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Th1 cells inducing IFNγ response improves immunotherapy efficacy in gastric cancer

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Chinese Journal of Cancer Research 2023年第3期35卷 299-315页

作者： qi cao Ruidong Xue Ning Zhang Translational Cancer Research Center Peking University First HospitalBeijing 100034China International Cancer Institute Peking University Health Science CenterBeijing 100191China Yunnan Baiyao Group Kunming 650500China

Objective: Cancer immunotherapy has made remarkable advances in recent years, but its effectiveness in treating gastric cancer is often limited by the complexity of the tumor microenvironment and the lack of effective biomarkers. This study aimed to identify effective biomarkers for immunotherapy treatment by characterizing the tumor ***: We retrieved the RNA-seq data from gastric cancer patients treated with the programmed death 1(PD-1) blockade pembrolizumab. Differentially expressed genes associated with clinical outcomes were identified and further analyzed using gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis. Gene signature scores were calculated by single sample Gene Set Enrichment Analysis(ssGSEA). The infiltration levels of immune cells were quantified using the xCell website. Cell type enrichment analysis was performed to compare treatment response and non-response groups, and regression analysis was used to investigate the relationship between interferon gamma(IFNγ) immune response and immune cell infiltration. Biomarkers were identified using least absolute shrinkage and selection operator(LASSO) ***: Compared to normal tissues, cytokine activity and interleukin-6 production were highly activated in gastric tumors. Responders to pembrolizumab showed significantly up-regulated expression of IFNγ responserelated genes. Cell type enrichment analysis revealed that Th1 cells were significantly enriched in the tumor microenvironment of responders. Regression analysis indicated that Th1 cells induced IFNγ response more efficiently than other cell types. Using signatures of Th1 cells, stromal cells and IFNγ response, a set of eight genes were identified that effectively predicted the efficacy of immunotherapy treatment and patient ***: Th1 cells promote therapeutic efficacy of PD-1 blockade by promoting IFNγ immune response in gastric cancer. The identified biomarkers have t

关键词： Gastric cancer immunotherapy Th1 cells IFNγresponse biomarkers

Adsorption limitation investigation on olefins for Cu–BTC

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Friction 2024年第4期12卷 606-617页

作者： Xiao YANG Yunbo WANG Weihua cao Ruizheng JIANG Guoxin XIE Yuying cao Xiaowen qi School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China Key Laboratory of Self-Lubricating Spherical Plain Bearing Technology of Hebei Province Yanshan UniversityQinhuangdao 066004China State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Aviation Key Laboratory of Science and Technology on Generic Technology of Self-Lubricating Spherical Plain Bearing Yanshan UniversityQinhuangdao 066004China

To utilize Cu-benzene-1,3,5-tricarboxylate(Cu-BTC)adsorbed lubricant oils in the self-lubricating field,the adsorption properties of Cu-BTC on different 1-olefins must be *** this work,1-hexene,1-octene,1-nonene,1-decene,1-undecene,and 1-dodecene were studied by the Monte Carlo method and *** adsorption limit of Cu-BTC for n-olefins was determined as 1-undecene by the adsorption *** suggested a limit for even straight-chain molecules to the adsorption of *** maximum ratio of the olefin length of the largest pore diameter(L/D)of Cu-BTC was approximately ***,theoretical calculations(radial distribution function(RDF))and experiments(infrared(IR)spectra)confirmed the interaction of n-olefin adsorbates and the Cu-BTC framework occurred between the-CH=of olefins and the Cu and O atoms of the Cu-BTC *** work adds to the understanding and investigation of the adsorption of liquid lubricants using Cu-BTC as a metal-organic framework(MOF).

关键词： metal-organic framework(MOF) Cu-benzene-1,3,5-tricarboxylate(Cu-BTC) Monte Carlo method adsorption properties 1-olefins

Electrocatalytic Activity of Pt/C Electrodes for Ethanol Oxidation in Vapor Phase

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Chemical Research in Chinese Universities 2005年第5期21卷 597-600页

作者： LIANG Hong ye Dai-qi LIN Wei-ming School of Biological and Chemical Engineering Guangzhou University Guangzhou 510091 P. R. China School of Environment Science and Engineering South China University of Technology Guangzhou 510640 P. R. China

High performance platinized-carbon electrodes have been developed for the electrocatalytic oxidation of ethanol to acetaldehyde in electrogenerative processes. A load current density of the electrode can be achieved as high as 600 mA per square centimeter for oxygen reducing in 3 mol/L sulfuric acid with a good stability. With these electrodes and sulfuric acid as an electrolyte in fuel cells, ethanol vapor carried by nitrogen gas can be oxidized selectively to acetaldehyde. Selectivity of acetaldehyde depends on the potential of the cell and the feed rate of ethanol vapor and it can be more than 80% under optimized conditions. The initial product of ethanol oxidized on a platinized-carbon electrode is acetaldehyde and the ethanol oxidation mechanism is discussed.

关键词： Ethanol Platinum Electrocatalytic oxidation Acetaldehyde

A Novel Plane-Based Control Bus Design with Distributed Registers in 3D NAND Flash Memories

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Chinese Journal of Electronics 2022年第4期31卷 647-651页

作者： cao Huamin WANG qi LIU Fei HUO Zongliang Institute of Microelectronics Chinese Academy of Science College of Microelectronics University of Chinese Academy of Sciences Yangtze Memory Technologies Company Ltd.

This work presents a novel plane-based area-saving control bus design with distributed registers in 3D NAND flash memory. 99.47% control signal routing wires are reduced compared to the conventional control circuit design. Independent multi-plane read is compatible with the existing read operations thanks to the register addresses are reasonably assigned. Furthermore,power-saving register group address-based plane gating scheme is proposed which saves about 2.9 m W bus toggling power. A four-plane control bus design with 20Kbits registers has been demonstrated in field programmable gate array tester. The results show that the planebased control bus design is beneficial to high-performance3D NAND flash memory design.

关键词： Plane-based control bus design Distributed register Independent multi-plane read Plane gating 3D NAND flash memory

Immune Responses to Varicella-Zoster Virus Glycoprotein E Formulated with Poly(Lactic-co-Glycolic Acid) Nanoparticles and Nucleic Acid Adjuvants in Mice

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Virologica Sinica 2021年第1期36卷 122-132页

作者： Yunfei Wang Jialong qi Han cao Cunbao Liu Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650118China

The subunit herpes zoster vaccine Shingrix is superior to attenuated vaccine Zostavax in both safety and efficacy,yet its unlyophilizable liposome delivery system and the limited supply of naturally sourced immunological adjuvant QS-21 still need to be *** on poly(lactic-co-glycolic acid)(PLGA)delivery systems that are stable during the lyophilization and rehydration process and using a double-emulsion(w/o/w)solvent evaporation method,we designed a series of nanoparticles with varicella-zoster virus antigen glycoprotein E(VZV-g E)as an antigen and nucleic acids including polyinosinic-polycytidylic acid(Poly I:C)and phosphodiester Cp G oligodeoxynucleotide(Cp G ODN),encapsulated as immune *** cationic lipids(DOTAP)have more potential than neutral lipids(DOPC)for activating g E-specific cell-mediated immunity(CMI)in immunized mice,especially when g E is encapsulated in and presented on the surface of nanoparticles,PLGA particles without lipids have the greatest potential to induce not only the highest g Especific Ig G titers but also the strongest g E-specific CMI responses,including the highest proportions of interferon-c(IFNc)-and interleukin-2(IL-2)-producing CD4?/CD8?T cells according to a flow cytometry assay and the greatest numbers of IFN-c-and IL-2-producing splenocytes according to an enzyme-linked immunospot(ELISPOT)*** results showed that immune-stimulating nucleic acids together with the PLGA delivery system showed promise as a safe and economical varicella and zoster vaccine candidate.

关键词： Varicella-zoster virus subunit vaccine Cell-mediated immunity Nucleic acid immune stimulator Poly I:C CpG ODN PLGA Nanoparticle

Productive Traits and Triploid Rate Stability in Triploidy-Induced ‘Haida No. 2’ Strain of the Pacific Oyster, Crassostrea gigas

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Journal of Ocean University of China 2023年第1期22卷 229-234页

作者： LI Yongguo LI qi LIU ye XU Chengxun Key Laboratory of Mariculture Ministry of EducationOcean University of ChinaQingdao 266003China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

In order to evaluate the effects of triploidy induction on a selected strain‘Haida No.2’of the Pacific oyster Crassostrea gigas,which is characterized with golden shell color and high growth rate,the growth,survival rate and stability of triploid rate were analyzed at different development stages in the present *** different conditions inhibiting the release of polar body Ⅱ or polar body Ⅰ were tested:(A)Cytochalasin-B(CB),0.5mg L^(−1) at 10min post-insemination for 15 min;(B)CB,0.5mg L^(−1)at 15 min postinsemination for 20 min;and(C)CB,0.7mg L^(−1),at 15 min post-insemination for 20 *** triploidy induction treatments significantly reduced the D-larvae and survival rates at the larvae stage but not at the juvenile and adult *** rate dramatically decreased at the larval stage and did not significantly change at the juvenile and adult *** the stability of the triploid rate,there was a significant difference between the three treatment *** from the treatment A and control groups exhibited higher growth rates in shell height than those from the other two treatment groups at day *** juveniles and adults from the treatment A group exhibited a higher wet weight than diploids from the control group and triploids from the other treatment *** induction did not affect the shell color of the *** results obtained in the study demonstrate that triploidy induction has the potential to be used to increase the production of *** variety‘Haida No.2’without modifying its golden shell color.

关键词： Crassostrea gigas selective strain triploidy induction survival growth triploid rate stability

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Stabilization of an uncertain multiple-oscillator system

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Control Theory and Technology 2022年第3期20卷 361-370页

作者： Huawen ye Chengkun Li Xianting qi Jun Liu School of Automation Central South UniversityChangsha410083HunanChina

For a multiple-oscillator system that is subject to the uncertain gains ranging within compact sets,this paper presents a constructive stabilization *** by nested-saturation control methods,a nested controller that contains multiplicative coefficients is directly designed,and these coefficients are then determined in the stability *** skillfully making transformations,elaborately constructing Lyapunov functions,and using an M-matrix principle,the stability analysis leads to the explicit inequality condition that is expressed by directly using the system parameters.

关键词： Stabilization Uncertain multiple-oscillator systems M-matrix principle

Machine-Learning-Assisted Optimization and Its Application to Antenna Designs: Opportunities and Challenges

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China Communications 2020年第4期17卷 152-164页

作者： qi Wu Yi cao Haiming Wang Wei Hong State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 211111China Purple Mountain Laboratories Nanjing 211111China

With the rapid development of modern wireless communications and radar, antennas and arrays are becoming more complex, therein having, e.g., more degrees of design freedom, integration and fabrication constraints and design objectives. While fullwave electromagnetic simulation can be very accurate and therefore essential to the design process, it is also very time consuming, which leads to many challenges for antenna design, optimization and sensitivity analysis(SA). Recently, machine-learning-assisted optimization(MLAO) has been widely introduced to accelerate the design process of antennas and arrays. Machine learning(ML) methods, including Gaussian process regression, support vector machine(SVM) and artificial neural networks(ANNs), have been applied to build surrogate models of antennas to achieve fast response prediction. With the help of these ML methods, various MLAO algorithms have been proposed for different applications. A comprehensive survey of recent advances in ML methods for antenna modeling is first presented. Then, algorithms for ML-assisted antenna design, including optimization and SA, are reviewed. Finally, some challenges facing future MLAO for antenna design are discussed.

关键词： Antenna designs machine learning optimization sensitivity analysis surrogate models

Trapping photons with optical black hole

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Light(Science & Applications) 2023年第4期12卷 507-508页

作者： You-Ling Chen qi-Tao cao Yun-Feng Xiao State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Frontiers Science Center for Nano-optoelectronics&School of Physics Peking UniversityBeijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006 ShanxiChina

An optical black-hole cavity based on transformation optics enables Q-factor enhancement and strong field confinement,by eliminating the intrinsic radiation loss of the conventional whispering-gallery modes,holding po... 详细信息

关键词： optics eliminating enable