRAF *** survival analysis,Annexin A10 expression was associated with poor overall survival and progression-free survival,especially in stage Ⅳ ***: Annexin A10 expression is associated with poor clinical behavior and can be used a supportive surrogate marker of the serrated neoplasia pathway in invasive CRCs.

关键词： Annexin A10 Serrated neoplasia pathway CpG island

Secondary structure characterization of mixed food protein complexes using microfluidic modulation spectroscopy(MMS)

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Food Bioscience 2023年第3期53卷 351-358页

作者： Woojeong kim Yong Wang Maria Ma Qianyu ye Valerie Ivancic Collins Cordelia Selomulya School of Chemical Engineering UNSW SydneyNSW2052Australia Redshift BioAnalytics Inc.BoxboroughMA01719United States

Microfluidic modulation spectroscopy(MMS)has been recognised as a novel technology for producing high quality and reproducible data at a wide concentration range to characterise protein *** this study,the use of MMS for food applications was explored through the structural analysis of pea protein,whey protein,and pea/whey protein complexes prepared by transglutaminase *** generated reproducible data with>99.5%repeatability in all protein *** cross-linking seemed to alter the structure of whey protein with isopeptide and hydrogen bond formation,more significantly than that of pea *** larger secondary and tertiary structural changes were observed with higher whey protein content in cross-linked pea/whey protein complex,which eventually increased the surface *** to the second derivatives analysis by MMS,β-sheet and random coil increased andβ-turn decreased in the pea protein,whereasα-helix,β-sheet,andβ-turn decreased and random coil increased in the whey protein after *** the pea/whey protein complex,β-turn shifted toβ-sheet due to *** are some discrepancies between the relative secondary structure contents obtained from MMS data compared to the data acquired from circular ***,MMS has the considerable advantage of being able to directly measure original samples without significant dilution as required for circular dichroism *** study provides evidence that MMS technology could be a robust technique to quantify the secondary structures of typical proteins in food with high reliability.

关键词： Microfluidic modulation technology Enzymatic cross-linking Protein blends Pea protein Whey protein Secondary structure

Design of Mechanical Smoke Exhaust System in Large Space of Convention Center

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Open Journal of Fluid Dynamics 2017年第3期7卷 386-396页

作者： Jung-Yup kim Chan-sol Ahn Multi Disaster Countermeasures Organization Korea Institute of Civil Engineering and Building Technology Goyang Korea

The volumetric flow rate of smoke generated from the fire in large space often reaches to hundreds of thousands CMH because of extended floor height and as it’s more difficult to isolate the smoke to the limited area, comparing to normal-scale building, design and operation of effective smoke control system for large space is more than important. In this study, with the analysis model for such a large space as exhibition hall or conference room in conventional center, design of mechanical smoke exhaust system was conducted based on currently-available design standard which was then followed by numerical analysis of the design using 3D numerical analysis method. For conference room at 2.0 MW heat release rate, 99,173 CMH flow rate is required, if smoke layer is maintained at 60% of the floor height and for exhibition hall at 8.8 MW with 80% of floor height, flow rate required is 219,802 CMH, which are incorporated into the design. In view of 3D numerical analysis, accuracy of the design according to algebraic expression is sufficient.

关键词： Smoke Control Mechanical Exhaust System Large Space Convention Center Numerical Analysis